Details of the Target

General Information of Target

Target ID LDTP04969
Target Name 14-3-3 protein epsilon (YWHAE)
Gene Name YWHAE
Gene ID 7531
Synonyms
14-3-3 protein epsilon; 14-3-3E
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASW
RIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVF
YYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVF
YYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGE
EQNKEALQDVEDENQ
Target Bioclass
Transporter and channel
Family
14-3-3 family
Subcellular location
Nucleus
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI. Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection. Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination.
Uniprot ID
P62258
Ensemble ID
ENST00000264335.13
HGNC ID
HGNC:12851
ChEMBL ID
CHEMBL3329082

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.L132R .
NCIH1793 SNV: p.V35L .
NCIH196 SNV: p.E253K DBIA    Probe Info 
RKO SNV: p.L224S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 49 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.92  LDD0402  [1]
P1
 Probe Info  		1.67  LDD0452  [2]
P2
 Probe Info  		10.00  LDD0449  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		3.46  LDD0215  [3]
CHEMBL5175495
 Probe Info  		6.57  LDD0196  [4]
CY-1
 Probe Info  		21.35  LDD0243  [5]
CY4
 Probe Info  		5.46  LDD0244  [5]
N1
 Probe Info  		7.51  LDD0242  [5]
TH211
 Probe Info  		Y214(20.00); Y49(14.89); Y131(11.73)  LDD0257  [6]
TH214
 Probe Info  		Y131(20.00); Y152(14.12); Y49(12.83); Y214(7.01)  LDD0258  [6]
TH216
 Probe Info  		Y122(20.00); Y214(20.00); Y49(20.00); Y152(18.17)  LDD0259  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
ONAyne
 Probe Info  		K125(0.00); K142(0.00); K69(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K125(1.05); K12(7.18)  LDD3494  [9]
Probe 1
 Probe Info  		Y9(24.17); Y20(20.62); Y131(21.00); Y152(24.04)  LDD3495  [10]
AZ-9
 Probe Info  		10.00  LDD2154  [11]
AHL-Pu-1
 Probe Info  		C98(2.01)  LDD0169  [12]
HHS-482
 Probe Info  		Y122(1.31); Y131(1.07); Y152(0.92); Y20(0.86)  LDD0285  [13]
HHS-475
 Probe Info  		Y122(0.70); Y131(0.93); Y214(1.01); Y49(1.35)  LDD0264  [14]
HHS-465
 Probe Info  		Y131(10.00); Y214(10.00); Y49(10.00)  LDD2237  [15]
DBIA
 Probe Info  		C97(0.51); C98(0.75)  LDD0531  [16]
5E-2FA
 Probe Info  		H167(0.00); H107(0.00)  LDD2235  [17]
AMP probe
 Probe Info  		K50(0.00); K69(0.00); K142(0.00); K73(0.00)  LDD0200  [18]
ATP probe
 Probe Info  		K50(0.00); K69(0.00); K142(0.00); K78(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C97(0.00); C98(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C98(0.00); C97(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		C98(0.00); C97(0.00)  LDD0030  [21]
IPIAA_L
 Probe Info  		C97(0.00); C98(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C97(0.00); C98(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		N.A.  LDD0035  [22]
WYneN
 Probe Info  		C97(0.00); C98(0.00)  LDD0021  [23]
WYneO
 Probe Info  		N.A.  LDD0022  [23]
aHNE
 Probe Info  		N.A.  LDD0001  [23]
IPM
 Probe Info  		C98(0.00); C97(0.00)  LDD0147  [24]
NHS
 Probe Info  		K12(0.00); K123(0.00); K118(0.00); K69(0.00)  LDD0010  [23]
OSF
 Probe Info  		N.A.  LDD0029  [25]
SF
 Probe Info  		Y131(0.00); Y49(0.00); K50(0.00)  LDD0028  [25]
STPyne
 Probe Info  		K50(0.00); K69(0.00)  LDD0009  [23]
TFBX
 Probe Info  		C97(0.00); C98(0.00)  LDD0148  [24]
VSF
 Probe Info  		N.A.  LDD0007  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
1c-yne
 Probe Info  		K69(0.00); K142(0.00); K29(0.00); K12(0.00)  LDD0228  [27]
Acrolein
 Probe Info  		H107(0.00); C97(0.00); C98(0.00)  LDD0217  [28]
Crotonaldehyde
 Probe Info  		C97(0.00); C98(0.00)  LDD0219  [28]
Methacrolein
 Probe Info  		H107(0.00); C98(0.00); H129(0.00)  LDD0218  [28]
W1
 Probe Info  		C98(0.00); C97(0.00)  LDD0236  [29]
AOyne
 Probe Info  		7.10  LDD0443  [30]
NAIA_5
 Probe Info  		C192(0.00); C98(0.00); C97(0.00)  LDD2223  [31]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		12.91  LDD1713  [32]
C191
 Probe Info  		9.92  LDD1868  [32]
C278
 Probe Info  		56.49  LDD1948  [32]
FFF probe12
 Probe Info  		5.56  LDD0473  [33]
FFF probe13
 Probe Info  		6.39  LDD0475  [33]
STS-2
 Probe Info  		N.A.  LDD0138  [34]
VE-P
 Probe Info  		N.A.  LDD0396  [35]
Diazir
 Probe Info  		Y131(0.00); C98(0.00); E212(0.00)  LDD0011  [23]
BD-F
 Probe Info  		Y214(0.00); E211(0.00); L206(0.00); T208(0.00)  LDD0024  [36]
LD-F
 Probe Info  		T208(0.00); I203(0.00); A204(0.00); E205(0.00)  LDD0015  [36]
DA-2
 Probe Info  		N.A.  LDD0070  [37]
STS-1
 Probe Info  		N.A.  LDD0068  [38]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C98(2.01)  LDD0169  [12]
 LDCM0214  AC1 HCT 116 C97(0.51); C98(0.75)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C97(0.50); C98(0.50)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C97(0.80); C98(0.73)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C97(0.36); C98(0.50)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C97(0.38); C98(0.46)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C97(0.24); C98(0.43)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C97(0.27); C98(0.54)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C97(0.30); C98(0.53)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C97(0.27); C98(0.36)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C97(0.21); C98(0.71)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C97(0.26); C98(0.37)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C97(0.33); C98(0.42)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C97(0.46); C98(0.46)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C97(0.26); C98(0.50)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C97(0.22); C98(0.49)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C97(0.25); C98(0.37)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C97(0.86); C98(0.94)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C97(0.98); C98(0.74)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C97(0.94); C98(0.60)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C97(0.89); C98(0.60)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C97(1.04); C98(0.77)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C97(1.02); C98(0.91)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C97(0.78); C98(0.77)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C97(0.74); C98(0.74)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C97(0.83); C98(0.65)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C97(0.85); C98(0.92)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C97(0.74); C98(0.84)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C97(0.99); C98(0.79)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C97(0.99); C98(0.86)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C97(0.88); C98(0.86)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C97(0.63); C98(0.60)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C97(0.68); C98(0.61)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C97(0.74); C98(0.74)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C97(1.30); C98(1.30)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C97(0.67); C98(0.67)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C97(1.22); C98(1.22)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C97(1.51); C98(1.51)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C97(0.97); C98(0.97)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C97(0.86); C98(0.86)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C97(0.91); C98(0.91)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C97(0.97); C98(0.97)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C97(1.15); C98(1.15)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C97(1.07); C98(1.07)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C97(1.09); C98(1.09)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C97(0.57); C98(0.57)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C97(1.04); C98(1.04)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C97(1.00); C98(1.00)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C97(1.62); C98(1.62)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C98(0.85); C97(1.06)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C97(0.52); C98(0.62)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C97(0.74); C98(0.78)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C97(0.55); C98(0.63)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C97(0.50); C98(0.62)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C97(0.32); C98(0.63)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C97(0.48); C98(0.63)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C97(0.53); C98(0.53)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C97(0.83); C98(0.92)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C97(0.86); C98(0.93)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C97(0.44); C98(0.58)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C97(0.24); C98(0.36)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C97(0.57); C98(0.67)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C97(0.56); C98(0.51)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C97(0.89); C98(0.68)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C97(0.85); C98(1.00)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C97(0.76); C98(1.04)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C97(0.37); C98(0.63)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C97(0.69); C98(1.00)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C97(0.69); C98(1.01)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C97(0.83); C98(1.06)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C97(0.60); C98(0.61)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C97(0.85); C98(0.96)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C97(0.63); C98(0.84)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C97(0.77); C98(1.18)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C97(0.74); C98(0.74)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C97(0.58); C98(0.58)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C97(0.54); C98(0.54)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C97(0.53); C98(0.53)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C97(0.55); C98(0.55)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C97(0.67); C98(0.87)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C97(0.55); C98(0.55)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C97(0.45); C98(0.45)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C97(0.36); C98(0.36)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C97(0.39); C98(0.39)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C97(0.34); C98(0.34)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C98(1.07); C97(1.08)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C97(1.19); C98(1.44)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C98(0.99); C97(1.10)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C98(0.98); C97(1.10)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C97(0.85); C98(0.87)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C97(0.45); C98(0.62)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C98(0.68); C97(0.78)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C98(1.11); C97(1.17)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C98(0.87); C97(0.94)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C98(0.74); C97(1.02)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C97(0.96); C98(1.00)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C98(0.72); C97(0.77)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C98(0.87); C97(0.91)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C98(0.79); C97(0.88)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C98(0.73); C97(1.01)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C97(0.50); C98(0.56)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C97(0.44); C98(0.70)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C97(0.51); C98(0.59)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C98(1.10); C97(1.74)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C97(0.96); C98(0.96)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C97(0.62); C98(0.69)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C97(0.70); C98(0.96)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C97(0.47); C98(0.72)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C97(0.23); C98(0.41)  LDD0636  [16]
 LDCM0320  AC57 PaTu 8988t C97(0.67); C98(0.67)  LDD1199  [16]
 LDCM0321  AC58 PaTu 8988t C97(0.77); C98(0.77)  LDD1200  [16]
 LDCM0322  AC59 PaTu 8988t C97(0.97); C98(0.97)  LDD1201  [16]
 LDCM0323  AC6 HCT 116 C97(0.51); C98(0.51)  LDD0640  [16]
 LDCM0324  AC60 PaTu 8988t C97(1.01); C98(1.01)  LDD1203  [16]
 LDCM0325  AC61 PaTu 8988t C97(0.85); C98(0.85)  LDD1204  [16]
 LDCM0326  AC62 PaTu 8988t C97(0.82); C98(0.82)  LDD1205  [16]
 LDCM0327  AC63 PaTu 8988t C97(0.80); C98(0.80)  LDD1206  [16]
 LDCM0328  AC64 PaTu 8988t C97(0.92); C98(0.92)  LDD1207  [16]
 LDCM0329  AC65 PaTu 8988t C97(1.07); C98(1.07)  LDD1208  [16]
 LDCM0330  AC66 PaTu 8988t C97(0.90); C98(0.90)  LDD1209  [16]
 LDCM0331  AC67 PaTu 8988t C97(0.96); C98(0.96)  LDD1210  [16]
 LDCM0332  AC68 HCT 116 C97(0.57); C98(0.59)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C97(0.62); C98(0.64)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C97(0.69); C98(0.69)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C97(0.48); C98(0.57)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C98(0.90); C97(0.90)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C97(0.77); C98(0.79)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C97(0.42); C98(0.44)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C97(0.38); C98(0.41)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C97(0.29); C98(0.30)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C97(0.67); C98(0.73)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C97(0.81); C98(0.83)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C97(0.69); C98(0.70)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C97(0.84); C98(0.95)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C97(0.54); C98(0.54)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C97(0.69); C98(0.70)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C97(0.67); C98(0.76)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C97(0.11); C98(0.14)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C97(0.27); C98(0.27)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C97(0.27); C98(0.27)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C97(0.43); C98(0.43)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C97(0.56); C98(0.56)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C97(0.77); C98(0.77)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C97(0.62); C98(0.62)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C97(0.40); C98(0.40)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C97(1.34); C98(1.34)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C97(0.34); C98(0.34)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C97(0.39); C98(0.39)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C97(0.53); C98(0.53)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C97(0.51); C98(0.51)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C97(0.59); C98(0.59)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C97(0.37); C98(0.37)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C97(0.40); C98(0.40)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C97(0.03); C98(0.29)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C97(0.39); C98(0.47)  LDD0683  [16]
 LDCM0248  AKOS034007472 HCT 116 C97(0.93); C98(0.93)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C97(0.65); C98(0.65)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C97(0.27); C98(0.27)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 11.91  LDD0403  [1]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [11]
 LDCM0630  CCW28-3 231MFP C98(1.51); C97(1.19)  LDD2214  [39]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C97(0.67); C97(0.36)  LDD2227  [31]
 LDCM0367  CL1 HCT 116 C97(0.90); C98(1.07)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C98(0.49); C97(0.57)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C97(0.49); C98(0.70)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C97(0.52); C98(0.52)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C97(0.80); C98(0.80)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C97(0.71); C98(0.71)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C97(0.76); C98(0.76)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C97(0.51); C98(0.71)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C97(0.23); C98(0.45)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C97(0.41); C98(0.62)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C97(0.36); C98(0.66)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C97(0.51); C98(0.86)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C98(0.44); C97(0.53)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C97(0.43); C98(0.65)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C98(0.47); C97(0.57)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C97(0.96); C98(0.96)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C97(0.40); C98(0.40)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C97(0.63); C98(0.63)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C97(0.53); C98(0.53)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C97(0.60); C98(0.60)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C98(0.58); C97(0.69)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C97(0.93); C98(0.98)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C98(0.72); C97(0.93)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C98(0.51); C97(0.62)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C98(0.91); C97(1.15)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C98(1.63); C97(2.07)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C97(0.57); C98(0.95)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C98(0.59); C97(0.62)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C97(0.56); C98(0.92)  LDD0712  [16]
 LDCM0396  CL125 PaTu 8988t C97(0.92); C98(0.92)  LDD1275  [16]
 LDCM0397  CL126 PaTu 8988t C97(0.99); C98(0.99)  LDD1276  [16]
 LDCM0398  CL127 PaTu 8988t C97(0.90); C98(0.90)  LDD1277  [16]
 LDCM0399  CL128 PaTu 8988t C97(0.81); C98(0.81)  LDD1278  [16]
 LDCM0400  CL13 HCT 116 C98(0.46); C97(0.49)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C97(0.64); C98(0.72)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C98(0.40); C97(0.47)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C97(0.81); C98(1.01)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C97(0.81); C98(0.97)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C97(0.54); C98(0.92)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C97(0.58); C98(0.79)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C97(0.91); C98(1.10)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C97(0.52); C98(0.78)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C97(0.36); C98(0.59)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C97(0.25); C98(0.43)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C97(0.58); C98(0.72)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C97(0.40); C98(0.68)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C97(0.51); C98(0.73)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C97(0.57); C98(0.78)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C97(0.70); C98(0.87)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C97(0.51); C98(0.72)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C97(0.49); C98(0.68)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C97(0.90); C98(0.94)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C97(0.80); C98(0.95)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C97(0.53); C98(0.67)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C97(0.38); C98(0.75)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C97(0.31); C98(0.58)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C97(0.22); C98(0.39)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C97(0.27); C98(0.68)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C97(0.33); C98(0.60)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C97(0.29); C98(0.53)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C97(0.28); C98(0.40)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C97(0.96); C98(1.00)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C97(0.36); C98(0.91)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C97(0.36); C98(0.70)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C97(0.15); C98(0.44)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C97(0.20); C98(0.42)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C97(0.19); C98(0.35)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C97(0.17); C98(0.29)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C97(1.25); C98(2.15)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C97(1.58); C98(1.88)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C97(1.40); C98(2.04)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C97(1.02); C98(1.40)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C97(0.78); C98(0.83)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C97(1.27); C98(1.81)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C97(1.18); C98(1.95)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C97(1.40); C98(1.99)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C97(1.21); C98(1.84)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C97(1.11); C98(1.90)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C97(1.40); C98(1.94)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C97(1.18); C98(1.27)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C97(1.41); C98(1.74)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C97(1.59); C98(2.03)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C97(1.01); C98(1.43)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C97(0.53); C98(0.57)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C97(1.10); C98(1.27)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C97(0.66); C98(0.70)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C97(0.46); C98(0.51)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C97(0.41); C98(0.47)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C97(0.37); C98(0.49)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C97(0.77); C98(0.82)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C97(0.35); C98(0.51)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C97(0.61); C98(0.73)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C97(0.60); C98(1.04)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C97(0.61); C98(0.61)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C97(0.52); C98(0.53)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C97(0.55); C98(0.64)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C97(0.47); C98(0.64)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C97(0.57); C98(0.65)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C97(0.37); C98(0.46)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C97(0.44); C98(0.53)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C97(0.56); C98(0.81)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C97(0.65); C98(0.59)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C97(0.64); C98(0.91)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C97(0.43); C98(0.90)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C97(0.47); C98(0.45)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C97(0.58); C98(0.81)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C97(0.54); C98(0.73)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C97(0.26); C98(0.83)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C97(0.29); C98(0.62)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C97(0.21); C98(0.67)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C97(0.51); C98(0.66)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C97(0.77); C98(1.66)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C97(0.55); C98(0.61)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C97(0.34); C98(0.49)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C97(0.13); C98(0.36)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C97(0.59); C98(0.64)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C97(0.84); C98(1.62)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C97(0.70); C98(0.81)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C97(0.67); C98(0.86)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C97(0.71); C98(0.70)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C97(0.47); C98(0.63)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C97(0.49); C98(0.56)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C97(0.67); C98(0.87)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C97(0.61); C98(0.77)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C97(0.49); C98(0.66)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C97(0.52); C98(0.74)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C97(0.86); C98(0.88)  LDD1698  [40]
 LDCM0625  F8 Ramos 0.78  LDD2187  [41]
 LDCM0572  Fragment10 Ramos 0.37  LDD2189  [41]
 LDCM0573  Fragment11 Ramos 0.04; C97(0.30)  LDD2190  [41]
 LDCM0574  Fragment12 Ramos 0.28  LDD2191  [41]
 LDCM0575  Fragment13 Ramos 0.96  LDD2192  [41]
 LDCM0576  Fragment14 Ramos 0.66; C97(1.00)  LDD2193  [41]
 LDCM0579  Fragment20 Ramos 0.25  LDD2194  [41]
 LDCM0580  Fragment21 Ramos 1.08  LDD2195  [41]
 LDCM0582  Fragment23 Ramos 2.02  LDD2196  [41]
 LDCM0578  Fragment27 Ramos 1.89  LDD2197  [41]
 LDCM0586  Fragment28 Ramos 0.52; C97(0.94)  LDD2198  [41]
 LDCM0588  Fragment30 Ramos 0.76  LDD2199  [41]
 LDCM0589  Fragment31 Ramos 1.80  LDD2200  [41]
 LDCM0590  Fragment32 Ramos 0.41  LDD2201  [41]
 LDCM0468  Fragment33 HCT 116 C97(0.87); C98(0.62)  LDD0785  [16]
 LDCM0596  Fragment38 Ramos 0.70  LDD2203  [41]
 LDCM0566  Fragment4 Ramos 1.24; C97(0.66)  LDD2184  [41]
 LDCM0427  Fragment51 HCT 116 C97(0.22); C98(0.37)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos 0.74  LDD2204  [41]
 LDCM0614  Fragment56 Ramos 0.59  LDD2205  [41]
 LDCM0569  Fragment7 Ramos 0.51; C97(0.35)  LDD2186  [41]
 LDCM0571  Fragment9 Ramos 0.51  LDD2188  [41]
 LDCM0116  HHS-0101 DM93 Y122(0.70); Y131(0.93); Y214(1.01); Y49(1.35)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y214(0.88); Y122(1.20); Y131(1.25); Y49(1.56)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y131(0.81); Y214(0.93); Y122(0.97); Y49(1.21)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y214(0.91); Y122(1.21); Y49(1.51); Y131(1.53)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y214(0.90); Y49(1.31); Y122(1.40); Y131(1.64)  LDD0268  [14]
 LDCM0107  IAA HeLa H107(0.00); H129(0.00)  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y122(1.31); Y131(1.07); Y152(0.92); Y20(0.86)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y122(1.35); Y131(0.55); Y152(0.32); Y20(1.52)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y122(0.80); Y131(1.10); Y152(1.13); Y20(1.51)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y131(3.63); Y152(3.64); Y20(3.66); Y49(10.90)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y122(1.42); Y131(2.06); Y152(2.08); Y20(1.88)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y122(0.21); Y131(1.15); Y152(1.02); Y20(0.39)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y122(1.04); Y131(0.38); Y152(0.34); Y20(0.74)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y122(0.93); Y131(1.00); Y152(0.75); Y20(0.82)  LDD0292  [13]
 LDCM0022  KB02 HEK-293T C98(1.01); C97(1.00); C98(1.00)  LDD1492  [40]
 LDCM0023  KB03 HEK-293T C98(0.94); C97(0.99); C98(0.99)  LDD1497  [40]
 LDCM0024  KB05 IGR39 C98(0.74)  LDD3315  [42]
 LDCM0109  NEM HeLa H107(0.00); H167(0.00); C98(0.00); C97(0.00)  LDD0223  [28]
 LDCM0627  NUDT7-COV-1 HEK-293T C98(0.68)  LDD2206  [43]
 LDCM0628  OTUB2-COV-1 HEK-293T C97(1.22)  LDD2207  [43]
 LDCM0131  RA190 MM1.R C97(1.19); C98(1.19)  LDD0304  [44]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Dihydrolipoyl dehydrogenase, mitochondrial (DLD) Class-I pyridine nucleotide-disulfide oxidoreductase family P09622
Histone deacetylase 4 (HDAC4) Histone deacetylase family P56524
Cyclin-dependent kinase 14 (CDK14) CMGC Ser/Thr protein kinase family O94921
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) STE Ser/Thr protein kinase family Q99759
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
14-3-3 protein theta (YWHAQ) 14-3-3 family P27348
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Voltage-dependent anion-selective channel protein 1 (VDAC1) Eukaryotic mitochondrial porin family P21796
Apoptotic protease-activating factor 1 (APAF1) . O14727
SH3 and cysteine-rich domain-containing protein (STAC) . Q99469
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein beta/alpha (YWHAB) 14-3-3 family P31946
14-3-3 protein eta (YWHAH) 14-3-3 family Q04917
Ataxin-1 (ATXN1) ATXN1 family P54253
Bcl2-associated agonist of cell death (BAD) Bcl-2 family Q92934
Protein chibby homolog 1 (CBY1) Chibby family Q9Y3M2
Protein Mdm4 (MDM4) MDM2/MDM4 family O15151
Myeloid leukemia factor 1 (MLF1) MLF family P58340
Nuclear distribution protein nudE homolog 1 (NDE1) NudE family Q9NXR1
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
Adrenocortical dysplasia protein homolog (ACD) . Q96AP0
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
F-box only protein 4 (FBXO4) . Q9UKT5
Rab11 family-interacting protein 2 (RAB11FIP2) . Q7L804
WW domain-containing transcription regulator protein 1 (WWTR1) . Q9GZV5

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695
Fusicoccin . DB01780

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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