Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | CR-1 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | 1 uM | |||||
| Criteria | Quantification: Probe vs (Probe+Competitor) | |||||
| Quantitative Method |
SILAC
|
|||||
| Competitor Name | Crenolanib | Competitor Info | ||||
| Competitor Concentration | 10 uM | |||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Lung | ||||
| Disease Model | Lung squamous cell carcinoma [ICD-11:2C25] | |||||
| Model Name | Human lung squamous cell carcinoma cells (NCI-H1703) | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP04884 | Proteasome subunit alpha type-6 (PSMA6) | 4.5 | ||||
| LDTP05029 | Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) | 3.5 | ||||
| LDTP03445 | Mitogen-activated protein kinase 1 (MAPK1) | 3.5 | ||||
| LDTP01205 | Citrate synthase, mitochondrial (CS) | 3.3 | ||||
| LDTP03689 | Serine hydroxymethyltransferase, mitochondrial (SHMT2) | 3.2 | ||||
| LDTP10159 | Pyrroline-5-carboxylate reductase 2 (PYCR2) | 3.1 | ||||
| LDTP02677 | Protein disulfide-isomerase A4 (PDIA4) | 2.6 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP01477 | AP-2 complex subunit alpha-2 (AP2A2) | 3.2 | ||||
| LDTP03385 | 14-3-3 protein theta (YWHAQ) | 3.0 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03346 | Moesin (MSN) | 4.6 | ||||
| LDTP08760 | Cell cycle and apoptosis regulator protein 2 (CCAR2) | 3.2 | ||||
| LDTP04108 | Large ribosomal subunit protein eL28 (RPL28) | 3.2 | ||||
| LDTP13797 | HIG1 domain family member 1A, mitochondrial (HIGD1A) | 3.1 | ||||
| LDTP02845 | Histone H1.2 (H1-2) | 3.0 | ||||
| LDTP03244 | Cofilin-1 (CFL1) | 2.6 | ||||