Details of the Target

General Information of Target

Target ID LDTP15371
Target Name Aldehyde dehydrogenase family 16 member A1 (ALDH16A1)
Gene Name ALDH16A1
Gene ID 126133
Synonyms
Aldehyde dehydrogenase family 16 member A1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWLDRRGWLRVLGHWRYDLRRPSFTRTWSGDKGPMAETVSTQVGTEGGLRASHQQNGDAG
GDAKVELSPGPPKPAGREVEPAPVGGEHPSAAAPGPGKHKKRRGATRERVVPPPKKRRTG
VSFGDEHFAETSYYFEGGLRKVRPYYFDFRTYCKGRWVGHSLLHVFSTEFRAQPLAYYEA
AVRAGRLQLNEKPVQDLNIVLKDNDFLRNTVHRHEPPVTAEPIRLLAENEDVVVVDKPSS
IPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSERIHEQVRDR
QLEKEYVCRVEGEFPTEEVTCKEPILVVSYKVGVCRVDPRGKPCETVFQRLSYNGQSSVV
RCRPLTGRTHQIRVHLQFLGHPILNDPIYNSVAWGPSRGRGGYIPKTNEELLRDLVAEHQ
AKQSLDVLDLCEGDLSPGLTDSTAPSSELGKDDLEELAAAAQKMEEVAEAAPQELDTIAL
ASEKAVETDVMNQETDPLCAECRLVRQDPLPQDLVMFLHALRYKGPGFEYFSPMPAWAQD
DWQKD
Target Bioclass
Enzyme
Family
Aldehyde dehydrogenase family
Uniprot ID
Q8IZ83
Ensemble ID
ENST00000293350.9
HGNC ID
HGNC:28114
ChEMBL ID
CHEMBL4295896

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.A347P DBIA    Probe Info 
EFO27 Deletion: p.F409SfsTer93 DBIA    Probe Info 
HCC1806 SNV: p.T513A DBIA    Probe Info 
HCT15 SNV: p.D372G DBIA    Probe Info 
HEC1 SNV: p.V287A DBIA    Probe Info 
HT1197 SNV: p.I13V DBIA    Probe Info 
IPC298 SNV: p.C59S; p.Q60H DBIA    Probe Info 
JURKAT SNV: p.L595P .
KYSE180 SNV: p.S751F DBIA    Probe Info 
MOLT4 SNV: p.A263V IA-alkyne    Probe Info 
RL952 SNV: p.Q324Ter DBIA    Probe Info 
SKMEL5 SNV: p.H475L DBIA    Probe Info 
SNU1 Deletion: p.A347LfsTer155 DBIA    Probe Info 
TOV21G SNV: p.R410L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K114(3.70); K413(6.67); K564(10.00)  LDD0277  [2]
THZ1-DTB
 Probe Info  		C71(1.03)  LDD0460  [3]
BTD
 Probe Info  		C350(3.40); C249(0.49)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C28(3.71)  LDD0169  [5]
DBIA
 Probe Info  		C249(0.92); C467(0.90)  LDD0078  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C39(0.00); C467(0.00); C472(0.00); C249(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C39(0.00); C467(0.00); C350(0.00); C249(0.00)  LDD0037  [8]
ATP probe
 Probe Info  		N.A.  LDD0035  [11]
NAIA_4
 Probe Info  		C28(0.00); C249(0.00); C266(0.00); C472(0.00)  LDD2226  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		N.A.  LDD0005  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
PF-06672131
 Probe Info  		N.A.  LDD0152  [14]
TFBX
 Probe Info  		C39(0.00); C496(0.00); C249(0.00); C350(0.00)  LDD0148  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		C350(0.00); C249(0.00)  LDD0217  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
W1
 Probe Info  		C350(0.00); C472(0.00); C249(0.00)  LDD0236  [18]
AOyne
 Probe Info  		7.60  LDD0443  [19]
NAIA_5
 Probe Info  		C732(0.00); C39(0.00); C472(0.00); C350(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [20]
DA-2
 Probe Info  		N.A.  LDD0070  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C350(1.23)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C350(1.74)  LDD2152  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C28(3.71)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C350(0.65); C59(1.04); C71(1.70)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C249(0.99); C71(1.07)  LDD0813  [6]
 LDCM0216  AC100 PaTu 8988t C59(1.34); C71(1.34)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C59(1.04); C71(1.04)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C59(0.72); C71(0.72)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C59(0.61); C71(0.61)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C59(0.66); C71(0.66)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C59(0.98); C71(0.98)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C59(1.05); C71(1.05)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C59(1.38); C71(1.38)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C59(0.81); C71(0.81)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C59(0.83); C71(0.83)  LDD1104  [6]
 LDCM0226  AC11 HEK-293T C249(0.86); C71(0.90)  LDD0824  [6]
 LDCM0227  AC110 PaTu 8988t C59(0.95); C71(0.95)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C59(1.27); C71(1.27)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C59(0.82); C71(0.82)  LDD1108  [6]
 LDCM0230  AC113 HCT 116 C467(1.30)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C467(0.93)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C467(1.09)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C467(1.00)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C467(1.09)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C467(0.96)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C467(1.26)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C249(1.18); C71(0.98)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C467(1.10)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C467(1.10)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C467(1.25)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C467(1.18)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C467(0.97)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C467(1.18)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C467(1.32)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C467(1.19)  LDD0562  [6]
 LDCM0246  AC128 HEK-293T C59(0.75)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C59(0.76)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C59(0.87)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C59(0.96)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C59(0.76)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C59(0.70)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C59(0.92)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C59(0.83)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C59(0.95)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C59(0.89)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C59(1.13)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C59(0.95)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C249(1.14); C71(1.05)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C59(0.82)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C59(0.93)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C59(1.01)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C59(0.84)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C59(1.14)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C59(1.10)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C59(1.08)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C59(1.22)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C59(0.94)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C59(0.92)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C249(1.23); C71(1.13)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C59(0.93)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C59(1.01)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C59(0.87)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C59(0.97)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C59(1.03)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C59(1.03)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C59(1.26)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C59(1.38)  LDD2165  [6]
 LDCM0276  AC17 HCT 116 C467(1.15)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C467(0.70)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C467(1.23)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C350(0.38); C59(0.91); C71(1.74)  LDD0877  [6]
 LDCM0280  AC20 HCT 116 C467(1.23)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C467(0.97)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C467(0.96)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C467(1.16)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C467(0.96)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C249(0.85); C59(1.09)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C249(0.96); C59(0.98)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C249(1.04); C59(0.94)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C249(0.70); C59(0.88)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C249(1.16); C59(0.88)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C350(0.46); C59(0.99); C71(1.58)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C249(1.25); C59(0.90)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C249(1.25); C59(0.98)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C249(1.15); C59(1.09)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C249(1.11); C59(0.94)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C249(1.17); C59(1.00)  LDD0893  [6]
 LDCM0296  AC35 HCT 116 C467(1.35)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C467(1.70)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C467(1.12)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C467(1.27)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C467(1.02)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C350(0.63); C59(1.02); C71(1.24)  LDD0899  [6]
 LDCM0302  AC40 HCT 116 C467(0.98)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C467(1.03)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C467(1.03)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C467(1.78)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C467(1.15)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C467(1.04)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C467(1.35)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C467(1.03)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C467(1.39)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C467(1.18)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C350(0.55); C59(1.14); C71(1.15)  LDD0910  [6]
 LDCM0313  AC50 HCT 116 C467(1.32)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C467(2.01)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C467(1.15)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C467(1.08)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C467(1.12)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C467(1.21)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C467(1.12)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C59(0.98)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C59(0.92)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C59(0.95)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C249(0.94); C71(0.58)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C59(0.83)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C59(0.76)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C59(0.85)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C59(0.87)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C59(0.84)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C59(0.85)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C59(0.84)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C59(0.89)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C59(0.92)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C59(0.88)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C249(1.19); C71(0.91)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C59(0.85)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C59(0.94)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C59(0.92)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C59(0.93)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C59(1.04)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C59(1.05)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C59(1.03)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C59(0.85)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C59(1.07)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C59(0.93)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C249(1.60); C71(0.77)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C59(1.01)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C59(0.90)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C59(0.97)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C350(1.76); C249(1.06); C59(1.00)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C350(0.99); C249(1.01); C59(0.86)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C350(0.74); C249(1.06); C59(0.94)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C350(0.93); C249(1.11); C59(1.02)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C350(0.71); C249(1.14); C59(0.90)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C350(0.85); C249(0.87); C59(0.89)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C350(0.80); C249(0.85); C59(0.90)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C350(1.27); C249(0.95); C59(0.90)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C350(1.11); C249(1.69); C59(0.98)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C350(2.02); C249(0.91); C59(0.82)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C350(4.05); C249(1.06); C59(0.76)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C350(1.05); C249(1.33); C59(0.85)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C350(0.69); C249(0.87); C59(0.88)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C350(1.06); C249(1.26); C59(0.93)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C350(1.05); C249(1.46); C59(1.31)  LDD0962  [6]
 LDCM0365  AC98 PaTu 8988t C59(0.66); C71(0.66)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C59(0.67); C71(0.67)  LDD1245  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C249(0.54)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C249(1.00); C71(0.90)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C249(1.47); C71(1.06)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C249(1.17); C71(0.88)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 9.81  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C249(0.92); C467(0.90)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C350(0.00); C249(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C39(20.00); C472(0.84)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C59(0.94)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C59(1.02)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C350(0.51); C59(0.94); C71(1.60)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C249(1.41); C71(0.77)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C249(1.11); C71(1.12)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C249(0.94); C71(1.06)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C249(0.92); C71(0.76)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C467(1.02)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C467(1.12)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C467(0.90)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C467(0.80)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C467(1.19)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C59(0.90)  LDD0977  [6]
 LDCM0380  CL110 HCT 116 C467(0.84)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C467(1.21)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C249(1.16); C59(0.88)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C249(1.05); C59(0.78)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C249(1.16); C59(0.70)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C249(1.09); C59(0.94)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C249(1.09); C59(0.84)  LDD0984  [6]
 LDCM0387  CL117 HCT 116 C467(1.26)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C467(0.81)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C467(1.07)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C59(1.01)  LDD0988  [6]
 LDCM0391  CL120 HCT 116 C467(1.29)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C467(0.99)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C467(1.13)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C467(1.02)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C467(1.09)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C59(0.83)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C59(0.72)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C59(0.85)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C59(0.97)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C59(0.82)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C59(0.90)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C59(0.84)  LDD1000  [6]
 LDCM0403  CL16 HEK-293T C59(0.84)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C59(0.67)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C59(0.90)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C59(1.15)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C59(0.95)  LDD1005  [6]
 LDCM0408  CL20 HEK-293T C59(0.92)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C59(0.86)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C59(0.89)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C59(0.94)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C59(0.81)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C59(0.71)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C59(0.73)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C59(0.90)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C59(1.04)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C59(1.08)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C59(1.08)  LDD1016  [6]
 LDCM0419  CL30 HEK-293T C59(0.86)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C350(0.56); C249(1.13); C59(1.08); C71(0.55)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C350(0.32); C249(1.04); C59(1.00); C71(0.98)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C350(0.48); C249(0.99); C59(0.89); C71(1.71)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C350(0.59); C249(1.16); C59(1.02); C71(1.04)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C350(0.31); C249(1.23); C59(0.99); C71(0.95)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C350(0.37); C249(1.06); C59(0.82); C71(1.04)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C350(0.31); C249(0.97); C59(0.94); C71(1.06)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C350(0.50); C249(1.36); C59(0.90); C71(1.44)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C59(0.88)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C350(0.68); C249(1.01); C59(0.85); C71(1.22)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C350(0.40); C249(1.13); C59(0.84); C71(1.84)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C350(0.41); C249(1.36); C59(0.87); C71(1.56)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C350(0.52); C249(1.13); C59(0.82); C71(1.63)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C350(0.41); C249(1.03); C59(0.92); C71(1.09)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C350(0.34); C249(1.14); C59(0.82); C71(1.55)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C249(0.87)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C249(0.83)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C249(0.90)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C249(0.84)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C59(0.94)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C249(0.93)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C249(0.86)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C249(0.74)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C249(0.75)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C249(0.85)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C249(0.88)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C249(1.03)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C249(0.70)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C249(0.80)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C249(0.86)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C59(0.91)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C249(0.91)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C350(0.70); C249(0.96); C71(0.69)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C350(0.89); C249(1.24); C71(0.95)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C350(1.02); C249(1.19); C71(0.68)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C350(0.91); C249(0.78); C71(0.91)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C350(0.57); C249(1.23); C71(0.83)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C350(0.77); C249(1.08); C71(0.77)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C350(0.64); C249(1.20); C71(0.95)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C350(0.54); C249(1.17); C71(1.35)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C350(1.00); C249(1.24); C71(0.93)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C59(0.86)  LDD1060  [6]
 LDCM0463  CL70 HEK-293T C350(0.70); C249(0.87); C71(1.21)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C350(1.03); C249(1.43); C71(0.96)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C350(0.92); C249(1.04); C71(0.76)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C350(0.57); C249(0.96); C71(1.33)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C350(1.00); C249(1.52); C71(1.37)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C59(1.16); C71(0.98)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C59(1.20); C71(0.93)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C59(2.24); C71(1.24)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C59(1.76); C71(1.08)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C59(0.72)  LDD1071  [6]
 LDCM0474  CL80 HEK-293T C59(1.52); C71(1.36)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C59(1.38); C71(1.15)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C59(1.04); C71(1.19)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C59(0.93); C71(0.99)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C59(1.48); C71(1.00)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C59(1.52); C71(1.09)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C59(1.60); C71(1.53)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C59(1.56); C71(1.00)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C59(1.20); C71(1.11)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C59(1.41); C71(1.14)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C59(0.94)  LDD1082  [6]
 LDCM0485  CL90 HEK-293T C59(1.13); C71(1.23)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C350(0.72); C59(1.17); C71(0.74)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C350(0.65); C59(1.19); C71(1.11)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C350(0.92); C59(1.29); C71(0.97)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C350(0.45); C59(1.18); C71(0.83)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C350(0.45); C59(1.29); C71(2.06)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C350(0.36); C59(1.02); C71(1.09)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C350(0.42); C59(1.13); C71(0.95)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C350(0.38); C59(0.93); C71(1.17)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C350(0.47); C59(1.14); C71(1.01)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C350(1.04); C39(0.89); C467(1.00); C249(0.97)  LDD1698  [22]
 LDCM0572  Fragment10 Ramos C350(0.41)  LDD2189  [23]
 LDCM0574  Fragment12 Ramos C350(0.39)  LDD2191  [23]
 LDCM0579  Fragment20 Ramos C350(0.42)  LDD2194  [23]
 LDCM0582  Fragment23 Ramos C350(0.52)  LDD2196  [23]
 LDCM0589  Fragment31 Ramos C350(0.85)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C350(0.53)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C350(0.67); C249(1.09); C71(1.02)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C350(0.45); C249(1.10); C59(0.93); C71(1.17)  LDD1025  [6]
 LDCM0571  Fragment9 Ramos C350(0.45)  LDD2188  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C350(0.88); C467(1.02); C39(0.97); C249(0.93)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C350(0.92); C467(1.04); C39(1.01); C249(1.03)  LDD1497  [22]
 LDCM0024  KB05 COLO792 C467(1.39); C350(1.37); C249(1.44)  LDD3310  [24]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C350(0.83); C249(2.62)  LDD2121  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C350(1.15)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C249(0.73)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C350(1.20); C249(0.93)  LDD2099  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C249(0.97)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C350(1.17)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C350(0.90)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C350(1.47)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C249(0.43)  LDD2119  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C249(1.83)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C350(1.10)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C350(1.03); C249(0.41)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C350(1.30)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C350(1.42)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C350(1.78)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C350(1.65)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C350(1.33)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C350(3.40); C249(0.49)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C350(1.05)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C350(1.09)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C249(0.76)  LDD2150  [4]
 LDCM0021  THZ1 HeLa S3 C71(1.03)  LDD0460  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deoxyribose-phosphate aldolase (DERA) DeoC/FbaB aldolase family Q9Y315
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840