Details of the Target

General Information of Target

Target ID LDTP12851
Target Name UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1)
Gene Name UGGT1
Gene ID 56886
Synonyms
GT; UGCGL1; UGGT; UGT1; UGTR; UDP-glucose:glycoprotein glucosyltransferase 1; UGT1; hUGT1; EC 2.4.1.-; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPAKATNVVRLLLGSTALWLSQLGSGTVAASKSVTAHLAAKWPETPLLLEASEFMAEES
NEKFWQFLETVQELAIYKQTESDYSYYNLILKKAGQFLDNLHINLLKFAFSIRAYSPAIQ
MFQQIAADEPPPDGCNAFVVIHKKHTCKINEIKKLLKKAASRTRPYLFKGDHKFPTNKEN
LPVVILYAEMGTRTFSAFHKVLSEKAQNEEILYVLRHYIQKPSSRKMYLSGYGVELAIKS
TEYKALDDTQVKTVTNTTVEDETETNEVQGFLFGKLKEIYSDLRDNLTAFQKYLIESNKQ
MMPLKVWELQDLSFQAASQIMSAPVYDSIKLMKDISQNFPIKARSLTRIAVNQHMREEIK
ENQKDLQVRFKIQPGDARLFINGLRVDMDVYDAFSILDMLKLEGKMMNGLRNLGINGEDM
SKFLKLNSHIWEYTYVLDIRHSSIMWINDLENDDLYITWPTSCQKLLKPVFPGSVPSIRR
NFHNLVLFIDPAQEYTLDFIKLADVFYSHEVPLRIGFVFILNTDDEVDGANDAGVALWRA
FNYIAEEFDISEAFISIVHMYQKVKKDQNILTVDNVKSVLQNTFPHANIWDILGIHSKYD
EERKAGASFYKMTGLGPLPQALYNGEPFKHEEMNIKELKMAVLQRMMDASVYLQREVFLG
TLNDRTNAIDFLMDRNNVVPRINTLILRTNQQYLNLISTSVTADVEDFSTFFFLDSQDKS
AVIAKNMYYLTQDDESIISAVTLWIIADFDKPSGRKLLFNALKHMKTSVHSRLGIIYNPT
SKINEENTAISRGILAAFLTQKNMFLRSFLGQLAKEEIATAIYSGDKIKTFLIEGMDKNA
FEKKYNTVGVNIFRTHQLFCQDVLKLRPGEMGIVSNGRFLGPLDEDFYAEDFYLLEKITF
SNLGEKIKGIVENMGINANNMSDFIMKVDALMSSVPKRASRYDVTFLRENHSVIKTNPQE
NDMFFNVIAIVDPLTREAQKMAQLLVVLGKIINMKIKLFMNCRGRLSEAPLESFYRFVLE
PELMSGANDVSSLGPVAKFLDIPESPLLILNMITPEGWLVETVHSNCDLDNIHLKDTEKT
VTAEYELEYLLLEGQCFDKVTEQPPRGLQFTLGTKNKPAVVDTIVMAHHGYFQLKANPGA
WILRLHQGKSEDIYQIVGHEGTDSQADLEDIIVVLNSFKSKILKVKVKKETDKIKEDILT
DEDEKTKGLWDSIKSFTVSLHKENKKEKDVLNIFSVASGHLYERFLRIMMLSVLRNTKTP
VKFWLLKNYLSPTFKEVIPHMAKEYGFRYELVQYRWPRWLRQQTERQRIIWGYKILFLDV
LFPLAVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWAS
HLLRRKYHISALYVVDLKKFRRIGAGDRLRSQYQALSQDPNSLSNLDQDLPNNMIYQVAI
KSLPQDWLWCETWCDDESKQRAKTIDLCNNPKTKESKLKAAARIVPEWVEYDAEIRQLLD
HLENKKQDTILTHDEL
Target Bioclass
Enzyme
Family
Glycosyltransferase 8 family
Subcellular location
Endoplasmic reticulum lumen
Function
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Uniprot ID
Q9NYU2
Ensemble ID
ENST00000259253.11
HGNC ID
HGNC:15663

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.P1496L DBIA    Probe Info 
CHL1 SNV: p.V600G DBIA    Probe Info 
DU145 SNV: p.V33I DBIA    Probe Info 
GB1 Deletion: p.E836GfsTer10 DBIA    Probe Info 
HCT15 SNV: p.V558I DBIA    Probe Info 
HELA SNV: p.S126C .
HEP3B217 SNV: p.G1337S DBIA    Probe Info 
HUH7 SNV: p.A1158T DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.D1185E DBIA    Probe Info 
MOLT4 SNV: p.D1223N IA-alkyne    Probe Info 
NALM6 SNV: p.A825T DBIA    Probe Info 
OCIAML5 Insertion: . DBIA    Probe Info 
RCC10RGB SNV: p.G837R .
SHP77 SNV: p.K306Q; p.W321Ter .
SNU245 SNV: p.R482Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		10.00  LDD0448  [1]
P2
 Probe Info  		10.00  LDD0449  [1]
P3
 Probe Info  		10.00  LDD0450  [1]
C-Sul
 Probe Info  		5.39  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K306(10.00); K356(4.35); K362(5.75); K744(1.89)  LDD0277  [4]
ONAyne
 Probe Info  		K217(5.00)  LDD0275  [4]
IPM
 Probe Info  		C880(0.00); C1024(0.00)  LDD0241  [5]
OPA-S-S-alkyne
 Probe Info  		K356(1.45); K362(3.31)  LDD3494  [6]
Probe 1
 Probe Info  		Y449(9.36); Y805(22.87); Y966(11.71)  LDD3495  [7]
BTD
 Probe Info  		C1024(3.38)  LDD1700  [8]
HHS-475
 Probe Info  		Y599(0.05)  LDD0264  [9]
HHS-465
 Probe Info  		Y671(4.99)  LDD2237  [10]
Acrolein
 Probe Info  		N.A.  LDD0221  [11]
DBIA
 Probe Info  		C1493(1.10)  LDD0080  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1386(0.00); C880(0.00); C147(0.00); C159(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C1386(0.00); C880(0.00); C147(0.00); C159(0.00)  LDD0037  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
NAIA_5
 Probe Info  		C1493(0.00); C1386(0.00); C159(0.00); C1118(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y1267(0.67)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C349
 Probe Info  		13.45  LDD2010  [19]
FFF probe12
 Probe Info  		13.25  LDD0473  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
DA-2
 Probe Info  		N.A.  LDD0070  [22]
OEA-DA
 Probe Info  		4.28  LDD0046  [23]
STS-1
 Probe Info  		N.A.  LDD0068  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1024(0.87)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1024(1.32)  LDD2152  [8]
 LDCM0214  AC1 HCT 116 C1386(1.02)  LDD0531  [12]
 LDCM0215  AC10 PaTu 8988t C1479(1.14); C1475(0.47)  LDD1094  [12]
 LDCM0216  AC100 HCT 116 C1386(0.77)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C1386(1.08)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C1386(0.80)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C1386(0.92)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C1386(1.02)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C1386(0.97)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C1386(0.74)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C1386(0.99)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C1386(0.82)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C1386(1.09)  LDD0542  [12]
 LDCM0226  AC11 PaTu 8988t C1479(1.50); C1475(0.67)  LDD1105  [12]
 LDCM0227  AC110 HCT 116 C1386(0.92)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C1386(1.51)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C1386(0.97)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C1386(0.72)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C1386(0.70)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C1386(0.61)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C1386(0.64)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C1386(0.73)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C1386(0.67)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C1386(0.75)  LDD0553  [12]
 LDCM0237  AC12 PaTu 8988t C1479(0.83); C1475(0.60)  LDD1116  [12]
 LDCM0238  AC120 HCT 116 C1386(1.17)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C1386(1.17)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C1386(0.68)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C1386(0.94)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C1386(0.78)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C1386(0.85)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C1386(0.89)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C1386(0.69)  LDD0562  [12]
 LDCM0246  AC128 HEK-293T C1475(0.81)  LDD0844  [12]
 LDCM0247  AC129 HEK-293T C1475(1.55)  LDD0845  [12]
 LDCM0249  AC130 HEK-293T C1475(1.15)  LDD0847  [12]
 LDCM0250  AC131 HEK-293T C1475(1.19)  LDD0848  [12]
 LDCM0251  AC132 HEK-293T C1475(0.86)  LDD0849  [12]
 LDCM0252  AC133 HEK-293T C1475(0.85)  LDD0850  [12]
 LDCM0253  AC134 HEK-293T C1475(1.47)  LDD0851  [12]
 LDCM0254  AC135 HEK-293T C1475(1.12)  LDD0852  [12]
 LDCM0255  AC136 HEK-293T C1475(1.09)  LDD0853  [12]
 LDCM0256  AC137 HEK-293T C1475(0.66)  LDD0854  [12]
 LDCM0257  AC138 HEK-293T C1475(0.78)  LDD0855  [12]
 LDCM0258  AC139 HEK-293T C1475(0.84)  LDD0856  [12]
 LDCM0259  AC14 PaTu 8988t C1479(1.16); C1475(0.60)  LDD1138  [12]
 LDCM0260  AC140 HEK-293T C1475(0.92)  LDD0858  [12]
 LDCM0261  AC141 HEK-293T C1475(0.73)  LDD0859  [12]
 LDCM0262  AC142 HEK-293T C1475(0.97)  LDD0860  [12]
 LDCM0263  AC143 HEK-293T C1475(1.03)  LDD0861  [12]
 LDCM0264  AC144 HEK-293T C1475(1.08)  LDD0862  [12]
 LDCM0265  AC145 HEK-293T C1475(1.08)  LDD0863  [12]
 LDCM0266  AC146 HEK-293T C1475(0.94)  LDD0864  [12]
 LDCM0267  AC147 HEK-293T C1475(0.86)  LDD0865  [12]
 LDCM0268  AC148 HEK-293T C1475(0.52)  LDD0866  [12]
 LDCM0269  AC149 HEK-293T C1475(0.78)  LDD0867  [12]
 LDCM0270  AC15 PaTu 8988t C1479(1.66); C1475(0.50)  LDD1149  [12]
 LDCM0271  AC150 HEK-293T C1475(1.10)  LDD0869  [12]
 LDCM0272  AC151 HEK-293T C1475(0.73)  LDD0870  [12]
 LDCM0273  AC152 HEK-293T C1475(0.77)  LDD0871  [12]
 LDCM0274  AC153 HEK-293T C1475(1.02)  LDD0872  [12]
 LDCM0621  AC154 HEK-293T C1475(0.92)  LDD2162  [12]
 LDCM0622  AC155 HEK-293T C1475(0.79)  LDD2163  [12]
 LDCM0623  AC156 HEK-293T C1475(0.75)  LDD2164  [12]
 LDCM0624  AC157 HEK-293T C1475(0.74)  LDD2165  [12]
 LDCM0276  AC17 PaTu 8988t C1479(1.24); C1475(1.24)  LDD1155  [12]
 LDCM0277  AC18 PaTu 8988t C1479(0.86); C1475(0.86)  LDD1156  [12]
 LDCM0278  AC19 PaTu 8988t C1479(0.99); C1475(0.99)  LDD1157  [12]
 LDCM0279  AC2 HCT 116 C1386(0.98)  LDD0596  [12]
 LDCM0280  AC20 PaTu 8988t C1479(1.09); C1475(1.09)  LDD1159  [12]
 LDCM0281  AC21 PaTu 8988t C1479(0.66); C1475(0.66)  LDD1160  [12]
 LDCM0282  AC22 PaTu 8988t C1479(0.68); C1475(0.68)  LDD1161  [12]
 LDCM0283  AC23 PaTu 8988t C1479(0.68); C1475(0.68)  LDD1162  [12]
 LDCM0284  AC24 PaTu 8988t C1479(0.78); C1475(0.78)  LDD1163  [12]
 LDCM0285  AC25 HEK-293T C1479(1.65)  LDD0883  [12]
 LDCM0286  AC26 HEK-293T C1479(1.66)  LDD0884  [12]
 LDCM0287  AC27 HEK-293T C1479(1.48)  LDD0885  [12]
 LDCM0288  AC28 HEK-293T C1479(1.75)  LDD0886  [12]
 LDCM0289  AC29 HEK-293T C1479(1.44)  LDD0887  [12]
 LDCM0290  AC3 HCT 116 C1386(1.05)  LDD0607  [12]
 LDCM0291  AC30 HEK-293T C1479(1.53)  LDD0889  [12]
 LDCM0292  AC31 HEK-293T C1479(1.38)  LDD0890  [12]
 LDCM0293  AC32 HEK-293T C1479(1.53)  LDD0891  [12]
 LDCM0294  AC33 HEK-293T C1479(1.47)  LDD0892  [12]
 LDCM0295  AC34 HEK-293T C1479(1.57)  LDD0893  [12]
 LDCM0296  AC35 PaTu 8988t C1479(1.16); C1475(1.16)  LDD1175  [12]
 LDCM0297  AC36 PaTu 8988t C1479(1.15); C1475(1.15)  LDD1176  [12]
 LDCM0298  AC37 PaTu 8988t C1479(0.95); C1475(0.95)  LDD1177  [12]
 LDCM0299  AC38 PaTu 8988t C1479(1.18); C1475(1.18)  LDD1178  [12]
 LDCM0300  AC39 PaTu 8988t C1479(1.18); C1475(1.18)  LDD1179  [12]
 LDCM0301  AC4 HCT 116 C1386(1.11)  LDD0618  [12]
 LDCM0302  AC40 PaTu 8988t C1479(1.14); C1475(1.14)  LDD1181  [12]
 LDCM0303  AC41 PaTu 8988t C1479(1.06); C1475(1.06)  LDD1182  [12]
 LDCM0304  AC42 PaTu 8988t C1479(1.16); C1475(1.16)  LDD1183  [12]
 LDCM0305  AC43 PaTu 8988t C1479(1.50); C1475(1.50)  LDD1184  [12]
 LDCM0306  AC44 PaTu 8988t C1479(0.87); C1475(0.87)  LDD1185  [12]
 LDCM0307  AC45 PaTu 8988t C1479(1.01); C1475(1.01)  LDD1186  [12]
 LDCM0308  AC46 HCT 116 C1386(0.71)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C1386(0.87)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C1386(0.86)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C1386(0.85)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C1386(1.04)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C1386(0.94)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C1386(0.99)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C1386(0.78)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C1386(0.91)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C1386(0.90)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C1386(0.83)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C1386(0.94)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C1386(1.09)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C1386(1.36)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C1386(1.08)  LDD0639  [12]
 LDCM0323  AC6 PaTu 8988t C1479(1.17); C1475(0.73)  LDD1202  [12]
 LDCM0324  AC60 HCT 116 C1386(1.09)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C1386(0.95)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C1386(0.99)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C1386(1.07)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C1386(1.01)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C1386(1.16)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C1386(1.35)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C1386(0.94)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C1386(1.16)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C1386(1.12)  LDD0650  [12]
 LDCM0334  AC7 PaTu 8988t C1479(0.93); C1475(0.69)  LDD1213  [12]
 LDCM0335  AC70 HCT 116 C1386(0.69)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C1386(0.95)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C1386(0.71)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C1386(0.81)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C1386(0.89)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C1386(0.85)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C1386(0.81)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C1386(1.14)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C1386(0.93)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C1386(0.89)  LDD0661  [12]
 LDCM0345  AC8 PaTu 8988t C1479(1.09); C1475(0.56)  LDD1224  [12]
 LDCM0346  AC80 HCT 116 C1386(0.88)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C1386(0.80)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C1386(0.71)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C1386(1.07)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C1386(1.19)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C1386(1.03)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C1386(1.08)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C1386(1.09)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C1386(1.09)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C1386(1.06)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C1386(0.78)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C1386(1.00)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C1386(0.82)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C1386(0.92)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C1386(0.84)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C1386(0.97)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C1386(0.92)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C1386(0.89)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C1386(0.87)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C1386(0.67)  LDD0683  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C1024(0.83)  LDD2113  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C1479(1.08); C1475(0.53)  LDD1127  [12]
 LDCM0356  AKOS034007680 PaTu 8988t C1479(0.88); C1475(0.71)  LDD1235  [12]
 LDCM0275  AKOS034007705 PaTu 8988t C1479(1.07); C1475(0.58)  LDD1154  [12]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C1475(1.00)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C1475(0.95)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C1386(1.06)  LDD0686  [12]
 LDCM0370  CL101 PaTu 8988t C1479(1.12); C1475(0.70)  LDD1249  [12]
 LDCM0371  CL102 PaTu 8988t C1479(1.01); C1475(0.79)  LDD1250  [12]
 LDCM0372  CL103 PaTu 8988t C1479(0.74); C1475(0.32)  LDD1251  [12]
 LDCM0373  CL104 PaTu 8988t C1479(1.03); C1475(0.71)  LDD1252  [12]
 LDCM0374  CL105 PaTu 8988t C1479(1.14); C1475(1.14)  LDD1253  [12]
 LDCM0375  CL106 PaTu 8988t C1479(0.95); C1475(0.95)  LDD1254  [12]
 LDCM0376  CL107 PaTu 8988t C1479(0.98); C1475(0.98)  LDD1255  [12]
 LDCM0377  CL108 PaTu 8988t C1479(1.13); C1475(1.13)  LDD1256  [12]
 LDCM0378  CL109 PaTu 8988t C1479(0.97); C1475(0.97)  LDD1257  [12]
 LDCM0379  CL11 HCT 116 C1475(1.01)  LDD0696  [12]
 LDCM0380  CL110 PaTu 8988t C1479(0.87); C1475(0.87)  LDD1259  [12]
 LDCM0381  CL111 PaTu 8988t C1479(0.62); C1475(0.62)  LDD1260  [12]
 LDCM0382  CL112 HEK-293T C1479(1.40)  LDD0980  [12]
 LDCM0383  CL113 HEK-293T C1479(1.42)  LDD0981  [12]
 LDCM0384  CL114 HEK-293T C1479(1.87)  LDD0982  [12]
 LDCM0385  CL115 HEK-293T C1479(1.97)  LDD0983  [12]
 LDCM0386  CL116 HEK-293T C1479(2.07)  LDD0984  [12]
 LDCM0387  CL117 PaTu 8988t C1479(1.01); C1475(1.01)  LDD1266  [12]
 LDCM0388  CL118 PaTu 8988t C1479(1.34); C1475(1.34)  LDD1267  [12]
 LDCM0389  CL119 PaTu 8988t C1479(1.22); C1475(1.22)  LDD1268  [12]
 LDCM0390  CL12 HCT 116 C1475(1.18)  LDD0707  [12]
 LDCM0391  CL120 PaTu 8988t C1479(1.24); C1475(1.24)  LDD1270  [12]
 LDCM0392  CL121 HCT 116 C1386(1.02)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C1386(1.01)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C1386(0.87)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C1386(0.68)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C1386(0.83)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C1386(1.08)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C1386(1.22)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C1386(0.88)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C1475(1.08)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C1475(1.22)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C1475(1.05)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C1475(0.88)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C1475(0.60); C1386(0.77)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C1386(0.78); C1475(0.91)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C1475(0.61); C1386(1.13)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C1475(1.12)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C1475(0.76); C1386(0.87)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C1475(0.40); C1386(0.84)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C1475(0.21); C1386(1.45)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C1386(0.74); C1475(1.67)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C1386(0.89); C1475(0.55)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C1386(0.86); C1475(0.46)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C1386(0.88); C1475(0.80)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C1386(1.09); C1475(0.85)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C1386(0.86); C1475(0.68)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C1386(1.13); C1475(0.59)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C1475(1.13)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C1386(0.75); C1475(0.67)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C1386(0.93); C1475(1.06)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C1475(0.94)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C1475(0.99)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C1475(0.91)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C1475(1.15)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C1475(1.18)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C1475(0.98)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C1475(1.07)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C1475(1.10)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C1475(1.13)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C1475(1.50)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C1475(0.50)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C1475(0.81)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C1475(0.89)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C1475(0.91)  LDD0752  [12]
 LDCM0436  CL46 HEK-293T C1479(1.28)  LDD1034  [12]
 LDCM0437  CL47 HEK-293T C1479(1.09)  LDD1035  [12]
 LDCM0438  CL48 HEK-293T C1479(1.11)  LDD1036  [12]
 LDCM0439  CL49 HEK-293T C1479(1.27)  LDD1037  [12]
 LDCM0440  CL5 HCT 116 C1475(1.17)  LDD0757  [12]
 LDCM0441  CL50 HEK-293T C1479(1.36)  LDD1039  [12]
 LDCM0442  CL51 HEK-293T C1479(1.15)  LDD1040  [12]
 LDCM0443  CL52 HEK-293T C1479(0.94)  LDD1041  [12]
 LDCM0444  CL53 HEK-293T C1479(1.03)  LDD1042  [12]
 LDCM0445  CL54 HEK-293T C1479(1.15)  LDD1043  [12]
 LDCM0446  CL55 HEK-293T C1479(1.41)  LDD1044  [12]
 LDCM0447  CL56 HEK-293T C1479(0.96)  LDD1045  [12]
 LDCM0448  CL57 HEK-293T C1479(1.18)  LDD1046  [12]
 LDCM0449  CL58 HEK-293T C1479(1.22)  LDD1047  [12]
 LDCM0450  CL59 HEK-293T C1479(1.36)  LDD1048  [12]
 LDCM0451  CL6 HCT 116 C1475(1.06)  LDD0768  [12]
 LDCM0452  CL60 HEK-293T C1479(1.55)  LDD1050  [12]
 LDCM0453  CL61 HCT 116 C1386(1.17); C1475(0.83)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C1386(1.05); C1475(0.79)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C1386(1.79); C1475(0.98)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C1386(1.18); C1475(0.83)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C1386(1.37); C1475(0.98)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C1386(1.16); C1475(0.93)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C1386(1.81); C1475(0.98)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C1386(3.04); C1475(0.92)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C1386(1.30); C1475(0.92)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C1475(1.10)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C1386(1.16); C1475(0.92)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C1386(1.38); C1475(0.88)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C1386(1.50); C1475(0.88)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C1386(1.63); C1475(0.76)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C1386(1.82); C1475(1.07)  LDD0784  [12]
 LDCM0469  CL76 PaTu 8988t C1475(0.89)  LDD1348  [12]
 LDCM0470  CL77 PaTu 8988t C1475(0.81)  LDD1349  [12]
 LDCM0471  CL78 PaTu 8988t C1475(1.16)  LDD1350  [12]
 LDCM0472  CL79 PaTu 8988t C1475(1.08)  LDD1351  [12]
 LDCM0473  CL8 HCT 116 C1475(0.99)  LDD0790  [12]
 LDCM0474  CL80 PaTu 8988t C1475(1.05)  LDD1353  [12]
 LDCM0475  CL81 PaTu 8988t C1475(0.94)  LDD1354  [12]
 LDCM0476  CL82 PaTu 8988t C1475(0.96)  LDD1355  [12]
 LDCM0477  CL83 PaTu 8988t C1475(1.07)  LDD1356  [12]
 LDCM0478  CL84 PaTu 8988t C1475(0.98)  LDD1357  [12]
 LDCM0479  CL85 PaTu 8988t C1475(1.01)  LDD1358  [12]
 LDCM0480  CL86 PaTu 8988t C1475(0.95)  LDD1359  [12]
 LDCM0481  CL87 PaTu 8988t C1475(0.95)  LDD1360  [12]
 LDCM0482  CL88 PaTu 8988t C1475(0.92)  LDD1361  [12]
 LDCM0483  CL89 PaTu 8988t C1475(0.91)  LDD1362  [12]
 LDCM0484  CL9 HCT 116 C1475(1.34)  LDD0801  [12]
 LDCM0485  CL90 PaTu 8988t C1475(0.97)  LDD1364  [12]
 LDCM0486  CL91 HCT 116 C1386(1.11)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C1386(1.12)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C1386(0.87)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C1386(1.05)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C1386(1.34)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C1386(1.13)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C1386(1.05)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C1386(0.95)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C1386(0.95)  LDD0811  [12]
 LDCM0191  Compound 21 HEK-293T 9.62  LDD0508  [20]
 LDCM0192  Compound 35 HEK-293T 6.54  LDD0509  [20]
 LDCM0193  Compound 36 HEK-293T 18.35  LDD0511  [20]
 LDCM0495  E2913 HEK-293T C1024(1.11); C880(1.11); C1475(2.11); C1479(0.84)  LDD1698  [25]
 LDCM0468  Fragment33 HCT 116 C1386(1.17); C1475(0.85)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C1475(0.63)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y599(0.05)  LDD0264  [9]
 LDCM0118  HHS-0301 DM93 Y599(2.36)  LDD0266  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C1493(1.10)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C1493(0.99)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C1493(1.06)  LDD0082  [12]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1024(1.08)  LDD2093  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1024(0.70)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1024(1.20)  LDD2099  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1024(1.06)  LDD2101  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1024(1.04)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1024(0.50)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1024(1.25)  LDD2111  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1024(0.50)  LDD2115  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1024(1.83)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1024(1.03)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1024(0.92)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1024(0.83)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1024(0.92); C1493(0.78)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1024(1.23)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1024(1.25)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1024(0.66)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1024(0.54)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1024(2.13)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1024(1.30)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1024(1.00)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1024(3.38)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1024(0.76)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1024(1.39)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1024(2.29)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1024(0.97)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1024(0.47)  LDD2148  [8]

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
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Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402