Details of the Target

General Information of Target

Target ID LDTP05688
Target Name Interleukin enhancer-binding factor 2 (ILF2)
Gene Name ILF2
Gene ID 3608
Synonyms
NF45; Interleukin enhancer-binding factor 2; Nuclear factor of activated T-cells 45 kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKR
NQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVA
DLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTV
PPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPL
TPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHT
VMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEK
PPEKKEGEEEEENTEEPPQGEEEESMETQE
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function
Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay. Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71.; (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3.
Uniprot ID
Q12905
Ensemble ID
ENST00000361891.9
HGNC ID
HGNC:6037
ChEMBL ID
CHEMBL4295811

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.05  LDD0402  [1]
CHEMBL5175495
 Probe Info  		6.45  LDD0196  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
W1
 Probe Info  		11.99  LDD0235  [4]
TH211
 Probe Info  		Y358(9.24)  LDD0257  [5]
TH216
 Probe Info  		Y358(8.25)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
ONAyne
 Probe Info  		K186(0.00); K59(0.00)  LDD0273  [7]
Probe 1
 Probe Info  		Y108(69.25); Y268(2.77); Y358(16.10)  LDD3495  [8]
BTD
 Probe Info  		C37(1.03)  LDD2117  [9]
DBIA
 Probe Info  		C311(1.01)  LDD0078  [10]
AMP probe
 Probe Info  		N.A.  LDD0200  [11]
ATP probe
 Probe Info  		K186(0.00); K59(0.00); K110(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C37(0.00); C311(0.00); C271(0.00); C291(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C271(0.00); C311(0.00)  LDD0032  [13]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C37(0.00); C311(0.00); C271(0.00); C291(0.00)  LDD0037  [12]
1d-yne
 Probe Info  		K328(0.00); K45(0.00)  LDD0356  [15]
IPM
 Probe Info  		N.A.  LDD0147  [16]
NHS
 Probe Info  		K186(0.00); K59(0.00); K45(0.00)  LDD0010  [17]
SF
 Probe Info  		Y358(0.00); K141(0.00); K186(0.00)  LDD0028  [18]
STPyne
 Probe Info  		N.A.  LDD0009  [17]
Phosphinate-6
 Probe Info  		C37(0.00); C311(0.00)  LDD0018  [19]
Ox-W18
 Probe Info  		W243(0.00); W346(0.00)  LDD2175  [20]
1c-yne
 Probe Info  		K45(0.00); K356(0.00); K328(0.00); K196(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		H117(0.00); C37(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		H323(0.00); C37(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
AOyne
 Probe Info  		12.30  LDD0443  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [23]
TER-AC
 Probe Info  		N.A.  LDD0426  [24]
HHS-475
 Probe Info  		Y358(1.19)  LDD2238  [25]
HHS-482
 Probe Info  		Y358(1.00)  LDD2239  [25]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C322
 Probe Info  		7.16  LDD1988  [26]
FFF probe13
 Probe Info  		7.25  LDD0475  [27]
FFF probe4
 Probe Info  		8.01  LDD0466  [27]
JN0003
 Probe Info  		5.78  LDD0469  [27]
DA-2
 Probe Info  		N.A.  LDD0070  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C37(1.03)  LDD2117  [9]
 LDCM0025  4SU-RNA HEK-293T C37(3.08)  LDD0371  [29]
 LDCM0214  AC1 HCT 116 C271(0.85); C291(0.89); C311(1.04); C37(0.82)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C271(0.76); C291(0.82); C311(1.05); C37(0.89)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C271(0.41); C291(0.47); C311(0.80)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C271(0.34); C291(0.50); C311(0.80)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C271(0.29); C291(0.36); C311(0.77)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C271(0.40); C291(0.48); C311(0.87)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C271(0.33); C291(0.44); C311(0.85)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C271(0.35); C291(0.48); C311(0.93)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C271(0.33); C291(0.41); C311(0.89)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C271(0.44); C291(0.41); C311(0.99)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C271(0.41); C291(0.46); C311(0.81)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C271(0.28); C291(0.51); C311(0.80)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C271(0.60); C291(0.67); C311(1.02); C37(1.12)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C271(0.21); C291(0.51); C311(0.78)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C271(0.27); C291(0.46); C311(0.82)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C271(0.34); C291(0.43); C311(0.83)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C271(0.74); C291(0.74); C311(0.94); C37(0.89)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C271(2.06); C291(0.89); C311(0.82); C37(1.54)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C271(2.31); C291(0.77); C311(1.02); C37(1.25)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C271(1.10); C291(0.88); C311(0.99); C37(1.30)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C271(1.47); C291(0.87); C311(0.89); C37(0.84)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C271(1.30); C291(0.70); C311(0.89); C37(0.77)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C271(2.53); C291(0.92); C311(0.92); C37(0.98)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C271(0.64); C291(0.64); C311(1.03); C37(0.95)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C271(1.37); C291(0.60); C311(0.82); C37(1.14)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C271(1.44); C291(0.86); C311(0.93); C37(1.01)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C271(1.77); C291(0.73); C311(1.03); C37(1.25)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C271(1.66); C291(0.70); C311(0.82); C37(0.98)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C271(1.44); C291(0.78); C311(1.16); C37(1.13)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C271(2.44); C291(1.08); C311(1.17); C37(1.08)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C271(1.02); C291(0.92); C311(1.02); C37(1.00)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C271(1.53); C291(0.94); C311(1.02); C37(1.17)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C271(1.11); C291(1.11); C311(1.39); C37(1.29)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C271(0.73); C291(0.73); C311(1.15); C37(1.12)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C271(0.80); C291(0.80); C311(1.41); C37(1.30)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C271(0.96); C291(0.96); C311(2.01); C37(1.41)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C271(0.59); C291(0.59); C311(1.02); C37(1.14)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C271(0.83); C291(0.83); C311(1.20); C37(1.09)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C271(0.59); C291(0.59); C311(1.25); C37(1.19)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C271(0.88); C291(0.88); C311(1.16); C37(1.22)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C271(0.64); C291(0.64); C311(1.14); C37(1.06)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C271(0.61); C291(0.61); C311(1.31); C37(1.06)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C271(0.47); C291(0.47); C311(1.48); C37(1.02)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C271(0.64); C291(0.64); C311(1.29); C37(1.38)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C271(0.80); C291(0.74); C311(1.23); C37(0.94)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C271(0.74); C291(0.74); C311(1.05); C37(1.23)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C271(0.70); C291(0.70); C311(1.17); C37(1.14)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C271(0.90); C291(0.90); C311(1.13); C37(1.17)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C311(0.75)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C311(1.12)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C311(1.39)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C311(1.22)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C311(1.07)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C311(1.12)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C311(0.96)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C271(0.71); C291(0.76); C37(1.02); C311(1.17)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C311(0.97)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C311(0.87)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C311(1.45)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C311(1.22)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C311(0.95)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C311(0.94)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C311(1.16)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C311(1.37)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C271(0.53); C291(0.79); C311(0.96); C37(1.04)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C271(0.52); C291(0.57); C37(0.77); C311(0.91)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C271(0.73); C311(0.89); C37(1.29); C291(1.32)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C37(0.74); C271(0.88); C291(0.98); C311(1.11)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C271(0.84); C311(0.93); C291(1.15); C37(1.29)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C271(0.51); C37(0.84); C291(0.85); C311(0.92)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C271(0.45); C311(0.85); C291(0.94); C37(0.95)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C311(0.94); C37(1.01); C271(1.34); C291(1.44)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C37(0.82); C311(1.07); C271(1.29); C291(1.37)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C311(0.88); C291(0.89); C271(0.93); C37(1.03)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C311(0.76); C291(0.78); C271(0.86); C37(0.87)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C291(0.77); C311(0.79); C271(0.83); C37(0.95)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C271(0.69); C291(0.77); C311(0.77); C37(0.84)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C291(0.82); C311(0.82); C37(0.91); C271(0.94)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C271(0.78); C37(0.85); C291(0.85); C311(1.05)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C311(0.80); C37(0.86); C291(0.92); C271(1.01)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C311(0.84); C291(0.85); C271(0.89); C37(0.92)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C291(0.72); C311(0.76); C37(0.80); C271(0.82)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C37(0.87); C291(0.87); C311(0.89); C271(1.03)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C291(0.83); C311(0.83); C271(0.93); C37(0.96)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C311(1.03)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C311(0.99)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C311(0.95)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C311(1.07)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C311(0.88)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C271(0.66); C291(0.75); C37(0.92); C311(1.20)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C311(1.10)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C311(1.01)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C311(1.03)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C311(0.96)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C311(1.04)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C311(1.08)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C311(0.84); C291(1.35)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C311(0.81); C291(1.59)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C311(0.71); C291(0.94)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C311(1.14); C291(1.15)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C271(0.66); C291(0.74); C37(0.86); C311(1.17)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C311(0.83); C291(1.56)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C311(0.91); C291(1.14)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C311(0.90); C291(1.01)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C311(0.99); C291(1.98)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C311(0.95); C291(1.12)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C311(1.06); C291(1.36)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C311(0.98); C291(1.46)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C311(1.18); C271(1.36); C291(1.36)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C271(0.75); C291(0.75); C311(1.25)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C271(0.93); C291(0.93); C311(1.69)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C311(0.98); C37(1.03); C271(1.04); C291(1.08)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C271(0.79); C291(0.79); C311(1.32)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C271(0.97); C291(0.97); C311(1.05)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C311(1.19); C271(1.48); C291(1.48)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C271(0.96); C291(0.96); C311(1.15)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C271(1.02); C291(1.02); C311(1.25)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C271(1.05); C291(1.05); C311(1.26)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C271(1.10); C291(1.10); C311(1.49)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C271(0.70); C291(0.70); C311(1.17)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C311(1.15); C291(1.30); C37(1.43)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C291(0.88); C311(1.17); C37(2.09)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C271(0.80); C291(0.81); C37(0.91); C311(1.00)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C311(0.99); C291(1.27); C37(1.37)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C291(0.86); C311(1.13); C37(2.27)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C311(1.07); C291(1.23); C37(1.53)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C311(1.06); C291(1.11); C37(2.06)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C311(1.14); C291(1.62); C37(2.09)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C311(1.11); C37(1.59); C291(2.18)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C291(1.04); C311(1.19); C37(1.69)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C311(0.95); C291(1.07); C37(1.90)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C311(0.95); C291(1.11); C37(1.79)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C291(0.88); C311(1.01); C37(2.44)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C271(0.56); C291(0.61); C37(1.00); C311(1.02)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C291(1.18); C311(1.19); C37(1.57)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C37(0.28); C291(0.54); C311(1.12)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C311(1.19); C291(1.63); C37(1.81)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C271(0.71); C291(0.80); C311(0.97)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C271(0.56); C291(0.62); C311(0.95)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C271(0.59); C291(0.63); C311(0.73)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C271(0.73); C291(0.77); C311(0.93)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C311(0.78); C291(0.86); C271(0.88)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C271(0.74); C291(0.79); C311(1.42)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C291(0.96); C271(0.96); C311(0.97)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C311(0.82); C291(0.98); C271(1.10)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C271(0.82); C311(0.86); C291(0.90)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C271(0.84); C291(0.86); C311(1.13)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C291(0.66); C271(0.68); C311(0.82)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C271(0.61); C291(0.67); C311(0.75)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C311(0.92); C271(1.03); C291(1.05)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C271(0.77); C291(0.85); C311(1.02)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C271(0.65); C291(0.67); C311(0.83)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C271(0.25); C291(0.42); C311(0.69)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C271(0.27); C291(0.35); C311(0.80)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C271(0.86); C291(0.88); C311(1.09); C37(0.99)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C271(0.70); C291(0.79); C37(0.95); C311(1.13)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C271(0.64); C291(0.71); C311(1.06); C37(1.26)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C311(1.01)  LDD0078  [10]
 LDCM0108  Chloroacetamide HeLa C37(0.00); H117(0.00)  LDD0222  [21]
 LDCM0367  CL1 HCT 116 C291(0.88); C311(0.93)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C291(0.79); C311(1.00)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C271(0.71); C291(0.82); C37(0.87); C311(0.97)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C291(0.74); C271(0.74); C311(1.12); C37(1.23)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C291(0.92); C271(0.93); C311(0.93); C37(1.15)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C291(0.85); C271(0.85); C37(0.94); C311(0.97)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C271(0.80); C291(0.86); C311(0.97); C37(1.30)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C271(0.72); C291(1.02); C311(1.02); C37(1.11)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C271(0.62); C291(0.79); C311(1.01); C37(1.01)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C271(0.47); C291(0.85); C311(1.06); C37(1.07)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C271(0.56); C291(1.05); C311(1.21); C37(1.31)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C271(0.54); C291(0.80); C311(0.87); C37(1.04)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C291(0.85); C311(1.07)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C271(0.46); C291(0.79); C311(0.92); C37(1.07)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C271(0.49); C291(0.70); C311(0.86); C37(0.95)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C311(0.80); C37(0.82); C291(0.83); C271(1.02)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C311(0.75); C291(0.80); C37(0.82); C271(0.90)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C311(0.76); C291(0.90); C37(0.98); C271(1.11)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C271(0.70); C291(0.75); C311(0.85); C37(0.85)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C291(0.72); C37(0.75); C311(0.75); C271(0.80)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C311(1.16)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C311(1.05)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C311(1.01)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C311(1.07); C291(1.10)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C311(0.82)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C311(0.76); C291(0.95)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C311(0.89); C291(1.08)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C311(1.02); C291(1.28)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C311(0.89); C291(1.13)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C271(0.94); C291(0.94); C311(1.12)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C271(0.90); C291(0.90); C311(0.91)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C311(0.93); C271(1.11); C291(1.11)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C271(1.03); C291(1.03); C311(1.40)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C291(0.77); C311(1.14)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C291(0.88); C311(1.09)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C291(0.70); C311(0.85)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C311(0.88); C271(0.96); C291(0.96)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C311(1.08); C271(1.10); C291(1.10)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C271(0.74); C291(0.74); C311(1.05)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C271(0.84); C291(0.84); C311(1.05)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C291(0.84); C311(1.02)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C271(1.02); C291(1.02); C311(1.16)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C271(0.85); C291(0.85); C311(1.08)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C271(0.93); C291(0.93); C311(1.25)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C271(0.87); C291(0.87); C311(1.15)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C271(0.88); C291(0.88); C311(1.09)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C271(1.03); C291(1.03); C311(1.19)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C271(0.82); C291(0.82); C311(0.98)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C271(1.02); C291(1.02); C311(1.00)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C271(0.80); C291(0.80); C311(0.95)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C271(0.82); C291(0.82); C311(1.01)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C291(0.94); C311(1.05)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C271(0.91); C291(0.91); C311(1.06)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C271(1.22); C291(1.22); C311(1.15); C37(1.25)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C271(1.08); C291(1.08); C311(0.90); C37(1.27)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C271(0.97); C291(0.97); C311(0.86); C37(2.18)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C271(0.96); C291(0.96); C311(1.41); C37(1.23)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C271(1.34); C291(1.34); C311(1.12); C37(1.28)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C271(1.38); C291(1.38); C311(1.16); C37(1.46)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C271(1.35); C291(1.35); C311(1.06); C37(1.55)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C271(1.17); C291(1.17); C311(1.23); C37(1.07)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C291(0.91); C311(0.90)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C271(1.13); C291(1.13); C311(0.98); C37(1.43)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C271(1.19); C291(1.19); C311(1.36); C37(1.20)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C271(0.91); C291(0.91); C311(1.25); C37(1.08)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C271(1.22); C291(1.22); C311(1.15); C37(1.46)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C271(1.12); C291(1.12); C311(1.07); C37(1.27)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C271(1.17); C291(1.17); C311(1.34); C37(1.11)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C311(0.89); C37(1.00)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C311(0.85); C37(0.64)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C311(1.05); C37(1.19)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C311(1.06); C37(0.77)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C291(0.99); C311(0.94)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C311(0.90); C37(0.99)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C311(0.90); C37(0.85)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C311(0.95); C37(0.99)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C311(0.91); C37(1.01)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C311(0.83); C37(1.03)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C311(1.08); C37(0.82)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C311(0.93); C37(0.66)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C311(1.00); C37(0.77)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C311(0.91); C37(1.03)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C311(1.07); C37(0.85)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C291(0.85); C311(1.05)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C311(0.94); C37(1.02)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C271(1.72); C291(1.27); C311(1.05)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C271(0.90); C291(0.84); C311(1.18)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C271(1.05); C291(0.85); C311(0.97)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C271(0.96); C291(0.89); C311(1.05)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C271(0.91); C291(0.89); C311(1.38)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C271(1.05); C291(0.90); C311(1.15)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C271(0.87); C291(0.86); C311(1.33)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C271(0.78); C291(0.82); C311(1.13)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C271(1.20); C291(1.11); C311(1.17)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C291(0.78); C311(1.20)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C271(1.23); C291(0.96); C311(1.05)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C271(0.98); C291(0.74); C311(1.02)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C271(0.97); C291(0.79); C311(0.86)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C271(0.87); C291(0.74); C311(1.59)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C271(0.90); C291(0.94); C311(1.19)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C271(1.12); C291(1.16); C311(1.01); C37(0.88)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C271(1.23); C291(1.05); C311(1.94); C37(1.28)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C271(1.02); C291(1.09); C311(1.14); C37(0.79)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C271(1.07); C291(1.11); C311(1.18); C37(0.87)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C291(0.94); C311(1.13)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C271(2.33); C291(1.80); C311(1.10); C37(1.05)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C271(1.31); C291(1.08); C311(0.95); C37(0.96)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C271(0.99); C291(0.98); C311(1.21); C37(0.89)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C271(1.04); C291(1.00); C311(1.08); C37(0.80)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C271(1.14); C291(1.06); C311(1.22); C37(0.73)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C271(1.33); C291(1.09); C311(0.94); C37(0.79)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C271(1.21); C291(0.95); C311(1.10); C37(0.69)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C271(1.03); C291(1.07); C311(1.07); C37(0.71)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C271(1.02); C291(1.11); C311(1.09); C37(0.71)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C271(1.03); C291(0.98); C311(1.21); C37(0.83)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C291(0.99); C311(0.95)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C271(1.32); C291(1.09); C311(1.01); C37(3.17)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C271(0.82); C291(0.88); C311(0.88); C37(0.84)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C271(0.81); C291(0.84); C311(1.00); C37(0.93)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C271(0.86); C291(0.91); C311(1.17); C37(0.90)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C271(0.68); C291(0.75); C311(1.04); C37(0.94)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C271(0.75); C291(0.79); C311(1.03); C37(0.90)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C271(0.80); C291(0.83); C311(0.96); C37(0.96)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C271(0.77); C291(0.80); C311(1.04); C37(0.90)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C271(0.70); C291(0.81); C311(0.94); C37(0.88)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C271(0.74); C291(0.80); C311(0.89); C37(0.81)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C311(0.93); C37(1.07); C291(0.91)  LDD1698  [30]
 LDCM0468  Fragment33 HCT 116 C271(0.95); C291(0.83); C311(1.20)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C271(1.09); C291(1.09); C311(1.49); C37(1.43)  LDD0744  [10]
 LDCM0107  IAA HeLa H117(0.00); H323(0.00); C37(0.00)  LDD0221  [21]
 LDCM0022  KB02 HCT 116 C311(2.41)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C311(4.27)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C311(3.84)  LDD0082  [10]
 LDCM0109  NEM HeLa H192(0.00); H117(0.00); H323(0.00)  LDD0223  [21]
 LDCM0627  NUDT7-COV-1 HEK-293T C311(1.13)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C311(0.52)  LDD2207  [31]
 LDCM0131  RA190 MM1.R C311(1.42); C271(1.19); C291(1.19)  LDD0304  [32]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase D (PPID) Cyclophilin-type PPIase family Q08752
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
PRKCA-binding protein (PICK1) . Q9NRD5
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
24 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
25 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.