Details of the Target

General Information of Target

Target ID LDTP02100
Target Name Alkaline phosphatase, placental type (ALPP)
Gene Name ALPP
Gene ID 250
Synonyms
PLAP; Alkaline phosphatase, placental type; EC 3.1.3.1; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLII
FLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA
YLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAG
TYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYP
DDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEI
HRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI
ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG
YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFI
AHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
Target Bioclass
Enzyme
Family
Alkaline phosphatase family
Subcellular location
Cell membrane
Function Alkaline phosphatase that can hydrolyze various phosphate compounds.
Uniprot ID
P05187
Ensemble ID
ENST00000392027.3
HGNC ID
HGNC:439
ChEMBL ID
CHEMBL4458

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K262(2.80)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K262(0.97); K84(1.24); K403(4.13)  LDD3494  [2]
DBIA
 Probe Info  		C123(2.08)  LDD3490  [3]
5E-2FA
 Probe Info  		H110(0.00); H184(0.00)  LDD2235  [4]
m-APA
 Probe Info  		H110(0.00); H184(0.00)  LDD2231  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0176  [5]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0070  [6]
STS-1
 Probe Info  		N.A.  LDD0068  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 C-4-II C123(1.92)  LDD2282  [3]
 LDCM0023  KB03 C-4-II C123(2.21)  LDD2699  [3]
 LDCM0024  KB05 WM 266-4 C123(2.08)  LDD3490  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-glutamine gamma-glutamyltransferase K (TGM1) Transglutaminase family P22735
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Nuclear receptor subfamily 4 group A member 3 (NR4A3) Nuclear hormone receptor family Q92570
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
POU domain, class 4, transcription factor 2 (POU4F2) POU transcription factor family Q12837
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C motif chemokine 5 (CXCL5) Intercrine alpha (chemokine CxC) family P42830
Other
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Late cornified envelope-like proline-rich protein 1 (LELP1) Cornifin (SPRR) family Q5T871
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Late cornified envelope protein 1D (LCE1D) LCE family Q5T752
Late cornified envelope protein 1E (LCE1E) LCE family Q5T753
Late cornified envelope protein 1F (LCE1F) LCE family Q5T754
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Late cornified envelope protein 3A (LCE3A) LCE family Q5TA76
Late cornified envelope protein 3B (LCE3B) LCE family Q5TA77
Late cornified envelope protein 3C (LCE3C) LCE family Q5T5A8
Late cornified envelope protein 3D (LCE3D) LCE family Q9BYE3
Late cornified envelope protein 3E (LCE3E) LCE family Q5T5B0
Late cornified envelope protein 5A (LCE5A) LCE family Q5TCM9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Cysteine-rich C-terminal protein 1 (CRCT1) . Q9UGL9
F-box only protein 34 (FBXO34) . Q9NWN3
Gem-associated protein 4 (GEMIN4) . P57678
Insulin-like growth factor-binding protein 6 (IGFBP6) . P24592
Regulator of G-protein signaling 19 (RGS19) . P49795
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium . DB01373
Methyl-phosphonic Acid Mono-(4-nitro-phenyl) Ester . DB08413

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
7 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.