Details of the Target

General Information of Target

Target ID LDTP10776
Target Name Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCC1)
Gene Name MCCC1
Gene ID 56922
Synonyms
MCCA; Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; EC 6.4.1.4; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRRLNRKKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWM
KYEYEVDKDFSSKLRINIDITVAMKCQYVGADVLDLAETMVASADGLVYEPTVFDLSPQQ
KEWQRMLQLIQSRLQEEHSLQDVIFKSAFKSTSTALPPREDDSSQSPNACRIHGHLYVNK
VAGNFHITVGKAIPHPRGHAHLAALVNHESYNFSHRIDHLSFGELVPAIINPLDGTEKIA
IDHNQMFQYFITVVPTKLHTYKISADTHQFSVTERERIINHAAGSHGVSGIFMKYDLSSL
MVTVTEEHMPFWQFFVRLCGIVGGIFSTTGMLHGIGKFIVEIICCRFRLGSYKPVNSVPF
EDGHTDNHLPLLENNTH
Target Bioclass
Enzyme
Subcellular location
Mitochondrion matrix
Function
Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
Uniprot ID
Q96RQ3
Ensemble ID
ENST00000265594.9
HGNC ID
HGNC:6936

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.36  LDD0215  [1]
C-Sul
 Probe Info  		18.72  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K295(7.63)  LDD0277  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
Probe 1
 Probe Info  		Y549(20.53)  LDD3495  [6]
AHL-Pu-1
 Probe Info  		C62(3.76)  LDD0170  [7]
DBIA
 Probe Info  		C129(1.10); C142(1.10); C332(1.05)  LDD0078  [8]
ATP probe
 Probe Info  		K284(0.00); K205(0.00)  LDD0199  [9]
m-APA
 Probe Info  		N.A.  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C509(0.00); C600(0.00); C190(0.00); C595(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		C190(0.00); C509(0.00)  LDD2226  [13]
TFBX
 Probe Info  		C600(0.00); C62(0.00)  LDD0148  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
MPP-AC
 Probe Info  		N.A.  LDD0428  [16]
NAIA_5
 Probe Info  		C509(0.00); C600(0.00); C190(0.00); C62(0.00)  LDD2223  [13]
TER-AC
 Probe Info  		N.A.  LDD0426  [16]
TPP-AC
 Probe Info  		N.A.  LDD0427  [16]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		1.11  LDD0137  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]
DA-2
 Probe Info  		N.A.  LDD0073  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C62(3.76)  LDD0170  [7]
 LDCM0214  AC1 HEK-293T C129(0.88); C332(0.87)  LDD0812  [8]
 LDCM0215  AC10 HCT 116 C595(0.96)  LDD0532  [8]
 LDCM0216  AC100 HEK-293T C129(0.87); C142(0.88); C332(0.78)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C129(0.94); C142(0.91); C332(0.93)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C129(0.94); C142(0.91); C332(0.68)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C129(0.95); C142(0.90); C332(0.74)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C129(0.86); C142(0.96); C332(0.84)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C129(1.01); C142(1.05); C332(0.96)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C129(1.20); C142(1.14); C332(0.92)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C129(0.96); C142(1.02); C332(0.79)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C129(0.97); C142(1.13); C332(1.16)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C129(1.03); C142(0.96); C332(1.01)  LDD0823  [8]
 LDCM0226  AC11 HCT 116 C595(1.03)  LDD0543  [8]
 LDCM0227  AC110 HEK-293T C129(0.97); C142(0.78); C332(0.84)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C129(0.87); C142(0.64); C332(0.78)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C129(0.98); C142(0.76); C332(0.75)  LDD0827  [8]
 LDCM0230  AC113 HEK-293T C129(0.89); C142(1.01); C332(1.11)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C129(0.79); C142(0.97); C332(0.83)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C129(0.78); C142(0.91); C332(0.95)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C129(0.78); C142(0.90); C332(0.86)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C129(0.77); C142(0.80); C332(1.02)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C129(0.84); C142(0.74); C332(0.82)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C129(0.77); C142(0.73); C332(0.83)  LDD0834  [8]
 LDCM0237  AC12 HCT 116 C595(1.11)  LDD0554  [8]
 LDCM0238  AC120 HEK-293T C129(0.75); C142(0.77); C332(0.78)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C129(0.71); C142(0.73); C332(0.86)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C129(0.77); C142(0.71); C332(1.07)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C129(0.76); C142(0.69); C332(0.96)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C129(0.70); C142(0.71); C332(0.92)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C129(0.71); C142(0.69); C332(0.70)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C129(0.81); C142(0.65); C332(0.74)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C129(0.75); C142(0.60); C332(0.82)  LDD0843  [8]
 LDCM0246  AC128 HEK-293T C129(1.38); C142(1.22); C332(1.01)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C129(1.12); C142(0.89); C332(0.73)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C129(1.01); C142(0.92); C332(0.78)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C129(1.22); C142(1.17); C332(1.07)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C129(0.96); C142(0.86); C332(0.75)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C129(0.96); C142(0.92); C332(0.82)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C129(1.02); C142(0.91); C332(0.78)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C129(0.85); C142(0.84); C332(0.70)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C129(0.92); C142(0.76); C332(0.70)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C129(0.99); C142(0.75); C332(0.67)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C129(1.03); C142(0.81); C332(0.75)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C129(0.95); C142(0.75); C332(0.81)  LDD0856  [8]
 LDCM0259  AC14 HCT 116 C595(1.22)  LDD0576  [8]
 LDCM0260  AC140 HEK-293T C129(1.03); C142(0.83); C332(0.75)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C129(0.99); C142(0.84); C332(0.80)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C129(0.91); C142(0.83); C332(0.73)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C129(0.84); C142(0.96); C332(0.81)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C129(0.98); C142(0.87); C332(1.06)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C129(0.98); C142(0.92); C332(0.93)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C129(0.95); C142(0.79); C332(1.00)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C129(0.95); C142(0.90); C332(0.93)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C129(1.05); C142(0.85); C332(0.87)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C129(1.05); C142(1.14); C332(0.97)  LDD0867  [8]
 LDCM0270  AC15 HCT 116 C595(1.14)  LDD0587  [8]
 LDCM0271  AC150 HEK-293T C129(0.94); C142(0.94); C332(0.85)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C129(0.97); C142(0.84); C332(0.97)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C129(0.99); C142(1.03); C332(1.07)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C129(1.11); C142(0.95); C332(1.02)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C129(1.01); C142(0.95); C332(1.06)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C129(0.94); C142(0.96); C332(1.00)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C129(0.94); C142(0.83); C332(1.02)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C129(0.93); C142(0.74); C332(0.90)  LDD2165  [8]
 LDCM0276  AC17 HCT 116 C129(0.76); C142(0.76); C595(1.01)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C129(0.66); C142(0.66); C595(1.21)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C129(1.00); C142(1.00); C595(1.22)  LDD0595  [8]
 LDCM0279  AC2 HEK-293T C129(0.75); C332(0.64)  LDD0877  [8]
 LDCM0280  AC20 HCT 116 C129(0.66); C142(0.66); C595(1.05)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C129(0.72); C142(0.72); C595(1.04)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C129(0.60); C142(0.60); C595(0.96)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C129(0.71); C142(0.71); C595(0.93)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C129(0.92); C142(0.92); C595(1.07)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C129(0.81); C142(0.81)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C129(0.80); C142(0.80)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C129(0.76); C142(0.76)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C129(0.77); C142(0.77)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C129(0.96); C142(0.96)  LDD0606  [8]
 LDCM0290  AC3 HEK-293T C129(1.00); C332(0.95)  LDD0888  [8]
 LDCM0291  AC30 HCT 116 C129(0.64); C142(0.64)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C129(1.18); C142(1.18)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C129(0.88); C142(0.88)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C129(0.71); C142(0.71)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C129(0.56); C142(0.56)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C129(1.22); C142(1.22)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C129(0.99); C142(0.99)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C129(1.13); C142(1.13)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C129(1.10); C142(1.10)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C129(0.93); C142(0.93)  LDD0617  [8]
 LDCM0301  AC4 HEK-293T C129(1.03); C332(1.26)  LDD0899  [8]
 LDCM0302  AC40 HCT 116 C129(0.79); C142(0.79)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C129(1.18); C142(1.18)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C129(1.18); C142(1.18)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C129(1.12); C142(1.12)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C129(1.10); C142(1.10)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C129(0.90); C142(0.90)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C129(1.16); C142(1.16)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C129(0.90); C142(0.90)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C129(1.40); C142(1.40)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C129(0.34); C142(0.34)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C129(0.80); C332(0.69)  LDD0910  [8]
 LDCM0313  AC50 HCT 116 C129(0.37); C142(0.37)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C129(1.34); C142(1.34)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C129(0.96); C142(0.96)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C129(0.54); C142(0.54)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C129(0.53); C142(0.53)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C129(0.33); C142(0.33)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C129(0.28); C142(0.28)  LDD0636  [8]
 LDCM0320  AC57 HEK-293T C129(1.06); C332(1.04)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C129(1.07); C332(1.02)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C129(1.03); C332(1.08)  LDD0920  [8]
 LDCM0323  AC6 HCT 116 C595(1.25)  LDD0640  [8]
 LDCM0324  AC60 HEK-293T C129(1.04); C332(1.24)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C129(0.89); C332(0.74)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C129(0.93); C332(0.89)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C129(0.87); C332(0.80)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C129(0.84); C332(0.84)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C129(0.80); C332(0.77)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C129(1.01); C332(0.94)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C129(1.02); C332(0.91)  LDD0929  [8]
 LDCM0332  AC68 HCT 116 C332(0.88); C129(1.73); C142(1.73)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C332(0.92); C129(1.08); C142(1.08)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C595(0.93)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C129(0.38); C142(0.38); C332(0.79)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C332(1.05); C129(1.16); C142(1.16)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C129(0.71); C142(0.71); C332(0.89)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C129(0.23); C142(0.23); C332(0.88)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C129(0.27); C142(0.27); C332(0.75)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C129(0.25); C142(0.25); C332(0.87)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C129(0.49); C142(0.49); C332(1.14)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C129(0.47); C142(0.47); C332(0.94)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C332(1.00); C129(1.42); C142(1.42)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C332(0.96); C129(1.03); C142(1.03)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C595(1.12)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C129(0.73); C142(0.73); C332(0.98)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C129(0.74); C142(0.74); C332(0.90)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C129(0.33); C142(0.33); C332(1.05)  LDD0665  [8]
 LDCM0349  AC83 HEK-293T C142(0.93); C332(0.99)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C142(0.69); C332(0.84)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C142(0.85); C332(0.79)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C142(0.76); C332(0.82)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C142(0.75); C332(0.84)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C142(0.70); C332(0.73)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C142(0.63); C332(0.82)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C142(0.67); C332(0.80)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C142(0.70); C332(0.79)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C142(0.73); C332(0.84)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C142(0.82); C332(0.84)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C142(0.71); C332(0.79)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C142(0.72); C332(0.82)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C142(0.68); C332(0.71)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C142(0.62); C332(0.72)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C129(0.92); C142(0.97); C332(0.86)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C129(0.92); C142(1.10); C332(0.94)  LDD0964  [8]
 LDCM0248  AKOS034007472 HCT 116 C595(0.97)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C595(0.96)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C595(0.67)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C129(1.10); C142(1.10); C332(1.05)  LDD0078  [8]
 LDCM0632  CL-Sc Hep-G2 C190(1.85); C332(0.83)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C129(1.17); C142(1.17)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C129(0.48); C142(0.48)  LDD0685  [8]
 LDCM0369  CL100 HEK-293T C129(0.74); C332(0.67)  LDD0967  [8]
 LDCM0370  CL101 HCT 116 C595(1.17)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C595(0.96)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C595(0.89)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C595(0.98)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C129(0.69); C142(0.69); C595(1.07)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C129(0.59); C142(0.59); C595(1.30)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C129(0.56); C142(0.56); C595(0.94)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C129(0.46); C142(0.46); C595(0.86)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C129(0.85); C142(0.85); C595(1.07)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C129(0.36); C142(0.36)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C129(0.76); C142(0.76); C595(0.96)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C129(1.09); C142(1.09); C595(1.11)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C129(0.98); C142(0.98)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C129(0.59); C142(0.59)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C129(1.16); C142(1.16)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C129(0.77); C142(0.77)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C129(0.74); C142(0.74)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C129(0.52); C142(0.52)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C129(1.13); C142(1.13)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C129(0.76); C142(0.76)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C129(0.31); C142(0.31)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C129(0.94); C142(0.94)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C129(0.83); C142(0.83)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C129(0.79); C142(0.79)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C129(0.39); C142(0.39)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C129(0.37); C142(0.37)  LDD0712  [8]
 LDCM0396  CL125 HEK-293T C129(1.07); C332(1.04)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C129(1.19); C332(1.02)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C129(0.97); C332(0.93)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C129(1.17); C332(1.13)  LDD0997  [8]
 LDCM0400  CL13 HCT 116 C129(0.92); C142(0.92)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C129(1.11); C142(1.11)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C129(1.15); C142(1.15)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C129(0.68); C142(0.68)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C129(0.85); C142(0.85)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C129(0.66); C142(0.66)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C129(1.21); C142(1.21)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C129(1.32); C142(1.32)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C129(0.57); C142(0.57)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C129(0.38); C142(0.38)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C129(0.32); C142(0.32)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C129(0.77); C142(0.77)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C129(0.39); C142(0.39)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C129(0.50); C142(0.50)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C129(1.06); C142(1.06)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C129(0.94); C142(0.94)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C129(0.78); C142(0.78)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C129(0.62); C142(0.62)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C129(1.33); C142(1.33)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C129(0.73); C142(0.73)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C129(0.95); C142(0.95); C332(1.05); C595(1.11)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C129(1.04); C142(1.04); C332(1.17); C595(0.81)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C129(1.12); C142(1.12); C332(0.71); C595(1.66)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C129(0.48); C142(0.48); C332(0.94); C595(1.17)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C129(0.48); C142(0.48); C332(0.81); C595(0.81)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C129(0.66); C142(0.66); C332(1.10); C595(1.08)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C129(0.44); C142(0.44); C332(0.89); C595(0.83)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C129(0.43); C142(0.43); C332(0.80); C595(0.93)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C129(1.31); C142(1.31)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C129(0.68); C142(0.68); C332(0.99); C595(0.76)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C129(0.92); C142(0.92); C332(0.99); C595(0.79)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C129(0.29); C142(0.29); C332(1.02); C595(1.08)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C129(0.35); C142(0.35); C332(0.86); C595(0.84)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C129(0.95); C142(0.95); C332(1.07); C595(1.05)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C129(0.52); C142(0.52); C332(1.06); C595(0.83)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C332(0.86)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C332(0.91)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C332(0.82)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C332(1.00)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C129(1.21); C142(1.21)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C332(1.09)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C332(1.12)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C332(0.93)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C332(0.87)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C332(0.90)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C332(0.92)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C332(0.93)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C332(1.13)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C332(1.10)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C332(1.14)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C129(1.30); C142(1.30)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C332(1.34)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C129(0.94); C142(0.94); C332(0.91); C595(0.91)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C129(1.15); C142(1.15); C332(0.95); C595(0.89)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C129(1.28); C142(1.28); C332(1.23); C595(0.97)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C129(0.81); C142(0.81); C332(1.05); C595(0.80)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C129(1.02); C142(1.02); C332(0.94); C595(1.01)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C129(0.57); C142(0.57); C332(1.20); C595(0.75)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C129(0.98); C142(0.98); C332(1.23); C595(1.07)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C129(1.10); C142(1.10); C332(1.19); C595(1.14)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C129(1.48); C142(1.48); C332(1.06); C595(1.05)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C129(0.59); C142(0.59)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C129(1.33); C142(1.33); C332(1.49); C595(1.14)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C129(1.05); C142(1.05); C332(1.01); C595(0.96)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C129(1.02); C142(1.02); C332(0.95); C595(1.06)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C129(0.99); C142(0.99); C332(1.07); C595(1.08)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C129(1.29); C142(1.29); C332(1.20); C595(1.01)  LDD0784  [8]
 LDCM0469  CL76 PaTu 8988t C129(1.19); C142(1.19)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C129(1.19); C142(1.19)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C129(1.15); C142(1.15)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C129(1.04); C142(1.04)  LDD1351  [8]
 LDCM0473  CL8 HCT 116 C129(0.26); C142(0.26)  LDD0790  [8]
 LDCM0474  CL80 PaTu 8988t C129(1.22); C142(1.22)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C129(0.92); C142(0.92)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C129(1.04); C142(1.04)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C129(0.87); C142(0.87)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C129(0.56); C142(0.56)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C129(1.08); C142(1.08)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C129(1.23); C142(1.23)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C129(0.51); C142(0.51)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C129(0.83); C142(0.83)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C129(0.61); C142(0.61)  LDD1362  [8]
 LDCM0484  CL9 HCT 116 C129(0.76); C142(0.76)  LDD0801  [8]
 LDCM0485  CL90 PaTu 8988t C129(0.57); C142(0.57)  LDD1364  [8]
 LDCM0486  CL91 HEK-293T C129(1.21); C332(1.23)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C129(0.94); C332(1.09)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C129(0.94); C332(0.94)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C129(0.81); C332(0.69)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C129(0.65); C332(0.59)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C129(0.79); C332(0.80)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C129(0.90); C332(0.97)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C129(0.88); C332(0.81)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C129(1.04); C332(0.82)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C332(1.02); C190(0.95); C595(0.97); C509(0.84)  LDD1698  [20]
 LDCM0468  Fragment33 HCT 116 C129(1.04); C142(1.04); C332(1.17); C595(1.09)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C129(0.31); C142(0.31); C332(0.94); C595(1.06)  LDD0744  [8]
 LDCM0022  KB02 HCT 116 C595(1.13)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C595(1.12)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C595(0.96)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0227  [15]
 LDCM0021  THZ1 HCT 116 C129(1.04); C142(1.04)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) AccD/PCCB family Q9HCC0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biotin Small molecular drug DB00121

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402