Details of the Target

General Information of Target

Target ID LDTP06905
Target Name Acylglycerol kinase, mitochondrial (AGK)
Gene Name AGK
Gene ID 55750
Synonyms
MULK; Acylglycerol kinase, mitochondrial; hAGK; EC 2.7.1.107; EC 2.7.1.138; EC 2.7.1.94; Multiple substrate lipid kinase; HsMuLK; MuLK; Multi-substrate lipid kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV
KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII
VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL
AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST
LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP
EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV
EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP
TQ
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
AGK family
Subcellular location
Mitochondrion inner membrane
Function
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide. Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol. Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.
TTD ID
T77616
Uniprot ID
Q53H12
DrugMap ID
TTJETQC
Ensemble ID
ENST00000492693.5
HGNC ID
HGNC:21869
ChEMBL ID
CHEMBL2417354

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.L275M DBIA    Probe Info 
GB2 SNV: p.F238C DBIA    Probe Info 
KATOIII SNV: p.I119V DBIA    Probe Info 
LN18 SNV: p.T363R DBIA    Probe Info 
SW480 SNV: p.A250T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		1.78  LDD0197  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
BTD
 Probe Info  		C72(1.71)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C34(2.14)  LDD0168  [5]
HPAP
 Probe Info  		3.04  LDD0062  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
DBIA
 Probe Info  		C34(0.99)  LDD0078  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K73(0.00); K75(0.00); K196(0.00); K199(0.00)  LDD0199  [10]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C34(0.00); C43(0.00); C72(0.00); C408(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C408(0.00); C334(0.00); C72(0.00); C43(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C408(0.00); C72(0.00); C334(0.00); C20(0.00)  LDD0037  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		C72(0.00); C34(0.00)  LDD0021  [14]
ENE
 Probe Info  		C72(0.00); C34(0.00)  LDD0006  [14]
IPM
 Probe Info  		C43(0.00); C34(0.00); C72(0.00); C408(0.00)  LDD0005  [14]
NHS
 Probe Info  		K233(0.00); K6(0.00)  LDD0010  [14]
PPMS
 Probe Info  		N.A.  LDD0008  [14]
STPyne
 Probe Info  		K233(0.00); K73(0.00)  LDD0009  [14]
VSF
 Probe Info  		C43(0.00); C334(0.00); C34(0.00)  LDD0007  [14]
Phosphinate-6
 Probe Info  		C408(0.00); C72(0.00)  LDD0018  [15]
1c-yne
 Probe Info  		K223(0.00); K171(0.00)  LDD0228  [16]
Acrolein
 Probe Info  		C72(0.00); H162(0.00); C408(0.00); C334(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C43(0.00); C72(0.00); C34(0.00); C408(0.00)  LDD2223  [19]
TPP-AC
 Probe Info  		N.A.  LDD0427  [20]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.57  LDD1740  [21]
C055
 Probe Info  		18.77  LDD1752  [21]
C106
 Probe Info  		17.03  LDD1793  [21]
C134
 Probe Info  		20.25  LDD1816  [21]
C161
 Probe Info  		10.13  LDD1841  [21]
C201
 Probe Info  		31.78  LDD1877  [21]
C210
 Probe Info  		61.82  LDD1884  [21]
C218
 Probe Info  		11.79  LDD1892  [21]
C228
 Probe Info  		14.83  LDD1901  [21]
C233
 Probe Info  		8.63  LDD1906  [21]
C246
 Probe Info  		12.82  LDD1919  [21]
C285
 Probe Info  		22.01  LDD1955  [21]
C289
 Probe Info  		27.47  LDD1959  [21]
C362
 Probe Info  		31.12  LDD2023  [21]
C388
 Probe Info  		43.41  LDD2047  [21]
C390
 Probe Info  		37.53  LDD2049  [21]
C403
 Probe Info  		15.45  LDD2061  [21]
C420
 Probe Info  		10.20  LDD2075  [21]
FFF probe11
 Probe Info  		16.55  LDD0471  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe15
 Probe Info  		9.03  LDD0478  [22]
FFF probe2
 Probe Info  		20.00  LDD0463  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
FFF probe4
 Probe Info  		12.83  LDD0466  [22]
FFF probe6
 Probe Info  		6.64  LDD0467  [22]
JN0003
 Probe Info  		20.00  LDD0469  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [23]
DA-2
 Probe Info  		N.A.  LDD0070  [24]
OEA-DA
 Probe Info  		4.65  LDD0046  [25]
STS-1
 Probe Info  		N.A.  LDD0068  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C34(1.05)  LDD2152  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C72(0.98)  LDD2131  [4]
 LDCM0025  4SU-RNA HEK-293T C34(2.14)  LDD0168  [5]
 LDCM0214  AC1 HCT 116 C34(1.18); C408(0.75); C72(0.99)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C408(0.67); C43(0.55); C72(0.79)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C408(0.53); C43(0.42); C72(0.81)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C408(0.54); C43(0.48); C72(0.73)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C408(0.52); C43(0.40); C72(0.73)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C408(0.39); C43(0.28); C72(0.63)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C408(0.50); C43(0.29); C72(0.78)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C408(0.43); C43(0.28); C72(0.75)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C408(0.45); C43(0.30); C72(0.74)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C408(0.44); C43(0.51); C72(0.67)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C408(0.72); C43(0.31); C72(0.74)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C408(0.63); C43(0.29); C72(0.85)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C408(0.55); C43(0.63); C72(0.88)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C408(0.54); C43(0.35); C72(0.74)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C408(0.53); C43(0.39); C72(0.73)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C408(0.46); C43(0.39); C72(0.72)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C34(0.93); C408(1.04); C72(0.99)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C34(0.95); C408(0.90); C72(0.87)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C34(0.87); C408(0.92); C72(0.98)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C34(1.01); C408(1.00); C72(0.74)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C34(1.07); C408(0.85); C72(0.89)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C34(1.16); C408(0.84); C72(0.93)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C34(0.94); C408(1.12); C72(1.24)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C408(0.94); C43(0.72); C72(0.96)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C34(0.93); C408(0.96); C72(0.82)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C34(1.47); C408(0.80); C72(1.13)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C34(1.00); C408(0.89); C72(0.85)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C34(1.21); C408(1.11); C72(0.98)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C34(1.21); C408(0.85); C72(1.01)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C34(1.04); C408(1.17); C72(0.89)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C34(1.24); C408(0.91); C72(1.26)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C34(1.27); C408(0.91); C72(1.14)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C34(0.62); C408(0.89); C72(1.05)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C34(0.72); C408(1.12); C72(1.21)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C34(0.60); C408(0.89); C72(0.98)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C34(1.34); C408(1.22); C72(1.04)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C34(0.80); C408(0.97); C72(0.97)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C34(0.97); C408(0.85); C72(1.01)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C34(1.11); C408(0.84); C72(0.86)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C34(0.72); C408(0.85); C72(1.04)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C34(0.72); C408(0.88); C72(0.89)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C34(0.94); C408(0.87); C72(0.92)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C34(0.77); C408(0.84); C72(0.84)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C34(0.92); C408(0.81); C72(0.92)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C408(0.67); C43(0.59); C72(0.85)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C34(0.76); C408(0.79); C72(0.81)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C34(1.00); C408(0.84); C72(0.81)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C34(0.99); C408(0.93); C72(0.93)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C34(0.82); C408(0.72); C43(0.81); C72(0.89)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C408(0.31); C72(1.09); C34(1.15); C43(1.16)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C408(0.60); C34(1.10); C72(1.13); C43(1.25)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C408(0.32); C72(1.13); C34(1.18); C43(1.31)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C408(0.30); C43(0.98); C72(1.04); C34(1.10)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C408(0.27); C72(1.13); C34(1.24); C43(1.25)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C408(0.27); C34(1.09); C72(1.26); C43(1.63)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C43(0.48); C408(0.75); C72(0.84)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C408(0.60); C72(1.18); C34(1.22); C43(1.22)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C408(0.70); C43(1.12); C34(1.12); C72(1.23)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C408(0.36); C43(1.06); C34(1.22); C72(1.38)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C408(0.27); C34(1.20); C72(1.44); C43(1.66)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C34(1.17); C408(0.37); C43(1.17); C72(1.25)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C34(1.28); C408(0.38); C43(1.31); C72(1.20)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C34(1.15); C408(0.78); C43(1.24); C72(1.09)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C34(1.18); C408(0.80); C43(1.23); C72(1.23)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C408(0.90); C43(0.92)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C43(0.53); C408(0.65)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C43(0.71); C408(0.75)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C408(0.78); C72(0.99); C34(1.07)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C408(0.93); C43(1.22)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C43(0.81); C408(0.99)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C43(0.95); C408(1.35)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C43(0.81); C408(0.97)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C408(1.02); C43(1.03)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C43(0.67); C408(0.96)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C43(0.78); C408(0.82)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C43(0.61); C408(0.83)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C43(0.76); C408(0.93)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C43(0.79); C408(0.93)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C408(0.82); C72(1.03); C34(1.32)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C408(0.59); C43(0.67)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C43(0.53); C408(0.72)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C43(0.51); C408(0.56)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C43(0.54); C408(0.71)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C43(0.50); C408(0.68)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C72(1.10); C43(1.22); C34(1.36); C408(1.49)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C43(0.73); C72(1.18); C408(1.31); C34(1.39)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C43(0.89); C34(1.16); C72(1.18); C408(1.21)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C43(0.96); C72(1.11); C34(1.13); C408(1.19)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C43(0.82); C408(0.97); C72(1.06); C34(1.12)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C408(0.71); C72(0.99); C34(1.53)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C43(0.68); C408(0.95); C34(0.95); C72(1.00)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C43(0.85); C408(1.07); C34(1.11); C72(1.16)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C43(0.72); C408(0.97); C72(1.06); C34(1.12)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C43(0.81); C408(0.93); C34(0.97); C72(1.04)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C43(0.79); C34(1.03); C408(1.06); C72(1.20)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C43(0.75); C34(0.90); C408(0.92); C72(0.99)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C72(0.92); C408(0.96); C34(1.00); C43(1.02)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C408(0.83); C43(0.92); C34(0.97); C72(1.06)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C408(0.65); C43(0.74); C72(0.92); C34(1.02)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C408(0.61); C43(0.78); C34(0.80); C72(0.81)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C408(0.72); C72(1.01); C34(1.48)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C408(0.62); C43(0.71); C34(0.83); C72(0.89)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C72(0.87); C43(1.09); C34(1.28); C408(1.41)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C72(0.90); C34(0.91); C43(0.99); C408(1.02)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C408(0.71); C43(0.76); C34(0.77); C72(0.98)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C408(0.80); C43(0.86); C34(0.89); C72(0.95)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C408(0.64); C43(0.73); C34(0.81); C72(1.10)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C408(0.68); C43(0.80); C34(0.82); C72(1.01)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C43(0.53); C408(0.63); C72(0.85); C34(0.88)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C43(0.51); C408(0.64); C72(0.65); C34(0.90)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C43(0.50); C72(0.65); C408(0.70); C34(1.00)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C408(0.66); C43(0.67); C72(0.94)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C43(0.49); C72(0.53); C408(0.76); C34(0.89)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C43(0.52); C72(0.61); C408(0.70); C34(0.96)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C43(0.45); C72(0.63); C408(0.74); C34(0.88)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C43(0.49); C72(0.50); C408(0.76); C34(0.91)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C43(0.49); C72(0.66); C408(0.73); C34(0.95)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C43(0.53); C72(0.65); C408(0.68); C34(0.92)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C43(0.51); C72(0.62); C408(0.69); C34(0.91)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C43(0.39); C72(0.49); C408(0.75); C34(0.78)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C408(0.81); C72(1.03); C34(1.05)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C408(0.75); C34(1.08); C72(1.15)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C43(0.58); C408(0.79); C72(1.00)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C408(0.73); C34(0.91); C72(1.11)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C408(0.88); C34(1.06); C72(1.17)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C408(0.83); C34(0.93); C72(1.04)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C408(0.77); C72(1.06); C34(1.08)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C408(0.68); C34(1.08); C72(1.11)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C408(0.81); C34(0.84); C72(1.07)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C408(0.79); C34(1.09); C72(1.11)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C408(0.85); C34(0.98); C72(1.00)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C408(0.91); C72(1.03); C34(1.13)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C408(0.90); C72(1.04); C34(1.15)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C43(0.61); C408(0.65); C72(0.90)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C408(0.85); C34(1.01); C72(1.11)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C34(0.96); C72(1.02); C408(1.17)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C408(0.79); C72(1.06); C34(1.08)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C43(0.41); C408(0.45); C34(0.88); C72(0.95)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C43(0.45); C408(0.49); C34(0.78); C72(0.86)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C43(0.53); C408(0.55); C34(0.70); C72(0.83)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C43(0.50); C408(0.57); C72(0.80); C34(0.83)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C408(0.84); C43(0.89); C72(0.94); C34(1.17)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C408(0.62); C43(0.74); C72(0.86); C34(1.03)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C43(0.44); C408(0.48); C72(0.76); C34(0.83)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C72(0.81); C43(0.88); C408(0.98); C34(1.10)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C43(0.43); C408(0.48); C34(0.74); C72(0.79)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C43(0.42); C408(0.51); C34(0.75); C72(0.86)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C43(0.57); C408(0.66); C34(0.84); C72(0.93)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C34(0.72); C43(0.73); C408(0.80); C72(0.81)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C408(0.69); C43(0.70); C72(0.82); C34(0.87)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C43(0.43); C408(0.71); C34(0.79); C72(0.79)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C43(0.38); C408(0.46); C34(0.78); C72(0.83)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C43(0.21); C408(0.38); C72(0.58)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C43(0.54); C408(0.63); C72(0.79)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C34(0.94)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C408(0.89); C43(0.70); C72(0.96)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C408(0.64); C43(0.73); C72(0.88)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C43(0.43); C408(0.65); C72(0.77)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C34(0.99)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C72(0.55); C34(0.79)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C334(0.00); C72(0.00); C408(0.00); H162(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C72(0.67)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C408(1.00); C72(1.12); C34(1.19); C43(1.36)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C43(0.79); C72(0.87); C34(0.92); C408(0.92)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C408(0.76); C34(0.94); C72(0.96)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C43(0.62); C408(0.68); C72(0.82)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C43(0.65); C408(0.83); C72(1.00)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C43(0.67); C408(0.87); C72(0.90)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C43(0.69); C408(0.78); C72(0.86)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C43(0.66); C408(0.73)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C43(0.55); C408(0.67)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C408(0.63); C43(0.73)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C43(0.53); C408(0.60)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C43(0.78); C408(0.80)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C43(0.85); C34(0.94); C72(1.00); C408(1.04)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C408(0.67); C43(0.75)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C43(0.64); C408(0.74)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C43(0.97); C408(1.02)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C408(0.58); C43(0.61)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C43(0.61); C408(0.81)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C43(0.60); C408(0.74)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C43(0.67); C408(0.75)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C43(0.74); C408(0.92); C72(0.96); C34(1.01)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C43(0.86); C408(0.96); C34(0.97); C72(1.09)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C43(0.78); C408(0.91); C34(0.92); C72(1.00)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C72(0.93); C43(0.96); C34(1.02); C408(1.06)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C43(0.77); C408(1.05); C72(1.13); C34(1.18)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C408(0.82); C43(0.84); C34(0.85); C72(0.94)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C408(0.64); C43(0.87); C34(0.88); C72(0.95)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C43(0.68); C408(0.71); C34(0.79); C72(0.94)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C408(0.65); C43(0.69); C34(0.76); C72(0.92)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C408(0.84); C72(0.85); C43(1.09); C34(1.22)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C72(0.67); C408(0.75); C43(0.76); C34(0.94)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C43(0.73); C408(0.80); C72(0.85); C34(1.00)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C43(0.52); C72(0.56); C408(0.68); C34(0.95)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C72(0.95); C43(1.03); C408(1.03); C34(1.04)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C408(1.01); C34(1.07); C43(1.14); C72(1.14)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C34(0.96); C43(0.97); C72(1.00); C408(1.18)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C43(0.70); C408(0.82); C34(0.85); C72(0.95)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C43(0.59); C34(0.78); C408(0.91); C72(1.03)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C43(0.61); C34(0.79); C408(0.81); C72(0.97)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C43(0.58); C408(0.76); C34(0.79); C72(1.02)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C408(0.94); C34(1.15); C43(1.20); C72(1.21)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C43(0.52); C34(0.73); C408(0.82); C72(0.98)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C43(0.51); C34(0.74); C408(0.76); C72(0.96)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C43(0.46); C408(0.71); C34(0.78); C72(1.15)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C43(0.57); C408(0.72); C34(0.79); C72(1.04)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C43(0.48); C408(0.65); C34(0.72); C72(0.99)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C34(0.86); C408(0.64); C43(0.46); C72(0.97)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C34(0.78); C408(0.72); C43(0.64); C72(0.98)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C34(0.80); C408(0.74); C43(0.58); C72(1.06)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C34(0.71); C408(0.69); C43(0.51); C72(0.98)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C34(0.67); C408(0.77); C43(0.46); C72(1.00)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C34(1.00); C408(1.10); C43(1.11); C72(1.10)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C34(1.03); C408(0.83); C43(0.67); C72(1.14)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C34(1.09); C408(0.75); C43(0.77); C72(0.85)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C34(1.08); C408(0.59); C43(0.56); C72(0.88)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C34(0.83); C408(0.61); C43(0.53); C72(0.79)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C34(0.99); C408(0.51); C43(0.46); C72(0.82)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C34(1.05); C408(0.61); C43(0.47); C72(0.82)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C34(0.87); C408(0.60); C43(0.50); C72(0.82)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C34(1.11); C408(0.60); C43(0.44); C72(0.78)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C34(0.90); C408(0.60); C43(0.50); C72(0.84)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C34(1.01); C408(1.00); C43(1.10); C72(0.96)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C34(0.79); C408(0.72); C43(0.48); C72(0.83)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C34(1.08); C408(0.63); C43(0.54); C72(0.86)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C34(0.92); C408(0.65); C43(0.45); C72(0.86)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C34(0.89); C408(0.55); C43(0.52); C72(0.85)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C34(1.18); C408(0.67); C43(0.50); C72(0.82)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C34(0.89); C408(0.59); C43(0.45); C72(0.81)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C408(0.86); C72(1.11)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C408(0.93); C72(1.18)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C408(0.82); C72(1.11)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C408(0.99); C72(1.13)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C34(1.05); C408(1.11); C43(0.94); C72(1.09)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C408(0.95); C72(1.03)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C408(1.03); C72(1.09)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C408(0.85); C72(1.01)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C408(1.05); C72(1.02)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C408(0.92); C72(1.04)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C408(1.24); C72(1.11)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C408(0.94); C72(1.08)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C408(1.20); C72(1.06)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C408(1.01); C72(1.06)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C408(1.00); C72(1.08)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C34(0.93); C408(1.00); C43(0.98); C72(0.94)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C408(0.80); C72(1.05)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C34(0.78); C408(0.95); C72(0.89)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C34(0.99); C408(0.94); C72(0.91)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C34(0.81); C408(0.74); C72(0.87)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C34(0.69); C408(0.73); C72(0.81)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C34(0.74); C408(0.83); C72(0.81)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C34(0.53); C408(0.50); C72(0.78)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C34(0.65); C408(0.65); C72(0.80)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C34(0.60); C408(0.68); C72(0.78)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C34(0.76); C408(0.87); C72(0.83)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C34(1.12); C408(1.15); C43(1.00); C72(0.96)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C34(0.65); C408(0.70); C72(0.86)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C34(0.62); C408(0.70); C72(0.87)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C34(0.70); C408(1.18); C72(0.94)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C34(0.62); C408(0.82); C72(0.88)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C34(0.70); C408(0.77); C72(0.84)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C34(0.79); C408(0.81); C43(0.75); C72(0.91)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C34(0.96); C408(0.97); C43(1.17); C72(1.02)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C34(0.75); C408(0.73); C43(0.70); C72(0.92)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C34(0.74); C408(0.71); C43(0.83); C72(0.85)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C34(0.85); C408(1.12); C43(0.92); C72(0.95)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C34(0.64); C408(0.86); C43(0.89); C72(0.95)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C34(0.80); C408(0.81); C43(0.91); C72(0.93)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C34(0.63); C408(0.92); C43(0.61); C72(0.91)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C34(0.63); C408(0.69); C43(0.68); C72(0.87)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C34(0.65); C408(0.59); C43(0.63); C72(0.82)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C34(0.81); C408(0.75); C43(0.77); C72(0.90)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C34(0.86); C408(0.91); C43(0.89); C72(0.95)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C34(0.72); C408(0.90); C43(0.82); C72(0.93)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C34(0.67); C408(0.79); C43(0.80); C72(0.86)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C34(0.63); C408(0.62); C43(0.66); C72(0.86)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C34(1.05); C408(0.99); C43(1.07); C72(1.05)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C34(1.76); C408(1.36); C43(1.08); C72(0.95)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C34(1.12); C408(0.83); C72(0.98)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C34(1.10); C408(0.94); C72(1.00)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C34(1.35); C408(0.81); C72(1.06)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C34(1.10); C408(0.85); C72(0.90)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C34(1.14); C408(0.74); C72(0.87)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C34(1.24); C408(0.75); C72(0.89)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C34(1.14); C408(0.67); C72(0.95)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C34(1.08); C408(0.70); C72(0.94)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C34(0.95); C408(0.70); C72(0.99)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C408(1.16); C72(1.19); C43(0.96); C334(1.11)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C408(7.00); C72(5.67)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0625  F8 Ramos C72(1.74); C43(0.57)  LDD2187  [28]
 LDCM0573  Fragment11 Ramos C72(0.76); C43(8.73)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C72(0.86)  LDD2191  [28]
 LDCM0576  Fragment14 Ramos C72(2.23)  LDD2193  [28]
 LDCM0580  Fragment21 Ramos C72(0.86)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C72(0.78)  LDD2196  [28]
 LDCM0588  Fragment30 Ramos C72(1.09)  LDD2199  [28]
 LDCM0468  Fragment33 HCT 116 C34(0.66); C408(0.82); C72(0.89)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C72(0.66)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C72(1.92); C43(0.15)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C34(0.98); C408(0.63); C43(0.43); C72(0.86)  LDD0744  [8]
 LDCM0614  Fragment56 Ramos C72(1.34)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C72(1.20)  LDD2186  [28]
 LDCM0107  IAA HeLa H162(0.00); C334(0.00)  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C34(1.50); C72(1.09)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C34(1.38); C72(1.04)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C34(1.82); C72(1.00)  LDD0082  [8]
 LDCM0109  NEM HeLa H162(0.00); H236(0.00)  LDD0223  [17]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C34(0.99)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C72(0.94)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C34(0.97)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C34(0.67)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C72(0.71); C34(1.08)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C72(0.98)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C34(1.05)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C34(1.11)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C34(1.88)  LDD2105  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C72(1.12)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C34(1.06)  LDD2111  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C72(0.74)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C34(0.76)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C72(1.02); C34(0.72)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C72(0.66)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C72(1.03)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C72(0.80)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C72(1.02)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C72(1.57)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C72(1.19)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C72(0.97)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C72(1.71)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C72(0.77); C34(0.69)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C34(0.85)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C72(1.06)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C72(2.77)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C72(1.04)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C72(1.89)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C72(0.82)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C72(0.41); C34(0.60)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C20(1.03); C72(0.65)  LDD2206  [29]
 LDCM0628  OTUB2-COV-1 HEK-293T C72(1.01); C20(0.89); C72(0.76)  LDD2207  [29]
 LDCM0014  Panhematin HEK-293T 3.04  LDD0062  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
25 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
26 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.