Details of the Target

General Information of Target

Target ID LDTP01205
Target Name Citrate synthase, mitochondrial (CS)
Gene Name CS
Gene ID 1431
Synonyms
Citrate synthase, mitochondrial; EC 2.3.3.1; Citrate; Si)-synthase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVV
GQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLF
WLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESN
FARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNF
TNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPL
HGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQ
REFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Citrate synthase family
Subcellular location
Mitochondrion matrix
TTD ID
T25690
Uniprot ID
O75390
DrugMap ID
TTZA6B3
Ensemble ID
ENST00000351328.8
HGNC ID
HGNC:2422
ChEMBL ID
CHEMBL4295678

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 54 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Hsieh_2
 Probe Info  		N.A.  LDD0425  [1]
A-EBA
 Probe Info  		3.79  LDD0215  [2]
CHEMBL5175495
 Probe Info  		7.17  LDD0196  [3]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
C-Sul
 Probe Info  		2.23  LDD0066  [5]
TH211
 Probe Info  		Y345(20.00); Y381(12.21); Y185(6.17)  LDD0257  [6]
TH214
 Probe Info  		Y381(20.00); Y345(6.10); Y185(6.01)  LDD0258  [6]
TH216
 Probe Info  		Y381(20.00); Y185(11.28)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
BTD
 Probe Info  		C211(5.44)  LDD1699  [8]
AZ-9
 Probe Info  		D330(10.00); E455(10.00)  LDD2209  [9]
OPA-S-S-alkyne
 Probe Info  		K327(0.33); K43(4.66); K76(5.03)  LDD3494  [10]
Probe 1
 Probe Info  		Y80(7.61); Y185(12.38); Y345(15.77); Y381(10,430.11)  LDD3495  [11]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [12]
AHL-Pu-1
 Probe Info  		C101(5.48)  LDD0169  [13]
DBIA
 Probe Info  		C101(4.94); C211(12.39)  LDD0209  [14]
HHS-482
 Probe Info  		Y185(0.50); Y345(1.05); Y381(0.79)  LDD0285  [15]
HHS-475
 Probe Info  		Y381(1.05)  LDD0264  [16]
5E-2FA
 Probe Info  		H163(0.00); H347(0.00)  LDD2235  [17]
ATP probe
 Probe Info  		K43(0.00); K103(0.00); K107(0.00); K459(0.00)  LDD0199  [18]
m-APA
 Probe Info  		H150(0.00); H238(0.00); H249(0.00); H163(0.00)  LDD2231  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C101(0.00); C211(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [20]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C101(0.00); C211(0.00)  LDD0037  [19]
Alkyne tyramide
 Probe Info  		Y185(0.00); Y345(0.00)  LDD0003  [22]
ATP probe
 Probe Info  		K382(0.00); K76(0.00)  LDD0035  [23]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [24]
TFBX
 Probe Info  		N.A.  LDD0027  [24]
WYneN
 Probe Info  		C211(0.00); C101(0.00)  LDD0021  [22]
WYneO
 Probe Info  		N.A.  LDD0022  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [25]
Compound 10
 Probe Info  		C101(0.00); C211(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		N.A.  LDD2213  [26]
ENE
 Probe Info  		N.A.  LDD0006  [22]
IPM
 Probe Info  		N.A.  LDD0005  [22]
NHS
 Probe Info  		K327(0.00); K76(0.00); K459(0.00); K43(0.00)  LDD0010  [22]
OSF
 Probe Info  		N.A.  LDD0029  [27]
PF-06672131
 Probe Info  		N.A.  LDD0152  [28]
SF
 Probe Info  		Y381(0.00); K382(0.00); Y345(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K76(0.00); K43(0.00)  LDD0009  [22]
Phosphinate-6
 Probe Info  		C101(0.00); C211(0.00); C359(0.00)  LDD0018  [29]
Ox-W18
 Probe Info  		W136(0.00); W236(0.00); W333(0.00); W438(0.00)  LDD2175  [30]
1c-yne
 Probe Info  		K76(0.00); K459(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		C101(0.00); C211(0.00)  LDD0217  [31]
Crotonaldehyde
 Probe Info  		H347(0.00); C101(0.00); C211(0.00)  LDD0219  [31]
Methacrolein
 Probe Info  		C101(0.00); C211(0.00)  LDD0218  [31]
W1
 Probe Info  		N.A.  LDD0236  [32]
MPP-AC
 Probe Info  		N.A.  LDD0428  [33]
NAIA_5
 Probe Info  		C101(0.00); C359(0.00); C211(0.00)  LDD2223  [34]
TER-AC
 Probe Info  		N.A.  LDD0426  [33]
TPP-AC
 Probe Info  		N.A.  LDD0427  [33]
HHS-465
 Probe Info  		K382(0.00); K459(0.00); K76(0.00); Y381(0.00)  LDD2240  [35]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
JN0003
 Probe Info  		5.09  LDD0469  [36]
STS-2
 Probe Info  		N.A.  LDD0138  [37]
CR-1
 Probe Info  		3.35  LDD0429  [38]
DA-2
 Probe Info  		N.A.  LDD0070  [39]
STS-1
 Probe Info  		N.A.  LDD0068  [40]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C211(0.96); C101(0.74)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C211(0.98); C101(0.57)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C211(0.97); C101(0.97)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C211(0.68); C101(0.62)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C211(1.11); C101(1.08)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C211(0.93); C101(1.28)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C101(0.50)  LDD2132  [8]
 LDCM0025  4SU-RNA DM93 C101(3.28)  LDD0170  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C101(5.48)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C211(1.07)  LDD0531  [41]
 LDCM0215  AC10 PaTu 8988t C101(0.47)  LDD1094  [41]
 LDCM0216  AC100 HCT 116 C101(0.95); C211(0.92)  LDD0533  [41]
 LDCM0217  AC101 HCT 116 C101(0.95); C211(1.07)  LDD0534  [41]
 LDCM0218  AC102 HCT 116 C101(0.89); C211(0.97)  LDD0535  [41]
 LDCM0219  AC103 HCT 116 C101(0.70); C211(1.13)  LDD0536  [41]
 LDCM0220  AC104 HCT 116 C101(0.83); C211(1.03)  LDD0537  [41]
 LDCM0221  AC105 HCT 116 C101(0.70); C211(1.06)  LDD0538  [41]
 LDCM0222  AC106 HCT 116 C101(0.80); C211(1.20)  LDD0539  [41]
 LDCM0223  AC107 HCT 116 C101(1.12); C211(1.03)  LDD0540  [41]
 LDCM0224  AC108 HCT 116 C101(0.84); C211(1.02)  LDD0541  [41]
 LDCM0225  AC109 HCT 116 C101(0.98); C211(1.03)  LDD0542  [41]
 LDCM0226  AC11 PaTu 8988t C101(0.58)  LDD1105  [41]
 LDCM0227  AC110 HCT 116 C101(0.98); C211(1.14)  LDD0544  [41]
 LDCM0228  AC111 HCT 116 C101(0.98); C211(1.09)  LDD0545  [41]
 LDCM0229  AC112 HCT 116 C101(0.96); C211(1.30)  LDD0546  [41]
 LDCM0230  AC113 HCT 116 C101(1.19); C211(0.84)  LDD0547  [41]
 LDCM0231  AC114 HCT 116 C101(1.11); C211(1.02)  LDD0548  [41]
 LDCM0232  AC115 HCT 116 C101(0.92); C211(1.07)  LDD0549  [41]
 LDCM0233  AC116 HCT 116 C101(1.02); C211(1.07)  LDD0550  [41]
 LDCM0234  AC117 HCT 116 C101(1.13); C211(0.94)  LDD0551  [41]
 LDCM0235  AC118 HCT 116 C101(1.17); C211(1.04)  LDD0552  [41]
 LDCM0236  AC119 HCT 116 C101(1.22); C211(0.95)  LDD0553  [41]
 LDCM0237  AC12 PaTu 8988t C101(0.61)  LDD1116  [41]
 LDCM0238  AC120 HCT 116 C101(1.07); C211(1.07)  LDD0555  [41]
 LDCM0239  AC121 HCT 116 C101(1.06); C211(0.90)  LDD0556  [41]
 LDCM0240  AC122 HCT 116 C101(1.18); C211(0.93)  LDD0557  [41]
 LDCM0241  AC123 HCT 116 C101(1.17); C211(0.94)  LDD0558  [41]
 LDCM0242  AC124 HCT 116 C101(1.15); C211(0.87)  LDD0559  [41]
 LDCM0243  AC125 HCT 116 C101(1.12); C211(0.98)  LDD0560  [41]
 LDCM0244  AC126 HCT 116 C101(0.83); C211(0.92)  LDD0561  [41]
 LDCM0245  AC127 HCT 116 C101(0.93); C211(0.92)  LDD0562  [41]
 LDCM0246  AC128 HCT 116 C211(0.29)  LDD0563  [41]
 LDCM0247  AC129 HCT 116 C211(1.37)  LDD0564  [41]
 LDCM0249  AC130 HCT 116 C211(0.76)  LDD0566  [41]
 LDCM0250  AC131 HCT 116 C211(1.16)  LDD0567  [41]
 LDCM0251  AC132 HCT 116 C211(1.27)  LDD0568  [41]
 LDCM0252  AC133 HCT 116 C211(0.77)  LDD0569  [41]
 LDCM0253  AC134 HCT 116 C211(0.64)  LDD0570  [41]
 LDCM0254  AC135 HCT 116 C211(0.61)  LDD0571  [41]
 LDCM0255  AC136 HCT 116 C211(0.85)  LDD0572  [41]
 LDCM0256  AC137 HCT 116 C211(1.13)  LDD0573  [41]
 LDCM0257  AC138 HCT 116 C211(0.84)  LDD0574  [41]
 LDCM0258  AC139 HCT 116 C211(0.94)  LDD0575  [41]
 LDCM0259  AC14 PaTu 8988t C101(1.20)  LDD1138  [41]
 LDCM0260  AC140 HCT 116 C211(0.72)  LDD0577  [41]
 LDCM0261  AC141 HCT 116 C211(1.02)  LDD0578  [41]
 LDCM0262  AC142 HCT 116 C211(1.42)  LDD0579  [41]
 LDCM0263  AC143 HCT 116 C101(1.05); C211(1.10)  LDD0580  [41]
 LDCM0264  AC144 HCT 116 C101(0.60); C211(0.87)  LDD0581  [41]
 LDCM0265  AC145 HCT 116 C211(0.97); C101(0.98)  LDD0582  [41]
 LDCM0266  AC146 HCT 116 C101(1.01); C211(1.12)  LDD0583  [41]
 LDCM0267  AC147 HCT 116 C101(0.43); C211(0.73)  LDD0584  [41]
 LDCM0268  AC148 HCT 116 C101(0.12); C211(1.27)  LDD0585  [41]
 LDCM0269  AC149 HCT 116 C101(0.40); C211(1.05)  LDD0586  [41]
 LDCM0270  AC15 PaTu 8988t C101(0.88)  LDD1149  [41]
 LDCM0271  AC150 HCT 116 C101(1.35); C211(1.48)  LDD0588  [41]
 LDCM0272  AC151 HCT 116 C101(1.20); C211(1.23)  LDD0589  [41]
 LDCM0273  AC152 HCT 116 C101(0.33); C211(0.80)  LDD0590  [41]
 LDCM0274  AC153 HCT 116 C101(0.09); C211(0.79)  LDD0591  [41]
 LDCM0621  AC154 HCT 116 C101(0.56); C211(0.79)  LDD2158  [41]
 LDCM0622  AC155 HCT 116 C101(0.69); C211(1.01)  LDD2159  [41]
 LDCM0623  AC156 HCT 116 C101(0.96); C211(1.04)  LDD2160  [41]
 LDCM0624  AC157 HCT 116 C101(0.83); C211(1.06)  LDD2161  [41]
 LDCM0276  AC17 HCT 116 C101(1.01); C211(1.09)  LDD0593  [41]
 LDCM0277  AC18 HCT 116 C211(0.86); C101(0.89)  LDD0594  [41]
 LDCM0278  AC19 HCT 116 C101(0.95); C211(1.03)  LDD0595  [41]
 LDCM0279  AC2 HCT 116 C211(1.12)  LDD0596  [41]
 LDCM0280  AC20 HCT 116 C211(1.02); C101(1.04)  LDD0597  [41]
 LDCM0281  AC21 HCT 116 C211(0.93); C101(1.09)  LDD0598  [41]
 LDCM0282  AC22 HCT 116 C211(0.94); C101(1.04)  LDD0599  [41]
 LDCM0283  AC23 HCT 116 C211(0.94); C101(0.99)  LDD0600  [41]
 LDCM0284  AC24 HCT 116 C211(1.01); C101(1.10)  LDD0601  [41]
 LDCM0285  AC25 HCT 116 C211(0.91)  LDD0602  [41]
 LDCM0286  AC26 HCT 116 C211(0.87)  LDD0603  [41]
 LDCM0287  AC27 HCT 116 C211(0.98)  LDD0604  [41]
 LDCM0288  AC28 HCT 116 C211(0.98)  LDD0605  [41]
 LDCM0289  AC29 HCT 116 C211(1.13)  LDD0606  [41]
 LDCM0290  AC3 HCT 116 C211(1.07)  LDD0607  [41]
 LDCM0291  AC30 HCT 116 C211(1.02)  LDD0608  [41]
 LDCM0292  AC31 HCT 116 C211(0.94)  LDD0609  [41]
 LDCM0293  AC32 HCT 116 C211(0.98)  LDD0610  [41]
 LDCM0294  AC33 HCT 116 C211(0.90)  LDD0611  [41]
 LDCM0295  AC34 HCT 116 C211(0.89)  LDD0612  [41]
 LDCM0296  AC35 HCT 116 C211(1.41); C101(1.98)  LDD0613  [41]
 LDCM0297  AC36 HCT 116 C211(1.53); C101(1.92)  LDD0614  [41]
 LDCM0298  AC37 HCT 116 C211(1.37); C101(1.80)  LDD0615  [41]
 LDCM0299  AC38 HCT 116 C211(1.33); C101(1.63)  LDD0616  [41]
 LDCM0300  AC39 HCT 116 C211(1.14); C101(1.31)  LDD0617  [41]
 LDCM0301  AC4 HCT 116 C211(1.00)  LDD0618  [41]
 LDCM0302  AC40 HCT 116 C101(0.50); C211(0.82)  LDD0619  [41]
 LDCM0303  AC41 HCT 116 C211(1.27); C101(1.39)  LDD0620  [41]
 LDCM0304  AC42 HCT 116 C101(0.94); C211(1.05)  LDD0621  [41]
 LDCM0305  AC43 HCT 116 C211(1.34); C101(1.49)  LDD0622  [41]
 LDCM0306  AC44 HCT 116 C101(0.84); C211(0.96)  LDD0623  [41]
 LDCM0307  AC45 HCT 116 C101(0.52); C211(0.81)  LDD0624  [41]
 LDCM0308  AC46 HCT 116 C101(0.95); C211(1.08)  LDD0625  [41]
 LDCM0309  AC47 HCT 116 C211(0.93); C101(0.97)  LDD0626  [41]
 LDCM0310  AC48 HCT 116 C101(0.92); C211(1.22)  LDD0627  [41]
 LDCM0311  AC49 HCT 116 C211(0.64); C101(1.03)  LDD0628  [41]
 LDCM0312  AC5 HCT 116 C211(0.97)  LDD0629  [41]
 LDCM0313  AC50 HCT 116 C211(0.66); C101(0.87)  LDD0630  [41]
 LDCM0314  AC51 HCT 116 C101(0.88); C211(1.32)  LDD0631  [41]
 LDCM0315  AC52 HCT 116 C101(0.96); C211(1.03)  LDD0632  [41]
 LDCM0316  AC53 HCT 116 C211(0.80); C101(0.94)  LDD0633  [41]
 LDCM0317  AC54 HCT 116 C211(0.67); C101(0.87)  LDD0634  [41]
 LDCM0318  AC55 HCT 116 C211(0.66); C101(1.25)  LDD0635  [41]
 LDCM0319  AC56 HCT 116 C211(0.55); C101(1.17)  LDD0636  [41]
 LDCM0320  AC57 HCT 116 C101(0.77); C211(0.85)  LDD0637  [41]
 LDCM0321  AC58 HCT 116 C101(0.75); C211(0.82)  LDD0638  [41]
 LDCM0322  AC59 HCT 116 C101(0.64); C211(0.67)  LDD0639  [41]
 LDCM0323  AC6 PaTu 8988t C101(1.18)  LDD1202  [41]
 LDCM0324  AC60 HCT 116 C211(1.08); C101(1.09)  LDD0641  [41]
 LDCM0325  AC61 HCT 116 C211(1.24); C101(1.33)  LDD0642  [41]
 LDCM0326  AC62 HCT 116 C101(0.65); C211(0.72)  LDD0643  [41]
 LDCM0327  AC63 HCT 116 C101(0.92); C211(1.06)  LDD0644  [41]
 LDCM0328  AC64 HCT 116 C211(0.79); C101(0.87)  LDD0645  [41]
 LDCM0329  AC65 HCT 116 C101(0.84); C211(0.93)  LDD0646  [41]
 LDCM0330  AC66 HCT 116 C101(0.92); C211(0.99)  LDD0647  [41]
 LDCM0331  AC67 HCT 116 C101(0.63); C211(0.68)  LDD0648  [41]
 LDCM0332  AC68 HCT 116 C211(0.73)  LDD0649  [41]
 LDCM0333  AC69 HCT 116 C211(0.72)  LDD0650  [41]
 LDCM0334  AC7 PaTu 8988t C101(0.97)  LDD1213  [41]
 LDCM0335  AC70 HCT 116 C211(0.25)  LDD0652  [41]
 LDCM0336  AC71 HCT 116 C211(1.07)  LDD0653  [41]
 LDCM0337  AC72 HCT 116 C211(0.58)  LDD0654  [41]
 LDCM0338  AC73 HCT 116 C211(0.15)  LDD0655  [41]
 LDCM0339  AC74 HCT 116 C211(0.20)  LDD0656  [41]
 LDCM0340  AC75 HCT 116 C211(0.11)  LDD0657  [41]
 LDCM0341  AC76 HCT 116 C211(0.39)  LDD0658  [41]
 LDCM0342  AC77 HCT 116 C211(0.41)  LDD0659  [41]
 LDCM0343  AC78 HCT 116 C211(1.36)  LDD0660  [41]
 LDCM0344  AC79 HCT 116 C211(0.91)  LDD0661  [41]
 LDCM0345  AC8 PaTu 8988t C101(1.18)  LDD1224  [41]
 LDCM0346  AC80 HCT 116 C211(0.47)  LDD0663  [41]
 LDCM0347  AC81 HCT 116 C211(1.03)  LDD0664  [41]
 LDCM0348  AC82 HCT 116 C211(0.11)  LDD0665  [41]
 LDCM0349  AC83 HCT 116 C211(0.75); C101(1.17)  LDD0666  [41]
 LDCM0350  AC84 HCT 116 C211(0.80); C101(1.24)  LDD0667  [41]
 LDCM0351  AC85 HCT 116 C101(1.19); C211(1.24)  LDD0668  [41]
 LDCM0352  AC86 HCT 116 C101(1.10); C211(1.14)  LDD0669  [41]
 LDCM0353  AC87 HCT 116 C211(1.03); C101(1.04)  LDD0670  [41]
 LDCM0354  AC88 HCT 116 C211(1.02); C101(1.08)  LDD0671  [41]
 LDCM0355  AC89 HCT 116 C211(0.95); C101(1.16)  LDD0672  [41]
 LDCM0357  AC90 HCT 116 C101(1.15); C211(1.24)  LDD0674  [41]
 LDCM0358  AC91 HCT 116 C211(0.73); C101(1.23)  LDD0675  [41]
 LDCM0359  AC92 HCT 116 C211(0.74); C101(0.79)  LDD0676  [41]
 LDCM0360  AC93 HCT 116 C101(0.88); C211(1.06)  LDD0677  [41]
 LDCM0361  AC94 HCT 116 C211(1.19); C101(1.42)  LDD0678  [41]
 LDCM0362  AC95 HCT 116 C211(1.09); C101(1.16)  LDD0679  [41]
 LDCM0363  AC96 HCT 116 C211(1.01); C101(1.13)  LDD0680  [41]
 LDCM0364  AC97 HCT 116 C211(1.02); C101(1.33)  LDD0681  [41]
 LDCM0365  AC98 HCT 116 C101(0.60); C211(1.14)  LDD0682  [41]
 LDCM0366  AC99 HCT 116 C101(1.04); C211(1.16)  LDD0683  [41]
 LDCM0545  Acetamide MDA-MB-231 C211(0.38); C101(0.49)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C211(0.73); C101(0.69)  LDD2113  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C101(1.41)  LDD1127  [41]
 LDCM0356  AKOS034007680 PaTu 8988t C101(0.20)  LDD1235  [41]
 LDCM0275  AKOS034007705 PaTu 8988t C101(0.38)  LDD1154  [41]
 LDCM0020  ARS-1620 HCC44 C101(1.04); C211(1.04)  LDD2171  [41]
 LDCM0498  BS-3668 MDA-MB-231 C211(0.50)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C101(0.00); C211(0.00); H367(0.00)  LDD0222  [31]
 LDCM0367  CL1 HCT 116 C211(1.29)  LDD0684  [41]
 LDCM0368  CL10 HCT 116 C211(1.33)  LDD0685  [41]
 LDCM0369  CL100 HCT 116 C211(1.08)  LDD0686  [41]
 LDCM0370  CL101 PaTu 8988t C101(0.88)  LDD1249  [41]
 LDCM0371  CL102 PaTu 8988t C101(0.60)  LDD1250  [41]
 LDCM0372  CL103 PaTu 8988t C101(0.70)  LDD1251  [41]
 LDCM0373  CL104 PaTu 8988t C101(0.85)  LDD1252  [41]
 LDCM0374  CL105 HCT 116 C211(1.08); C101(1.15)  LDD0691  [41]
 LDCM0375  CL106 HCT 116 C211(0.85); C101(1.03)  LDD0692  [41]
 LDCM0376  CL107 HCT 116 C211(0.75); C101(0.96)  LDD0693  [41]
 LDCM0377  CL108 HCT 116 C211(0.73); C101(0.78)  LDD0694  [41]
 LDCM0378  CL109 HCT 116 C101(1.10); C211(1.15)  LDD0695  [41]
 LDCM0379  CL11 HCT 116 C211(1.40)  LDD0696  [41]
 LDCM0380  CL110 HCT 116 C101(1.00); C211(1.18)  LDD0697  [41]
 LDCM0381  CL111 HCT 116 C101(1.07); C211(1.22)  LDD0698  [41]
 LDCM0382  CL112 HCT 116 C211(1.09)  LDD0699  [41]
 LDCM0383  CL113 HCT 116 C211(0.96)  LDD0700  [41]
 LDCM0384  CL114 HCT 116 C211(1.33)  LDD0701  [41]
 LDCM0385  CL115 HCT 116 C211(1.01)  LDD0702  [41]
 LDCM0386  CL116 HCT 116 C211(0.97)  LDD0703  [41]
 LDCM0387  CL117 HCT 116 C101(0.19); C211(0.70)  LDD0704  [41]
 LDCM0388  CL118 HCT 116 C101(0.96); C211(1.34)  LDD0705  [41]
 LDCM0389  CL119 HCT 116 C101(0.80); C211(0.99)  LDD0706  [41]
 LDCM0390  CL12 HCT 116 C211(1.14)  LDD0707  [41]
 LDCM0391  CL120 HCT 116 C211(1.23); C101(1.42)  LDD0708  [41]
 LDCM0392  CL121 HCT 116 C211(0.85); C101(1.28)  LDD0709  [41]
 LDCM0393  CL122 HCT 116 C101(1.03); C211(1.31)  LDD0710  [41]
 LDCM0394  CL123 HCT 116 C101(0.97); C211(1.27)  LDD0711  [41]
 LDCM0395  CL124 HCT 116 C211(0.91); C101(1.18)  LDD0712  [41]
 LDCM0396  CL125 HCT 116 C211(1.14); C101(1.21)  LDD0713  [41]
 LDCM0397  CL126 HCT 116 C211(1.13); C101(1.19)  LDD0714  [41]
 LDCM0398  CL127 HCT 116 C101(0.98); C211(1.15)  LDD0715  [41]
 LDCM0399  CL128 HCT 116 C101(0.69); C211(0.76)  LDD0716  [41]
 LDCM0400  CL13 HCT 116 C211(1.12)  LDD0717  [41]
 LDCM0401  CL14 HCT 116 C211(1.22)  LDD0718  [41]
 LDCM0402  CL15 HCT 116 C211(1.46)  LDD0719  [41]
 LDCM0403  CL16 HCT 116 C211(0.91)  LDD0720  [41]
 LDCM0404  CL17 HCT 116 C211(1.66)  LDD0721  [41]
 LDCM0405  CL18 HCT 116 C211(1.36)  LDD0722  [41]
 LDCM0406  CL19 HCT 116 C211(1.01)  LDD0723  [41]
 LDCM0407  CL2 HCT 116 C211(1.14)  LDD0724  [41]
 LDCM0408  CL20 HCT 116 C211(0.76)  LDD0725  [41]
 LDCM0409  CL21 HCT 116 C211(0.86)  LDD0726  [41]
 LDCM0410  CL22 HCT 116 C211(0.55)  LDD0727  [41]
 LDCM0411  CL23 HCT 116 C211(1.24)  LDD0728  [41]
 LDCM0412  CL24 HCT 116 C211(0.62)  LDD0729  [41]
 LDCM0413  CL25 HCT 116 C211(0.87)  LDD0730  [41]
 LDCM0414  CL26 HCT 116 C211(0.89)  LDD0731  [41]
 LDCM0415  CL27 HCT 116 C211(0.83)  LDD0732  [41]
 LDCM0416  CL28 HCT 116 C211(0.82)  LDD0733  [41]
 LDCM0417  CL29 HCT 116 C211(0.77)  LDD0734  [41]
 LDCM0418  CL3 HCT 116 C211(0.99)  LDD0735  [41]
 LDCM0419  CL30 HCT 116 C211(1.12)  LDD0736  [41]
 LDCM0420  CL31 HCT 116 C211(1.05)  LDD0737  [41]
 LDCM0421  CL32 HCT 116 C211(1.20)  LDD0738  [41]
 LDCM0422  CL33 HCT 116 C211(1.42)  LDD0739  [41]
 LDCM0423  CL34 HCT 116 C211(0.81)  LDD0740  [41]
 LDCM0424  CL35 HCT 116 C211(0.69)  LDD0741  [41]
 LDCM0425  CL36 HCT 116 C211(0.78)  LDD0742  [41]
 LDCM0426  CL37 HCT 116 C211(0.60)  LDD0743  [41]
 LDCM0428  CL39 HCT 116 C211(0.73)  LDD0745  [41]
 LDCM0429  CL4 HCT 116 C211(1.29)  LDD0746  [41]
 LDCM0430  CL40 HCT 116 C211(0.93)  LDD0747  [41]
 LDCM0431  CL41 HCT 116 C211(0.90)  LDD0748  [41]
 LDCM0432  CL42 HCT 116 C211(0.62)  LDD0749  [41]
 LDCM0433  CL43 HCT 116 C211(0.69)  LDD0750  [41]
 LDCM0434  CL44 HCT 116 C211(0.99)  LDD0751  [41]
 LDCM0435  CL45 HCT 116 C211(1.02)  LDD0752  [41]
 LDCM0436  CL46 HCT 116 C101(1.23); C211(1.17)  LDD0753  [41]
 LDCM0437  CL47 HCT 116 C101(1.09); C211(0.95)  LDD0754  [41]
 LDCM0438  CL48 HCT 116 C101(1.12); C211(1.09)  LDD0755  [41]
 LDCM0439  CL49 HCT 116 C101(1.03); C211(0.94)  LDD0756  [41]
 LDCM0440  CL5 HCT 116 C211(0.91)  LDD0757  [41]
 LDCM0441  CL50 HCT 116 C101(1.10); C211(1.09)  LDD0758  [41]
 LDCM0442  CL51 HCT 116 C101(1.21); C211(1.22)  LDD0759  [41]
 LDCM0443  CL52 HCT 116 C101(1.11); C211(1.08)  LDD0760  [41]
 LDCM0444  CL53 HCT 116 C101(1.12); C211(1.11)  LDD0761  [41]
 LDCM0445  CL54 HCT 116 C101(0.98); C211(1.32)  LDD0762  [41]
 LDCM0446  CL55 HCT 116 C101(1.16); C211(0.99)  LDD0763  [41]
 LDCM0447  CL56 HCT 116 C101(1.00); C211(0.93)  LDD0764  [41]
 LDCM0448  CL57 HCT 116 C101(1.23); C211(1.14)  LDD0765  [41]
 LDCM0449  CL58 HCT 116 C101(1.15); C211(0.93)  LDD0766  [41]
 LDCM0450  CL59 HCT 116 C101(1.09); C211(0.97)  LDD0767  [41]
 LDCM0451  CL6 HCT 116 C211(1.30)  LDD0768  [41]
 LDCM0452  CL60 HCT 116 C101(1.20); C211(1.16)  LDD0769  [41]
 LDCM0453  CL61 HCT 116 C211(1.12)  LDD0770  [41]
 LDCM0454  CL62 HCT 116 C211(1.19)  LDD0771  [41]
 LDCM0455  CL63 HCT 116 C211(1.32)  LDD0772  [41]
 LDCM0456  CL64 HCT 116 C211(0.95)  LDD0773  [41]
 LDCM0457  CL65 HCT 116 C211(1.08)  LDD0774  [41]
 LDCM0458  CL66 HCT 116 C211(0.82)  LDD0775  [41]
 LDCM0459  CL67 HCT 116 C211(0.88)  LDD0776  [41]
 LDCM0460  CL68 HCT 116 C211(1.29)  LDD0777  [41]
 LDCM0461  CL69 HCT 116 C211(1.48)  LDD0778  [41]
 LDCM0462  CL7 HCT 116 C211(1.09)  LDD0779  [41]
 LDCM0463  CL70 HCT 116 C211(1.25)  LDD0780  [41]
 LDCM0464  CL71 HCT 116 C211(1.04)  LDD0781  [41]
 LDCM0465  CL72 HCT 116 C211(1.12)  LDD0782  [41]
 LDCM0466  CL73 HCT 116 C211(1.29)  LDD0783  [41]
 LDCM0467  CL74 HCT 116 C211(1.01)  LDD0784  [41]
 LDCM0469  CL76 HCT 116 C101(0.96); C211(1.23)  LDD0786  [41]
 LDCM0470  CL77 HCT 116 C101(0.86); C211(1.09)  LDD0787  [41]
 LDCM0471  CL78 HCT 116 C101(0.72); C211(0.89)  LDD0788  [41]
 LDCM0472  CL79 HCT 116 C101(0.30); C211(0.43)  LDD0789  [41]
 LDCM0473  CL8 HCT 116 C211(1.61)  LDD0790  [41]
 LDCM0474  CL80 HCT 116 C101(1.28); C211(1.26)  LDD0791  [41]
 LDCM0475  CL81 HCT 116 C101(0.65); C211(0.85)  LDD0792  [41]
 LDCM0476  CL82 HCT 116 C101(0.17); C211(0.24)  LDD0793  [41]
 LDCM0477  CL83 HCT 116 C101(0.25); C211(0.37)  LDD0794  [41]
 LDCM0478  CL84 HCT 116 C101(0.10); C211(0.16)  LDD0795  [41]
 LDCM0479  CL85 HCT 116 C101(0.73); C211(1.11)  LDD0796  [41]
 LDCM0480  CL86 HCT 116 C101(1.27); C211(2.06)  LDD0797  [41]
 LDCM0481  CL87 HCT 116 C101(0.70); C211(1.03)  LDD0798  [41]
 LDCM0482  CL88 HCT 116 C101(0.25); C211(0.36)  LDD0799  [41]
 LDCM0483  CL89 HCT 116 C101(0.08); C211(0.13)  LDD0800  [41]
 LDCM0484  CL9 HCT 116 C211(1.24)  LDD0801  [41]
 LDCM0485  CL90 HCT 116 C101(0.98); C211(1.58)  LDD0802  [41]
 LDCM0486  CL91 HCT 116 C211(0.97)  LDD0803  [41]
 LDCM0487  CL92 HCT 116 C211(1.40)  LDD0804  [41]
 LDCM0488  CL93 HCT 116 C211(1.25)  LDD0805  [41]
 LDCM0489  CL94 HCT 116 C211(1.15)  LDD0806  [41]
 LDCM0490  CL95 HCT 116 C211(1.40)  LDD0807  [41]
 LDCM0491  CL96 HCT 116 C211(1.21)  LDD0808  [41]
 LDCM0492  CL97 HCT 116 C211(1.36)  LDD0809  [41]
 LDCM0493  CL98 HCT 116 C211(1.16)  LDD0810  [41]
 LDCM0494  CL99 HCT 116 C211(1.05)  LDD0811  [41]
 LDCM0168  Crenolanib NCI-H1703 3.35  LDD0429  [38]
 LDCM0495  E2913 HEK-293T C211(0.98); C101(0.93)  LDD1698  [42]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C211(4.88); C101(2.34)  LDD1702  [8]
 LDCM0625  F8 Ramos C211(0.81); C101(0.78)  LDD2187  [43]
 LDCM0572  Fragment10 Ramos C211(0.58); C101(0.55)  LDD2189  [43]
 LDCM0573  Fragment11 Ramos C211(0.74); C101(0.04)  LDD2190  [43]
 LDCM0574  Fragment12 Ramos C211(0.54); C101(0.52)  LDD2191  [43]
 LDCM0575  Fragment13 Ramos C211(0.79); C101(0.95)  LDD2192  [43]
 LDCM0576  Fragment14 Ramos C211(0.92); C101(1.35)  LDD2193  [43]
 LDCM0579  Fragment20 Ramos C211(0.41); C101(0.47)  LDD2194  [43]
 LDCM0580  Fragment21 Ramos C211(0.69); C101(0.93)  LDD2195  [43]
 LDCM0582  Fragment23 Ramos C211(1.08); C101(1.06)  LDD2196  [43]
 LDCM0578  Fragment27 Ramos C211(0.66); C101(1.06)  LDD2197  [43]
 LDCM0586  Fragment28 Ramos C211(0.79); C101(1.30)  LDD2198  [43]
 LDCM0588  Fragment30 Ramos C211(0.93); C101(1.05)  LDD2199  [43]
 LDCM0589  Fragment31 Ramos C211(1.04); C101(0.98)  LDD2200  [43]
 LDCM0590  Fragment32 Ramos C211(0.47); C101(0.52)  LDD2201  [43]
 LDCM0468  Fragment33 HCT 116 C211(1.14)  LDD0785  [41]
 LDCM0596  Fragment38 Ramos C211(0.77); C101(1.77)  LDD2203  [43]
 LDCM0566  Fragment4 Ramos C211(0.62); C101(0.83)  LDD2184  [43]
 LDCM0427  Fragment51 HCT 116 C211(0.64)  LDD0744  [41]
 LDCM0610  Fragment52 Ramos C211(1.22); C101(1.56)  LDD2204  [43]
 LDCM0614  Fragment56 Ramos C211(0.98); C101(1.31)  LDD2205  [43]
 LDCM0569  Fragment7 Ramos C211(0.62); C101(0.66)  LDD2186  [43]
 LDCM0571  Fragment9 Ramos C211(0.45); C101(0.40)  LDD2188  [43]
 LDCM0116  HHS-0101 DM93 Y381(1.05)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y381(1.08)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y381(0.78)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y381(1.13)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y381(1.39)  LDD0268  [16]
 LDCM0107  IAA HeLa C101(0.00); H347(0.00); H367(0.00); C211(0.00)  LDD0221  [31]
 LDCM0123  JWB131 DM93 Y185(0.50); Y345(1.05); Y381(0.79)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y185(2.03); Y345(0.73); Y381(0.73)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y185(0.74); Y345(1.00); Y381(0.97)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y185(1.19); Y345(4.75); Y381(2.70)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y345(2.57); Y381(1.75)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y185(0.26); Y345(1.54); Y381(1.09)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y185(0.63); Y345(0.98); Y381(0.49)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y345(1.27); Y381(0.97)  LDD0292  [15]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [12]
 LDCM0022  KB02 HEK-293T C211(1.01); C101(1.00)  LDD1492  [42]
 LDCM0023  KB03 Jurkat C101(4.94); C211(12.39)  LDD0209  [14]
 LDCM0024  KB05 COLO792 C101(1.18)  LDD3310  [44]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C101(1.30)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C101(0.58)  LDD2121  [8]
 LDCM0109  NEM HeLa H347(0.00); H367(0.00); C101(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C211(0.55)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C101(1.32)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C211(1.01); C101(0.96)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C211(1.12); C101(1.13)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C211(1.10)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C211(0.88)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C211(0.78); C101(0.63)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C211(1.03)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C211(0.79); C101(0.66)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C211(0.87)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C211(1.23); C101(1.39)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C211(0.74)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C101(1.56)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C211(0.70)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C211(0.71); C101(0.59)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C211(0.86); C101(0.50)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C211(0.66); C101(0.60)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C211(1.08)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C211(0.83); C101(0.74)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C211(0.73)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C211(0.63)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C211(1.00)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C211(1.20); C101(0.59)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C211(2.75); C101(2.14)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C211(0.89); C101(0.73)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C211(0.94); C101(0.26)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C211(0.81); C101(0.67)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C211(0.91)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C211(0.72); C101(0.68)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C211(1.11); C101(0.38)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C211(0.74); C101(0.64)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C211(0.90); C101(1.17)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C211(0.90); C101(0.79)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C211(0.79)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C211(0.55); C101(0.44)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C211(1.04); C101(1.03)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C211(0.87); C101(0.83)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C211(0.91)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C211(1.69); C101(1.27)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C211(0.62); C101(0.60)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C211(0.60); C101(0.71)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C211(1.01); C101(0.99)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C211(3.92); C101(3.40)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C211(1.01)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C211(0.75); C101(0.73)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C211(3.18); C101(3.39)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C211(0.68); C101(0.56)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C211(1.26)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C211(0.47)  LDD2150  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C211(0.12)  LDD2207  [45]
 LDCM0131  RA190 MM1.R C101(1.34); C211(1.11)  LDD0304  [46]
 LDCM0021  THZ1 HCT 116 C101(1.04); C211(1.04)  LDD2173  [41]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Citric Acid Small molecular drug DB04272
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Coenzyme A Small molecular drug DB01992
Alpha-fluoro-carboxymethyldethia Coenzyme A Complex . DB03182
D-malic Acid . DB03499
Nitromethyldethia Coenzyme A . DB04230
Oxaloacetate Ion . DB02637
Trifluoroacetonyl Coenzyme A . DB01969

References

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Mass spectrometry data entry: PXD037665
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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