Details of the Target

General Information of Target

Target ID LDTP06094
Target Name Src substrate cortactin (CTTN)
Gene Name CTTN
Gene ID 2017
Synonyms
EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT
DRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ
DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE
KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV
YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP
AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL
FPANYVELRQ
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Function
Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
Uniprot ID
Q14247
Ensemble ID
ENST00000301843.13
HGNC ID
HGNC:3338
ChEMBL ID
CHEMBL4295820

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.A321V .
MEWO SNV: p.D167N DBIA    Probe Info 
NCIH1975 SNV: p.K205T DBIA    Probe Info 
NCIH82 SNV: p.Q409K .
YSCCC SNV: p.R537Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 47 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P2
 Probe Info  		1.59  LDD0449  [2]
P3
 Probe Info  		4.38  LDD0450  [2]
P8
 Probe Info  		2.65  LDD0451  [2]
AZ-9
 Probe Info  		2.15  LDD0393  [3]
DAyne
 Probe Info  		3.00  LDD0261  [4]
CY-1
 Probe Info  		100.00  LDD0243  [5]
CY4
 Probe Info  		100.00  LDD0244  [5]
TH211
 Probe Info  		Y104(16.96); Y162(10.02); Y84(7.34); Y199(5.38)  LDD0257  [6]
TH216
 Probe Info  		Y199(20.00); Y84(14.54); Y104(5.39); Y162(5.30)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
ONAyne
 Probe Info  		K107(0.46); K87(0.59)  LDD0274  [8]
BTD
 Probe Info  		C112(7.40)  LDD1699  [9]
OPA-S-S-alkyne
 Probe Info  		K390(0.39); K184(1.50); K235(1.56); K272(1.57)  LDD3494  [10]
Probe 1
 Probe Info  		Y84(80.20); Y104(60.92); Y141(37.14); Y154(64.63)  LDD3495  [11]
DBIA
 Probe Info  		C246(1.61); C112(1.78)  LDD3311  [12]
DA-P3
 Probe Info  		6.54  LDD0181  [13]
AHL-Pu-1
 Probe Info  		C246(3.23)  LDD0171  [14]
EA-probe
 Probe Info  		N.A.  LDD0440  [15]
HHS-482
 Probe Info  		Y104(0.95); Y141(0.76); Y154(1.03); Y162(1.02)  LDD0285  [16]
HHS-475
 Probe Info  		Y433(0.64); Y178(0.72); Y310(0.73); Y538(0.74)  LDD0264  [17]
HHS-465
 Probe Info  		Y104(9.63); Y141(7.27); Y154(10.00); Y162(4.93)  LDD2237  [18]
5E-2FA
 Probe Info  		H66(0.00); H111(0.00); H296(0.00); H259(0.00)  LDD2235  [19]
AMP probe
 Probe Info  		N.A.  LDD0200  [20]
ATP probe
 Probe Info  		K110(0.00); K235(0.00); K263(0.00); K266(0.00)  LDD0199  [20]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [21]
ATP probe
 Probe Info  		K266(0.00); K42(0.00); K295(0.00); K161(0.00)  LDD0035  [22]
NAIA_4
 Probe Info  		C112(0.00); C246(0.00)  LDD2226  [23]
TFBX
 Probe Info  		N.A.  LDD0027  [24]
WYneC
 Probe Info  		C112(0.00); C246(0.00)  LDD0014  [25]
WYneN
 Probe Info  		C112(0.00); C246(0.00)  LDD0021  [25]
WYneO
 Probe Info  		C112(0.00); C246(0.00)  LDD0022  [25]
ENE
 Probe Info  		C246(0.00); C112(0.00)  LDD0006  [25]
IPM
 Probe Info  		C246(0.00); C112(0.00)  LDD0005  [25]
NHS
 Probe Info  		K359(0.00); K87(0.00); K152(0.00); K208(0.00)  LDD0010  [25]
PF-06672131
 Probe Info  		N.A.  LDD0017  [26]
PPMS
 Probe Info  		N.A.  LDD0008  [25]
SF
 Probe Info  		Y265(0.00); Y162(0.00); Y334(0.00); Y104(0.00)  LDD0028  [27]
STPyne
 Probe Info  		N.A.  LDD0009  [25]
Phosphinate-6
 Probe Info  		C112(0.00); C246(0.00)  LDD0018  [28]
Ox-W18
 Probe Info  		W39(0.00); W22(0.00)  LDD2175  [29]
1c-yne
 Probe Info  		K171(0.00); K336(0.00); K295(0.00)  LDD0228  [30]
Acrolein
 Probe Info  		H52(0.00); C112(0.00); H102(0.00); H111(0.00)  LDD0217  [31]
Methacrolein
 Probe Info  		N.A.  LDD0218  [31]
W1
 Probe Info  		N.A.  LDD0236  [32]
AOyne
 Probe Info  		15.00  LDD0443  [33]
NAIA_5
 Probe Info  		C246(0.00); C112(0.00)  LDD2223  [23]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		18.00  LDD1865  [34]
C191
 Probe Info  		15.03  LDD1868  [34]
C193
 Probe Info  		5.98  LDD1869  [34]
FFF probe13
 Probe Info  		20.00  LDD0475  [35]
FFF probe14
 Probe Info  		20.00  LDD0477  [35]
FFF probe2
 Probe Info  		7.18  LDD0463  [35]
FFF probe3
 Probe Info  		5.81  LDD0464  [35]
FFF probe9
 Probe Info  		6.39  LDD0470  [35]
JN0003
 Probe Info  		20.00  LDD0469  [35]
DA-2
 Probe Info  		N.A.  LDD0070  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C246(0.71); C112(0.87)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C246(1.06); C112(0.87)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C246(0.78); C112(0.51)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C112(0.87)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C246(1.20); C112(0.83)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C246(1.55); C112(1.07)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C246(0.67); C112(0.49)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C112(0.55)  LDD2131  [9]
 LDCM0026  4SU-RNA+native RNA DM93 C246(3.23)  LDD0171  [14]
 LDCM0214  AC1 HEK-293T C112(1.11); C246(1.05)  LDD1507  [37]
 LDCM0215  AC10 HEK-293T C112(0.99); C246(1.05)  LDD1508  [37]
 LDCM0226  AC11 HEK-293T C112(0.93); C246(0.97)  LDD1509  [37]
 LDCM0237  AC12 HEK-293T C112(0.92); C246(0.95)  LDD1510  [37]
 LDCM0259  AC14 HEK-293T C112(0.81); C246(0.97)  LDD1512  [37]
 LDCM0270  AC15 HEK-293T C112(0.99); C246(0.92)  LDD1513  [37]
 LDCM0276  AC17 HEK-293T C112(1.16); C246(1.17)  LDD1515  [37]
 LDCM0277  AC18 HEK-293T C112(1.07); C246(1.11)  LDD1516  [37]
 LDCM0278  AC19 HEK-293T C112(0.99); C246(1.26)  LDD1517  [37]
 LDCM0279  AC2 HEK-293T C112(1.03); C246(1.00)  LDD1518  [37]
 LDCM0280  AC20 HEK-293T C112(0.88); C246(1.01)  LDD1519  [37]
 LDCM0281  AC21 HEK-293T C112(1.02); C246(0.93)  LDD1520  [37]
 LDCM0282  AC22 HEK-293T C112(0.95); C246(0.96)  LDD1521  [37]
 LDCM0283  AC23 HEK-293T C112(0.98); C246(0.94)  LDD1522  [37]
 LDCM0284  AC24 HEK-293T C112(1.00); C246(0.99)  LDD1523  [37]
 LDCM0285  AC25 HEK-293T C112(1.06); C246(1.05)  LDD1524  [37]
 LDCM0286  AC26 HEK-293T C112(1.02); C246(0.99)  LDD1525  [37]
 LDCM0287  AC27 HEK-293T C112(1.01); C246(1.03)  LDD1526  [37]
 LDCM0288  AC28 HEK-293T C112(0.96); C246(0.95)  LDD1527  [37]
 LDCM0289  AC29 HEK-293T C112(1.07); C246(1.06)  LDD1528  [37]
 LDCM0290  AC3 HEK-293T C112(1.09); C246(1.02)  LDD1529  [37]
 LDCM0291  AC30 HEK-293T C112(0.88); C246(0.95)  LDD1530  [37]
 LDCM0292  AC31 HEK-293T C112(0.96); C246(1.03)  LDD1531  [37]
 LDCM0293  AC32 HEK-293T C112(0.99); C246(0.99)  LDD1532  [37]
 LDCM0294  AC33 HEK-293T C112(1.06); C246(0.99)  LDD1533  [37]
 LDCM0295  AC34 HEK-293T C112(1.01); C246(1.00)  LDD1534  [37]
 LDCM0296  AC35 HEK-293T C112(1.02); C246(0.98)  LDD1535  [37]
 LDCM0297  AC36 HEK-293T C112(1.17); C246(0.87)  LDD1536  [37]
 LDCM0298  AC37 HEK-293T C112(1.12); C246(0.88)  LDD1537  [37]
 LDCM0299  AC38 HEK-293T C112(0.82); C246(0.94)  LDD1538  [37]
 LDCM0300  AC39 HEK-293T C112(0.98); C246(0.86)  LDD1539  [37]
 LDCM0301  AC4 HEK-293T C112(1.06); C246(1.01)  LDD1540  [37]
 LDCM0302  AC40 HEK-293T C112(1.08); C246(0.86)  LDD1541  [37]
 LDCM0303  AC41 HEK-293T C112(1.12); C246(0.93)  LDD1542  [37]
 LDCM0304  AC42 HEK-293T C112(1.05); C246(1.03)  LDD1543  [37]
 LDCM0305  AC43 HEK-293T C112(0.94); C246(0.94)  LDD1544  [37]
 LDCM0306  AC44 HEK-293T C112(0.90); C246(0.93)  LDD1545  [37]
 LDCM0307  AC45 HEK-293T C112(1.10); C246(0.81)  LDD1546  [37]
 LDCM0308  AC46 HEK-293T C112(0.76); C246(0.87)  LDD1547  [37]
 LDCM0309  AC47 HEK-293T C112(0.98); C246(0.87)  LDD1548  [37]
 LDCM0310  AC48 HEK-293T C112(0.90); C246(0.91)  LDD1549  [37]
 LDCM0311  AC49 HEK-293T C112(1.11); C246(1.04)  LDD1550  [37]
 LDCM0312  AC5 HEK-293T C112(1.09); C246(0.90)  LDD1551  [37]
 LDCM0313  AC50 HEK-293T C112(1.01); C246(1.04)  LDD1552  [37]
 LDCM0314  AC51 HEK-293T C112(0.88); C246(0.97)  LDD1553  [37]
 LDCM0315  AC52 HEK-293T C112(0.96); C246(0.99)  LDD1554  [37]
 LDCM0316  AC53 HEK-293T C112(1.00); C246(0.91)  LDD1555  [37]
 LDCM0317  AC54 HEK-293T C112(0.66); C246(0.94)  LDD1556  [37]
 LDCM0318  AC55 HEK-293T C112(0.90); C246(0.96)  LDD1557  [37]
 LDCM0319  AC56 HEK-293T C112(1.03); C246(0.90)  LDD1558  [37]
 LDCM0320  AC57 HEK-293T C112(1.00); C246(0.94)  LDD1559  [37]
 LDCM0321  AC58 HEK-293T C112(0.96); C246(0.98)  LDD1560  [37]
 LDCM0322  AC59 HEK-293T C112(0.93); C246(0.96)  LDD1561  [37]
 LDCM0323  AC6 HEK-293T C112(1.06); C246(0.97)  LDD1562  [37]
 LDCM0324  AC60 HEK-293T C112(1.27); C246(0.96)  LDD1563  [37]
 LDCM0325  AC61 HEK-293T C112(0.99); C246(0.92)  LDD1564  [37]
 LDCM0326  AC62 HEK-293T C112(0.91); C246(0.92)  LDD1565  [37]
 LDCM0327  AC63 HEK-293T C112(0.95); C246(0.91)  LDD1566  [37]
 LDCM0328  AC64 HEK-293T C112(0.91); C246(0.87)  LDD1567  [37]
 LDCM0334  AC7 HEK-293T C112(0.96); C246(0.94)  LDD1568  [37]
 LDCM0345  AC8 HEK-293T C112(1.00); C246(0.95)  LDD1569  [37]
 LDCM0545  Acetamide MDA-MB-231 C246(0.57); C112(0.66)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C112(0.82)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C112(1.08); C246(0.97)  LDD1511  [37]
 LDCM0356  AKOS034007680 HEK-293T C112(1.09); C246(0.99)  LDD1570  [37]
 LDCM0275  AKOS034007705 HEK-293T C112(1.01); C246(1.00)  LDD1514  [37]
 LDCM0156  Aniline NCI-H1299 11.36  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C246(0.69); C112(0.53)  LDD2091  [9]
 LDCM0630  CCW28-3 231MFP C246(1.21)  LDD2214  [38]
 LDCM0108  Chloroacetamide HeLa H49(0.00); H56(0.00); H52(0.00); C112(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C246(8.53); C246(1.72); C246(0.92); C112(0.88)  LDD2227  [23]
 LDCM0367  CL1 HEK-293T C112(0.88); C246(0.87)  LDD1571  [37]
 LDCM0368  CL10 HEK-293T C112(1.29); C246(0.90)  LDD1572  [37]
 LDCM0369  CL100 HEK-293T C112(1.07); C246(0.97)  LDD1573  [37]
 LDCM0370  CL101 HEK-293T C112(1.12); C246(0.99)  LDD1574  [37]
 LDCM0371  CL102 HEK-293T C112(0.97); C246(0.96)  LDD1575  [37]
 LDCM0372  CL103 HEK-293T C112(1.14); C246(0.97)  LDD1576  [37]
 LDCM0373  CL104 HEK-293T C112(0.97); C246(0.95)  LDD1577  [37]
 LDCM0374  CL105 HEK-293T C112(1.04); C246(1.03)  LDD1578  [37]
 LDCM0375  CL106 HEK-293T C112(0.92); C246(1.00)  LDD1579  [37]
 LDCM0376  CL107 HEK-293T C112(0.96); C246(1.07)  LDD1580  [37]
 LDCM0377  CL108 HEK-293T C112(0.96); C246(1.05)  LDD1581  [37]
 LDCM0378  CL109 HEK-293T C112(0.99); C246(0.99)  LDD1582  [37]
 LDCM0379  CL11 HEK-293T C112(0.99); C246(0.94)  LDD1583  [37]
 LDCM0380  CL110 HEK-293T C112(0.94); C246(1.03)  LDD1584  [37]
 LDCM0381  CL111 HEK-293T C112(0.95); C246(1.01)  LDD1585  [37]
 LDCM0382  CL112 HEK-293T C112(1.11); C246(1.08)  LDD1586  [37]
 LDCM0383  CL113 HEK-293T C112(1.07); C246(0.89)  LDD1587  [37]
 LDCM0384  CL114 HEK-293T C112(0.98); C246(0.87)  LDD1588  [37]
 LDCM0385  CL115 HEK-293T C112(1.08); C246(0.98)  LDD1589  [37]
 LDCM0386  CL116 HEK-293T C112(1.01); C246(1.03)  LDD1590  [37]
 LDCM0387  CL117 HEK-293T C112(1.00); C246(0.96)  LDD1591  [37]
 LDCM0388  CL118 HEK-293T C112(1.01); C246(0.99)  LDD1592  [37]
 LDCM0389  CL119 HEK-293T C112(1.01); C246(0.93)  LDD1593  [37]
 LDCM0390  CL12 HEK-293T C112(1.06); C246(0.85)  LDD1594  [37]
 LDCM0391  CL120 HEK-293T C112(1.04); C246(1.01)  LDD1595  [37]
 LDCM0392  CL121 HEK-293T C112(1.02); C246(0.95)  LDD1596  [37]
 LDCM0393  CL122 HEK-293T C112(0.91); C246(0.95)  LDD1597  [37]
 LDCM0394  CL123 HEK-293T C112(0.87); C246(0.89)  LDD1598  [37]
 LDCM0395  CL124 HEK-293T C112(1.01); C246(1.04)  LDD1599  [37]
 LDCM0396  CL125 HEK-293T C112(0.79); C246(0.96)  LDD1600  [37]
 LDCM0397  CL126 HEK-293T C112(0.77); C246(0.91)  LDD1601  [37]
 LDCM0398  CL127 HEK-293T C112(0.86); C246(0.88)  LDD1602  [37]
 LDCM0399  CL128 HEK-293T C112(0.86); C246(1.01)  LDD1603  [37]
 LDCM0400  CL13 HEK-293T C112(1.03); C246(1.04)  LDD1604  [37]
 LDCM0401  CL14 HEK-293T C112(0.90); C246(0.95)  LDD1605  [37]
 LDCM0402  CL15 HEK-293T C112(0.90); C246(0.94)  LDD1606  [37]
 LDCM0403  CL16 HEK-293T C112(1.12); C246(1.08)  LDD1607  [37]
 LDCM0404  CL17 HEK-293T C112(1.09); C246(0.91)  LDD1608  [37]
 LDCM0405  CL18 HEK-293T C112(1.04); C246(1.12)  LDD1609  [37]
 LDCM0406  CL19 HEK-293T C112(0.85); C246(1.03)  LDD1610  [37]
 LDCM0407  CL2 HEK-293T C112(0.85); C246(0.94)  LDD1611  [37]
 LDCM0408  CL20 HEK-293T C112(1.05); C246(1.08)  LDD1612  [37]
 LDCM0409  CL21 HEK-293T C112(1.18); C246(0.86)  LDD1613  [37]
 LDCM0410  CL22 HEK-293T C112(0.96); C246(0.91)  LDD1614  [37]
 LDCM0411  CL23 HEK-293T C112(0.99); C246(0.97)  LDD1615  [37]
 LDCM0412  CL24 HEK-293T C112(1.16); C246(0.90)  LDD1616  [37]
 LDCM0413  CL25 HEK-293T C112(0.87); C246(0.94)  LDD1617  [37]
 LDCM0414  CL26 HEK-293T C112(0.97); C246(1.09)  LDD1618  [37]
 LDCM0415  CL27 HEK-293T C112(1.15); C246(1.05)  LDD1619  [37]
 LDCM0416  CL28 HEK-293T C112(1.02); C246(1.18)  LDD1620  [37]
 LDCM0417  CL29 HEK-293T C112(1.16); C246(1.12)  LDD1621  [37]
 LDCM0418  CL3 HEK-293T C112(0.87); C246(1.00)  LDD1622  [37]
 LDCM0419  CL30 HEK-293T C112(1.07); C246(1.06)  LDD1623  [37]
 LDCM0420  CL31 HEK-293T C112(0.93); C246(1.13)  LDD1624  [37]
 LDCM0421  CL32 HEK-293T C112(0.69); C246(1.19)  LDD1625  [37]
 LDCM0422  CL33 HEK-293T C112(1.08); C246(0.92)  LDD1626  [37]
 LDCM0423  CL34 HEK-293T C112(0.84); C246(1.00)  LDD1627  [37]
 LDCM0424  CL35 HEK-293T C112(1.13); C246(1.09)  LDD1628  [37]
 LDCM0425  CL36 HEK-293T C112(1.18); C246(1.06)  LDD1629  [37]
 LDCM0426  CL37 HEK-293T C112(0.93); C246(0.98)  LDD1630  [37]
 LDCM0428  CL39 HEK-293T C112(1.15); C246(1.16)  LDD1632  [37]
 LDCM0429  CL4 HEK-293T C112(0.97); C246(1.00)  LDD1633  [37]
 LDCM0430  CL40 HEK-293T C112(0.98); C246(1.07)  LDD1634  [37]
 LDCM0431  CL41 HEK-293T C112(1.15); C246(1.04)  LDD1635  [37]
 LDCM0432  CL42 HEK-293T C112(1.11); C246(1.09)  LDD1636  [37]
 LDCM0433  CL43 HEK-293T C112(1.11); C246(1.05)  LDD1637  [37]
 LDCM0434  CL44 HEK-293T C112(1.16); C246(1.03)  LDD1638  [37]
 LDCM0435  CL45 HEK-293T C112(1.28); C246(1.15)  LDD1639  [37]
 LDCM0436  CL46 HEK-293T C112(1.03); C246(1.05)  LDD1640  [37]
 LDCM0437  CL47 HEK-293T C112(1.16); C246(1.14)  LDD1641  [37]
 LDCM0438  CL48 HEK-293T C112(1.10); C246(1.03)  LDD1642  [37]
 LDCM0439  CL49 HEK-293T C112(0.91); C246(0.82)  LDD1643  [37]
 LDCM0440  CL5 HEK-293T C112(1.01); C246(0.95)  LDD1644  [37]
 LDCM0441  CL50 HEK-293T C112(0.93); C246(0.86)  LDD1645  [37]
 LDCM0443  CL52 HEK-293T C112(1.03); C246(0.98)  LDD1646  [37]
 LDCM0444  CL53 HEK-293T C112(1.10); C246(1.02)  LDD1647  [37]
 LDCM0445  CL54 HEK-293T C112(0.99); C246(0.99)  LDD1648  [37]
 LDCM0446  CL55 HEK-293T C112(1.16); C246(0.98)  LDD1649  [37]
 LDCM0447  CL56 HEK-293T C112(1.24); C246(1.04)  LDD1650  [37]
 LDCM0448  CL57 HEK-293T C112(1.18); C246(0.91)  LDD1651  [37]
 LDCM0449  CL58 HEK-293T C112(0.66); C246(0.99)  LDD1652  [37]
 LDCM0450  CL59 HEK-293T C112(1.11); C246(0.97)  LDD1653  [37]
 LDCM0451  CL6 HEK-293T C112(0.98); C246(1.01)  LDD1654  [37]
 LDCM0452  CL60 HEK-293T C112(1.10); C246(0.93)  LDD1655  [37]
 LDCM0453  CL61 HEK-293T C112(0.99); C246(0.87)  LDD1656  [37]
 LDCM0454  CL62 HEK-293T C112(0.95); C246(0.90)  LDD1657  [37]
 LDCM0455  CL63 HEK-293T C112(1.09); C246(0.94)  LDD1658  [37]
 LDCM0456  CL64 HEK-293T C112(1.13); C246(0.98)  LDD1659  [37]
 LDCM0457  CL65 HEK-293T C112(1.18); C246(1.02)  LDD1660  [37]
 LDCM0458  CL66 HEK-293T C112(1.13); C246(1.04)  LDD1661  [37]
 LDCM0459  CL67 HEK-293T C112(1.06); C246(1.01)  LDD1662  [37]
 LDCM0460  CL68 HEK-293T C112(1.06); C246(1.05)  LDD1663  [37]
 LDCM0461  CL69 HEK-293T C112(1.15); C246(0.88)  LDD1664  [37]
 LDCM0462  CL7 HEK-293T C112(1.03); C246(1.02)  LDD1665  [37]
 LDCM0463  CL70 HEK-293T C112(0.95); C246(0.97)  LDD1666  [37]
 LDCM0464  CL71 HEK-293T C112(1.02); C246(1.02)  LDD1667  [37]
 LDCM0465  CL72 HEK-293T C112(1.16); C246(0.97)  LDD1668  [37]
 LDCM0466  CL73 HEK-293T C112(1.03); C246(0.96)  LDD1669  [37]
 LDCM0467  CL74 HEK-293T C112(0.94); C246(0.96)  LDD1670  [37]
 LDCM0469  CL76 HEK-293T C112(0.99); C246(0.94)  LDD1672  [37]
 LDCM0470  CL77 HEK-293T C112(1.07); C246(1.01)  LDD1673  [37]
 LDCM0471  CL78 HEK-293T C112(1.05); C246(1.04)  LDD1674  [37]
 LDCM0472  CL79 HEK-293T C112(0.94); C246(1.05)  LDD1675  [37]
 LDCM0473  CL8 HEK-293T C112(1.00); C246(0.92)  LDD1676  [37]
 LDCM0474  CL80 HEK-293T C112(0.93); C246(0.98)  LDD1677  [37]
 LDCM0475  CL81 HEK-293T C112(1.26); C246(1.07)  LDD1678  [37]
 LDCM0476  CL82 HEK-293T C112(0.91); C246(0.98)  LDD1679  [37]
 LDCM0477  CL83 HEK-293T C112(1.04); C246(0.97)  LDD1680  [37]
 LDCM0478  CL84 HEK-293T C112(0.96); C246(0.88)  LDD1681  [37]
 LDCM0479  CL85 HEK-293T C112(0.77); C246(0.84)  LDD1682  [37]
 LDCM0480  CL86 HEK-293T C112(0.69); C246(0.84)  LDD1683  [37]
 LDCM0481  CL87 HEK-293T C112(0.82); C246(0.90)  LDD1684  [37]
 LDCM0482  CL88 HEK-293T C112(0.85); C246(0.95)  LDD1685  [37]
 LDCM0483  CL89 HEK-293T C112(0.95); C246(0.97)  LDD1686  [37]
 LDCM0484  CL9 HEK-293T C112(1.12); C246(0.84)  LDD1687  [37]
 LDCM0485  CL90 HEK-293T C112(0.89); C246(0.92)  LDD1688  [37]
 LDCM0486  CL91 HEK-293T C112(1.00); C246(0.93)  LDD1689  [37]
 LDCM0487  CL92 HEK-293T C112(1.10); C246(1.08)  LDD1690  [37]
 LDCM0488  CL93 HEK-293T C112(0.90); C246(0.87)  LDD1691  [37]
 LDCM0489  CL94 HEK-293T C112(1.16); C246(0.92)  LDD1692  [37]
 LDCM0490  CL95 HEK-293T C112(1.02); C246(0.90)  LDD1693  [37]
 LDCM0491  CL96 HEK-293T C112(0.77); C246(0.87)  LDD1694  [37]
 LDCM0492  CL97 HEK-293T C112(1.00); C246(0.89)  LDD1695  [37]
 LDCM0493  CL98 HEK-293T C112(1.00); C246(0.96)  LDD1696  [37]
 LDCM0494  CL99 HEK-293T C112(1.03); C246(1.03)  LDD1697  [37]
 LDCM0634  CY-0357 Hep-G2 C112(2.47); C246(0.66); C246(0.63)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C112(1.10); C246(1.13)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C246(1.34); C112(1.30)  LDD1702  [9]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.27  LDD0183  [13]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [15]
 LDCM0625  F8 Ramos C112(2.15); C246(1.39)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C112(3.06); C246(2.02)  LDD2189  [39]
 LDCM0574  Fragment12 Ramos C112(0.95); C246(1.45)  LDD2191  [39]
 LDCM0575  Fragment13 Ramos C112(1.01); C246(1.25)  LDD2192  [39]
 LDCM0576  Fragment14 Ramos C112(0.68); C246(1.12)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C112(1.07); C246(1.46)  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C112(0.95); C246(1.68)  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C112(1.10); C246(1.82)  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C112(1.04); C246(1.83)  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C112(0.86); C246(0.84)  LDD2198  [39]
 LDCM0588  Fragment30 Ramos C112(1.23); C246(1.65)  LDD2199  [39]
 LDCM0589  Fragment31 Ramos C112(0.90); C246(1.52)  LDD2200  [39]
 LDCM0590  Fragment32 Ramos C112(4.43)  LDD2201  [39]
 LDCM0468  Fragment33 HEK-293T C112(0.98); C246(0.98)  LDD1671  [37]
 LDCM0596  Fragment38 Ramos C112(1.42); C246(1.41)  LDD2203  [39]
 LDCM0566  Fragment4 Ramos C112(1.06); C246(1.01)  LDD2184  [39]
 LDCM0427  Fragment51 HEK-293T C112(1.07); C246(0.98)  LDD1631  [37]
 LDCM0610  Fragment52 Ramos C112(1.18); C246(1.53)  LDD2204  [39]
 LDCM0614  Fragment56 Ramos C112(1.33); C246(1.37)  LDD2205  [39]
 LDCM0569  Fragment7 Ramos C112(1.27); C246(1.53)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C112(1.16); C246(1.90)  LDD2188  [39]
 LDCM0116  HHS-0101 DM93 Y433(0.64); Y178(0.72); Y310(0.73); Y538(0.74)  LDD0264  [17]
 LDCM0117  HHS-0201 DM93 Y433(0.60); Y289(0.65); Y141(0.66); Y538(0.67)  LDD0265  [17]
 LDCM0118  HHS-0301 DM93 Y433(0.53); Y289(0.62); Y178(0.63); Y141(0.65)  LDD0266  [17]
 LDCM0119  HHS-0401 DM93 Y433(0.60); Y84(0.72); Y538(0.78); Y162(0.79)  LDD0267  [17]
 LDCM0120  HHS-0701 DM93 Y433(0.35); Y84(0.66); Y178(0.67); Y141(0.73)  LDD0268  [17]
 LDCM0107  IAA HeLa H296(0.00); H102(0.00); H111(0.00); H52(0.00)  LDD0221  [31]
 LDCM0123  JWB131 DM93 Y104(0.95); Y141(0.76); Y154(1.03); Y162(1.02)  LDD0285  [16]
 LDCM0124  JWB142 DM93 Y104(0.76); Y141(0.82); Y154(0.78); Y162(0.88)  LDD0286  [16]
 LDCM0125  JWB146 DM93 Y104(1.05); Y141(0.83); Y154(0.99); Y162(1.02)  LDD0287  [16]
 LDCM0126  JWB150 DM93 Y104(2.90); Y141(3.77); Y154(3.51); Y162(2.76)  LDD0288  [16]
 LDCM0127  JWB152 DM93 Y104(1.96); Y141(7.72); Y154(2.07); Y162(1.77)  LDD0289  [16]
 LDCM0128  JWB198 DM93 Y104(1.22); Y141(0.16); Y154(1.30); Y162(0.85)  LDD0290  [16]
 LDCM0129  JWB202 DM93 Y104(0.60); Y141(0.71); Y154(0.62); Y162(0.71)  LDD0291  [16]
 LDCM0130  JWB211 DM93 Y104(1.02); Y141(0.87); Y154(1.06); Y162(1.37)  LDD0292  [16]
 LDCM0022  KB02 HEK-293T C112(1.08); C246(0.88)  LDD1492  [37]
 LDCM0023  KB03 HEK-293T C112(0.87); C246(0.99)  LDD1497  [37]
 LDCM0024  KB05 G361 C246(1.61); C112(1.78)  LDD3311  [12]
 LDCM0030  Luteolin HEK-293T 7.29  LDD0182  [13]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C246(0.84)  LDD2121  [9]
 LDCM0109  NEM HeLa H52(0.00); H49(0.00); H66(0.00); H102(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C246(0.87); C112(0.81)  LDD2089  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C246(0.74); C112(0.90)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C246(0.94); C112(0.96)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C246(1.06); C112(1.15)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C246(0.91); C112(0.71)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C112(1.22)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C246(1.10); C112(0.61)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C246(0.96); C112(0.91)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C246(0.77); C112(0.70)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C112(1.34)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C246(0.97); C112(1.00)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C246(1.12); C112(1.54)  LDD2105  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C112(0.71)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C112(0.74)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C246(0.95); C112(0.70)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C246(1.45)  LDD2110  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C246(0.74); C112(0.93)  LDD2114  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C246(0.92); C112(0.89)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C112(0.70)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C246(0.83); C112(1.80)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C246(0.84); C112(0.68)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C246(1.04); C112(1.08)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C246(0.92); C112(0.71)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C246(0.94); C112(0.90)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C246(0.87); C112(0.72)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C112(0.82)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C246(1.20); C112(0.78)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C246(0.92); C112(0.72)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C246(0.80); C112(0.72)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C112(0.59)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C112(0.59)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C246(0.71); C112(0.61)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C246(1.70); C112(1.05)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C246(0.99); C112(0.86)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C112(1.01)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C246(0.67); C112(0.74)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C246(0.75); C112(0.78)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C246(0.86); C112(0.96)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C246(2.29); C112(2.61)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C246(0.94); C112(0.73)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C246(3.30); C112(3.65)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C112(0.47)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C112(1.02)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C246(0.56); C112(0.49)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C112(1.24)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C246(1.13)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C112(1.28); C112(0.11)  LDD2206  [40]
 LDCM0032  Oleacein HEK-293T 4.60  LDD0184  [13]
 LDCM0628  OTUB2-COV-1 HEK-293T C246(1.09); C112(0.82); C246(0.79); C112(0.67)  LDD2207  [40]
 LDCM0029  Quercetin HEK-293T 6.54  LDD0181  [13]
 LDCM0110  W12 Hep-G2 C112(31.61)  LDD0237  [32]
 LDCM0111  W14 Hep-G2 C112(24.30)  LDD0238  [32]
 LDCM0112  W16 Hep-G2 C112(0.51)  LDD0239  [32]
 LDCM0113  W17 Hep-G2 C112(26.47)  LDD0240  [32]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 6 (HDAC6) Histone deacetylase family Q9UBN7
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) Protein-tyrosine phosphatase family P18031
Dynamin-2 (DNM2) Dynamin/Fzo/YdjA family P50570
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Actin nucleation-promoting factor WAS (WAS) . P42768
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) . Q9ULH1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
16 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
17 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
20 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
29 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
30 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
31 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
32 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
33 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
34 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
35 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
36 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
37 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
38 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
39 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
40 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.