Details of the Target

General Information of Target

Target ID LDTP03871
Target Name Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)
Gene Name ANP32A
Gene ID 8125
Synonyms
C15orf1; LANP; MAPM; PHAP1; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic nuclear phosphoprotein pp32; pp32; Leucine-rich acidic nuclear protein; LANP; Mapmodulin; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Putative HLA-DR-associated protein I; PHAPI
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEMGRRIHLELRNRTPSDVKELVLDNSRSNEGKLEGLTDEFEELEFLSTINVGLTSIANL
PKLNKLKKLELSDNRVSGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL
FNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYD
EDAQVVEDEEDEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEELGEEERGQKRKRE
PEDEGEDDD
Target Bioclass
Other
Family
ANP32 family
Subcellular location
Nucleus
Function
Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A.; (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication. Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region. Also plays an essential role in foamy virus mRNA export from the nucleus.
Uniprot ID
P39687
Ensemble ID
ENST00000465139.6
HGNC ID
HGNC:13233
ChEMBL ID
CHEMBL4295758

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		4.39  LDD0393  [1]
FBPP2
 Probe Info  		2.87  LDD0318  [2]
FBP2
 Probe Info  		3.09  LDD0323  [2]
TH216
 Probe Info  		Y131(10.80)  LDD0259  [3]
ONAyne
 Probe Info  		K68(0.00); K20(0.00)  LDD0273  [4]
Probe 1
 Probe Info  		Y131(16.37); Y148(19.32)  LDD3495  [5]
DBIA
 Probe Info  		C87(1.17)  LDD3312  [6]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [7]
THZ1-DTB
 Probe Info  		C123(1.07)  LDD0460  [7]
BTD
 Probe Info  		C87(1.28)  LDD2090  [8]
AHL-Pu-1
 Probe Info  		C123(3.35)  LDD0171  [9]
HHS-482
 Probe Info  		Y131(2.52)  LDD0285  [10]
5E-2FA
 Probe Info  		H92(0.00); H8(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K99(0.00); K101(0.00); K68(0.00); K20(0.00)  LDD0199  [12]
m-APA
 Probe Info  		N.A.  LDD2231  [11]
1d-yne
 Probe Info  		N.A.  LDD0358  [13]
N1
 Probe Info  		N.A.  LDD0245  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C87(0.00); C123(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C87(0.00); C123(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		C123(0.00); C87(0.00)  LDD0030  [17]
IPIAA_L
 Probe Info  		C87(0.00); C123(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C87(0.00); C123(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		K99(0.00); K86(0.00)  LDD0035  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
IPM
 Probe Info  		C123(0.00); C87(0.00)  LDD0147  [20]
OSF
 Probe Info  		N.A.  LDD0029  [21]
STPyne
 Probe Info  		N.A.  LDD0009  [22]
TFBX
 Probe Info  		N.A.  LDD0148  [20]
YN-1
 Probe Info  		N.A.  LDD0446  [23]
1c-yne
 Probe Info  		K137(0.00); K20(0.00); K116(0.00)  LDD0228  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [24]
NAIA_5
 Probe Info  		C87(0.00); C123(0.00)  LDD2223  [25]
HHS-465
 Probe Info  		K101(0.00); K110(0.00); K111(0.00); K99(0.00)  LDD2240  [26]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		8.63  LDD1728  [27]
FFF probe12
 Probe Info  		6.38  LDD0473  [28]
FFF probe13
 Probe Info  		6.44  LDD0475  [28]
DA-2
 Probe Info  		N.A.  LDD0070  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C87(0.47)  LDD2142  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C87(1.11)  LDD2117  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C87(1.07)  LDD2103  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C123(3.35)  LDD0171  [9]
 LDCM0214  AC1 HEK-293T C87(0.87); C123(1.10)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C87(0.95); C123(0.90)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C87(0.98); C123(1.01)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C87(1.03); C123(0.97)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C87(1.19); C123(1.00)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C87(0.99); C123(0.79)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C87(0.92); C123(0.89)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C87(1.02); C123(1.01)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C87(0.90); C123(0.89)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C87(0.95); C123(1.02)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C87(1.08); C123(1.00)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C87(1.10); C123(1.06)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C87(1.16); C123(0.99)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C87(1.22); C123(0.95)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C87(1.10); C123(1.09)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C87(0.90); C123(0.96)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C87(0.99); C123(0.98)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C87(1.06); C123(1.05)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C87(1.13); C123(1.09)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C87(1.14); C123(1.08)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C87(0.99); C123(1.12)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C87(1.19); C123(1.04)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C87(1.06); C123(1.04)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C87(1.03); C123(1.06)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C87(0.81); C123(0.87)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C87(0.94); C123(1.00)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C87(0.97); C123(1.04)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C87(1.00); C123(1.09)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C87(1.14); C123(1.18)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C87(1.27); C123(1.00)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C87(0.99); C123(0.91)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C87(1.06); C123(1.21)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C87(1.09); C123(1.04)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C87(0.83); C123(0.83)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C87(0.89); C123(0.93)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C87(0.98); C123(0.93)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C87(0.98); C123(1.09)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C87(1.08); C123(1.16)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C87(1.24); C123(1.07)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C87(0.97); C123(1.11)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C87(1.12); C123(1.11)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C87(0.91); C123(0.90)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C87(1.09); C123(1.27)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C87(1.02); C123(1.00)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C87(1.04); C123(1.06)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C87(0.97); C123(1.00)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C87(1.03); C123(1.12)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C87(1.12); C123(0.92)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C87(1.03); C123(0.94)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C87(1.07); C123(1.08)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C87(0.84); C123(0.87)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C87(0.98); C123(1.11)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C87(1.04); C123(1.11)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C87(1.13); C123(0.97)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C87(0.96); C123(1.08)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C87(1.10); C123(1.28)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C87(1.12); C123(0.99)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C87(0.95); C123(1.10)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C87(1.12); C123(1.35)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C87(1.00); C123(1.02)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C87(1.10); C123(1.19)  LDD1569  [30]
 LDCM0248  AKOS034007472 HEK-293T C87(1.09); C123(1.22)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C87(0.80); C123(0.77)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C87(1.11); C123(1.00)  LDD1514  [30]
 LDCM0630  CCW28-3 231MFP C123(1.49)  LDD2214  [31]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C123(20.00)  LDD2227  [25]
 LDCM0367  CL1 HEK-293T C87(0.90); C123(0.95)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C87(0.82); C123(0.50)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C87(0.92); C123(1.01)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C87(0.91); C123(1.02)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C87(0.92); C123(0.86)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C87(0.99); C123(0.85)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C87(0.88); C123(0.99)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C87(1.01); C123(0.97)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C87(1.02); C123(0.94)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C87(1.09); C123(1.09)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C87(1.07); C123(1.05)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C87(1.02); C123(1.00)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C87(0.89); C123(0.21)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C87(0.95); C123(0.90)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C87(1.03); C123(0.89)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C87(0.96); C123(1.00)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C87(0.92); C123(1.01)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C87(0.92); C123(0.94)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C87(1.03); C123(1.07)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C87(0.95); C123(1.04)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C87(0.97); C123(0.97)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C87(1.00); C123(1.02)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C87(1.06); C123(0.96)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C87(1.03); C123(0.32)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C87(0.92); C123(1.06)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C87(1.00); C123(1.05)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C87(0.99); C123(1.00)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C87(0.93); C123(1.03)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C87(0.95); C123(1.02)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C87(0.98); C123(1.07)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C87(0.94); C123(1.12)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C87(0.96); C123(1.26)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C87(0.98); C123(1.22)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C87(0.78); C123(0.83)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C87(1.01); C123(0.88)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C87(0.75); C123(0.55)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C87(0.91); C123(0.81)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C87(0.58); C123(0.39)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C87(0.92); C123(0.69)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C87(0.93); C123(0.57)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C87(0.93); C123(0.82)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C87(0.96); C123(0.56)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C87(0.93); C123(0.29)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C87(1.12); C123(0.66)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C87(0.99); C123(0.22)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C87(1.09); C123(0.32)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C87(0.86); C123(1.01)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C87(0.99); C123(0.85)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C87(1.03); C123(0.87)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C87(0.96); C123(0.85)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C87(0.93); C123(0.62)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C87(0.92); C123(0.68)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C87(1.06); C123(0.80)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C87(0.96); C123(0.57)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C87(1.03); C123(0.59)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C87(0.91); C123(0.34)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C87(1.13); C123(0.66)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C87(1.10); C123(0.21)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C87(1.14); C123(0.33)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C87(0.94); C123(0.94)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C87(0.95); C123(0.81)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C87(0.76); C123(0.81)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C87(0.95); C123(0.96)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C87(0.85); C123(0.61)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C87(1.01); C123(0.91)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C87(1.18); C123(0.70)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C87(1.07); C123(0.65)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C87(1.01); C123(0.36)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C87(1.22); C123(0.69)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C87(1.06); C123(0.23)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C87(1.10); C123(0.40)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C87(0.96); C123(1.07)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C87(0.73); C123(0.64)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C87(0.92); C123(0.85)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C87(0.92); C123(0.84)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C87(0.76); C123(0.56)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C87(0.88); C123(0.80)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C87(1.03); C123(0.60)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C87(0.94); C123(0.67)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C87(1.00); C123(0.38)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C87(1.20); C123(0.68)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C87(1.00); C123(0.26)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C87(0.73); C123(0.68)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C87(1.14); C123(0.36)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C87(0.93); C123(1.00)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C87(1.00); C123(1.04)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C87(1.02); C123(1.04)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C87(0.83); C123(0.87)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C87(0.81); C123(0.70)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C87(0.88); C123(0.82)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C87(1.02); C123(0.77)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C87(0.99); C123(0.70)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C87(1.08); C123(0.50)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C87(0.90); C123(0.67)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C87(1.20); C123(0.70)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C87(1.03); C123(0.29)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C87(1.02); C123(0.40)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C87(0.93); C123(0.96)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C87(1.03); C123(1.04)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C87(0.91); C123(1.03)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C87(0.76); C123(0.77)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C87(0.97); C123(0.87)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C87(1.16); C123(0.80)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C87(0.71); C123(0.59)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C87(1.23); C123(0.89)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C87(1.12); C123(0.50)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C87(1.26); C123(0.85)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C87(1.10); C123(0.36)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C87(1.10); C123(0.55)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C87(0.91); C123(1.07)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C87(0.89); C123(1.09)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C87(0.91); C123(1.49)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C87(0.89); C123(1.24)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C87(0.81); C123(1.07)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C87(0.92); C123(0.35)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C87(0.69); C123(0.83)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C87(1.02); C123(0.98)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C87(0.95); C123(0.89)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C87(1.02); C123(0.57)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C87(1.09); C123(0.86)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C87(0.70); C123(0.38)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C87(0.99); C123(0.85)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C87(0.92); C123(0.94)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C87(0.99); C123(1.01)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C87(1.10); C123(1.29)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C87(0.86); C123(0.83)  LDD1698  [30]
 LDCM0625  F8 Ramos C123(0.54); C87(0.73)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C123(0.68); C87(0.47)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C123(0.30); C87(0.10)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C123(0.68); C87(0.51)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C123(0.84); C87(0.77)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C123(1.08); C87(0.99)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C123(0.74); C87(0.36)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C123(0.93); C87(0.96)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C123(1.18); C87(1.31)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C123(0.98); C87(1.31)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C123(0.42); C87(0.70)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C123(1.12); C87(0.71)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C123(1.36); C87(1.19)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C123(0.74); C87(0.42)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C87(1.01); C123(1.08)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C123(0.97); C87(1.75)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C123(0.87); C87(0.57)  LDD2184  [32]
 LDCM0427  Fragment51 HEK-293T C87(1.01); C123(0.95)  LDD1631  [30]
 LDCM0610  Fragment52 Ramos C123(1.00); C87(0.99)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C123(1.07); C87(0.75)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C123(0.79); C87(0.34)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C123(0.56); C87(0.31)  LDD2188  [32]
 LDCM0123  JWB131 DM93 Y131(2.52)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y131(1.17)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y131(0.72)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y131(7.34)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y131(2.51)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y131(0.84)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y131(0.56)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y131(3.02)  LDD0292  [10]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [7]
 LDCM0022  KB02 HEK-293T C87(1.00); C123(0.99)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C87(1.00); C123(1.01)  LDD1497  [30]
 LDCM0024  KB05 HMCB C87(1.17)  LDD3312  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C87(0.95)  LDD2102  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [24]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C87(1.28)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C87(1.24)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C87(1.02)  LDD2093  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C87(1.14)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C87(1.12)  LDD2099  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C87(0.33)  LDD2104  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C87(0.43)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C87(1.07)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C87(0.68)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C87(0.42)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C87(1.18)  LDD2111  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C87(0.99)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C87(0.90)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C87(0.93)  LDD2127  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C87(0.98)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C87(1.02)  LDD2137  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C87(0.51)  LDD2141  [8]
 LDCM0131  RA190 MM1.R C87(1.69); C123(1.36)  LDD0304  [33]
 LDCM0021  THZ1 HeLa S3 C123(1.07)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Transcription factor E4F1 (E4F1) . Q66K89
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Axin-1 (AXIN1) . O15169

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.