Details of the Target

General Information of Target

Target ID LDTP03511
Target Name Flavin reductase (NADPH) (BLVRB)
Gene Name BLVRB
Gene ID 645
Synonyms
FLR; Flavin reductase; NADPH; FR; EC 1.5.1.30; Biliverdin reductase B; BVR-B; EC 1.3.1.24; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
LGHFMLRCLTTDEYDGHSTYPSHQYQ
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Uniprot ID
P30043
Ensemble ID
ENST00000263368.9
HGNC ID
HGNC:1063
ChEMBL ID
CHEMBL5019

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		20.00  LDD0385  [1]
A-EBA
 Probe Info  		3.55  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
C-Sul
 Probe Info  		4.18  LDD0066  [4]
P11
 Probe Info  		20.00  LDD0201  [5]
DBIA
 Probe Info  		C109(1.35)  LDD3310  [6]
Jackson_14
 Probe Info  		2.08  LDD0123  [7]
HPAP
 Probe Info  		3.41  LDD0063  [8]
HHS-475
 Probe Info  		Y163(1.00); Y146(1.43)  LDD0264  [9]
5E-2FA
 Probe Info  		H49(0.00); H153(0.00)  LDD2235  [10]
m-APA
 Probe Info  		H197(0.00); H49(0.00); H153(0.00); H183(0.00)  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C188(0.00); C109(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C188(0.00); C109(0.00)  LDD0037  [11]
ATP probe
 Probe Info  		N.A.  LDD0035  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
Acrolein
 Probe Info  		H179(0.00); H49(0.00)  LDD0217  [16]
NAIA_5
 Probe Info  		C109(0.00); C188(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		21.11  LDD1760  [18]
C087
 Probe Info  		10.34  LDD1779  [18]
C429
 Probe Info  		30.27  LDD2084  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe2
 Probe Info  		20.00  LDD0463  [19]
FFF probe3
 Probe Info  		5.01  LDD0465  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [20]
Kambe_22
 Probe Info  		3.14  LDD0132  [21]
DA-2
 Probe Info  		N.A.  LDD0070  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C109(1.04)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C109(1.06)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C109(0.88)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C109(0.96)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C109(1.08)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C109(1.01)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C109(0.99)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C109(1.00)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C109(0.82)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C109(0.95)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C109(1.02)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C109(0.95)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C109(1.11)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C109(0.99)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C109(0.96)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C109(1.11)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C109(1.02)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C109(0.90)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C109(1.14)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C109(0.97)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C109(0.88)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C109(0.95)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C109(1.05)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C109(0.98)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C109(0.95)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C109(1.16)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C109(0.94)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C109(0.99)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C109(0.93)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C109(1.00)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C109(0.94)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C109(1.06)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C109(0.98)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C109(1.04)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C109(0.98)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C109(0.94)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C109(0.97)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C109(0.97)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C109(0.95)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C109(1.09)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C109(0.95)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C109(1.02)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C109(0.99)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C109(1.02)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C109(0.87)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C109(1.07)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C109(1.02)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C109(1.03)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C109(1.05)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C109(0.93)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C109(0.86)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C109(1.10)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C109(1.04)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C109(1.03)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C109(1.15)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C109(1.10)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C109(1.04)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C109(0.98)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C109(1.16)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C109(1.04)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C109(1.17)  LDD1569  [23]
 LDCM0248  AKOS034007472 HEK-293T C109(0.98)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C109(1.04)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C109(1.00)  LDD1514  [23]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [5]
 LDCM0108  Chloroacetamide HeLa H179(0.00); H49(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C109(2.04); C188(1.16)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C109(1.06)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C109(0.91)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C109(1.12)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C109(1.04)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C109(1.05)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C109(0.98)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C109(1.13)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C109(1.00)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C109(1.07)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C109(1.00)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C109(1.01)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C109(1.00)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C109(1.09)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C109(0.95)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C109(1.02)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C109(1.14)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C109(0.97)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C109(1.03)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C109(1.04)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C109(1.01)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C109(1.07)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C109(1.02)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C109(1.03)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C109(0.88)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C109(1.09)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C109(1.00)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C109(0.99)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C109(1.09)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C109(1.08)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C109(1.14)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C109(1.13)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C109(1.07)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C109(1.11)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C109(0.85)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C109(0.93)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C109(0.85)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C109(0.94)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C109(0.86)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C109(0.84)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C109(0.73)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C109(0.89)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C109(0.92)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C109(0.78)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C109(0.86)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C109(1.09)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C109(0.85)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C109(0.88)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C109(0.94)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C109(0.95)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C109(1.02)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C109(0.92)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C109(0.91)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C109(0.86)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C109(0.70)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C109(0.85)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C109(0.93)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C109(0.87)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C109(1.01)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C109(0.89)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C109(1.02)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C109(0.95)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C109(0.97)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C109(1.06)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C109(0.88)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C109(0.92)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C109(0.73)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C109(0.93)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C109(0.79)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C109(0.86)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C109(0.94)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C109(0.84)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C109(1.13)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C109(0.74)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C109(1.01)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C109(1.01)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C109(0.74)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C109(0.86)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C109(0.81)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C109(0.91)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C109(0.76)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C109(0.98)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C109(0.93)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C109(0.82)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C109(0.93)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C109(1.09)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C109(1.02)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C109(0.92)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C109(1.01)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C109(0.84)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C109(0.92)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C109(0.75)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C109(0.96)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C109(0.81)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C109(0.75)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C109(0.85)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C109(0.98)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C109(0.76)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C109(1.12)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C109(1.02)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C109(1.05)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C109(0.93)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C109(0.97)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C109(0.73)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C109(0.91)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C109(0.89)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C109(0.82)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C109(0.79)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C109(1.01)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C109(0.86)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C109(1.13)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C109(1.06)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C109(1.00)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C109(1.03)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C109(1.13)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C109(0.75)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C109(1.11)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C109(0.81)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C109(0.97)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C109(0.78)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C109(0.87)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C109(0.92)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C109(0.93)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C109(0.94)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C109(1.14)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C109(1.20)  LDD1697  [23]
 LDCM0495  E2913 HEK-293T C109(0.93)  LDD1698  [23]
 LDCM0625  F8 Ramos C188(0.97)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C188(0.64)  LDD2189  [24]
 LDCM0574  Fragment12 Ramos C188(0.53)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C188(1.07)  LDD2192  [24]
 LDCM0579  Fragment20 Ramos C188(0.43)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C188(0.78)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C188(0.87)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C188(0.95)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C188(0.60)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C188(1.29)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C188(0.87)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C188(0.46)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C109(1.04)  LDD1671  [23]
 LDCM0596  Fragment38 Ramos C188(0.83)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C188(0.76)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C109(1.03)  LDD1631  [23]
 LDCM0610  Fragment52 Ramos C188(2.23)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C188(1.28)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C188(0.79)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C188(0.68)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y163(1.00); Y146(1.43)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y163(1.29)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y163(0.76); Y146(0.80)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y163(1.28); Y146(2.02)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y163(0.64); Y146(0.75)  LDD0268  [9]
 LDCM0107  IAA HeLa H49(0.00); H179(0.00)  LDD0221  [16]
 LDCM0076  kambe_cp71 PC-3 3.14  LDD0132  [21]
 LDCM0022  KB02 Ramos C188(0.76)  LDD2182  [24]
 LDCM0023  KB03 Ramos C188(0.66)  LDD2183  [24]
 LDCM0024  KB05 COLO792 C109(1.35)  LDD3310  [6]
 LDCM0109  NEM HeLa H183(0.00); H49(0.00); H203(0.00)  LDD0223  [16]
 LDCM0014  Panhematin K562 3.41  LDD0063  [8]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.08  LDD0123  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A10 (ANXA10) Annexin family Q9UJ72

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Riboflavin Small molecular drug DB00140
Flavin Mononucleotide . DB03247
Methylene Blue . DB09241
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biliverdine Ix Alpha Small molecular drug DB02073
Lumichrome . DB04345
Mesobiliverdin Iv Alpha . DB04363
Nicotinamide Adenine Dinucleotide Phosphate . DB03461

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
22 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578