Details of the Target

General Information of Target

Target ID LDTP05991
Target Name Spliceosome RNA helicase DDX39B (DDX39B)
Gene Name DDX39B
Gene ID 7919
Synonyms
BAT1; UAP56; Spliceosome RNA helicase DDX39B; EC 3.6.4.13; 56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; DEAD box protein UAP56; HLA-B-associated transcript 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAI
VDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMC
HTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALA
RNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCR
KFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRC
IALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAF
NYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDI
SSYIEQTR
Target Bioclass
Enzyme
Family
DEAD box helicase family, DECD subfamily
Subcellular location
Nucleus
Function
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.; Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [] reporting a stimulatory effect.; (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Uniprot ID
Q13838
Ensemble ID
ENST00000383508.6
HGNC ID
HGNC:13917

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.H220PfsTer34 DBIA    Probe Info 
HCT116 Deletion: p.F149LfsTer13 .
HCT15 SNV: p.R181Q DBIA    Probe Info 
HT SNV: p.E134G DBIA    Probe Info 
IM95 SNV: p.M321K DBIA    Probe Info 
JURKAT SNV: p.Q128Ter Compound 10    Probe Info 
MOLT4 SNV: p.R135H; p.M140I; p.Q244Ter IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 46 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.53  LDD0402  [1]
AZ-9
 Probe Info  		7.03  LDD0393  [2]
CHEMBL5175495
 Probe Info  		7.18  LDD0196  [3]
CY4
 Probe Info  		2.16  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y362(20.00); Y39(12.10); Y266(10.55); Y265(10.22)  LDD0257  [5]
TH214
 Probe Info  		Y39(6.58); Y266(6.45)  LDD0258  [5]
TH216
 Probe Info  		Y265(11.41); Y39(9.90); Y266(7.89)  LDD0259  [5]
STPyne
 Probe Info  		K163(5.16); K183(4.74); K188(9.80); K241(9.40)  LDD0277  [6]
ONAyne
 Probe Info  		K334(0.00); K53(0.00)  LDD0273  [6]
Probe 1
 Probe Info  		Y139(16.64); Y362(8.63)  LDD3495  [7]
DBIA
 Probe Info  		C315(1.53); C180(2.01)  LDD3311  [8]
THZ1-DTB
 Probe Info  		C75(1.11)  LDD0460  [9]
AHL-Pu-1
 Probe Info  		C198(2.56)  LDD0171  [10]
HHS-482
 Probe Info  		Y39(0.61)  LDD0285  [11]
HHS-475
 Probe Info  		Y39(0.75); Y266(1.15); Y265(1.70)  LDD0264  [12]
HHS-465
 Probe Info  		Y265(10.00); Y266(10.00); Y39(10.00)  LDD2237  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
AMP probe
 Probe Info  		N.A.  LDD0200  [15]
ATP probe
 Probe Info  		K36(0.00); K163(0.00); K241(0.00); K156(0.00)  LDD0199  [15]
1d-yne
 Probe Info  		N.A.  LDD0358  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C300(0.00); C198(0.00); C165(0.00); C120(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C198(0.00); C300(0.00); C165(0.00); C63(0.00)  LDD0032  [18]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [19]
IPIAA_L
 Probe Info  		C198(0.00); C63(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C300(0.00); C239(0.00); C198(0.00); C165(0.00)  LDD0037  [17]
BTD
 Probe Info  		N.A.  LDD0004  [20]
IPM
 Probe Info  		N.A.  LDD0025  [21]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [21]
NAIA_4
 Probe Info  		C75(0.00); C63(0.00); C198(0.00)  LDD2226  [22]
TFBX
 Probe Info  		N.A.  LDD0027  [21]
WYneN
 Probe Info  		C165(0.00); C239(0.00)  LDD0021  [20]
Compound 10
 Probe Info  		C165(0.00); C198(0.00)  LDD2216  [23]
NHS
 Probe Info  		K268(0.00); K36(0.00); K53(0.00); K241(0.00)  LDD0010  [20]
OSF
 Probe Info  		Y39(0.00); H373(0.00)  LDD0029  [24]
SF
 Probe Info  		K188(0.00); K156(0.00); K334(0.00); Y362(0.00)  LDD0028  [24]
Phosphinate-6
 Probe Info  		C63(0.00); C87(0.00)  LDD0018  [25]
1c-yne
 Probe Info  		K384(0.00); K241(0.00)  LDD0228  [16]
Acrolein
 Probe Info  		C165(0.00); C198(0.00); H192(0.00)  LDD0217  [26]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [26]
Crotonaldehyde
 Probe Info  		C198(0.00); C165(0.00); C239(0.00); H167(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C165(0.00); C198(0.00); H167(0.00)  LDD0218  [26]
W1
 Probe Info  		C239(0.00); C198(0.00); C165(0.00); K53(0.00)  LDD0236  [27]
AOyne
 Probe Info  		8.50  LDD0443  [28]
NAIA_5
 Probe Info  		C300(0.00); C165(0.00); C239(0.00); C198(0.00)  LDD2223  [22]
TER-AC
 Probe Info  		N.A.  LDD0426  [29]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.50  LDD0475  [30]
STS-2
 Probe Info  		3.86  LDD0138  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [33]
DA-2
 Probe Info  		N.A.  LDD0070  [34]
STS-1
 Probe Info  		N.A.  LDD0069  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C165(0.68); C239(0.83)  LDD2142  [36]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C165(0.90); C239(0.86)  LDD2112  [36]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C165(0.82); C239(0.58)  LDD2095  [36]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C165(1.02); C239(0.85)  LDD2130  [36]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C165(0.98); C239(1.07)  LDD2117  [36]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C165(1.33); C239(1.36); C198(2.75)  LDD2152  [36]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C165(0.71); C239(0.88)  LDD2103  [36]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C165(0.49); C239(0.63)  LDD2132  [36]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C165(0.60); C239(0.87)  LDD2131  [36]
 LDCM0026  4SU-RNA+native RNA DM93 C198(2.56)  LDD0171  [10]
 LDCM0214  AC1 HEK-293T C300(1.06)  LDD0812  [37]
 LDCM0215  AC10 HEK-293T C300(1.03)  LDD0813  [37]
 LDCM0216  AC100 HEK-293T C300(1.17)  LDD0814  [37]
 LDCM0217  AC101 HEK-293T C300(1.17)  LDD0815  [37]
 LDCM0218  AC102 HEK-293T C300(1.09)  LDD0816  [37]
 LDCM0219  AC103 HEK-293T C300(1.31)  LDD0817  [37]
 LDCM0220  AC104 HEK-293T C300(1.30)  LDD0818  [37]
 LDCM0221  AC105 HEK-293T C300(0.78)  LDD0819  [37]
 LDCM0222  AC106 HEK-293T C300(0.89)  LDD0820  [37]
 LDCM0223  AC107 HEK-293T C300(1.08)  LDD0821  [37]
 LDCM0224  AC108 HEK-293T C300(1.01)  LDD0822  [37]
 LDCM0225  AC109 HEK-293T C300(0.92)  LDD0823  [37]
 LDCM0226  AC11 HEK-293T C300(0.91)  LDD0824  [37]
 LDCM0227  AC110 HEK-293T C300(1.30)  LDD0825  [37]
 LDCM0228  AC111 HEK-293T C300(1.29)  LDD0826  [37]
 LDCM0229  AC112 HEK-293T C300(1.47)  LDD0827  [37]
 LDCM0230  AC113 HEK-293T C300(1.04)  LDD0828  [37]
 LDCM0231  AC114 HEK-293T C300(1.01)  LDD0829  [37]
 LDCM0232  AC115 HEK-293T C300(1.09)  LDD0830  [37]
 LDCM0233  AC116 HEK-293T C300(0.94)  LDD0831  [37]
 LDCM0234  AC117 HEK-293T C300(1.07)  LDD0832  [37]
 LDCM0235  AC118 HEK-293T C300(1.19)  LDD0833  [37]
 LDCM0236  AC119 HEK-293T C300(1.15)  LDD0834  [37]
 LDCM0237  AC12 HEK-293T C300(1.07)  LDD0835  [37]
 LDCM0238  AC120 HEK-293T C300(1.14)  LDD0836  [37]
 LDCM0239  AC121 HEK-293T C300(1.35)  LDD0837  [37]
 LDCM0240  AC122 HEK-293T C300(1.42)  LDD0838  [37]
 LDCM0241  AC123 HEK-293T C300(1.45)  LDD0839  [37]
 LDCM0242  AC124 HEK-293T C300(1.28)  LDD0840  [37]
 LDCM0243  AC125 HEK-293T C300(1.37)  LDD0841  [37]
 LDCM0244  AC126 HEK-293T C300(1.64)  LDD0842  [37]
 LDCM0245  AC127 HEK-293T C300(1.76)  LDD0843  [37]
 LDCM0246  AC128 HEK-293T C300(1.11)  LDD0844  [37]
 LDCM0247  AC129 HEK-293T C300(1.27)  LDD0845  [37]
 LDCM0249  AC130 HEK-293T C300(1.07)  LDD0847  [37]
 LDCM0250  AC131 HEK-293T C300(0.97)  LDD0848  [37]
 LDCM0251  AC132 HEK-293T C300(1.39)  LDD0849  [37]
 LDCM0252  AC133 HEK-293T C300(1.68)  LDD0850  [37]
 LDCM0253  AC134 HEK-293T C300(1.26)  LDD0851  [37]
 LDCM0254  AC135 HEK-293T C300(1.24)  LDD0852  [37]
 LDCM0255  AC136 HEK-293T C300(1.68)  LDD0853  [37]
 LDCM0256  AC137 HEK-293T C300(1.59)  LDD0854  [37]
 LDCM0257  AC138 HEK-293T C300(1.77)  LDD0855  [37]
 LDCM0258  AC139 HEK-293T C300(1.43)  LDD0856  [37]
 LDCM0259  AC14 HEK-293T C300(1.12)  LDD0857  [37]
 LDCM0260  AC140 HEK-293T C300(1.26)  LDD0858  [37]
 LDCM0261  AC141 HEK-293T C300(1.54)  LDD0859  [37]
 LDCM0262  AC142 HEK-293T C300(1.23)  LDD0860  [37]
 LDCM0263  AC143 HEK-293T C300(1.07)  LDD0861  [37]
 LDCM0264  AC144 HEK-293T C300(1.18)  LDD0862  [37]
 LDCM0265  AC145 HEK-293T C300(1.44)  LDD0863  [37]
 LDCM0266  AC146 HEK-293T C300(1.37)  LDD0864  [37]
 LDCM0267  AC147 HEK-293T C300(1.47)  LDD0865  [37]
 LDCM0268  AC148 HEK-293T C300(1.44)  LDD0866  [37]
 LDCM0269  AC149 HEK-293T C300(0.99)  LDD0867  [37]
 LDCM0270  AC15 HEK-293T C300(1.32)  LDD0868  [37]
 LDCM0271  AC150 HEK-293T C300(1.28)  LDD0869  [37]
 LDCM0272  AC151 HEK-293T C300(1.12)  LDD0870  [37]
 LDCM0273  AC152 HEK-293T C300(1.14)  LDD0871  [37]
 LDCM0274  AC153 HEK-293T C300(1.20)  LDD0872  [37]
 LDCM0621  AC154 HEK-293T C300(1.02)  LDD2162  [37]
 LDCM0622  AC155 HEK-293T C300(1.02)  LDD2163  [37]
 LDCM0623  AC156 HEK-293T C300(1.47)  LDD2164  [37]
 LDCM0624  AC157 HEK-293T C300(1.75)  LDD2165  [37]
 LDCM0276  AC17 HEK-293T C300(2.25)  LDD0874  [37]
 LDCM0277  AC18 HEK-293T C300(1.37)  LDD0875  [37]
 LDCM0278  AC19 HEK-293T C300(1.46)  LDD0876  [37]
 LDCM0279  AC2 HEK-293T C300(1.29)  LDD0877  [37]
 LDCM0280  AC20 HEK-293T C300(2.25)  LDD0878  [37]
 LDCM0281  AC21 HEK-293T C300(1.78)  LDD0879  [37]
 LDCM0282  AC22 HEK-293T C300(1.66)  LDD0880  [37]
 LDCM0283  AC23 HEK-293T C300(1.37)  LDD0881  [37]
 LDCM0284  AC24 HEK-293T C300(1.31)  LDD0882  [37]
 LDCM0285  AC25 HEK-293T C300(1.13)  LDD0883  [37]
 LDCM0286  AC26 HEK-293T C300(1.22)  LDD0884  [37]
 LDCM0287  AC27 HEK-293T C300(1.07)  LDD0885  [37]
 LDCM0288  AC28 HEK-293T C300(1.41)  LDD0886  [37]
 LDCM0289  AC29 HEK-293T C300(1.18)  LDD0887  [37]
 LDCM0290  AC3 HEK-293T C300(1.18)  LDD0888  [37]
 LDCM0291  AC30 HEK-293T C300(1.02)  LDD0889  [37]
 LDCM0292  AC31 HEK-293T C300(0.95)  LDD0890  [37]
 LDCM0293  AC32 HEK-293T C300(0.97)  LDD0891  [37]
 LDCM0294  AC33 HEK-293T C300(1.17)  LDD0892  [37]
 LDCM0295  AC34 HEK-293T C300(0.98)  LDD0893  [37]
 LDCM0296  AC35 HEK-293T C300(1.29)  LDD0894  [37]
 LDCM0297  AC36 HEK-293T C300(1.40)  LDD0895  [37]
 LDCM0298  AC37 HEK-293T C300(1.42)  LDD0896  [37]
 LDCM0299  AC38 HEK-293T C300(1.25)  LDD0897  [37]
 LDCM0300  AC39 HEK-293T C300(1.39)  LDD0898  [37]
 LDCM0301  AC4 HEK-293T C300(1.32)  LDD0899  [37]
 LDCM0302  AC40 HEK-293T C300(1.23)  LDD0900  [37]
 LDCM0303  AC41 HEK-293T C300(1.26)  LDD0901  [37]
 LDCM0304  AC42 HEK-293T C300(1.10)  LDD0902  [37]
 LDCM0305  AC43 HEK-293T C300(1.25)  LDD0903  [37]
 LDCM0306  AC44 HEK-293T C300(1.35)  LDD0904  [37]
 LDCM0307  AC45 HEK-293T C300(1.36)  LDD0905  [37]
 LDCM0308  AC46 HEK-293T C300(1.22)  LDD0906  [37]
 LDCM0309  AC47 HEK-293T C300(1.29)  LDD0907  [37]
 LDCM0310  AC48 HEK-293T C300(1.20)  LDD0908  [37]
 LDCM0311  AC49 HEK-293T C300(1.14)  LDD0909  [37]
 LDCM0312  AC5 HEK-293T C300(1.22)  LDD0910  [37]
 LDCM0313  AC50 HEK-293T C300(1.13)  LDD0911  [37]
 LDCM0314  AC51 HEK-293T C300(1.26)  LDD0912  [37]
 LDCM0315  AC52 HEK-293T C300(1.24)  LDD0913  [37]
 LDCM0316  AC53 HEK-293T C300(1.10)  LDD0914  [37]
 LDCM0317  AC54 HEK-293T C300(1.46)  LDD0915  [37]
 LDCM0318  AC55 HEK-293T C300(1.29)  LDD0916  [37]
 LDCM0319  AC56 HEK-293T C300(1.39)  LDD0917  [37]
 LDCM0320  AC57 HEK-293T C300(1.02)  LDD0918  [37]
 LDCM0321  AC58 HEK-293T C300(1.16)  LDD0919  [37]
 LDCM0322  AC59 HEK-293T C300(1.07)  LDD0920  [37]
 LDCM0323  AC6 HEK-293T C300(0.92)  LDD0921  [37]
 LDCM0324  AC60 HEK-293T C300(1.09)  LDD0922  [37]
 LDCM0325  AC61 HEK-293T C300(1.43)  LDD0923  [37]
 LDCM0326  AC62 HEK-293T C300(1.08)  LDD0924  [37]
 LDCM0327  AC63 HEK-293T C300(1.32)  LDD0925  [37]
 LDCM0328  AC64 HEK-293T C300(1.02)  LDD0926  [37]
 LDCM0329  AC65 HEK-293T C300(1.39)  LDD0927  [37]
 LDCM0330  AC66 HEK-293T C300(1.14)  LDD0928  [37]
 LDCM0331  AC67 HEK-293T C300(1.34)  LDD0929  [37]
 LDCM0332  AC68 HEK-293T C300(1.19)  LDD0930  [37]
 LDCM0333  AC69 HEK-293T C300(1.10)  LDD0931  [37]
 LDCM0334  AC7 HEK-293T C300(1.19)  LDD0932  [37]
 LDCM0335  AC70 HEK-293T C300(1.52)  LDD0933  [37]
 LDCM0336  AC71 HEK-293T C300(1.14)  LDD0934  [37]
 LDCM0337  AC72 HEK-293T C300(1.31)  LDD0935  [37]
 LDCM0338  AC73 HEK-293T C300(1.24)  LDD0936  [37]
 LDCM0339  AC74 HEK-293T C300(1.04)  LDD0937  [37]
 LDCM0340  AC75 HEK-293T C300(1.25)  LDD0938  [37]
 LDCM0341  AC76 HEK-293T C300(1.36)  LDD0939  [37]
 LDCM0342  AC77 HEK-293T C300(1.46)  LDD0940  [37]
 LDCM0343  AC78 HEK-293T C300(1.26)  LDD0941  [37]
 LDCM0344  AC79 HEK-293T C300(1.26)  LDD0942  [37]
 LDCM0345  AC8 HEK-293T C300(1.15)  LDD0943  [37]
 LDCM0346  AC80 HEK-293T C300(1.36)  LDD0944  [37]
 LDCM0347  AC81 HEK-293T C300(1.40)  LDD0945  [37]
 LDCM0348  AC82 HEK-293T C300(1.63)  LDD0946  [37]
 LDCM0349  AC83 HEK-293T C300(0.92)  LDD0947  [37]
 LDCM0350  AC84 HEK-293T C300(1.13)  LDD0948  [37]
 LDCM0351  AC85 HEK-293T C300(1.09)  LDD0949  [37]
 LDCM0352  AC86 HEK-293T C300(1.04)  LDD0950  [37]
 LDCM0353  AC87 HEK-293T C300(1.10)  LDD0951  [37]
 LDCM0354  AC88 HEK-293T C300(1.21)  LDD0952  [37]
 LDCM0355  AC89 HEK-293T C300(1.12)  LDD0953  [37]
 LDCM0357  AC90 HEK-293T C300(1.13)  LDD0955  [37]
 LDCM0358  AC91 HEK-293T C300(1.10)  LDD0956  [37]
 LDCM0359  AC92 HEK-293T C300(0.95)  LDD0957  [37]
 LDCM0360  AC93 HEK-293T C300(1.10)  LDD0958  [37]
 LDCM0361  AC94 HEK-293T C300(1.43)  LDD0959  [37]
 LDCM0362  AC95 HEK-293T C300(1.13)  LDD0960  [37]
 LDCM0363  AC96 HEK-293T C300(1.10)  LDD0961  [37]
 LDCM0364  AC97 HEK-293T C300(1.64)  LDD0962  [37]
 LDCM0365  AC98 HEK-293T C300(0.81)  LDD0963  [37]
 LDCM0366  AC99 HEK-293T C300(0.74)  LDD0964  [37]
 LDCM0545  Acetamide MDA-MB-231 C165(0.43); C239(0.42)  LDD2138  [36]
 LDCM0520  AKOS000195272 MDA-MB-231 C165(0.80); C239(0.83)  LDD2113  [36]
 LDCM0248  AKOS034007472 HEK-293T C300(1.15)  LDD0846  [37]
 LDCM0356  AKOS034007680 HEK-293T C300(1.33)  LDD0954  [37]
 LDCM0275  AKOS034007705 HEK-293T C300(1.15)  LDD0873  [37]
 LDCM0498  BS-3668 MDA-MB-231 C165(0.50)  LDD2091  [36]
 LDCM0108  Chloroacetamide HeLa C165(0.00); C198(0.00); H192(0.00); H167(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C198(1.18); C165(0.83)  LDD2227  [22]
 LDCM0367  CL1 HEK-293T C300(1.53)  LDD0965  [37]
 LDCM0368  CL10 HEK-293T C300(2.02)  LDD0966  [37]
 LDCM0369  CL100 HEK-293T C300(1.24)  LDD0967  [37]
 LDCM0370  CL101 HEK-293T C300(1.09)  LDD0968  [37]
 LDCM0371  CL102 HEK-293T C300(1.10)  LDD0969  [37]
 LDCM0372  CL103 HEK-293T C300(1.17)  LDD0970  [37]
 LDCM0373  CL104 HEK-293T C300(1.05)  LDD0971  [37]
 LDCM0374  CL105 HEK-293T C300(1.25)  LDD0972  [37]
 LDCM0375  CL106 HEK-293T C300(1.37)  LDD0973  [37]
 LDCM0376  CL107 HEK-293T C300(1.81)  LDD0974  [37]
 LDCM0377  CL108 HEK-293T C300(1.73)  LDD0975  [37]
 LDCM0378  CL109 HEK-293T C300(1.37)  LDD0976  [37]
 LDCM0379  CL11 HEK-293T C300(1.93)  LDD0977  [37]
 LDCM0380  CL110 HEK-293T C300(1.28)  LDD0978  [37]
 LDCM0381  CL111 HEK-293T C300(1.23)  LDD0979  [37]
 LDCM0382  CL112 HEK-293T C300(1.06)  LDD0980  [37]
 LDCM0383  CL113 HEK-293T C300(1.06)  LDD0981  [37]
 LDCM0384  CL114 HEK-293T C300(1.29)  LDD0982  [37]
 LDCM0385  CL115 HEK-293T C300(1.07)  LDD0983  [37]
 LDCM0386  CL116 HEK-293T C300(1.11)  LDD0984  [37]
 LDCM0387  CL117 HEK-293T C300(1.18)  LDD0985  [37]
 LDCM0388  CL118 HEK-293T C300(1.56)  LDD0986  [37]
 LDCM0389  CL119 HEK-293T C300(1.30)  LDD0987  [37]
 LDCM0390  CL12 HEK-293T C300(1.30)  LDD0988  [37]
 LDCM0391  CL120 HEK-293T C300(1.44)  LDD0989  [37]
 LDCM0392  CL121 HEK-293T C300(1.15)  LDD0990  [37]
 LDCM0393  CL122 HEK-293T C300(1.26)  LDD0991  [37]
 LDCM0394  CL123 HEK-293T C300(1.64)  LDD0992  [37]
 LDCM0395  CL124 HEK-293T C300(0.98)  LDD0993  [37]
 LDCM0396  CL125 HEK-293T C300(1.12)  LDD0994  [37]
 LDCM0397  CL126 HEK-293T C300(1.73)  LDD0995  [37]
 LDCM0398  CL127 HEK-293T C300(0.99)  LDD0996  [37]
 LDCM0399  CL128 HEK-293T C300(1.02)  LDD0997  [37]
 LDCM0400  CL13 HEK-293T C300(1.35)  LDD0998  [37]
 LDCM0401  CL14 HEK-293T C300(1.14)  LDD0999  [37]
 LDCM0402  CL15 HEK-293T C300(1.92)  LDD1000  [37]
 LDCM0403  CL16 PaTu 8988t C198(0.86); C165(0.52)  LDD1282  [37]
 LDCM0404  CL17 PaTu 8988t C198(0.81); C165(1.02)  LDD1283  [37]
 LDCM0405  CL18 PaTu 8988t C198(0.70); C165(0.88)  LDD1284  [37]
 LDCM0406  CL19 PaTu 8988t C198(0.78); C165(0.67)  LDD1285  [37]
 LDCM0407  CL2 HEK-293T C300(1.03)  LDD1005  [37]
 LDCM0408  CL20 PaTu 8988t C198(0.74); C165(0.66)  LDD1287  [37]
 LDCM0409  CL21 PaTu 8988t C198(0.53); C165(0.50)  LDD1288  [37]
 LDCM0410  CL22 PaTu 8988t C198(0.63); C165(0.69)  LDD1289  [37]
 LDCM0411  CL23 PaTu 8988t C198(0.73); C165(0.89)  LDD1290  [37]
 LDCM0412  CL24 PaTu 8988t C198(0.81); C165(0.91)  LDD1291  [37]
 LDCM0413  CL25 PaTu 8988t C198(0.63); C165(0.68)  LDD1292  [37]
 LDCM0414  CL26 PaTu 8988t C198(0.68); C165(0.60)  LDD1293  [37]
 LDCM0415  CL27 PaTu 8988t C198(0.74); C165(0.86)  LDD1294  [37]
 LDCM0416  CL28 PaTu 8988t C198(0.67); C165(0.69)  LDD1295  [37]
 LDCM0417  CL29 PaTu 8988t C198(0.68); C165(0.64)  LDD1296  [37]
 LDCM0418  CL3 HEK-293T C300(0.96)  LDD1016  [37]
 LDCM0419  CL30 PaTu 8988t C198(0.52); C165(0.48)  LDD1298  [37]
 LDCM0420  CL31 HEK-293T C300(1.19)  LDD1018  [37]
 LDCM0421  CL32 HEK-293T C300(1.75)  LDD1019  [37]
 LDCM0422  CL33 HEK-293T C300(1.41)  LDD1020  [37]
 LDCM0423  CL34 HEK-293T C300(1.28)  LDD1021  [37]
 LDCM0424  CL35 HEK-293T C300(1.30)  LDD1022  [37]
 LDCM0425  CL36 HEK-293T C300(1.58)  LDD1023  [37]
 LDCM0426  CL37 HEK-293T C300(1.30)  LDD1024  [37]
 LDCM0428  CL39 HEK-293T C300(1.85)  LDD1026  [37]
 LDCM0429  CL4 HEK-293T C300(1.18)  LDD1027  [37]
 LDCM0430  CL40 HEK-293T C300(1.49)  LDD1028  [37]
 LDCM0431  CL41 HEK-293T C300(1.89)  LDD1029  [37]
 LDCM0432  CL42 HEK-293T C300(1.76)  LDD1030  [37]
 LDCM0433  CL43 HEK-293T C300(2.01)  LDD1031  [37]
 LDCM0434  CL44 HEK-293T C300(1.56)  LDD1032  [37]
 LDCM0435  CL45 HEK-293T C300(1.54)  LDD1033  [37]
 LDCM0436  CL46 HEK-293T C300(1.11)  LDD1034  [37]
 LDCM0437  CL47 HEK-293T C300(1.04)  LDD1035  [37]
 LDCM0438  CL48 HEK-293T C300(0.91)  LDD1036  [37]
 LDCM0439  CL49 HEK-293T C300(1.00)  LDD1037  [37]
 LDCM0440  CL5 HEK-293T C300(1.38)  LDD1038  [37]
 LDCM0441  CL50 HEK-293T C300(1.28)  LDD1039  [37]
 LDCM0442  CL51 HEK-293T C300(1.13)  LDD1040  [37]
 LDCM0443  CL52 HEK-293T C300(0.88)  LDD1041  [37]
 LDCM0444  CL53 HEK-293T C300(0.87)  LDD1042  [37]
 LDCM0445  CL54 HEK-293T C300(1.08)  LDD1043  [37]
 LDCM0446  CL55 HEK-293T C300(1.11)  LDD1044  [37]
 LDCM0447  CL56 HEK-293T C300(1.02)  LDD1045  [37]
 LDCM0448  CL57 HEK-293T C300(0.93)  LDD1046  [37]
 LDCM0449  CL58 HEK-293T C300(0.95)  LDD1047  [37]
 LDCM0450  CL59 HEK-293T C300(1.15)  LDD1048  [37]
 LDCM0451  CL6 HEK-293T C300(1.64)  LDD1049  [37]
 LDCM0452  CL60 HEK-293T C300(1.36)  LDD1050  [37]
 LDCM0453  CL61 HEK-293T C300(1.05)  LDD1051  [37]
 LDCM0454  CL62 HEK-293T C300(1.19)  LDD1052  [37]
 LDCM0455  CL63 HEK-293T C300(1.31)  LDD1053  [37]
 LDCM0456  CL64 HEK-293T C300(0.93)  LDD1054  [37]
 LDCM0457  CL65 HEK-293T C300(1.31)  LDD1055  [37]
 LDCM0458  CL66 HEK-293T C300(1.17)  LDD1056  [37]
 LDCM0459  CL67 HEK-293T C300(1.21)  LDD1057  [37]
 LDCM0460  CL68 HEK-293T C300(1.49)  LDD1058  [37]
 LDCM0461  CL69 HEK-293T C300(1.29)  LDD1059  [37]
 LDCM0462  CL7 HEK-293T C300(1.29)  LDD1060  [37]
 LDCM0463  CL70 HEK-293T C300(1.31)  LDD1061  [37]
 LDCM0464  CL71 HEK-293T C300(1.30)  LDD1062  [37]
 LDCM0465  CL72 HEK-293T C300(1.10)  LDD1063  [37]
 LDCM0466  CL73 HEK-293T C300(1.25)  LDD1064  [37]
 LDCM0467  CL74 HEK-293T C300(1.72)  LDD1065  [37]
 LDCM0469  CL76 PaTu 8988t C198(0.74); C165(0.81)  LDD1348  [37]
 LDCM0470  CL77 PaTu 8988t C198(0.86); C165(0.83)  LDD1349  [37]
 LDCM0471  CL78 PaTu 8988t C198(1.05); C165(1.33)  LDD1350  [37]
 LDCM0472  CL79 PaTu 8988t C198(1.24); C165(1.42)  LDD1351  [37]
 LDCM0473  CL8 HEK-293T C300(1.70)  LDD1071  [37]
 LDCM0474  CL80 PaTu 8988t C198(0.72); C165(0.91)  LDD1353  [37]
 LDCM0475  CL81 PaTu 8988t C198(0.90); C165(1.09)  LDD1354  [37]
 LDCM0476  CL82 PaTu 8988t C198(0.80); C165(0.78)  LDD1355  [37]
 LDCM0477  CL83 PaTu 8988t C198(0.91); C165(1.15)  LDD1356  [37]
 LDCM0478  CL84 PaTu 8988t C198(0.93); C165(1.17)  LDD1357  [37]
 LDCM0479  CL85 PaTu 8988t C198(1.06); C165(1.23)  LDD1358  [37]
 LDCM0480  CL86 PaTu 8988t C198(0.70); C165(0.87)  LDD1359  [37]
 LDCM0481  CL87 PaTu 8988t C198(0.78); C165(0.92)  LDD1360  [37]
 LDCM0482  CL88 PaTu 8988t C198(0.79); C165(1.01)  LDD1361  [37]
 LDCM0483  CL89 PaTu 8988t C198(0.96); C165(1.18)  LDD1362  [37]
 LDCM0484  CL9 HEK-293T C300(1.26)  LDD1082  [37]
 LDCM0485  CL90 PaTu 8988t C198(0.99); C165(1.08)  LDD1364  [37]
 LDCM0486  CL91 HEK-293T C300(1.18)  LDD1084  [37]
 LDCM0487  CL92 HEK-293T C300(1.22)  LDD1085  [37]
 LDCM0488  CL93 HEK-293T C300(1.11)  LDD1086  [37]
 LDCM0489  CL94 HEK-293T C300(1.23)  LDD1087  [37]
 LDCM0490  CL95 HEK-293T C300(1.45)  LDD1088  [37]
 LDCM0491  CL96 HEK-293T C300(1.08)  LDD1089  [37]
 LDCM0492  CL97 HEK-293T C300(1.07)  LDD1090  [37]
 LDCM0493  CL98 HEK-293T C300(1.37)  LDD1091  [37]
 LDCM0494  CL99 HEK-293T C300(1.26)  LDD1092  [37]
 LDCM0634  CY-0357 Hep-G2 C198(2.08)  LDD2228  [22]
 LDCM0495  E2913 HEK-293T C239(0.95); C165(1.00); C198(1.03); C63(1.07)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C165(0.70); C239(0.67); C198(0.62)  LDD1702  [36]
 LDCM0625  F8 Ramos C165(0.90); C239(0.99); C300(0.50)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C165(0.63); C239(0.70); C300(0.74)  LDD2189  [39]
 LDCM0573  Fragment11 Ramos C165(2.22); C239(0.01); C300(0.76); C63(0.38)  LDD2190  [39]
 LDCM0574  Fragment12 Ramos C165(0.57); C239(0.42); C300(0.98)  LDD2191  [39]
 LDCM0575  Fragment13 Ramos C165(1.15); C239(1.23)  LDD2192  [39]
 LDCM0576  Fragment14 Ramos C165(0.42); C239(0.43); C300(1.38)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C165(0.41); C239(0.36); C300(0.80)  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C165(0.85); C239(0.86); C300(1.74)  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C165(0.13); C239(0.17); C300(1.54); C63(4.60)  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C165(1.04); C239(1.03)  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C165(0.80); C239(0.48); C300(0.48)  LDD2198  [39]
 LDCM0588  Fragment30 Ramos C165(1.42); C239(1.04); C300(0.97)  LDD2199  [39]
 LDCM0589  Fragment31 Ramos C165(1.00); C239(0.96)  LDD2200  [39]
 LDCM0590  Fragment32 Ramos C165(0.50); C239(0.40); C300(0.74)  LDD2201  [39]
 LDCM0468  Fragment33 HEK-293T C300(1.69)  LDD1066  [37]
 LDCM0596  Fragment38 Ramos C165(1.14); C239(1.06)  LDD2203  [39]
 LDCM0566  Fragment4 Ramos C165(0.79); C239(0.66); C300(0.57)  LDD2184  [39]
 LDCM0427  Fragment51 HEK-293T C300(1.47)  LDD1025  [37]
 LDCM0610  Fragment52 Ramos C165(1.68); C239(1.22)  LDD2204  [39]
 LDCM0614  Fragment56 Ramos C165(1.19); C239(1.09); C300(0.80)  LDD2205  [39]
 LDCM0569  Fragment7 Ramos C165(0.55); C239(0.41); C300(0.35); C63(2.73)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C165(0.42); C239(0.39); C300(0.85)  LDD2188  [39]
 LDCM0116  HHS-0101 DM93 Y39(0.75); Y266(1.15); Y265(1.70)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y39(0.69); Y266(0.87); Y265(1.38)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y39(0.63); Y266(1.13); Y265(1.80)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y39(0.77); Y266(1.46); Y265(1.71)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y39(0.80); Y265(0.91); Y266(1.32)  LDD0268  [12]
 LDCM0107  IAA HeLa H192(0.00); C198(0.00); C165(0.00); H167(0.00)  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y39(0.61)  LDD0285  [11]
 LDCM0125  JWB146 DM93 Y39(0.72)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y39(2.35)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y39(1.23)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y39(1.35)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y39(0.67)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y39(0.62)  LDD0292  [11]
 LDCM0022  KB02 HEK-293T C239(1.00); C165(0.97); C198(1.00); C63(1.14)  LDD1492  [38]
 LDCM0023  KB03 HEK-293T C239(0.95); C165(1.02); C198(0.95); C63(0.98)  LDD1497  [38]
 LDCM0024  KB05 G361 C315(1.53); C180(2.01)  LDD3311  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C165(0.78); C239(0.88)  LDD2102  [36]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C165(0.53); C239(0.45)  LDD2121  [36]
 LDCM0109  NEM HeLa H373(0.00); H192(0.00); C198(0.00); H167(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C165(0.55); C239(0.81)  LDD2089  [36]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C165(1.32); C239(1.07)  LDD2090  [36]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C165(0.73); C239(0.95)  LDD2092  [36]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C165(0.96); C239(1.10)  LDD2093  [36]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C165(1.15); C239(1.19)  LDD2094  [36]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C165(0.96); C239(0.14)  LDD2096  [36]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C165(0.66); C239(0.73)  LDD2097  [36]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C165(0.79); C239(0.71)  LDD2098  [36]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C165(1.01); C239(0.99)  LDD2099  [36]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C165(0.68); C239(0.64)  LDD2100  [36]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C165(0.69); C239(1.39)  LDD2101  [36]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C165(0.84); C239(0.98)  LDD2104  [36]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C165(1.37); C239(1.34)  LDD2105  [36]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C165(0.61); C239(0.65)  LDD2106  [36]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C165(0.97); C239(0.98)  LDD2107  [36]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C165(0.87); C239(0.73)  LDD2108  [36]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C165(0.67); C239(0.65)  LDD2109  [36]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C165(0.88); C239(2.14)  LDD2110  [36]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C165(0.99); C239(1.11)  LDD2111  [36]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C165(0.62); C239(0.84)  LDD2114  [36]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C165(0.44); C239(0.65); C198(0.94)  LDD2115  [36]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C165(1.13); C239(0.24)  LDD2116  [36]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C165(0.97); C239(0.21)  LDD2118  [36]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C165(1.26); C239(2.83)  LDD2119  [36]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C165(0.79); C239(0.96)  LDD2120  [36]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C165(1.02); C239(0.19)  LDD2122  [36]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C165(0.86); C239(0.97); C198(1.23)  LDD2123  [36]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C165(1.02); C239(0.27)  LDD2124  [36]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C165(0.84); C239(0.81)  LDD2125  [36]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C165(0.81); C239(0.30)  LDD2126  [36]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C165(0.97); C239(1.07); C198(1.21)  LDD2127  [36]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C165(0.85); C239(1.05)  LDD2128  [36]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C165(1.03); C239(1.18)  LDD2129  [36]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C165(0.49); C198(0.55)  LDD2134  [36]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C165(1.10); C239(1.48)  LDD2135  [36]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C165(1.19); C239(1.33); C198(2.39)  LDD2136  [36]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C165(0.93); C239(1.02); C198(2.33)  LDD2137  [36]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C239(1.85); C165(1.48)  LDD1700  [36]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C165(0.82); C239(0.77)  LDD2140  [36]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C165(0.65); C239(0.76)  LDD2141  [36]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C165(0.98); C239(1.01)  LDD2143  [36]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C165(1.97); C239(2.78); C198(1.28)  LDD2144  [36]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C165(4.81); C239(6.62)  LDD2145  [36]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C165(0.85); C239(0.92)  LDD2146  [36]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C165(2.54); C239(3.30)  LDD2147  [36]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C165(0.49); C239(0.51)  LDD2148  [36]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C165(1.37)  LDD2149  [36]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C165(0.66); C239(0.39)  LDD2150  [36]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C165(1.08); C239(0.20)  LDD2151  [36]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C165(2.04); C239(2.00)  LDD2153  [36]
 LDCM0627  NUDT7-COV-1 HEK-293T C63(2.86)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C63(0.84); C165(0.42)  LDD2207  [40]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [33]
 LDCM0021  THZ1 HeLa S3 C75(1.11)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DDX39A (DDX39A) DEAD box helicase family O00148
Spliceosome RNA helicase DDX39B (DDX39B) DEAD box helicase family Q13838
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THO complex subunit 4 (ALYREF) ALYREF family Q86V81
UAP56-interacting factor (FYTTD1) UIF family Q96QD9
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Chromatin target of PRMT1 protein (CHTOP) . Q9Y3Y2
Leucine zipper protein 4 (LUZP4) . Q9P127
SAP domain-containing ribonucleoprotein (SARNP) . P82979

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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