Details of the Target

General Information of Target

Target ID LDTP04108
Target Name Large ribosomal subunit protein eL28 (RPL28)
Gene Name RPL28
Gene ID 6158
Synonyms
Large ribosomal subunit protein eL28; 60S ribosomal protein L28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGV
VVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRS
QKPVMVKRKRTRPTKSS
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL28 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P46779
Ensemble ID
ENST00000344063.7
HGNC ID
HGNC:10330

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 Substitution: p.R113K DBIA    Probe Info 
KO52 SNV: p.I64V .
NCIH1155 SNV: p.R94K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.63  LDD0402  [1]
A-EBA
 Probe Info  		3.88  LDD0215  [2]
C-Sul
 Probe Info  		5.71  LDD0066  [3]
TH211
 Probe Info  		Y40(6.32)  LDD0257  [4]
TH214
 Probe Info  		Y40(9.44)  LDD0258  [4]
TH216
 Probe Info  		Y40(15.57); Y102(14.53); Y25(13.86); Y77(13.74)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
STPyne
 Probe Info  		K101(6.67); K127(5.26); K47(10.00)  LDD0277  [6]
ONAyne
 Probe Info  		K47(0.00); K84(0.00); K72(0.00); K122(0.00)  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K19(0.79); K72(2.12); K84(2.27); K135(3.84)  LDD3494  [7]
Probe 1
 Probe Info  		Y25(26.72); Y77(57.59)  LDD3495  [8]
BTD
 Probe Info  		C13(1.58)  LDD1700  [9]
EA-probe
 Probe Info  		N.A.  LDD0440  [10]
DBIA
 Probe Info  		C13(9.24)  LDD0209  [11]
HHS-482
 Probe Info  		Y25(0.34); Y40(0.92)  LDD0285  [12]
HHS-465
 Probe Info  		Y40(7.77)  LDD2237  [13]
ATP probe
 Probe Info  		K47(0.00); K22(0.00); K58(0.00); K65(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
ATP probe
 Probe Info  		K19(0.00); K65(0.00); K22(0.00)  LDD0035  [17]
IPM
 Probe Info  		N.A.  LDD0025  [18]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [20]
OSF
 Probe Info  		N.A.  LDD0029  [21]
SF
 Probe Info  		K22(0.00); K72(0.00); Y40(0.00); K127(0.00)  LDD0028  [21]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K22(0.00); K47(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		N.A.  LDD0217  [25]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [25]
Methacrolein
 Probe Info  		N.A.  LDD0218  [25]
AOyne
 Probe Info  		9.30  LDD0443  [26]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
TER-AC
 Probe Info  		N.A.  LDD0426  [27]
HHS-475
 Probe Info  		Y40(1.18)  LDD2238  [13]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		20.11  LDD1865  [28]
C191
 Probe Info  		14.62  LDD1868  [28]
C193
 Probe Info  		8.40  LDD1869  [28]
STS-1
 Probe Info  		N.A.  LDD0137  [29]
CR-1
 Probe Info  		3.20  LDD0429  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C13(0.96)  LDD2142  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C13(1.31)  LDD2152  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C13(0.54)  LDD2131  [9]
 LDCM0214  AC1 HEK-293T C13(1.06)  LDD1507  [31]
 LDCM0215  AC10 HEK-293T C13(1.24)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C13(1.16)  LDD1509  [31]
 LDCM0237  AC12 HEK-293T C13(1.08)  LDD1510  [31]
 LDCM0270  AC15 HEK-293T C13(1.16)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C13(1.09)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C13(1.06)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C13(1.25)  LDD1517  [31]
 LDCM0279  AC2 HEK-293T C13(1.00)  LDD1518  [31]
 LDCM0280  AC20 HEK-293T C13(1.07)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C13(1.11)  LDD1520  [31]
 LDCM0283  AC23 HEK-293T C13(1.14)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C13(1.00)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C13(1.12)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C13(1.11)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C13(1.10)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C13(1.06)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C13(1.11)  LDD1528  [31]
 LDCM0290  AC3 HEK-293T C13(1.06)  LDD1529  [31]
 LDCM0292  AC31 HEK-293T C13(1.17)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C13(1.07)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C13(1.15)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C13(1.22)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C13(1.16)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C13(1.06)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C13(1.05)  LDD1537  [31]
 LDCM0300  AC39 HEK-293T C13(1.19)  LDD1539  [31]
 LDCM0301  AC4 HEK-293T C13(1.08)  LDD1540  [31]
 LDCM0302  AC40 HEK-293T C13(1.16)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C13(1.22)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C13(1.17)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C13(1.10)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C13(1.14)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C13(1.14)  LDD1546  [31]
 LDCM0309  AC47 HEK-293T C13(1.05)  LDD1548  [31]
 LDCM0310  AC48 HEK-293T C13(1.12)  LDD1549  [31]
 LDCM0311  AC49 HEK-293T C13(1.17)  LDD1550  [31]
 LDCM0312  AC5 HEK-293T C13(1.05)  LDD1551  [31]
 LDCM0313  AC50 HEK-293T C13(1.20)  LDD1552  [31]
 LDCM0314  AC51 HEK-293T C13(1.03)  LDD1553  [31]
 LDCM0315  AC52 HEK-293T C13(1.10)  LDD1554  [31]
 LDCM0316  AC53 HEK-293T C13(1.05)  LDD1555  [31]
 LDCM0318  AC55 HEK-293T C13(1.24)  LDD1557  [31]
 LDCM0319  AC56 HEK-293T C13(1.18)  LDD1558  [31]
 LDCM0320  AC57 HEK-293T C13(0.96)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C13(1.03)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C13(1.10)  LDD1561  [31]
 LDCM0324  AC60 HEK-293T C13(0.97)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C13(0.95)  LDD1564  [31]
 LDCM0327  AC63 HEK-293T C13(1.01)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C13(1.02)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C13(1.01)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C13(1.03)  LDD1569  [31]
 LDCM0545  Acetamide MDA-MB-231 C13(0.58)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C13(1.05)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C13(1.04)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C13(1.11)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C13(1.15)  LDD1514  [31]
 LDCM0156  Aniline NCI-H1299 11.48  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C13(0.74)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C13(0.98); C13(0.93)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C13(1.23)  LDD1571  [31]
 LDCM0369  CL100 HEK-293T C13(1.08)  LDD1573  [31]
 LDCM0370  CL101 HEK-293T C13(1.15)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C13(1.18)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C13(1.22)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C13(1.10)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C13(1.02)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C13(1.34)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C13(1.20)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C13(1.16)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C13(1.11)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C13(0.92)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C13(1.24)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C13(1.10)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C13(1.15)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C13(1.22)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C13(1.15)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C13(1.21)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C13(1.12)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C13(1.23)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C13(1.31)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C13(1.22)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C13(1.01)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C13(1.09)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C13(1.13)  LDD1596  [31]
 LDCM0393  CL122 HEK-293T C13(1.24)  LDD1597  [31]
 LDCM0394  CL123 HEK-293T C13(1.32)  LDD1598  [31]
 LDCM0395  CL124 HEK-293T C13(1.29)  LDD1599  [31]
 LDCM0396  CL125 HEK-293T C13(1.08)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C13(1.05)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C13(1.13)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C13(0.99)  LDD1603  [31]
 LDCM0400  CL13 HEK-293T C13(1.30)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C13(1.25)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C13(1.44)  LDD1606  [31]
 LDCM0403  CL16 HEK-293T C13(1.20)  LDD1607  [31]
 LDCM0404  CL17 HEK-293T C13(1.10)  LDD1608  [31]
 LDCM0405  CL18 HEK-293T C13(1.32)  LDD1609  [31]
 LDCM0406  CL19 HEK-293T C13(1.41)  LDD1610  [31]
 LDCM0407  CL2 HEK-293T C13(1.12)  LDD1611  [31]
 LDCM0408  CL20 HEK-293T C13(1.09)  LDD1612  [31]
 LDCM0409  CL21 HEK-293T C13(1.06)  LDD1613  [31]
 LDCM0411  CL23 HEK-293T C13(1.04)  LDD1615  [31]
 LDCM0412  CL24 HEK-293T C13(1.04)  LDD1616  [31]
 LDCM0413  CL25 HEK-293T C13(1.11)  LDD1617  [31]
 LDCM0414  CL26 HEK-293T C13(1.29)  LDD1618  [31]
 LDCM0415  CL27 HEK-293T C13(1.17)  LDD1619  [31]
 LDCM0416  CL28 HEK-293T C13(1.13)  LDD1620  [31]
 LDCM0417  CL29 HEK-293T C13(1.20)  LDD1621  [31]
 LDCM0418  CL3 HEK-293T C13(1.36)  LDD1622  [31]
 LDCM0419  CL30 HEK-293T C13(1.19)  LDD1623  [31]
 LDCM0420  CL31 HEK-293T C13(1.12)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C13(1.12)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C13(1.08)  LDD1626  [31]
 LDCM0424  CL35 HEK-293T C13(0.97)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C13(1.00)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C13(1.06)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C13(1.14)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C13(1.12)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C13(1.04)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C13(1.27)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C13(1.01)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C13(1.04)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C13(0.98)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C13(1.05)  LDD1639  [31]
 LDCM0437  CL47 HEK-293T C13(0.93)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C13(0.88)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C13(1.30)  LDD1643  [31]
 LDCM0440  CL5 HEK-293T C13(1.03)  LDD1644  [31]
 LDCM0441  CL50 HEK-293T C13(1.27)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C13(1.13)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C13(1.13)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C13(1.43)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C13(1.24)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C13(1.08)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C13(1.11)  LDD1651  [31]
 LDCM0450  CL59 HEK-293T C13(1.04)  LDD1653  [31]
 LDCM0451  CL6 HEK-293T C13(1.09)  LDD1654  [31]
 LDCM0452  CL60 HEK-293T C13(1.02)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C13(1.04)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C13(1.21)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C13(1.23)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C13(1.11)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C13(1.11)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C13(1.10)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C13(1.18)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C13(1.01)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C13(1.04)  LDD1664  [31]
 LDCM0462  CL7 HEK-293T C13(1.26)  LDD1665  [31]
 LDCM0464  CL71 HEK-293T C13(1.13)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C13(1.03)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C13(1.11)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C13(1.28)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C13(1.09)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C13(1.12)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C13(1.22)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C13(1.21)  LDD1675  [31]
 LDCM0473  CL8 HEK-293T C13(1.05)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C13(1.11)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C13(1.20)  LDD1678  [31]
 LDCM0477  CL83 HEK-293T C13(1.16)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C13(1.05)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C13(1.24)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C13(1.10)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C13(1.22)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C13(1.00)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C13(1.09)  LDD1686  [31]
 LDCM0484  CL9 HEK-293T C13(1.01)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C13(1.28)  LDD1688  [31]
 LDCM0486  CL91 HEK-293T C13(1.06)  LDD1689  [31]
 LDCM0487  CL92 HEK-293T C13(0.97)  LDD1690  [31]
 LDCM0488  CL93 HEK-293T C13(1.04)  LDD1691  [31]
 LDCM0490  CL95 HEK-293T C13(0.92)  LDD1693  [31]
 LDCM0491  CL96 HEK-293T C13(1.31)  LDD1694  [31]
 LDCM0492  CL97 HEK-293T C13(1.10)  LDD1695  [31]
 LDCM0493  CL98 HEK-293T C13(1.12)  LDD1696  [31]
 LDCM0494  CL99 HEK-293T C13(1.08)  LDD1697  [31]
 LDCM0168  Crenolanib NCI-H1703 3.20  LDD0429  [30]
 LDCM0495  E2913 HEK-293T C13(1.35)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C13(2.11)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [10]
 LDCM0625  F8 Ramos C13(1.54)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C13(0.84)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C13(1.91)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C13(0.93)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C13(0.92)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C13(0.91)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C13(1.02)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C13(0.87)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C13(0.69)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C13(0.80)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C13(1.15)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C13(0.78)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C13(0.75)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C13(0.87)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C13(1.27)  LDD1671  [31]
 LDCM0596  Fragment38 Ramos C13(0.61)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C13(1.29)  LDD2184  [32]
 LDCM0427  Fragment51 HEK-293T C13(1.29)  LDD1631  [31]
 LDCM0610  Fragment52 Ramos C13(0.76)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C13(0.85)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C13(1.22)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C13(1.11)  LDD2188  [32]
 LDCM0123  JWB131 DM93 Y25(0.34); Y40(0.92)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y25(0.78); Y40(0.89)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y25(0.24); Y40(5.83)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y25(0.84); Y40(6.97)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y25(1.08); Y40(6.47)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y25(1.67); Y40(5.87)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y25(0.44); Y40(5.31)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y25(1.35); Y40(5.76)  LDD0292  [12]
 LDCM0022  KB02 HEK-293T C13(1.14)  LDD1492  [31]
 LDCM0023  KB03 Jurkat C13(9.24)  LDD0209  [11]
 LDCM0024  KB05 COLO792 C13(2.82)  LDD3310  [33]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C13(1.20)  LDD2102  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [25]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C13(0.90)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C13(0.83)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C13(1.25)  LDD2093  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C13(0.53)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C13(1.37)  LDD2097  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C13(1.08)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C13(1.03)  LDD2100  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C13(0.87)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C13(1.12)  LDD2105  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C13(1.13)  LDD2107  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C13(0.82)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C13(1.04)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C13(0.77)  LDD2114  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C13(0.80)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C13(0.79)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C13(1.46)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C13(0.94)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C13(0.50)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C13(0.92)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C13(0.59)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C13(0.82)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C13(0.62)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C13(1.13)  LDD2127  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C13(1.19)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C13(0.78)  LDD2133  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C13(1.13)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C13(1.00)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C13(1.58)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C13(0.88)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C13(0.74)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C13(0.98)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C13(1.58)  LDD2144  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C13(1.41)  LDD2147  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C13(0.87)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C13(0.62)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C13(0.73)  LDD2151  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C13(1.34); C13(1.32)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C13(0.81); C13(0.75)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C13(1.46)  LDD0304  [35]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Netrin receptor DCC (DCC) DCC family P43146
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Large ribosomal subunit protein uL4 (RPL4) Universal ribosomal protein uL4 family P36578
Microtubule-associated protein tau (MAPT) . P10636

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
28 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Crenolanib-Derived Probes Suitable for Cell- and Tissue-Based Protein Profiling and Single-Cell Imaging. Chembiochem. 2019 Jul 15;20(14):1783-1788. doi: 10.1002/cbic.201900067. Epub 2019 Jul 3.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
35 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.