General Information of Experiment

Probe Name Hsieh_2  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lung
Disease Model Lung adenocarcinoma [ICD-11:2C25]
Model Name Human lung adenocarcinoma cells (PC-9)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name
 LDTP02159  Alpha-enolase (ENO1)
 LDTP04561  ATP-citrate synthase (ACLY)
 LDTP01205  Citrate synthase, mitochondrial (CS)
 LDTP01766  L-lactate dehydrogenase A chain (LDHA)
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2)
 LDTP06848  Malonate--CoA ligase ACSF3, mitochondrial (ACSF3)
 LDTP06638  Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
 LDTP01787  Phosphoglycerate kinase 1 (PGK1)
 LDTP02733  Pyruvate kinase PKM (PKM)

References

1 Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors. J Med Chem. 2019 Sep 26;62(18):8497-8510. doi: 10.1021/acs.jmedchem.9b00763. Epub 2019 Sep 16.