Details of the Target

General Information of Target

Target ID LDTP02845
Target Name Histone H1.2 (H1-2)
Gene Name H1-2
Gene ID 3006
Synonyms
H1F2; HIST1H1C; Histone H1.2; Histone H1c; Histone H1d; Histone H1s-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLA
ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKV
KKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVA
KPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK
Target Bioclass
Other
Family
Histone H1/H5 family
Subcellular location
Nucleus
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Uniprot ID
P16403
Ensemble ID
ENST00000343677.4
HGNC ID
HGNC:4716

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		2.62  LDD0448  [1]
P2
 Probe Info  		5.85  LDD0449  [1]
P3
 Probe Info  		2.08  LDD0450  [1]
P8
 Probe Info  		2.37  LDD0451  [1]
C-Sul
 Probe Info  		5.39  LDD0066  [2]
AZ-9
 Probe Info  		D72(0.95); E42(10.00); E74(10.00)  LDD2208  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
AF-1
 Probe Info  		3.58  LDD0421  [5]
W1
 Probe Info  		R54(0.58)  LDD0237  [6]
ATP probe
 Probe Info  		K140(0.00); K148(0.00); K149(0.00); K168(0.00)  LDD0199  [7]
aONE
 Probe Info  		N.A.  LDD0002  [8]
NHS
 Probe Info  		K34(0.00); K97(0.00); K75(0.00); K46(0.00)  LDD0010  [8]
SF
 Probe Info  		K196(0.00); K63(0.00); K106(0.00); K129(0.00)  LDD0028  [9]
STPyne
 Probe Info  		K106(0.00); K46(0.00); K129(0.00); K90(0.00)  LDD0009  [8]
1c-yne
 Probe Info  		K17(0.00); K97(0.00); K34(0.00); K46(0.00)  LDD0228  [10]
MPP-AC
 Probe Info  		N.A.  LDD0428  [11]
TER-AC
 Probe Info  		N.A.  LDD0426  [11]
TPP-AC
 Probe Info  		N.A.  LDD0427  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
JN0003
 Probe Info  		6.62  LDD0469  [12]
CR-1
 Probe Info  		3.03  LDD0429  [13]
Diazir
 Probe Info  		E3(0.00); E16(0.00)  LDD0011  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0166  Afatinib A431 3.58  LDD0421  [5]
 LDCM0168  Crenolanib NCI-H1703 3.03  LDD0429  [13]
 LDCM0110  W12 Hep-G2 R54(0.58)  LDD0237  [6]
 LDCM0112  W16 Hep-G2 E53(0.72); R54(0.72); K63(0.75)  LDD0239  [6]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Crenolanib-Derived Probes Suitable for Cell- and Tissue-Based Protein Profiling and Single-Cell Imaging. Chembiochem. 2019 Jul 15;20(14):1783-1788. doi: 10.1002/cbic.201900067. Epub 2019 Jul 3.