Details of the Target

General Information of Target

Target ID LDTP05689
Target Name Interleukin enhancer-binding factor 3 (ILF3)
Gene Name ILF3
Gene ID 3609
Synonyms
DRBF; MPHOSPH4; NF90; Interleukin enhancer-binding factor 3; Double-stranded RNA-binding protein 76; DRBP76; M-phase phosphoprotein 4; MPP4; Nuclear factor associated with dsRNA; NFAR; Nuclear factor of activated T-cells 90 kDa; NF-AT-90; Translational control protein 80; TCP80
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA
ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP
TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM
EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV
PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT
DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP
PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL
VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE
DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLK
YELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANK
KKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGA
NHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGD
NYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHG
QGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGS
GGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.; (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3.
Uniprot ID
Q12906
Ensemble ID
ENST00000250241.12
HGNC ID
HGNC:6038

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.00  LDD0402  [1]
P2
 Probe Info  		10.00  LDD0449  [2]
P8
 Probe Info  		2.12  LDD0451  [2]
A-EBA
 Probe Info  		3.55  LDD0215  [3]
CHEMBL5175495
 Probe Info  		6.10  LDD0196  [4]
CY-1
 Probe Info  		41.95  LDD0243  [5]
N1
 Probe Info  		9.64  LDD0242  [5]
TH211
 Probe Info  		Y891(20.00); Y809(18.09); Y22(10.03)  LDD0260  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
YN-4
 Probe Info  		100.00  LDD0445  [7]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K535(0.98); K214(1.16); K553(4.76)  LDD3494  [9]
Probe 1
 Probe Info  		Y22(8.72); Y365(9.69); Y579(21.07); Y803(52.34)  LDD3495  [10]
DBIA
 Probe Info  		C203(12.89); C116(2.24); C255(6.41); C226(4.31)  LDD3311  [11]
BTD
 Probe Info  		C203(1.81)  LDD1700  [12]
EA-probe
 Probe Info  		N.A.  LDD0440  [13]
5E-2FA
 Probe Info  		H887(0.00); H833(0.00)  LDD2235  [14]
AMP probe
 Probe Info  		N.A.  LDD0200  [15]
ATP probe
 Probe Info  		K454(0.00); K577(0.00); K573(0.00); K574(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C203(0.00); C116(0.00); C295(0.00); C278(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C116(0.00); C278(0.00); C226(0.00)  LDD0032  [17]
Lodoacetamide azide
 Probe Info  		C203(0.00); C116(0.00); C295(0.00); C278(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		N.A.  LDD0035  [18]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
TFBX
 Probe Info  		C226(0.00); C203(0.00)  LDD0027  [20]
1d-yne
 Probe Info  		K478(0.00); K587(0.00); K161(0.00)  LDD0356  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
ENE
 Probe Info  		C203(0.00); C278(0.00)  LDD0006  [23]
IPM
 Probe Info  		N.A.  LDD0005  [23]
NHS
 Probe Info  		K332(0.00); K460(0.00); K413(0.00); K81(0.00)  LDD0010  [23]
SF
 Probe Info  		K573(0.00); Y846(0.00); Y828(0.00); K214(0.00)  LDD0028  [24]
STPyne
 Probe Info  		N.A.  LDD0009  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [25]
Ox-W18
 Probe Info  		W48(0.00); W243(0.00)  LDD2175  [26]
1c-yne
 Probe Info  		K396(0.00); K806(0.00); K17(0.00); K161(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		H18(0.00); H37(0.00); H833(0.00); H331(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		H305(0.00); H320(0.00)  LDD0219  [27]
W1
 Probe Info  		C295(0.00); D313(0.00); E312(0.00)  LDD0236  [28]
NAIA_5
 Probe Info  		C203(0.00); C255(0.00); C237(0.00); C116(0.00)  LDD2223  [19]
HHS-482
 Probe Info  		Y821(0.88); Y828(0.99)  LDD2239  [29]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		6.97  LDD0472  [30]
FFF probe13
 Probe Info  		13.38  LDD0475  [30]
FFF probe2
 Probe Info  		7.04  LDD0463  [30]
FFF probe3
 Probe Info  		11.18  LDD0465  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
DA-2
 Probe Info  		N.A.  LDD0071  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C203(0.51)  LDD2142  [12]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C203(0.94)  LDD2112  [12]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C226(0.50)  LDD2095  [12]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C226(0.86)  LDD2130  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C226(1.06); C203(0.72)  LDD2117  [12]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C203(0.92)  LDD2152  [12]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C203(1.23)  LDD2103  [12]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C203(0.37)  LDD2132  [12]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C226(0.66)  LDD2131  [12]
 LDCM0214  AC1 HEK-293T C226(0.93); C203(1.05); C255(0.93); C116(0.94)  LDD1507  [33]
 LDCM0215  AC10 HEK-293T C226(0.92); C203(1.11); C255(0.96); C116(1.02)  LDD1508  [33]
 LDCM0226  AC11 HEK-293T C226(1.02); C203(1.03); C255(0.96); C116(0.88)  LDD1509  [33]
 LDCM0237  AC12 HEK-293T C226(0.88); C203(1.10); C255(0.93); C116(1.07)  LDD1510  [33]
 LDCM0259  AC14 HEK-293T C226(1.01); C203(1.13); C255(1.07); C116(0.97)  LDD1512  [33]
 LDCM0270  AC15 HEK-293T C226(1.01); C203(1.04); C255(0.98); C116(0.98)  LDD1513  [33]
 LDCM0276  AC17 HEK-293T C226(0.93); C203(0.96); C255(0.95); C116(0.94)  LDD1515  [33]
 LDCM0277  AC18 HEK-293T C226(1.02); C203(0.98); C255(0.92); C116(1.02)  LDD1516  [33]
 LDCM0278  AC19 HEK-293T C226(0.93); C203(1.06); C255(0.99); C116(0.89)  LDD1517  [33]
 LDCM0279  AC2 HEK-293T C226(0.95); C203(1.08); C255(0.96); C116(0.96)  LDD1518  [33]
 LDCM0280  AC20 HEK-293T C226(0.88); C203(0.98); C255(0.97); C116(1.02)  LDD1519  [33]
 LDCM0281  AC21 HEK-293T C226(0.97); C203(1.05); C255(1.05); C116(1.05)  LDD1520  [33]
 LDCM0282  AC22 HEK-293T C226(0.99); C203(1.18); C255(1.13); C116(1.02)  LDD1521  [33]
 LDCM0283  AC23 HEK-293T C226(1.08); C203(0.93); C255(0.99); C116(0.94)  LDD1522  [33]
 LDCM0284  AC24 HEK-293T C226(0.98); C203(1.03); C255(0.99); C116(1.00)  LDD1523  [33]
 LDCM0285  AC25 HEK-293T C226(0.83); C203(1.01); C255(0.96); C116(0.92)  LDD1524  [33]
 LDCM0286  AC26 HEK-293T C226(1.07); C203(0.98); C255(0.96); C116(0.94)  LDD1525  [33]
 LDCM0287  AC27 HEK-293T C226(0.93); C203(1.05); C255(0.98); C116(1.12)  LDD1526  [33]
 LDCM0288  AC28 HEK-293T C226(0.97); C203(1.06); C255(0.98); C116(0.99)  LDD1527  [33]
 LDCM0289  AC29 HEK-293T C226(0.99); C203(1.01); C255(1.05); C116(1.03)  LDD1528  [33]
 LDCM0290  AC3 HEK-293T C226(0.93); C203(1.01); C255(1.00); C116(0.87)  LDD1529  [33]
 LDCM0291  AC30 HEK-293T C226(0.99); C203(1.12); C255(1.11); C116(1.01)  LDD1530  [33]
 LDCM0292  AC31 HEK-293T C226(1.06); C203(0.96); C255(1.02); C116(1.01)  LDD1531  [33]
 LDCM0293  AC32 HEK-293T C226(1.01); C203(1.06); C255(0.96); C116(0.97)  LDD1532  [33]
 LDCM0294  AC33 HEK-293T C226(0.88); C203(1.04); C255(0.91); C116(0.93)  LDD1533  [33]
 LDCM0295  AC34 HEK-293T C226(0.88); C203(1.08); C255(0.94); C116(0.92)  LDD1534  [33]
 LDCM0296  AC35 HEK-293T C226(0.89); C203(1.05); C255(0.97); C116(0.91)  LDD1535  [33]
 LDCM0297  AC36 HEK-293T C226(0.90); C203(1.12); C255(0.93); C116(1.01)  LDD1536  [33]
 LDCM0298  AC37 HEK-293T C226(0.94); C203(1.12); C255(1.05); C116(0.97)  LDD1537  [33]
 LDCM0299  AC38 HEK-293T C226(0.94); C203(1.11); C255(1.02); C116(0.91)  LDD1538  [33]
 LDCM0300  AC39 HEK-293T C226(0.87); C203(1.01); C255(0.95); C116(1.02)  LDD1539  [33]
 LDCM0301  AC4 HEK-293T C226(0.91); C203(1.11); C255(0.93); C116(1.11)  LDD1540  [33]
 LDCM0302  AC40 HEK-293T C226(0.95); C203(1.12); C255(0.95); C116(0.96)  LDD1541  [33]
 LDCM0303  AC41 HEK-293T C226(0.89); C203(1.08); C255(0.96); C116(0.90)  LDD1542  [33]
 LDCM0304  AC42 HEK-293T C226(0.90); C203(1.17); C255(1.01); C116(0.94)  LDD1543  [33]
 LDCM0305  AC43 HEK-293T C226(0.96); C203(1.18); C255(0.91); C116(0.96)  LDD1544  [33]
 LDCM0306  AC44 HEK-293T C226(0.84); C203(1.18); C255(0.92); C116(0.94)  LDD1545  [33]
 LDCM0307  AC45 HEK-293T C226(0.89); C203(1.05); C255(0.98); C116(1.00)  LDD1546  [33]
 LDCM0308  AC46 HEK-293T C226(1.00); C203(1.21); C255(1.02); C116(1.03)  LDD1547  [33]
 LDCM0309  AC47 HEK-293T C226(0.98); C203(1.07); C255(0.99); C116(1.02)  LDD1548  [33]
 LDCM0310  AC48 HEK-293T C226(0.91); C203(1.00); C255(0.93); C116(0.89)  LDD1549  [33]
 LDCM0311  AC49 HEK-293T C226(0.87); C203(1.05); C255(0.91); C116(0.93)  LDD1550  [33]
 LDCM0312  AC5 HEK-293T C226(0.99); C203(1.06); C255(1.01); C116(0.99)  LDD1551  [33]
 LDCM0313  AC50 HEK-293T C226(1.02); C203(1.08); C255(0.94); C116(1.02)  LDD1552  [33]
 LDCM0314  AC51 HEK-293T C226(0.94); C203(1.10); C255(0.95); C116(0.96)  LDD1553  [33]
 LDCM0315  AC52 HEK-293T C226(0.93); C203(1.04); C255(0.97); C116(0.94)  LDD1554  [33]
 LDCM0316  AC53 HEK-293T C226(0.97); C203(1.06); C255(1.03); C116(1.01)  LDD1555  [33]
 LDCM0317  AC54 HEK-293T C226(0.94); C203(1.16); C255(0.96); C116(0.97)  LDD1556  [33]
 LDCM0318  AC55 HEK-293T C226(0.99); C203(1.05); C255(0.96); C116(1.00)  LDD1557  [33]
 LDCM0319  AC56 HEK-293T C226(0.94); C203(1.09); C255(0.94); C116(0.94)  LDD1558  [33]
 LDCM0320  AC57 HEK-293T C226(0.86); C203(1.00); C255(0.96); C116(0.91)  LDD1559  [33]
 LDCM0321  AC58 HEK-293T C226(0.94); C203(1.11); C255(0.99); C116(0.88)  LDD1560  [33]
 LDCM0322  AC59 HEK-293T C226(0.93); C203(1.10); C255(0.98); C116(0.93)  LDD1561  [33]
 LDCM0323  AC6 HEK-293T C226(0.97); C203(1.14); C255(0.99); C116(0.95)  LDD1562  [33]
 LDCM0324  AC60 HEK-293T C226(0.85); C203(1.11); C255(0.93); C116(0.96)  LDD1563  [33]
 LDCM0325  AC61 HEK-293T C226(0.89); C203(1.05); C255(1.01); C116(0.98)  LDD1564  [33]
 LDCM0326  AC62 HEK-293T C226(0.99); C203(1.19); C255(0.95); C116(0.98)  LDD1565  [33]
 LDCM0327  AC63 HEK-293T C226(0.98); C203(1.03); C255(1.02); C116(0.99)  LDD1566  [33]
 LDCM0328  AC64 HEK-293T C226(0.94); C203(1.04); C255(0.99); C116(0.93)  LDD1567  [33]
 LDCM0334  AC7 HEK-293T C226(0.91); C203(1.00); C255(0.98); C116(0.99)  LDD1568  [33]
 LDCM0345  AC8 HEK-293T C226(0.94); C203(1.01); C255(1.01); C116(0.82)  LDD1569  [33]
 LDCM0545  Acetamide MDA-MB-231 C203(0.35)  LDD2138  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C226(0.79); C203(0.63)  LDD2113  [12]
 LDCM0248  AKOS034007472 HEK-293T C226(0.98); C203(1.08); C255(1.01); C116(1.02)  LDD1511  [33]
 LDCM0356  AKOS034007680 HEK-293T C226(0.92); C203(1.00); C255(0.92); C116(0.88)  LDD1570  [33]
 LDCM0275  AKOS034007705 HEK-293T C226(1.02); C203(1.03); C255(0.94); C116(0.97)  LDD1514  [33]
 LDCM0498  BS-3668 MDA-MB-231 C203(0.59)  LDD2091  [12]
 LDCM0108  Chloroacetamide HeLa H37(0.00); H18(0.00); H320(0.00); C203(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C255(1.84); C203(0.87)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C226(0.92); C203(1.09); C255(1.00); C116(0.94)  LDD1571  [33]
 LDCM0368  CL10 HEK-293T C226(1.12); C203(1.39); C255(1.08); C116(0.95)  LDD1572  [33]
 LDCM0369  CL100 HEK-293T C226(0.99); C203(1.06); C255(0.99); C116(0.91)  LDD1573  [33]
 LDCM0370  CL101 HEK-293T C226(0.97); C203(1.10); C255(0.97); C116(1.00)  LDD1574  [33]
 LDCM0371  CL102 HEK-293T C226(1.06); C203(1.12); C255(0.98); C116(1.01)  LDD1575  [33]
 LDCM0372  CL103 HEK-293T C226(1.01); C203(0.99); C255(0.88); C116(1.03)  LDD1576  [33]
 LDCM0373  CL104 HEK-293T C226(0.97); C203(1.11); C255(0.95); C116(0.94)  LDD1577  [33]
 LDCM0374  CL105 HEK-293T C226(0.95); C203(1.02); C255(0.96); C116(0.97)  LDD1578  [33]
 LDCM0375  CL106 HEK-293T C226(1.16); C203(1.04); C255(1.02); C116(0.96)  LDD1579  [33]
 LDCM0376  CL107 HEK-293T C226(0.98); C203(0.98); C255(0.98); C116(1.06)  LDD1580  [33]
 LDCM0377  CL108 HEK-293T C226(0.88); C203(1.03); C255(1.03); C116(0.97)  LDD1581  [33]
 LDCM0378  CL109 HEK-293T C226(1.00); C203(1.14); C255(0.98); C116(1.03)  LDD1582  [33]
 LDCM0379  CL11 HEK-293T C226(1.17); C203(1.00); C255(1.04); C116(0.93)  LDD1583  [33]
 LDCM0380  CL110 HEK-293T C226(1.15); C203(1.20); C255(1.03); C116(0.95)  LDD1584  [33]
 LDCM0381  CL111 HEK-293T C226(0.98); C203(1.13); C255(0.98); C116(0.96)  LDD1585  [33]
 LDCM0382  CL112 HEK-293T C226(1.00); C203(1.08); C255(0.97); C116(0.93)  LDD1586  [33]
 LDCM0383  CL113 HEK-293T C226(0.94); C203(1.10); C255(0.91); C116(0.94)  LDD1587  [33]
 LDCM0384  CL114 HEK-293T C226(1.01); C203(1.22); C255(1.12); C116(1.02)  LDD1588  [33]
 LDCM0385  CL115 HEK-293T C226(0.92); C203(1.13); C255(0.95); C116(0.96)  LDD1589  [33]
 LDCM0386  CL116 HEK-293T C226(0.95); C203(1.08); C255(0.98); C116(0.90)  LDD1590  [33]
 LDCM0387  CL117 HEK-293T C226(0.91); C203(1.14); C255(0.97); C116(1.03)  LDD1591  [33]
 LDCM0388  CL118 HEK-293T C226(0.98); C203(1.14); C255(0.94); C116(1.04)  LDD1592  [33]
 LDCM0389  CL119 HEK-293T C226(0.96); C203(1.06); C255(0.94); C116(1.06)  LDD1593  [33]
 LDCM0390  CL12 HEK-293T C226(1.05); C203(1.01); C255(0.98); C116(0.87)  LDD1594  [33]
 LDCM0391  CL120 HEK-293T C226(0.91); C203(1.08); C255(1.00); C116(0.86)  LDD1595  [33]
 LDCM0392  CL121 HEK-293T C226(0.94); C203(1.05); C255(0.92); C116(0.95)  LDD1596  [33]
 LDCM0393  CL122 HEK-293T C226(0.96); C203(1.11); C255(0.99); C116(1.03)  LDD1597  [33]
 LDCM0394  CL123 HEK-293T C226(1.01); C203(1.27); C255(1.02); C116(1.05)  LDD1598  [33]
 LDCM0395  CL124 HEK-293T C226(0.91); C203(1.18); C255(0.96); C116(0.85)  LDD1599  [33]
 LDCM0396  CL125 HEK-293T C226(0.96); C203(1.09); C255(0.94); C116(1.00)  LDD1600  [33]
 LDCM0397  CL126 HEK-293T C226(1.10); C203(1.11); C255(1.03); C116(0.97)  LDD1601  [33]
 LDCM0398  CL127 HEK-293T C226(0.94); C203(1.06); C255(0.98); C116(0.69)  LDD1602  [33]
 LDCM0399  CL128 HEK-293T C226(0.98); C203(1.17); C255(1.02); C116(0.91)  LDD1603  [33]
 LDCM0400  CL13 HEK-293T C226(0.80); C203(1.08); C255(0.89); C116(0.90)  LDD1604  [33]
 LDCM0401  CL14 HEK-293T C226(1.05); C203(0.98); C255(0.92); C116(0.93)  LDD1605  [33]
 LDCM0402  CL15 HEK-293T C226(1.05); C203(1.06); C255(0.90); C116(0.96)  LDD1606  [33]
 LDCM0403  CL16 HEK-293T C226(0.92); C203(1.00); C255(1.01); C116(0.85)  LDD1607  [33]
 LDCM0404  CL17 HEK-293T C226(1.05); C203(1.05); C255(1.00); C116(0.85)  LDD1608  [33]
 LDCM0405  CL18 HEK-293T C226(0.99); C203(1.04); C255(0.95); C116(1.05)  LDD1609  [33]
 LDCM0406  CL19 HEK-293T C226(0.90); C203(1.09); C255(1.01); C116(0.93)  LDD1610  [33]
 LDCM0407  CL2 HEK-293T C226(0.96); C203(0.96); C255(0.92); C116(1.02)  LDD1611  [33]
 LDCM0408  CL20 HEK-293T C226(0.98); C203(0.99); C255(1.01); C116(0.98)  LDD1612  [33]
 LDCM0409  CL21 HEK-293T C226(1.17); C203(1.22); C255(1.05); C116(1.02)  LDD1613  [33]
 LDCM0410  CL22 HEK-293T C226(1.12); C203(1.10); C255(1.07); C116(1.05)  LDD1614  [33]
 LDCM0411  CL23 HEK-293T C226(1.15); C203(1.10); C255(0.98); C116(1.03)  LDD1615  [33]
 LDCM0412  CL24 HEK-293T C226(1.03); C203(1.09); C255(0.97); C116(1.04)  LDD1616  [33]
 LDCM0413  CL25 HEK-293T C226(0.97); C203(1.21); C255(1.02); C116(1.04)  LDD1617  [33]
 LDCM0414  CL26 HEK-293T C226(0.92); C203(0.94); C255(0.96); C116(1.00)  LDD1618  [33]
 LDCM0415  CL27 HEK-293T C226(0.94); C203(1.15); C255(0.99); C116(1.06)  LDD1619  [33]
 LDCM0416  CL28 HEK-293T C226(0.96); C203(1.06); C255(0.99); C116(0.81)  LDD1620  [33]
 LDCM0417  CL29 HEK-293T C226(1.08); C203(1.01); C255(0.94); C116(0.85)  LDD1621  [33]
 LDCM0418  CL3 HEK-293T C226(0.95); C203(1.00); C255(1.08); C116(1.03)  LDD1622  [33]
 LDCM0419  CL30 HEK-293T C226(1.06); C203(1.07); C255(0.99); C116(0.96)  LDD1623  [33]
 LDCM0420  CL31 HEK-293T C226(1.01); C203(1.08); C255(0.98); C116(0.90)  LDD1624  [33]
 LDCM0421  CL32 HEK-293T C226(0.99); C203(1.10); C255(0.99); C116(0.92)  LDD1625  [33]
 LDCM0422  CL33 HEK-293T C226(1.31); C203(1.53); C255(1.12); C116(1.06)  LDD1626  [33]
 LDCM0423  CL34 HEK-293T C226(1.15); C203(1.26); C255(1.12); C116(1.02)  LDD1627  [33]
 LDCM0424  CL35 HEK-293T C226(1.25); C203(1.00); C255(0.99); C116(1.11)  LDD1628  [33]
 LDCM0425  CL36 HEK-293T C226(1.12); C203(1.10); C255(1.02); C116(1.14)  LDD1629  [33]
 LDCM0426  CL37 HEK-293T C226(0.94); C203(1.06); C255(0.93); C116(1.00)  LDD1630  [33]
 LDCM0428  CL39 HEK-293T C226(0.98); C203(0.96); C255(0.96); C116(0.95)  LDD1632  [33]
 LDCM0429  CL4 HEK-293T C226(0.91); C203(1.01); C255(1.00); C116(0.96)  LDD1633  [33]
 LDCM0430  CL40 HEK-293T C226(1.03); C203(1.05); C255(0.98); C116(0.87)  LDD1634  [33]
 LDCM0431  CL41 HEK-293T C226(1.02); C203(1.08); C255(0.94); C116(0.90)  LDD1635  [33]
 LDCM0432  CL42 HEK-293T C226(1.15); C203(1.06); C255(1.05); C116(0.98)  LDD1636  [33]
 LDCM0433  CL43 HEK-293T C226(1.07); C203(1.04); C255(0.96); C116(0.81)  LDD1637  [33]
 LDCM0434  CL44 HEK-293T C226(0.97); C203(1.15); C255(0.98); C116(0.90)  LDD1638  [33]
 LDCM0435  CL45 HEK-293T C226(1.01); C203(1.16); C255(1.09); C116(1.10)  LDD1639  [33]
 LDCM0436  CL46 HEK-293T C226(1.11); C203(1.15); C255(1.02); C116(1.05)  LDD1640  [33]
 LDCM0437  CL47 HEK-293T C226(1.18); C203(0.99); C255(1.02); C116(1.10)  LDD1641  [33]
 LDCM0438  CL48 HEK-293T C226(1.12); C203(1.02); C255(1.02); C116(0.92)  LDD1642  [33]
 LDCM0439  CL49 HEK-293T C226(0.89); C203(1.14); C255(0.96); C116(0.99)  LDD1643  [33]
 LDCM0440  CL5 HEK-293T C226(0.94); C203(1.04); C255(0.99); C116(0.92)  LDD1644  [33]
 LDCM0441  CL50 HEK-293T C226(1.06); C203(1.06); C255(0.94); C116(1.08)  LDD1645  [33]
 LDCM0443  CL52 HEK-293T C226(0.93); C203(1.07); C255(0.95); C116(0.92)  LDD1646  [33]
 LDCM0444  CL53 HEK-293T C226(1.05); C203(1.18); C255(0.93); C116(0.88)  LDD1647  [33]
 LDCM0445  CL54 HEK-293T C226(1.08); C203(1.47); C255(1.08); C116(1.15)  LDD1648  [33]
 LDCM0446  CL55 HEK-293T C226(1.02); C203(1.25); C255(1.02); C116(0.85)  LDD1649  [33]
 LDCM0447  CL56 HEK-293T C226(0.96); C203(1.09); C255(0.97); C116(0.93)  LDD1650  [33]
 LDCM0448  CL57 HEK-293T C226(1.02); C203(1.34); C255(1.07); C116(1.00)  LDD1651  [33]
 LDCM0449  CL58 HEK-293T C226(1.15); C203(1.36); C255(1.03); C116(1.05)  LDD1652  [33]
 LDCM0450  CL59 HEK-293T C226(1.19); C203(1.08); C255(0.99); C116(1.09)  LDD1653  [33]
 LDCM0451  CL6 HEK-293T C226(1.04); C203(1.15); C255(0.95); C116(1.00)  LDD1654  [33]
 LDCM0452  CL60 HEK-293T C226(1.14); C203(1.10); C255(1.03); C116(0.93)  LDD1655  [33]
 LDCM0453  CL61 HEK-293T C226(0.91); C203(1.10); C255(0.94); C116(0.92)  LDD1656  [33]
 LDCM0454  CL62 HEK-293T C226(0.95); C203(1.04); C255(0.95); C116(1.05)  LDD1657  [33]
 LDCM0455  CL63 HEK-293T C226(0.94); C203(0.89); C255(0.97); C116(0.94)  LDD1658  [33]
 LDCM0456  CL64 HEK-293T C226(0.99); C203(1.18); C255(1.08); C116(0.90)  LDD1659  [33]
 LDCM0457  CL65 HEK-293T C226(0.90); C203(1.01); C255(0.97); C116(0.83)  LDD1660  [33]
 LDCM0458  CL66 HEK-293T C226(0.95); C203(1.16); C255(0.96); C116(1.00)  LDD1661  [33]
 LDCM0459  CL67 HEK-293T C226(1.04); C203(1.07); C255(1.01); C116(0.97)  LDD1662  [33]
 LDCM0460  CL68 HEK-293T C226(0.96); C203(1.13); C255(0.96); C116(0.98)  LDD1663  [33]
 LDCM0461  CL69 HEK-293T C226(1.17); C203(1.19); C255(1.02); C116(1.10)  LDD1664  [33]
 LDCM0462  CL7 HEK-293T C226(1.02); C203(1.06); C255(0.99); C116(0.85)  LDD1665  [33]
 LDCM0463  CL70 HEK-293T C226(1.13); C203(1.18); C255(1.10); C116(1.05)  LDD1666  [33]
 LDCM0464  CL71 HEK-293T C226(1.14); C203(1.05); C255(1.02); C116(1.05)  LDD1667  [33]
 LDCM0465  CL72 HEK-293T C226(1.13); C203(1.11); C255(0.92); C116(0.95)  LDD1668  [33]
 LDCM0466  CL73 HEK-293T C226(0.98); C203(1.18); C255(0.97); C116(1.01)  LDD1669  [33]
 LDCM0467  CL74 HEK-293T C226(0.91); C203(1.04); C255(1.00); C116(1.07)  LDD1670  [33]
 LDCM0469  CL76 HEK-293T C226(0.93); C203(1.06); C255(0.97); C116(0.94)  LDD1672  [33]
 LDCM0470  CL77 HEK-293T C226(1.10); C203(1.09); C255(1.01); C116(0.83)  LDD1673  [33]
 LDCM0471  CL78 HEK-293T C226(1.01); C203(1.10); C255(1.00); C116(1.01)  LDD1674  [33]
 LDCM0472  CL79 HEK-293T C226(1.02); C203(1.06); C255(0.99); C116(1.04)  LDD1675  [33]
 LDCM0473  CL8 HEK-293T C226(1.37); C203(1.89); C255(0.75); C116(1.25)  LDD1676  [33]
 LDCM0474  CL80 HEK-293T C226(1.01); C203(1.14); C255(1.04); C116(0.94)  LDD1677  [33]
 LDCM0475  CL81 HEK-293T C226(1.06); C203(1.07); C255(1.06); C116(1.09)  LDD1678  [33]
 LDCM0476  CL82 HEK-293T C226(1.15); C203(1.24); C255(1.19); C116(1.09)  LDD1679  [33]
 LDCM0477  CL83 HEK-293T C226(1.23); C203(1.17); C255(1.19); C116(1.08)  LDD1680  [33]
 LDCM0478  CL84 HEK-293T C226(1.24); C203(1.19); C255(1.02); C116(1.05)  LDD1681  [33]
 LDCM0479  CL85 HEK-293T C226(0.94); C203(1.20); C255(0.89); C116(1.05)  LDD1682  [33]
 LDCM0480  CL86 HEK-293T C226(0.98); C203(1.01); C255(0.93); C116(1.04)  LDD1683  [33]
 LDCM0481  CL87 HEK-293T C226(0.90); C203(0.98); C255(0.92); C116(0.96)  LDD1684  [33]
 LDCM0482  CL88 HEK-293T C226(0.93); C203(1.06); C255(0.98); C116(0.83)  LDD1685  [33]
 LDCM0483  CL89 HEK-293T C226(0.96); C203(1.07); C255(0.96); C116(0.87)  LDD1686  [33]
 LDCM0484  CL9 HEK-293T C226(1.04); C203(1.03); C255(1.00); C116(1.07)  LDD1687  [33]
 LDCM0485  CL90 HEK-293T C226(0.97); C203(1.70); C255(1.22); C116(0.69)  LDD1688  [33]
 LDCM0486  CL91 HEK-293T C226(1.05); C203(1.06); C255(0.95); C116(0.92)  LDD1689  [33]
 LDCM0487  CL92 HEK-293T C226(0.93); C203(1.20); C255(0.98); C116(0.90)  LDD1690  [33]
 LDCM0488  CL93 HEK-293T C226(1.04); C203(1.27); C255(1.09); C116(1.02)  LDD1691  [33]
 LDCM0489  CL94 HEK-293T C226(1.02); C203(1.21); C255(1.07); C116(1.07)  LDD1692  [33]
 LDCM0490  CL95 HEK-293T C226(1.13); C203(1.17); C255(1.19); C116(0.95)  LDD1693  [33]
 LDCM0491  CL96 HEK-293T C226(1.22); C203(1.29); C255(0.99); C116(1.00)  LDD1694  [33]
 LDCM0492  CL97 HEK-293T C226(0.91); C203(1.16); C255(1.01); C116(0.96)  LDD1695  [33]
 LDCM0493  CL98 HEK-293T C226(0.99); C203(1.05); C255(0.99); C116(0.99)  LDD1696  [33]
 LDCM0494  CL99 HEK-293T C226(0.90); C203(1.11); C255(0.99); C116(1.04)  LDD1697  [33]
 LDCM0495  E2913 HEK-293T C226(0.98); C203(1.04); C255(0.94); C116(1.13)  LDD1698  [33]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C203(5.52)  LDD1702  [12]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [13]
 LDCM0625  F8 Ramos C203(0.64)  LDD2187  [34]
 LDCM0572  Fragment10 Ramos C203(0.92)  LDD2189  [34]
 LDCM0573  Fragment11 Ramos C203(20.00)  LDD2190  [34]
 LDCM0574  Fragment12 Ramos C203(1.23)  LDD2191  [34]
 LDCM0575  Fragment13 Ramos C203(1.29)  LDD2192  [34]
 LDCM0576  Fragment14 Ramos C203(1.86)  LDD2193  [34]
 LDCM0579  Fragment20 Ramos C203(1.39)  LDD2194  [34]
 LDCM0580  Fragment21 Ramos C203(0.93)  LDD2195  [34]
 LDCM0582  Fragment23 Ramos C203(1.42)  LDD2196  [34]
 LDCM0578  Fragment27 Ramos C203(1.13)  LDD2197  [34]
 LDCM0586  Fragment28 Ramos C203(1.12)  LDD2198  [34]
 LDCM0588  Fragment30 Ramos C203(1.28)  LDD2199  [34]
 LDCM0589  Fragment31 Ramos C203(1.77)  LDD2200  [34]
 LDCM0590  Fragment32 Ramos C203(0.79)  LDD2201  [34]
 LDCM0468  Fragment33 HEK-293T C226(0.97); C203(1.04); C255(0.89); C116(0.88)  LDD1671  [33]
 LDCM0596  Fragment38 Ramos C203(1.02)  LDD2203  [34]
 LDCM0566  Fragment4 Ramos C203(1.11)  LDD2184  [34]
 LDCM0427  Fragment51 HEK-293T C226(0.98); C203(1.03); C255(1.03); C116(1.02)  LDD1631  [33]
 LDCM0610  Fragment52 Ramos C203(1.67)  LDD2204  [34]
 LDCM0614  Fragment56 Ramos C203(1.32)  LDD2205  [34]
 LDCM0569  Fragment7 Ramos C203(0.86)  LDD2186  [34]
 LDCM0571  Fragment9 Ramos C203(0.94)  LDD2188  [34]
 LDCM0107  IAA HeLa H18(0.00); H37(0.00); H320(0.00); H170(0.00)  LDD0221  [27]
 LDCM0022  KB02 HEK-293T C226(0.90); C203(0.91); C255(0.98); C278(1.02)  LDD1492  [33]
 LDCM0023  KB03 HEK-293T C226(0.96); C203(1.01); C255(0.92); C278(0.92)  LDD1497  [33]
 LDCM0024  KB05 G361 C203(12.89); C116(2.24); C255(6.41); C226(4.31)  LDD3311  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C226(1.10); C203(1.06)  LDD2102  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C226(1.26)  LDD2121  [12]
 LDCM0109  NEM HeLa H37(0.00); H18(0.00); H320(0.00); H833(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C226(1.36)  LDD2089  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C203(1.53)  LDD2090  [12]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C226(1.42); C203(1.67)  LDD2092  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C203(1.17)  LDD2093  [12]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C226(2.06); C203(3.83)  LDD2094  [12]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C203(0.22)  LDD2096  [12]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C226(0.87); C203(0.49)  LDD2097  [12]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C203(0.64)  LDD2098  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C203(0.83)  LDD2099  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C203(0.49)  LDD2100  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C226(1.00)  LDD2101  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C203(0.97)  LDD2104  [12]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C203(1.50)  LDD2105  [12]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C226(0.39)  LDD2106  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C203(0.67)  LDD2107  [12]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C203(0.52)  LDD2108  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C203(0.49)  LDD2109  [12]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C226(1.15); C203(0.84)  LDD2111  [12]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C203(0.99)  LDD2114  [12]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C203(0.36)  LDD2115  [12]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C226(0.68); C203(0.68)  LDD2116  [12]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C226(0.79); C203(0.66)  LDD2118  [12]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C226(1.24); C203(1.82)  LDD2119  [12]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C203(0.93)  LDD2120  [12]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C203(0.36); C237(0.14)  LDD2122  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C203(0.67)  LDD2123  [12]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C203(0.37)  LDD2124  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C226(1.02); C203(0.68)  LDD2125  [12]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C226(0.47); C203(0.32)  LDD2126  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C203(0.80)  LDD2127  [12]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C226(0.71); C203(1.00)  LDD2128  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C226(1.33); C203(1.02)  LDD2129  [12]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C226(0.50); C203(0.63)  LDD2133  [12]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C203(0.40)  LDD2134  [12]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C226(1.48); C203(0.95)  LDD2135  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C203(0.92)  LDD2136  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C203(0.74)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C203(1.81)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C226(1.17); C203(0.68)  LDD2140  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C203(0.31)  LDD2141  [12]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C226(0.45); C203(0.72)  LDD2143  [12]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C226(1.57); C203(1.94)  LDD2144  [12]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C226(1.30)  LDD2145  [12]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C226(0.91); C203(0.68)  LDD2146  [12]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C226(0.89); C203(3.42)  LDD2147  [12]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C226(0.43); C203(0.46)  LDD2148  [12]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C226(0.64)  LDD2149  [12]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C226(1.02)  LDD2150  [12]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C203(0.38)  LDD2151  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C203(0.56)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C203(0.69)  LDD2207  [35]
 LDCM0131  RA190 MM1.R C278(1.50); C295(1.50)  LDD0304  [36]
 LDCM0111  W14 Hep-G2 H331(1.05); K332(1.13)  LDD0238  [28]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 1 (PRMT1) Protein arginine N-methyltransferase family Q99873
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

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3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD022279
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
26 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
29 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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32 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
34 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
36 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.