Details of the Target

General Information of Target

Target ID LDTP13797
Target Name HIG1 domain family member 1A, mitochondrial (HIGD1A)
Gene Name HIGD1A
Gene ID 25994
Synonyms
HIG1; HIG1 domain family member 1A, mitochondrial; Hypoxia-inducible gene 1 protein; RCF1 homolog A; RCF1a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAAWLLGALVVPQLLGFGHGARGAEREWEGGWGGAQEEEREREALMLKHLQEALGLPAG
RGDENPAGTVEGKEDWEMEEDQGEEEEEEATPTPSSGPSPSPTPEDIVTYILGRLAGLDA
GLHQLHVRLHALDTRVVELTQGLRQLRNAAGDTRDAVQALQEAQGRAEREHGRLEGCLKG
LRLGHKCFLLSRDFEAQAAAQARCTARGGSLAQPADRQQMEALTRYLRAALAPYNWPVWL
GVHDRRAEGLYLFENGQRVSFFAWHRSPRPELGAQPSASPHPLSPDQPNGGTLENCVAQA
SDDGSWWDHDCQRRLYYVCEFPF
Target Bioclass
Other
Subcellular location
Mitochondrion membrane
Function
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes.
Uniprot ID
Q9Y241
Ensemble ID
ENST00000321331.12
HGNC ID
HGNC:29527

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		4.87  LDD0326  [1]
STPyne
 Probe Info  		K47(2.13)  LDD2217  [2]
Jackson_14
 Probe Info  		3.23  LDD0123  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
NHS
 Probe Info  		N.A.  LDD0010  [5]
SF
 Probe Info  		N.A.  LDD0028  [6]
PAL-AfBPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C039
 Probe Info  		5.39  LDD1739  [7]
C040
 Probe Info  		51.98  LDD1740  [7]
C041
 Probe Info  		15.03  LDD1741  [7]
C049
 Probe Info  		10.93  LDD1747  [7]
C055
 Probe Info  		25.81  LDD1752  [7]
C056
 Probe Info  		41.07  LDD1753  [7]
C063
 Probe Info  		36.50  LDD1760  [7]
C091
 Probe Info  		19.16  LDD1782  [7]
C092
 Probe Info  		28.44  LDD1783  [7]
C094
 Probe Info  		48.50  LDD1785  [7]
C112
 Probe Info  		57.68  LDD1799  [7]
C130
 Probe Info  		6.45  LDD1812  [7]
C141
 Probe Info  		22.47  LDD1823  [7]
C143
 Probe Info  		31.78  LDD1825  [7]
C243
 Probe Info  		11.24  LDD1916  [7]
C246
 Probe Info  		18.51  LDD1919  [7]
C264
 Probe Info  		43.41  LDD1935  [7]
C265
 Probe Info  		20.68  LDD1936  [7]
C269
 Probe Info  		5.66  LDD1939  [7]
C270
 Probe Info  		8.11  LDD1940  [7]
C285
 Probe Info  		36.50  LDD1955  [7]
C287
 Probe Info  		11.47  LDD1957  [7]
C288
 Probe Info  		7.78  LDD1958  [7]
C289
 Probe Info  		77.71  LDD1959  [7]
C290
 Probe Info  		5.35  LDD1960  [7]
C388
 Probe Info  		70.03  LDD2047  [7]
C407
 Probe Info  		28.84  LDD2064  [7]
C413
 Probe Info  		27.10  LDD2069  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe13
 Probe Info  		14.93  LDD0475  [8]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
CR-1
 Probe Info  		3.15  LDD0429  [9]
OEA-DA
 Probe Info  		17.93  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0168  Crenolanib NCI-H1703 3.15  LDD0429  [9]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 3.23  LDD0123  [3]

References

1 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Crenolanib-Derived Probes Suitable for Cell- and Tissue-Based Protein Profiling and Single-Cell Imaging. Chembiochem. 2019 Jul 15;20(14):1783-1788. doi: 10.1002/cbic.201900067. Epub 2019 Jul 3.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570