Details of the Target

General Information of Target

Target ID LDTP12610
Target Name Obg-like ATPase 1 (OLA1)
Gene Name OLA1
Gene ID 29789
Synonyms
GTPBP9; Obg-like ATPase 1; DNA damage-regulated overexpressed in cancer 45; DOC45; GTP-binding protein 9
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRSRLLLSVAHLPTIRETTEEMLLGGPGQEPPPSPSLDDYVRSISRLAQPTSVLDKATAQ
GQPRPPHRPAQACRKGRPAVSLRDITARFSGQQPTLPMADTVDPLDWLFGESQEKQPSQR
DLPRRTGPSAGLWGPHRQMDSSKPMGAPRGRLCEARMPGHSLARPPQDGQQSSDLRSWTF
GQSAQAMASRHRPRPSSVLRTLYSHLPVIHEL
Target Bioclass
Enzyme
Family
TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, YchF/OLA1 subfamily
Subcellular location
Cytoplasm
Function Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. {|HAMAP-Rule:MF_03167}.
Uniprot ID
Q9NTK5
Ensemble ID
ENST00000284719.8
HGNC ID
HGNC:28833
ChEMBL ID
CHEMBL4105704

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P59S DBIA    Probe Info 
HT1197 SNV: p.R143Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		6.78  LDD0215  [2]
TH211
 Probe Info  		Y282(5.75)  LDD0260  [3]
TH216
 Probe Info  		Y350(11.17)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K11(7.26); K180(1.01); K190(5.00); K242(10.00)  LDD0277  [5]
ONAyne
 Probe Info  		K248(10.00); K363(10.00)  LDD0275  [5]
Probe 1
 Probe Info  		Y254(82.46)  LDD3495  [6]
BTD
 Probe Info  		C187(1.48)  LDD2089  [7]
AHL-Pu-1
 Probe Info  		C75(8.46); C187(4.93)  LDD0170  [8]
HHS-475
 Probe Info  		Y203(1.15); Y77(1.51); Y254(1.67)  LDD0264  [9]
HHS-465
 Probe Info  		Y203(10.00); Y254(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C55(2.05); C187(1.06)  LDD0080  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		K79(0.00); K190(0.00); K5(0.00); K234(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C75(0.00); C117(0.00); C187(0.00); C55(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C75(0.00); C117(0.00); C187(0.00); C55(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		N.A.  LDD0035  [16]
NAIA_4
 Probe Info  		C55(0.00); C187(0.00)  LDD2226  [17]
IPM
 Probe Info  		N.A.  LDD0005  [18]
NHS
 Probe Info  		K354(0.00); K333(0.00); K294(0.00)  LDD0010  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
TFBX
 Probe Info  		N.A.  LDD0148  [20]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
1c-yne
 Probe Info  		K11(0.00); K386(0.00); K248(0.00); C55(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C55(0.00); C187(0.00); C75(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
AOyne
 Probe Info  		12.00  LDD0443  [24]
NAIA_5
 Probe Info  		C75(0.00); C117(0.00); C187(0.00); C55(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		9.19  LDD1725  [25]
C140
 Probe Info  		7.94  LDD1822  [25]
C160
 Probe Info  		43.71  LDD1840  [25]
C178
 Probe Info  		19.56  LDD1857  [25]
C191
 Probe Info  		30.48  LDD1868  [25]
C197
 Probe Info  		6.19  LDD1873  [25]
C211
 Probe Info  		19.70  LDD1885  [25]
C213
 Probe Info  		18.25  LDD1887  [25]
C220
 Probe Info  		28.25  LDD1894  [25]
C228
 Probe Info  		16.34  LDD1901  [25]
C244
 Probe Info  		16.45  LDD1917  [25]
C265
 Probe Info  		27.67  LDD1936  [25]
C277
 Probe Info  		8.22  LDD1947  [25]
C293
 Probe Info  		18.77  LDD1963  [25]
C303
 Probe Info  		5.21  LDD1972  [25]
C337
 Probe Info  		4.96  LDD2000  [25]
C342
 Probe Info  		7.94  LDD2004  [25]
C387
 Probe Info  		6.96  LDD2046  [25]
C388
 Probe Info  		36.25  LDD2047  [25]
C407
 Probe Info  		21.71  LDD2064  [25]
C419
 Probe Info  		10.85  LDD2074  [25]
FFF probe11
 Probe Info  		20.00  LDD0471  [26]
FFF probe13
 Probe Info  		20.00  LDD0475  [26]
FFF probe2
 Probe Info  		7.38  LDD0463  [26]
FFF probe3
 Probe Info  		7.94  LDD0464  [26]
JN0003
 Probe Info  		15.25  LDD0469  [26]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [29]
DA-2
 Probe Info  		N.A.  LDD0070  [30]
STS-1
 Probe Info  		N.A.  LDD0068  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C187(0.62)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C187(1.05)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C187(1.24); C75(0.83)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C187(1.33)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C187(0.98); C75(1.22)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C187(0.74); C75(0.74)  LDD2132  [7]
 LDCM0025  4SU-RNA DM93 C75(8.46); C187(4.93)  LDD0170  [8]
 LDCM0214  AC1 HCT 116 C187(1.04); C55(1.44); C75(1.34)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C187(1.02); C55(1.53); C75(0.62)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C187(0.86); C55(0.73); C75(0.56)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C187(0.76); C55(0.76); C75(0.50)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C187(0.86); C55(0.73); C75(0.74)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C187(0.75); C55(0.88); C75(0.43)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C187(0.90); C55(0.85); C75(0.93)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C187(0.85); C55(0.76); C75(0.51)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C187(0.80); C55(0.89); C75(0.41)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C187(0.80); C55(0.83); C75(0.56)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C187(0.77); C55(0.74); C75(0.59)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C187(0.89); C55(0.68); C75(0.92)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C187(1.11); C55(1.72); C75(0.60)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C187(0.94); C55(0.69); C75(0.42)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C187(0.70); C55(0.77); C75(0.38)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C187(0.73); C55(0.67); C75(0.43)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C187(0.96); C55(1.06); C75(1.18)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C187(0.89); C55(1.28); C75(0.86)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C187(1.02); C55(1.30); C75(0.68)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C187(0.92); C55(1.43); C75(0.71)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C187(0.94); C55(1.02); C75(1.05)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C187(1.09); C55(1.15); C75(1.02)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C187(1.02); C55(1.08); C75(0.93)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C187(1.17); C55(1.25); C75(0.86)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C187(1.12); C55(1.16); C75(0.75)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C187(1.02); C55(1.07); C75(1.25)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C187(1.02); C55(1.21); C75(0.94)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C187(1.31); C55(1.10); C75(1.57)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C187(0.99); C55(1.03); C75(1.17)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C187(1.04); C55(1.37); C75(0.96)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C187(0.89); C55(1.28); C75(0.85)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C187(0.98); C55(1.31); C75(0.97)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C187(0.70); C75(1.66)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C187(0.93); C75(1.56)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C187(0.77); C75(1.12)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C187(0.79); C75(1.14)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C187(0.82); C75(0.87)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C187(0.96); C75(1.21)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C187(0.86); C75(0.84)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C187(0.79); C75(0.71)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C187(0.83); C75(0.66)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C187(0.84); C75(0.69)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C187(0.91); C75(0.43)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C187(0.84); C75(0.49)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C187(1.13); C55(1.54); C75(0.57)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C187(0.82); C75(0.42)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C187(0.80); C75(0.41)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C187(0.79); C75(0.68)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C187(1.02); C55(1.29)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C187(0.73); C55(1.49)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C55(1.21); C187(1.24)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C187(0.78); C55(1.29)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C187(1.08); C55(1.33)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C187(0.45); C55(1.38)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C187(0.76); C55(1.52)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C75(0.63); C187(1.08); C55(1.33)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C187(1.30); C55(1.31)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C187(1.06); C55(1.11)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C187(0.91); C55(1.56)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C187(0.49); C55(1.58)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C187(1.02); C55(1.21)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C187(0.91); C55(1.55)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C187(0.98); C55(1.12)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C187(1.25); C55(1.28)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C187(0.86); C75(0.92)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C187(1.00); C75(1.08)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C187(0.78); C75(1.13)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C75(0.96); C187(1.08); C55(1.53)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C75(0.84); C187(0.90)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C187(0.76); C75(0.93)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C187(0.83); C75(0.89)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C187(0.89); C75(1.00)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C75(0.81); C187(0.88)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C187(0.82); C55(1.03); C75(1.17)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C75(0.67); C187(0.78); C55(1.24)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C75(0.70); C187(0.79); C55(1.33)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C187(0.74); C55(1.15); C75(1.18)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C75(0.30); C187(0.73); C55(1.29)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C187(1.14); C75(1.22); C55(1.25)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C75(0.32); C187(0.67); C55(1.50)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C75(0.48); C187(0.79); C55(1.28)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C75(0.38); C187(0.68); C55(1.55)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C187(0.74); C75(0.77); C55(1.52)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C75(0.67); C187(0.80); C55(1.83)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C55(0.90); C187(1.02); C75(1.42)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C75(0.92); C55(0.98); C187(1.07)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C75(0.77); C55(1.01); C187(1.14)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C55(0.91); C187(0.91); C75(1.00)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C187(0.97); C55(1.02); C75(1.14)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C187(1.13); C75(1.44); C55(1.74)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C75(0.88); C187(0.88); C55(1.22)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C75(0.42); C187(0.95); C55(1.05)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C75(0.68); C187(1.00); C55(1.11)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C75(0.47); C187(0.81); C55(1.03)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C75(0.52); C55(0.99); C187(0.99)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C75(0.47); C187(0.84); C55(1.18)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C75(0.50); C187(0.86); C55(1.05)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C75(0.66); C187(0.92); C55(1.15)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C75(0.63); C187(0.67); C55(0.99)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C187(0.56); C75(0.61); C55(1.41)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C187(1.14); C75(1.41); C55(1.76)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C187(0.60); C75(0.69); C55(1.13)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C75(0.62); C187(0.85); C55(0.92)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C75(0.58); C187(0.88); C55(1.01)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C75(0.74); C187(0.77); C55(1.22)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C75(0.78); C187(0.78); C55(1.26)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C187(0.61); C75(0.93); C55(1.40)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C75(0.61); C187(0.66); C55(1.65)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C187(0.98); C75(1.17); C55(1.21)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C187(0.86); C75(1.09); C55(1.52)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C75(0.59); C187(0.93); C55(1.31)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C75(0.59); C187(0.97); C55(1.54)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C75(0.47); C187(0.89); C55(1.33)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C187(0.86); C75(0.94); C55(1.37)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C75(0.57); C187(0.84); C55(1.78)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C75(0.57); C187(0.96); C55(1.42)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C75(0.61); C187(0.83); C55(1.62)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C75(0.70); C187(0.92); C55(1.71)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C187(1.01); C75(1.07); C55(1.55)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C75(0.53); C187(0.65); C55(1.64)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C75(0.60); C187(0.93); C55(1.34)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C75(0.72); C187(0.91); C55(1.12)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C75(0.79); C187(1.12); C55(1.26)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C75(0.40); C187(0.59); C55(1.19)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C75(1.05); C187(1.09); C55(1.09)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C75(0.65); C187(0.81); C55(1.38)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C75(0.43); C187(0.56); C55(1.71)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C187(0.66); C75(0.67); C55(1.42)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C75(0.46); C187(0.60); C55(1.57)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C75(0.71); C187(0.74); C55(1.42)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C75(0.53); C187(0.67); C55(1.23)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C75(0.68); C187(0.81); C55(1.13)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C75(0.76); C187(0.92); C55(1.35)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C75(0.86); C187(1.03); C55(1.42)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C75(0.84); C187(0.86); C55(1.30)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C75(0.95); C187(1.11); C55(1.25)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C75(0.55); C187(0.72); C55(1.81)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C187(0.79); C75(0.98)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C187(0.77); C75(0.94)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C187(0.87); C75(1.01)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C75(0.65); C187(0.84)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C75(0.56); C187(0.84)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C75(0.51); C187(0.92)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C75(0.64); C187(0.80)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C75(0.49); C187(0.89)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C187(0.70); C75(1.22)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C187(0.79); C75(1.18)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C75(0.94); C187(0.96)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C187(1.00); C75(2.05)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C75(0.52); C187(0.80)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C187(0.92); C75(1.90)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C75(0.53); C187(0.84)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C75(0.44); C187(0.55); C55(0.72)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C75(0.56); C55(0.68); C187(0.93)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C187(0.96)  LDD2138  [7]
 LDCM0248  AKOS034007472 HCT 116 C187(1.17); C55(1.17); C75(1.13)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C75(0.83); C187(1.11); C55(1.22)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C75(0.23); C187(0.78); C55(1.92)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.72  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C187(1.06); C75(0.94)  LDD2171  [11]
 LDCM0498  BS-3668 MDA-MB-231 C187(1.15)  LDD2091  [7]
 LDCM0630  CCW28-3 231MFP C55(1.56)  LDD2214  [32]
 LDCM0108  Chloroacetamide HeLa C75(0.00); C187(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C75(20.00); C117(0.74)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C55(0.88); C187(0.89); C75(0.89)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C75(0.72); C187(0.89); C55(1.14)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C187(1.07); C75(1.15); C55(1.38)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C75(0.69); C187(1.00); C55(1.59)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C75(0.81); C187(1.08); C55(1.25)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C75(0.95); C187(1.03); C55(1.10)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C187(1.02); C75(1.04); C55(1.30)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C187(1.07); C75(1.35)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C187(0.94); C75(1.56)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C187(0.87); C75(1.19)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C187(0.90); C75(1.07)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C187(0.82); C75(0.98)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C187(0.79); C75(1.17); C55(1.32)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C187(0.84); C75(0.99)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C187(0.80); C75(0.96)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C75(0.77); C187(0.84); C55(1.03)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C75(0.34); C187(0.80); C55(1.45)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C75(0.32); C187(0.70); C55(1.24)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C75(0.47); C187(0.76); C55(1.22)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C75(0.69); C187(0.83); C55(1.42)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C187(0.69); C75(1.12); C55(1.32)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C75(0.82); C187(0.91); C55(0.98)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C75(0.71); C187(0.78); C55(1.00)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C187(0.70); C75(0.97); C55(1.41)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C75(0.61); C187(0.92); C55(0.98)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C75(0.56); C187(0.79); C55(1.13)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C75(0.57); C187(0.80); C55(1.25)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C187(0.72); C75(0.81); C55(1.03)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C75(0.63); C187(0.67); C55(1.17)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C75(0.81); C55(0.90); C187(1.00)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C75(1.00); C55(1.08); C187(1.13)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C75(0.79); C187(1.02); C55(1.09)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C187(0.94); C75(1.12); C55(1.30)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C187(0.79); C75(1.03); C55(1.19)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C75(0.71); C187(0.82); C55(1.15)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C187(0.77); C55(1.05); C75(1.18)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C75(0.45); C187(0.99); C55(1.14)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C187(0.91); C75(1.11); C55(1.12)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C75(0.77); C187(0.80); C55(1.20)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C187(0.86); C75(0.95); C55(1.28)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C75(0.73); C187(0.84); C55(0.90)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C75(0.80); C187(0.85); C55(1.50)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C187(0.76); C75(1.01); C55(1.57)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C187(0.71); C75(1.01); C55(1.76)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C75(0.84); C187(0.90); C55(1.24)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C187(0.67); C75(0.75); C55(1.56)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C187(0.81); C55(1.45); C75(0.72)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C187(0.90); C55(1.15); C75(0.63)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C187(0.92); C55(1.19); C75(0.93)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C187(0.76); C55(1.39); C75(0.65)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C187(0.79); C55(1.36); C75(0.93)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C187(0.90); C55(1.13); C75(0.70)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C187(0.90); C55(1.16); C75(0.84)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C187(0.92); C55(1.01); C75(0.94)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C187(0.74); C55(1.07); C75(0.72)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C187(0.75); C55(1.00); C75(0.67)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C187(0.67); C55(1.49); C75(0.71)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C187(0.65); C55(1.26); C75(0.71)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C187(0.75); C55(1.07); C75(0.76)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C187(0.62); C55(1.43); C75(0.85)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C187(0.69); C55(1.27); C75(0.97)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C187(0.83); C55(0.88); C75(1.07)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C187(0.77); C55(1.23); C75(0.64)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C187(0.83); C55(1.08); C75(0.82)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C187(0.69); C55(1.66); C75(0.80)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C187(0.61); C55(1.44); C75(0.97)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C187(0.74); C55(1.17); C75(0.81)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C187(0.66); C55(1.53); C75(0.70)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C187(0.90); C55(0.64)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C187(1.18); C55(0.64)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C187(0.97); C55(0.66)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C187(0.96); C55(0.77)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C187(0.92); C55(0.95); C75(1.08)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C187(0.89); C55(0.65)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C187(0.89); C55(0.71)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C187(0.84); C55(0.70)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C187(0.92); C55(0.65)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C187(0.82); C55(0.72)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C187(1.02); C55(0.68)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C187(1.04); C55(0.82)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C187(0.93); C55(0.64)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C187(0.97); C55(0.74)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C187(0.89); C55(0.71)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C187(0.72); C55(1.17); C75(0.74)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C187(0.92); C55(0.73)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C187(1.08); C55(1.01); C75(0.92)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C187(0.94); C55(0.97); C75(0.84)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C187(1.07); C55(1.08); C75(0.79)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C187(1.00); C55(1.19); C75(0.69)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C187(1.08); C55(1.07); C75(0.88)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C187(0.95); C55(1.29); C75(0.42)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C187(1.10); C55(1.39); C75(0.60)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C187(1.07); C55(1.23); C75(0.61)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C187(0.92); C55(1.02); C75(0.91)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C187(0.84); C55(1.23); C75(0.87)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C187(0.98); C55(1.04); C75(0.68)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C187(1.02); C55(1.13); C75(0.77)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C187(1.05); C55(0.90); C75(0.98)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C187(1.04); C55(1.43); C75(0.81)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C187(0.99); C55(1.25); C75(0.71)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C187(0.92); C75(1.02)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C187(1.10); C75(1.01)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C187(1.00); C75(0.97)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C187(1.03); C75(1.07)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C187(0.68); C55(1.09); C75(0.93)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C187(0.98); C75(1.04)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C187(1.13); C75(1.22)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C187(0.83); C75(1.64)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C187(0.88); C75(1.18)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C187(0.77); C75(0.83)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C187(1.00); C75(0.73)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C187(1.20); C75(0.88)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C187(1.04); C75(1.32)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C187(0.93); C75(1.38)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C187(0.84); C75(0.86)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C187(0.81); C55(1.03); C75(0.79)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C187(1.01); C75(1.15)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C187(0.98); C55(1.26); C75(0.94)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C187(1.03); C55(1.25); C75(1.20)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C187(1.08); C55(1.20); C75(1.35)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C187(0.96); C55(1.37); C75(1.52)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C187(1.01); C55(1.52); C75(1.07)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C187(1.03); C55(1.39); C75(1.02)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C187(0.96); C55(1.28); C75(0.88)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C187(1.00); C55(1.31); C75(0.93)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C187(1.17); C55(1.58); C75(1.10)  LDD0811  [11]
 LDCM0185  Compound 17 HEK-293T 5.05  LDD0504  [26]
 LDCM0184  Compound 20 HEK-293T 11.79  LDD0503  [26]
 LDCM0191  Compound 21 HEK-293T 4.03  LDD0508  [26]
 LDCM0186  Compound 31 HEK-293T 8.28  LDD0506  [26]
 LDCM0187  Compound 32 HEK-293T 37.95  LDD0507  [26]
 LDCM0188  Compound 33 HEK-293T 7.04  LDD0505  [26]
 LDCM0190  Compound 34 HEK-293T 3.68  LDD0510  [26]
 LDCM0193  Compound 36 HEK-293T 3.50  LDD0511  [26]
 LDCM0495  E2913 HEK-293T C187(0.89); C75(0.85); C55(1.00)  LDD1698  [33]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C75(0.87); C187(0.58)  LDD1702  [7]
 LDCM0625  F8 Ramos C55(1.82); C187(0.57); C117(0.69)  LDD2187  [34]
 LDCM0572  Fragment10 Ramos C55(1.34); C187(0.70); C117(2.06)  LDD2189  [34]
 LDCM0573  Fragment11 Ramos C55(1.67); C187(15.70); C117(20.00)  LDD2190  [34]
 LDCM0574  Fragment12 Ramos C55(0.58); C187(0.97); C117(1.92)  LDD2191  [34]
 LDCM0575  Fragment13 Ramos C55(0.58); C187(1.16)  LDD2192  [34]
 LDCM0576  Fragment14 Ramos C55(1.40); C187(0.68); C117(0.58)  LDD2193  [34]
 LDCM0579  Fragment20 Ramos C55(0.53); C187(0.97); C117(0.98)  LDD2194  [34]
 LDCM0580  Fragment21 Ramos C55(0.66); C187(0.91)  LDD2195  [34]
 LDCM0582  Fragment23 Ramos C55(1.11)  LDD2196  [34]
 LDCM0578  Fragment27 Ramos C55(0.71); C187(1.20)  LDD2197  [34]
 LDCM0586  Fragment28 Ramos C55(0.58); C187(0.74); C117(2.25)  LDD2198  [34]
 LDCM0588  Fragment30 Ramos C55(0.89); C187(1.15); C117(1.51)  LDD2199  [34]
 LDCM0589  Fragment31 Ramos C55(0.66); C187(1.18)  LDD2200  [34]
 LDCM0590  Fragment32 Ramos C55(0.92); C187(0.80); C117(1.06)  LDD2201  [34]
 LDCM0468  Fragment33 HCT 116 C187(1.11); C55(1.18); C75(0.88)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C55(1.38); C187(1.22)  LDD2203  [34]
 LDCM0566  Fragment4 Ramos C55(1.52); C187(0.48); C117(0.43)  LDD2184  [34]
 LDCM0427  Fragment51 HCT 116 C187(0.57); C55(1.60); C75(0.51)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C55(0.67); C187(1.56)  LDD2204  [34]
 LDCM0614  Fragment56 Ramos C55(0.72); C187(1.37); C117(1.28)  LDD2205  [34]
 LDCM0569  Fragment7 Ramos C55(2.02); C187(0.22); C117(0.32)  LDD2186  [34]
 LDCM0571  Fragment9 Ramos C55(0.66); C187(0.61); C117(0.72)  LDD2188  [34]
 LDCM0116  HHS-0101 DM93 Y203(1.15); Y77(1.51); Y254(1.67)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y254(0.95); Y203(1.13); Y77(1.23)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y203(1.00); Y254(1.22); Y77(1.73)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y203(0.86); Y254(1.05); Y77(1.41)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y254(1.16); Y77(1.38); Y203(2.52)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C55(2.05); C187(1.06)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C55(1.32); C187(1.06)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C55(1.46); C187(1.07)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C187(1.11)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C187(1.48)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C187(0.90)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C187(1.00)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C187(1.23); C75(1.40)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C187(1.36); C75(0.97)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C187(0.27); C75(0.66)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C187(1.09)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C187(0.44); C75(0.80)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C187(1.13); C75(1.54)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C187(0.49)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C187(0.19)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C187(1.09)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C187(0.66)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C187(1.09); C75(1.18)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C187(0.72); C75(0.68)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C75(0.63)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C187(1.28)  LDD2111  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C187(0.51)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C187(0.38); C75(0.96)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C187(1.81); C75(1.66)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C187(1.02)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C187(0.31); C75(0.88)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C187(0.96); C75(1.01)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C187(0.33); C75(0.97)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C187(1.09); C75(1.03)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C187(0.30)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C187(1.28); C75(1.14)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C187(1.12); C75(0.71)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C187(1.50)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C187(0.81)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C187(1.51); C75(1.61)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C187(1.22); C75(1.43)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C187(1.00); C75(1.11)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C187(1.19); C75(1.02)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C187(0.90)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C187(1.41); C75(2.14)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C187(1.02); C75(1.07)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C187(1.59)  LDD2147  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C75(0.99)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C187(0.85)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C187(0.31); C75(0.89)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C187(1.86); C75(2.55)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C55(0.64)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C55(2.35)  LDD2207  [35]
 LDCM0131  RA190 MM1.R C187(1.13); C55(1.00)  LDD0304  [36]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [29]
 LDCM0021  THZ1 HCT 116 C187(1.06); C75(0.94)  LDD2173  [11]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
30 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
31 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
32 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
34 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
36 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.