Details of the Target

General Information of Target

Target ID LDTP12867
Target Name Very-long-chain enoyl-CoA reductase (TECR)
Gene Name TECR
Gene ID 9524
Synonyms
GPSN2; SC2; Very-long-chain enoyl-CoA reductase; EC 1.3.1.93; Synaptic glycoprotein SC2; Trans-2,3-enoyl-CoA reductase; TER
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFSYPQDGWTDSD
PVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKG
SYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWA
CKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGTGVTTTSTVR
LDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSL
TLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGTGTSRPVSQVT
LAAVGGAGATALAFLSFCIIFIIVRSCRKKSARPAAGVGDTGMEDAKAIRGSASQGPLTE
SWKDGNPLKKPPPAVAPSSGEEGELHYATLSFHKVKPQDPQGQEATDSEYSEIKIHKRET
AETQACLRNHNPSSKEVRG
Target Bioclass
Enzyme
Family
Steroid 5-alpha reductase family
Subcellular location
Endoplasmic reticulum membrane
Function
Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA.
Uniprot ID
Q9NZ01
Ensemble ID
ENST00000215567.10
HGNC ID
HGNC:4551

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.V23M .
IM95 SNV: p.M261T DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.A83PfsTer6 .
SKMEL2 SNV: p.T145A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.47  LDD0402  [1]
HDSF-alk
 Probe Info  		2.03  LDD0197  [2]
P3
 Probe Info  		3.42  LDD0450  [3]
CHEMBL5175495
 Probe Info  		8.92  LDD0196  [4]
CY-1
 Probe Info  		100.00  LDD0243  [5]
CY4
 Probe Info  		100.00  LDD0244  [5]
N1
 Probe Info  		100.00  LDD0242  [5]
TH211
 Probe Info  		Y44(20.00); Y77(20.00); Y4(18.42); Y117(16.81)  LDD0260  [6]
TH216
 Probe Info  		Y44(16.88)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
AF-1
 Probe Info  		10.00  LDD0421  [9]
BTD
 Probe Info  		C18(2.08)  LDD1700  [10]
EA-probe
 Probe Info  		C18(1.06); C18(1.10)  LDD2210  [11]
DBIA
 Probe Info  		C18(192.49)  LDD0209  [12]
ATP probe
 Probe Info  		K12(0.00); K2(0.00); K60(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [14]
ATP probe
 Probe Info  		N.A.  LDD0035  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
ENE
 Probe Info  		N.A.  LDD0006  [21]
IPM
 Probe Info  		N.A.  LDD0005  [21]
NHS
 Probe Info  		K60(0.00); K38(0.00)  LDD0010  [21]
SF
 Probe Info  		N.A.  LDD0028  [22]
STPyne
 Probe Info  		N.A.  LDD0009  [21]
TFBX
 Probe Info  		N.A.  LDD0148  [18]
VSF
 Probe Info  		N.A.  LDD0007  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [23]
Acrolein
 Probe Info  		H3(0.00); C18(0.00); H26(0.00); K2(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		H153(0.00); H3(0.00); H40(0.00); H149(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C18(0.00); K22(0.00); H3(0.00)  LDD0218  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
TER-AC
 Probe Info  		N.A.  LDD0426  [26]
PAL-AfBPP Probe
Click To Hide/Show 57 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		32.67  LDD1740  [27]
C051
 Probe Info  		5.03  LDD1749  [27]
C053
 Probe Info  		4.96  LDD1751  [27]
C091
 Probe Info  		10.27  LDD1782  [27]
C092
 Probe Info  		49.87  LDD1783  [27]
C094
 Probe Info  		31.12  LDD1785  [27]
C107
 Probe Info  		9.78  LDD1794  [27]
C112
 Probe Info  		28.44  LDD1799  [27]
C130
 Probe Info  		9.45  LDD1812  [27]
C139
 Probe Info  		22.94  LDD1821  [27]
C140
 Probe Info  		9.99  LDD1822  [27]
C161
 Probe Info  		10.48  LDD1841  [27]
C183
 Probe Info  		5.28  LDD1861  [27]
C186
 Probe Info  		25.81  LDD1864  [27]
C196
 Probe Info  		11.88  LDD1872  [27]
C201
 Probe Info  		29.45  LDD1877  [27]
C218
 Probe Info  		18.38  LDD1892  [27]
C219
 Probe Info  		14.42  LDD1893  [27]
C220
 Probe Info  		24.42  LDD1894  [27]
C225
 Probe Info  		5.35  LDD1898  [27]
C231
 Probe Info  		41.36  LDD1904  [27]
C235
 Probe Info  		31.12  LDD1908  [27]
C240
 Probe Info  		16.68  LDD1913  [27]
C246
 Probe Info  		20.82  LDD1919  [27]
C252
 Probe Info  		8.94  LDD1925  [27]
C255
 Probe Info  		9.38  LDD1928  [27]
C270
 Probe Info  		6.41  LDD1940  [27]
C277
 Probe Info  		8.51  LDD1947  [27]
C282
 Probe Info  		23.26  LDD1952  [27]
C287
 Probe Info  		12.21  LDD1957  [27]
C288
 Probe Info  		6.23  LDD1958  [27]
C289
 Probe Info  		47.50  LDD1959  [27]
C307
 Probe Info  		5.31  LDD1975  [27]
C310
 Probe Info  		7.94  LDD1977  [27]
C339
 Probe Info  		6.54  LDD2002  [27]
C349
 Probe Info  		8.57  LDD2010  [27]
C380
 Probe Info  		7.57  LDD2039  [27]
C382
 Probe Info  		11.88  LDD2041  [27]
C386
 Probe Info  		9.58  LDD2045  [27]
C403
 Probe Info  		15.89  LDD2061  [27]
C407
 Probe Info  		11.63  LDD2064  [27]
C423
 Probe Info  		26.54  LDD2078  [27]
C426
 Probe Info  		15.56  LDD2081  [27]
C429
 Probe Info  		29.45  LDD2084  [27]
FFF probe11
 Probe Info  		20.00  LDD0471  [28]
FFF probe13
 Probe Info  		17.21  LDD0475  [28]
FFF probe14
 Probe Info  		20.00  LDD0477  [28]
FFF probe15
 Probe Info  		7.42  LDD0478  [28]
FFF probe2
 Probe Info  		18.49  LDD0463  [28]
FFF probe3
 Probe Info  		16.76  LDD0464  [28]
FFF probe4
 Probe Info  		15.82  LDD0466  [28]
FFF probe7
 Probe Info  		12.66  LDD0483  [28]
JN0003
 Probe Info  		20.00  LDD0469  [28]
STS-1
 Probe Info  		N.A.  LDD0137  [29]
STS-2
 Probe Info  		N.A.  LDD0138  [29]
DA-2
 Probe Info  		N.A.  LDD0071  [30]
OEA-DA
 Probe Info  		13.86  LDD0046  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C18(0.98)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C18(1.06)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C18(0.68)  LDD2095  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C18(0.64)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C18(1.20)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C18(1.41)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C18(0.90)  LDD2103  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C18(0.57)  LDD2132  [10]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C18(0.64)  LDD2131  [10]
 LDCM0214  AC1 HEK-293T C165(0.96); C133(1.15); C131(1.01); C133(1.01)  LDD1507  [32]
 LDCM0215  AC10 HEK-293T C131(0.91); C133(0.91)  LDD1508  [32]
 LDCM0226  AC11 HEK-293T C165(0.88); C131(1.05); C133(0.84); C131(1.34)  LDD1509  [32]
 LDCM0237  AC12 HEK-293T C133(0.86)  LDD1510  [32]
 LDCM0259  AC14 HEK-293T C131(1.16)  LDD1512  [32]
 LDCM0270  AC15 HEK-293T C165(0.94); C131(0.95); C133(0.95)  LDD1513  [32]
 LDCM0276  AC17 HEK-293T C165(1.21); C133(0.98); C131(0.94); C133(0.94)  LDD1515  [32]
 LDCM0277  AC18 HEK-293T C131(0.84); C133(0.84)  LDD1516  [32]
 LDCM0278  AC19 HEK-293T C165(0.84); C131(0.75); C133(0.71); C131(1.65)  LDD1517  [32]
 LDCM0279  AC2 HEK-293T C131(0.91); C133(0.91)  LDD1518  [32]
 LDCM0280  AC20 HEK-293T C133(0.89)  LDD1519  [32]
 LDCM0282  AC22 HEK-293T C131(1.10)  LDD1521  [32]
 LDCM0283  AC23 HEK-293T C165(1.12); C131(0.96); C133(0.96)  LDD1522  [32]
 LDCM0285  AC25 HEK-293T C165(1.07); C133(1.02); C131(0.89); C133(0.89)  LDD1524  [32]
 LDCM0286  AC26 HEK-293T C131(0.88); C133(0.88)  LDD1525  [32]
 LDCM0287  AC27 HEK-293T C165(0.76); C131(0.96); C133(0.90); C131(1.41)  LDD1526  [32]
 LDCM0288  AC28 HEK-293T C133(0.87)  LDD1527  [32]
 LDCM0290  AC3 HEK-293T C165(0.65); C131(0.93); C133(0.93); C131(1.39)  LDD1529  [32]
 LDCM0291  AC30 HEK-293T C131(0.96)  LDD1530  [32]
 LDCM0292  AC31 HEK-293T C165(0.87); C131(1.02); C133(1.02)  LDD1531  [32]
 LDCM0294  AC33 HEK-293T C165(1.02); C133(1.06); C131(1.06); C133(1.06)  LDD1533  [32]
 LDCM0295  AC34 HEK-293T C131(0.80); C133(0.80)  LDD1534  [32]
 LDCM0296  AC35 HEK-293T C165(0.71); C131(1.08); C133(0.95); C131(1.04)  LDD1535  [32]
 LDCM0297  AC36 HEK-293T C133(0.97)  LDD1536  [32]
 LDCM0299  AC38 HEK-293T C131(1.06)  LDD1538  [32]
 LDCM0300  AC39 HEK-293T C165(0.85); C131(0.93); C133(0.93)  LDD1539  [32]
 LDCM0301  AC4 HEK-293T C133(0.88)  LDD1540  [32]
 LDCM0303  AC41 HEK-293T C165(0.85); C133(1.10); C131(1.03); C133(1.03)  LDD1542  [32]
 LDCM0304  AC42 HEK-293T C131(0.82); C133(0.82)  LDD1543  [32]
 LDCM0305  AC43 HEK-293T C165(0.86); C131(1.09); C133(0.92); C131(1.34)  LDD1544  [32]
 LDCM0306  AC44 HEK-293T C133(0.94)  LDD1545  [32]
 LDCM0308  AC46 HEK-293T C131(1.18)  LDD1547  [32]
 LDCM0309  AC47 HEK-293T C165(1.03); C131(0.95); C133(0.95)  LDD1548  [32]
 LDCM0311  AC49 HEK-293T C165(1.22); C133(0.90); C131(0.96); C133(0.96)  LDD1550  [32]
 LDCM0313  AC50 HEK-293T C131(0.81); C133(0.81)  LDD1552  [32]
 LDCM0314  AC51 HEK-293T C165(0.72); C131(0.98); C133(0.84); C131(1.12)  LDD1553  [32]
 LDCM0315  AC52 HEK-293T C133(0.99)  LDD1554  [32]
 LDCM0317  AC54 HEK-293T C131(1.01)  LDD1556  [32]
 LDCM0318  AC55 HEK-293T C165(1.11); C131(0.93); C133(0.93)  LDD1557  [32]
 LDCM0320  AC57 HEK-293T C165(0.94); C133(1.16); C131(1.02); C133(1.02)  LDD1559  [32]
 LDCM0321  AC58 HEK-293T C131(0.85); C133(0.85)  LDD1560  [32]
 LDCM0322  AC59 HEK-293T C165(0.89); C131(1.00); C133(0.90); C131(1.05)  LDD1561  [32]
 LDCM0323  AC6 HEK-293T C131(1.17)  LDD1562  [32]
 LDCM0324  AC60 HEK-293T C133(0.97)  LDD1563  [32]
 LDCM0326  AC62 HEK-293T C131(1.00)  LDD1565  [32]
 LDCM0327  AC63 HEK-293T C165(0.83); C131(0.96); C133(0.96)  LDD1566  [32]
 LDCM0334  AC7 HEK-293T C165(0.89); C131(0.95); C133(0.95)  LDD1568  [32]
 LDCM0545  Acetamide MDA-MB-231 C18(0.46)  LDD2138  [10]
 LDCM0166  Afatinib A431 10.00  LDD0421  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C18(0.85)  LDD2113  [10]
 LDCM0356  AKOS034007680 HEK-293T C165(0.93); C133(1.05); C131(0.98); C133(0.98)  LDD1570  [32]
 LDCM0156  Aniline NCI-H1299 11.36  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C18(0.00); H3(0.00); H40(0.00); H153(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C18(0.86)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C165(0.96); C131(1.30); C133(1.30)  LDD1571  [32]
 LDCM0368  CL10 HEK-293T C131(3.01)  LDD1572  [32]
 LDCM0369  CL100 HEK-293T C131(1.08); C133(1.08)  LDD1573  [32]
 LDCM0370  CL101 HEK-293T C165(1.05); C131(1.01); C133(1.01)  LDD1574  [32]
 LDCM0371  CL102 HEK-293T C165(1.15)  LDD1575  [32]
 LDCM0373  CL104 HEK-293T C131(1.09); C133(1.09)  LDD1577  [32]
 LDCM0374  CL105 HEK-293T C165(0.84); C131(1.03); C133(1.03)  LDD1578  [32]
 LDCM0375  CL106 HEK-293T C165(1.22)  LDD1579  [32]
 LDCM0377  CL108 HEK-293T C131(0.94); C133(0.94)  LDD1581  [32]
 LDCM0378  CL109 HEK-293T C165(1.55); C131(1.18); C133(1.18)  LDD1582  [32]
 LDCM0379  CL11 HEK-293T C165(1.29); C131(1.67); C133(1.67)  LDD1583  [32]
 LDCM0380  CL110 HEK-293T C165(1.41)  LDD1584  [32]
 LDCM0382  CL112 HEK-293T C131(1.00); C133(1.00)  LDD1586  [32]
 LDCM0383  CL113 HEK-293T C165(0.85); C131(0.87); C133(0.87)  LDD1587  [32]
 LDCM0384  CL114 HEK-293T C165(1.65)  LDD1588  [32]
 LDCM0386  CL116 HEK-293T C131(0.94); C133(0.94)  LDD1590  [32]
 LDCM0387  CL117 HEK-293T C165(0.90); C131(1.02); C133(1.02)  LDD1591  [32]
 LDCM0388  CL118 HEK-293T C165(0.90)  LDD1592  [32]
 LDCM0391  CL120 HEK-293T C131(1.05); C133(1.05)  LDD1595  [32]
 LDCM0392  CL121 HEK-293T C165(0.96); C131(0.88); C133(0.88)  LDD1596  [32]
 LDCM0393  CL122 HEK-293T C165(1.08)  LDD1597  [32]
 LDCM0395  CL124 HEK-293T C131(1.05); C133(1.05)  LDD1599  [32]
 LDCM0396  CL125 HEK-293T C165(1.04); C131(1.01); C133(1.01)  LDD1600  [32]
 LDCM0397  CL126 HEK-293T C165(1.06)  LDD1601  [32]
 LDCM0399  CL128 HEK-293T C131(0.91); C133(0.91)  LDD1603  [32]
 LDCM0400  CL13 HEK-293T C165(1.06); C131(1.00); C133(1.00)  LDD1604  [32]
 LDCM0401  CL14 HEK-293T C165(0.99)  LDD1605  [32]
 LDCM0403  CL16 HEK-293T C131(1.06); C133(1.06)  LDD1607  [32]
 LDCM0404  CL17 HEK-293T C165(1.60); C133(1.63); C131(1.75); C133(1.75)  LDD1608  [32]
 LDCM0405  CL18 HEK-293T C131(0.93); C133(0.93)  LDD1609  [32]
 LDCM0406  CL19 HEK-293T C165(1.12); C131(1.16); C133(0.91); C131(0.99)  LDD1610  [32]
 LDCM0407  CL2 HEK-293T C165(0.94)  LDD1611  [32]
 LDCM0408  CL20 HEK-293T C133(1.13)  LDD1612  [32]
 LDCM0410  CL22 HEK-293T C131(1.52)  LDD1614  [32]
 LDCM0411  CL23 HEK-293T C165(1.04); C131(1.25); C133(1.25)  LDD1615  [32]
 LDCM0413  CL25 HEK-293T C165(0.91); C131(1.92); C133(1.92)  LDD1617  [32]
 LDCM0414  CL26 HEK-293T C165(1.30)  LDD1618  [32]
 LDCM0416  CL28 HEK-293T C131(1.14); C133(1.14)  LDD1620  [32]
 LDCM0417  CL29 HEK-293T C165(0.83); C133(0.96); C131(0.94); C133(0.94)  LDD1621  [32]
 LDCM0419  CL30 HEK-293T C131(0.87); C133(0.87)  LDD1623  [32]
 LDCM0420  CL31 HEK-293T C165(0.95); C131(1.13); C133(0.87); C131(1.23)  LDD1624  [32]
 LDCM0421  CL32 HEK-293T C133(1.05)  LDD1625  [32]
 LDCM0423  CL34 HEK-293T C131(1.32)  LDD1627  [32]
 LDCM0424  CL35 HEK-293T C165(1.21); C131(1.18); C133(1.18)  LDD1628  [32]
 LDCM0426  CL37 HEK-293T C165(0.93); C131(1.07); C133(1.07)  LDD1630  [32]
 LDCM0429  CL4 HEK-293T C131(1.14); C133(1.14)  LDD1633  [32]
 LDCM0430  CL40 HEK-293T C131(0.89); C133(0.89)  LDD1634  [32]
 LDCM0431  CL41 HEK-293T C165(1.10); C133(1.37); C131(1.17); C133(1.17)  LDD1635  [32]
 LDCM0432  CL42 HEK-293T C131(0.78); C133(0.78)  LDD1636  [32]
 LDCM0433  CL43 HEK-293T C165(0.79); C131(0.89); C133(0.93); C131(1.39)  LDD1637  [32]
 LDCM0434  CL44 HEK-293T C133(0.99)  LDD1638  [32]
 LDCM0436  CL46 HEK-293T C131(1.63)  LDD1640  [32]
 LDCM0437  CL47 HEK-293T C165(1.18); C131(1.30); C133(1.30)  LDD1641  [32]
 LDCM0439  CL49 HEK-293T C165(1.18); C131(1.01); C133(1.01)  LDD1643  [32]
 LDCM0440  CL5 HEK-293T C165(1.05); C133(1.00); C131(1.03); C133(1.03)  LDD1644  [32]
 LDCM0441  CL50 HEK-293T C165(1.03)  LDD1645  [32]
 LDCM0443  CL52 HEK-293T C131(0.89); C133(0.89)  LDD1646  [32]
 LDCM0444  CL53 HEK-293T C165(1.31); C133(1.58); C131(1.57); C133(1.57)  LDD1647  [32]
 LDCM0445  CL54 HEK-293T C131(1.71); C133(1.71)  LDD1648  [32]
 LDCM0446  CL55 HEK-293T C165(0.95); C131(1.09); C133(0.98); C131(1.02)  LDD1649  [32]
 LDCM0447  CL56 HEK-293T C133(0.95)  LDD1650  [32]
 LDCM0449  CL58 HEK-293T C131(1.40)  LDD1652  [32]
 LDCM0450  CL59 HEK-293T C165(1.25); C131(1.19); C133(1.19)  LDD1653  [32]
 LDCM0451  CL6 HEK-293T C131(1.29); C133(1.29)  LDD1654  [32]
 LDCM0453  CL61 HEK-293T C165(0.60); C131(0.99); C133(0.99)  LDD1656  [32]
 LDCM0454  CL62 HEK-293T C165(0.98)  LDD1657  [32]
 LDCM0456  CL64 HEK-293T C131(1.44); C133(1.44)  LDD1659  [32]
 LDCM0457  CL65 HEK-293T C165(1.18); C133(0.96); C131(1.02); C133(1.02)  LDD1660  [32]
 LDCM0458  CL66 HEK-293T C131(0.90); C133(0.90)  LDD1661  [32]
 LDCM0459  CL67 HEK-293T C165(0.81); C131(1.08); C133(1.01); C131(1.11)  LDD1662  [32]
 LDCM0460  CL68 HEK-293T C133(0.94)  LDD1663  [32]
 LDCM0462  CL7 HEK-293T C165(0.79); C131(1.10); C133(1.01); C131(1.32)  LDD1665  [32]
 LDCM0463  CL70 HEK-293T C131(1.34)  LDD1666  [32]
 LDCM0464  CL71 HEK-293T C165(1.17); C131(1.30); C133(1.30)  LDD1667  [32]
 LDCM0466  CL73 HEK-293T C165(1.00); C131(1.04); C133(1.04)  LDD1669  [32]
 LDCM0467  CL74 HEK-293T C165(1.17)  LDD1670  [32]
 LDCM0469  CL76 HEK-293T C131(0.92); C133(0.92)  LDD1672  [32]
 LDCM0470  CL77 HEK-293T C165(1.31); C133(1.25); C131(1.45); C133(1.45)  LDD1673  [32]
 LDCM0471  CL78 HEK-293T C131(0.88); C133(0.88)  LDD1674  [32]
 LDCM0472  CL79 HEK-293T C165(0.74); C131(1.03); C133(0.86); C131(0.97)  LDD1675  [32]
 LDCM0473  CL8 HEK-293T C133(2.22)  LDD1676  [32]
 LDCM0474  CL80 HEK-293T C133(0.83)  LDD1677  [32]
 LDCM0476  CL82 HEK-293T C131(1.19)  LDD1679  [32]
 LDCM0477  CL83 HEK-293T C165(0.94); C131(1.19); C133(1.19)  LDD1680  [32]
 LDCM0479  CL85 HEK-293T C165(0.98); C131(0.98); C133(0.98)  LDD1682  [32]
 LDCM0480  CL86 HEK-293T C165(0.88)  LDD1683  [32]
 LDCM0482  CL88 HEK-293T C131(0.86); C133(0.86)  LDD1685  [32]
 LDCM0483  CL89 HEK-293T C165(0.84); C133(0.97); C131(0.86); C133(0.86)  LDD1686  [32]
 LDCM0485  CL90 HEK-293T C131(2.29); C133(2.29)  LDD1688  [32]
 LDCM0486  CL91 HEK-293T C165(0.56); C131(0.86); C133(0.81); C131(0.99)  LDD1689  [32]
 LDCM0487  CL92 HEK-293T C133(1.10)  LDD1690  [32]
 LDCM0489  CL94 HEK-293T C131(1.58)  LDD1692  [32]
 LDCM0490  CL95 HEK-293T C165(0.94); C131(1.93); C133(1.93)  LDD1693  [32]
 LDCM0492  CL97 HEK-293T C165(1.08); C131(1.23); C133(1.23)  LDD1695  [32]
 LDCM0493  CL98 HEK-293T C165(1.05)  LDD1696  [32]
 LDCM0185  Compound 17 HEK-293T 10.31  LDD0512  [28]
 LDCM0191  Compound 21 HEK-293T 8.14  LDD0508  [28]
 LDCM0190  Compound 34 HEK-293T 9.47  LDD0510  [28]
 LDCM0192  Compound 35 HEK-293T 5.53  LDD0509  [28]
 LDCM0193  Compound 36 HEK-293T 7.52  LDD0511  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C18(4.30)  LDD1702  [10]
 LDCM0175  Ethacrynic acid HeLa C18(1.06); C18(1.10)  LDD2210  [11]
 LDCM0625  F8 Ramos C18(2.10)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C18(2.46)  LDD2189  [33]
 LDCM0574  Fragment12 Ramos C18(3.93)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C18(0.92)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C18(3.39)  LDD2193  [33]
 LDCM0580  Fragment21 Ramos C18(0.95)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C18(0.77)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C18(1.00)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C18(0.99)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C18(0.86)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C18(0.86)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C18(3.27)  LDD2201  [33]
 LDCM0468  Fragment33 Ramos C18(1.04)  LDD2202  [33]
 LDCM0596  Fragment38 Ramos C18(1.27)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C18(2.71)  LDD2184  [33]
 LDCM0427  Fragment51 HEK-293T C165(0.92)  LDD1631  [32]
 LDCM0610  Fragment52 Ramos C18(1.12)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C18(0.75)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C18(2.56)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C18(7.39)  LDD2188  [33]
 LDCM0015  HNE MDA-MB-231 C18(1.10)  LDD0346  [33]
 LDCM0107  IAA HeLa H3(0.00); H153(0.00); H40(0.00); H26(0.00)  LDD0221  [24]
 LDCM0022  KB02 HEK-293T C131(0.82); C133(0.82)  LDD1492  [32]
 LDCM0023  KB03 Jurkat C18(192.49)  LDD0209  [12]
 LDCM0024  KB05 IGR37 C18(1.29)  LDD3314  [34]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C18(1.03)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C18(0.62)  LDD2121  [10]
 LDCM0109  NEM HeLa H3(0.00); H153(0.00); H40(0.00); H26(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C18(0.97)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C18(1.22)  LDD2090  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C18(0.95)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C18(1.25)  LDD2093  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C18(1.10)  LDD2094  [10]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C18(0.75)  LDD2097  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C18(0.94)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C18(1.14)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C18(0.86)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C18(1.05)  LDD2101  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C18(0.89)  LDD2104  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C18(1.08)  LDD2105  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C18(0.66)  LDD2106  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C18(1.08)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C18(0.64)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C18(0.97)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C18(1.21)  LDD2110  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C18(1.18)  LDD2111  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C18(0.58)  LDD2115  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C18(0.37)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C18(1.86)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C18(0.78)  LDD2120  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C18(0.93)  LDD2123  [10]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C18(1.41)  LDD2124  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C18(1.05)  LDD2125  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C18(3.13)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C18(1.11)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C18(1.07)  LDD2128  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C18(1.15)  LDD2129  [10]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C18(0.80)  LDD2133  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C18(0.53)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C18(1.12)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C18(1.76)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C18(0.87)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C18(2.08)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C18(1.02)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C18(0.42)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C18(0.93)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C18(2.09)  LDD2144  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C18(1.01)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C18(1.06)  LDD2146  [10]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C18(2.67)  LDD2147  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C18(0.49)  LDD2148  [10]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C18(3.24)  LDD2149  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C18(0.59)  LDD2150  [10]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C18(3.21)  LDD2151  [10]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C18(1.53)  LDD2153  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C18(1.35); C18(1.01); C18(0.96)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C18(0.92); C18(0.74); C18(0.47); C18(0.42)  LDD2207  [35]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Vesicle transport protein GOT1A (GOLT1A) GOT1 family Q6ZVE7
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (HACD1) Very long-chain fatty acids dehydratase HACD family B0YJ81
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) Very long-chain fatty acids dehydratase HACD family Q6Y1H2
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 7 member 14 (SLC7A14) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8TBB6
Stomatin (STOM) Band 7/mec-2 family P27105
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Claudin-5 (CLDN5) Claudin family O00501
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Transcription factor A, mitochondrial (TFAM) . Q00059
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21) VMA21 family Q3ZAQ7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
31 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.