Details of the Target

General Information of Target

Target ID LDTP11509
Target Name L-lactate dehydrogenase A-like 6B (LDHAL6B)
Gene Name LDHAL6B
Gene ID 92483
Synonyms
LDHAL6; LDHL; L-lactate dehydrogenase A-like 6B; EC 1.1.1.27
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDDDTAVLVIDNGSGMCKAGFAGDDAPQAVFPSIVGRPRHQGMMEGMHQKESYVGKEAQS
KRGMLTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYTSGRTTGIVMDSGDGFTHTVPIYEGNALPHATLRLDL
AGRELTDYLMKILTERGYRFTTTAEQEIVRDIKEKLCYVALDSEQEMAMAASSSSVEKSY
ELPDGQVITIGNERFRCPEALFQPCFLGMESCGIHKTTFNSIVKSDVDIRKDLYTNTVLS
GGTTMYPGIAHRMQKEITALAPSIMKIKIIAPPKRKYSVWVGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Target Bioclass
Enzyme
Family
LDH/MDH superfamily, LDH family
Uniprot ID
Q9BYZ2
Ensemble ID
ENST00000307144.6
HGNC ID
HGNC:21481

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y194(0.83)  LDD0264  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
HHS-465
 Probe Info  		Y194(0.00); K198(0.00)  LDD2240  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0073  [4]
STS-1
 Probe Info  		N.A.  LDD0068  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0116  HHS-0101 DM93 Y194(0.83)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y194(0.79)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y194(0.80)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y194(0.85)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y194(0.73)  LDD0268  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Protein NDRG1 (NDRG1) NDRG family Q92597
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) Ser/Thr protein kinase family Q9BXM7
Tyrosyl-DNA phosphodiesterase 1 (TDP1) Tyrosyl-DNA phosphodiesterase family Q9NUW8
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858
Alpha-synuclein (SNCA) Synuclein family P37840
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) . Q14103
TAR DNA-binding protein 43 (TARDBP) . Q13148

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
5 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.