Details of the Target

General Information of Target

Target ID LDTP03610
Target Name Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1)
Gene Name UQCRC1
Gene ID 7384
Synonyms
Cytochrome b-c1 complex subunit 1, mitochondrial; Complex III subunit 1; Core protein I; Ubiquinol-cytochrome-c reductase complex core protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASVVCRAATAGAQVLLRARRSPALLRTPALRSTATFAQALQFVPETQVSLLDNGLRVA
SEQSSQPTCTVGVWIDVGSRFETEKNNGAGYFLEHLAFKGTKNRPGSALEKEVESMGAHL
NAYSTREHTAYYIKALSKDLPKAVELLGDIVQNCSLEDSQIEKERDVILREMQENDASMR
DVVFNYLHATAFQGTPLAQAVEGPSENVRKLSRADLTEYLSTHYKAPRMVLAAAGGVEHQ
QLLDLAQKHLGGIPWTYAEDAVPTLTPCRFTGSEIRHRDDALPFAHVAIAVEGPGWASPD
NVALQVANAIIGHYDCTYGGGVHLSSPLASGAVANKLCQSFQTFSICYAETGLLGAHFVC
DRMKIDDMMFVLQGQWMRLCTSATESEVARGKNILRNALVSHLDGTTPVCEDIGRSLLTY
GRRIPLAEWESRIAEVDASVVREICSKYIYDQCPAVAGYGPIEQLPDYNRIRSGMFWLRF
Target Bioclass
Enzyme
Family
Peptidase M16 family, UQCRC1/QCR1 subfamily
Subcellular location
Mitochondrion inner membrane
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons.
Uniprot ID
P31930
Ensemble ID
ENST00000203407.6
HGNC ID
HGNC:12585

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.09  LDD0402  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
W1
 Probe Info  		17.50  LDD0235  [3]
TH211
 Probe Info  		Y132(20.00)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		K225(8.33)  LDD0274  [6]
STPyne
 Probe Info  		K134(2.04); K138(8.13); K225(10.00)  LDD0277  [6]
Probe 1
 Probe Info  		Y123(17.38); Y420(25.02)  LDD3495  [7]
JZ128-DTB
 Probe Info  		C453(0.00); C410(0.00)  LDD0462  [8]
EA-probe
 Probe Info  		C453(0.78)  LDD2210  [9]
DBIA
 Probe Info  		C453(0.87)  LDD0078  [10]
5E-2FA
 Probe Info  		H119(0.00); H402(0.00)  LDD2235  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C154(0.00); C268(0.00); C380(0.00); C410(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C268(0.00); C380(0.00); C154(0.00); C410(0.00)  LDD0032  [13]
IPIAA_L
 Probe Info  		C380(0.00); C154(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C154(0.00); C268(0.00); C380(0.00); C410(0.00)  LDD0037  [12]
Alkyne tyramide
 Probe Info  		Y123(0.00); Y420(0.00)  LDD0003  [15]
BTD
 Probe Info  		N.A.  LDD0004  [15]
IPM
 Probe Info  		C154(0.00); C380(0.00); C453(0.00); C410(0.00)  LDD0025  [16]
JW-RF-010
 Probe Info  		C410(0.00); C154(0.00); C453(0.00); C380(0.00)  LDD0026  [16]
NAIA_4
 Probe Info  		C154(0.00); C268(0.00); C380(0.00); C410(0.00)  LDD2226  [17]
TFBX
 Probe Info  		C380(0.00); C7(0.00); C445(0.00)  LDD0027  [16]
WYneN
 Probe Info  		C154(0.00); C410(0.00); C380(0.00)  LDD0021  [15]
WYneO
 Probe Info  		C380(0.00); C410(0.00)  LDD0022  [15]
Compound 10
 Probe Info  		C268(0.00); C380(0.00); C410(0.00); C453(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		C268(0.00); C380(0.00); C410(0.00)  LDD2213  [18]
PF-06672131
 Probe Info  		N.A.  LDD0152  [19]
SF
 Probe Info  		Y219(0.00); Y420(0.00)  LDD0028  [20]
Phosphinate-6
 Probe Info  		C410(0.00); C154(0.00); C453(0.00); C268(0.00)  LDD0018  [21]
Ox-W18
 Probe Info  		W429(0.00); W255(0.00)  LDD2175  [22]
1c-yne
 Probe Info  		N.A.  LDD0228  [23]
Acrolein
 Probe Info  		C410(0.00); C154(0.00); C453(0.00); C380(0.00)  LDD0217  [24]
Cinnamaldehyde
 Probe Info  		C380(0.00); C410(0.00)  LDD0220  [24]
Crotonaldehyde
 Probe Info  		C410(0.00); C380(0.00); C453(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C410(0.00); C380(0.00)  LDD0218  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
MPP-AC
 Probe Info  		N.A.  LDD0428  [26]
NAIA_5
 Probe Info  		C154(0.00); C268(0.00); C380(0.00); C410(0.00)  LDD2223  [17]
TER-AC
 Probe Info  		N.A.  LDD0426  [26]
TPP-AC
 Probe Info  		N.A.  LDD0427  [26]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C139
 Probe Info  		10.56  LDD1821  [27]
C217
 Probe Info  		5.31  LDD1891  [27]
C234
 Probe Info  		5.58  LDD1907  [27]
C366
 Probe Info  		6.28  LDD2027  [27]
C423
 Probe Info  		7.46  LDD2078  [27]
FFF probe11
 Probe Info  		12.73  LDD0471  [28]
FFF probe13
 Probe Info  		15.96  LDD0475  [28]
FFF probe14
 Probe Info  		14.59  LDD0477  [28]
FFF probe2
 Probe Info  		12.29  LDD0463  [28]
FFF probe3
 Probe Info  		11.41  LDD0464  [28]
FFF probe4
 Probe Info  		12.39  LDD0466  [28]
FFF probe7
 Probe Info  		12.33  LDD0483  [28]
JN0003
 Probe Info  		13.11  LDD0469  [28]
BD-F
 Probe Info  		G405(0.00); A457(0.00); P454(0.00); E411(0.00)  LDD0024  [29]
LD-F
 Probe Info  		E411(0.00); V409(0.00); P408(0.00)  LDD0015  [29]
OEA-DA
 Probe Info  		6.66  LDD0046  [30]
STS-1
 Probe Info  		N.A.  LDD0069  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C380(0.98)  LDD2142  [32]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C380(1.10); C410(0.99)  LDD2112  [32]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C380(0.57); C410(0.51)  LDD2095  [32]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C380(0.59); C410(0.80)  LDD2130  [32]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C380(1.00); C410(0.88)  LDD2117  [32]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C410(1.44)  LDD2152  [32]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C380(0.52); C410(0.64)  LDD2132  [32]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C380(0.45)  LDD2131  [32]
 LDCM0214  AC1 HCT 116 C453(1.02)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C453(0.41); C268(0.72); C410(0.96)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C453(0.93); C380(0.95); C410(1.54)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C453(1.04); C380(0.94); C410(1.22)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C453(1.24); C380(0.91); C410(1.08)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C453(1.27); C380(0.64); C410(1.22)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C453(1.11); C380(0.60); C410(1.39)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C453(1.13); C380(0.84); C410(1.23)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C453(1.25); C380(0.79); C410(1.40)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C453(1.05); C380(0.76); C410(1.33)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C453(1.13); C380(0.86); C410(1.15)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C453(1.09); C380(0.70); C410(1.06)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C453(0.47); C268(0.68); C410(0.63)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C453(1.36); C380(0.79); C410(1.45)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C453(1.31); C380(0.71); C410(1.05)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C453(1.32); C380(0.92); C410(0.82)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C453(1.13); C268(1.15); C380(0.93)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C453(0.90); C268(0.87); C380(0.82)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C453(0.99); C268(1.00); C380(0.89)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C453(0.90); C268(1.08); C380(0.94)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C453(0.94); C268(1.16); C380(0.87)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C453(0.89); C268(1.12); C380(1.03)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C453(0.88); C268(1.38); C380(1.00)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C453(0.63); C268(0.75); C410(0.78)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C453(2.07); C268(0.81); C380(1.13)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C453(1.29); C268(1.39); C380(0.89)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C453(1.08); C268(0.93); C380(0.97)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C453(2.04); C268(1.09); C380(1.14)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C453(0.95); C268(1.32); C380(0.89)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C453(1.31); C268(1.02); C380(1.00)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C453(1.10); C268(1.04); C380(0.98)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C453(1.16); C268(1.01); C380(0.84)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C453(3.12); C410(0.86)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C453(1.19); C410(1.78)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C453(1.13); C410(1.19)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C453(2.71); C410(2.02)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C453(1.03); C410(2.20)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C453(2.55); C410(1.46)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C453(3.70); C410(1.48)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C453(1.02); C410(1.44)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C453(1.48); C410(1.12)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C453(1.18); C410(1.37)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C453(1.51); C410(1.34)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C453(0.98); C410(1.78)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C453(0.87); C268(0.86); C410(0.92)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C453(1.04); C410(1.53)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C453(1.15); C410(1.50)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C453(0.96); C410(2.15)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C453(0.82); C410(0.75)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C410(0.57); C453(1.38)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C410(0.66); C453(0.96)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C410(0.65); C453(1.13)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C410(0.49); C453(1.24)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C410(0.41); C453(1.00)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C410(0.55); C453(1.05)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C410(0.72); C453(0.82); C268(0.98)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C410(0.77); C453(0.95)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C410(0.87); C453(0.92)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C410(0.43); C453(1.24)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C410(0.39); C453(0.76)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C453(0.86); C410(0.56)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C453(0.63); C410(0.60)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C453(0.93); C410(1.07)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C453(0.93); C410(1.17)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C410(0.77); C380(1.29); C453(1.71)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C410(0.37); C453(0.91); C380(1.14)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C410(0.68); C380(1.36); C453(1.73)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C453(0.71)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C410(0.89); C453(1.52); C380(1.76)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C410(0.77); C380(1.23); C453(1.31)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C410(0.70); C453(1.30); C380(1.33)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C410(0.84); C453(1.56); C380(1.72)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C380(1.32); C410(1.37); C453(1.80)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C453(1.01); C380(1.49)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C380(0.54); C453(0.87)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C380(0.64); C453(1.38)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C380(1.00); C453(1.12)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C380(0.66); C453(0.96)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C453(0.78)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C380(0.56); C453(0.95)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C380(0.72); C453(0.99)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C380(0.61); C453(1.00)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C380(0.92); C453(1.28)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C380(0.73); C453(1.36)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C453(0.84); C380(0.86); C410(1.01)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C380(0.76); C453(0.84); C410(1.61)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C453(0.85); C380(1.04); C410(1.41)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C453(0.73); C380(0.74); C410(1.64)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C453(0.68); C380(0.73); C410(0.93)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C453(0.64)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C410(0.69); C453(0.78); C380(0.81)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C453(0.94); C380(1.05); C410(1.09)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C453(0.87); C410(0.91); C380(0.92)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C453(0.69); C380(0.73); C410(1.07)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C410(0.85); C453(1.03); C380(1.54)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C410(0.67); C453(0.84); C380(0.92)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C380(0.40); C453(0.83); C268(0.99)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C380(0.38); C268(0.66); C453(0.81)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C380(0.51); C268(0.66); C453(0.67)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C380(0.33); C268(0.40); C453(1.20)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C453(0.53)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C380(0.31); C268(0.36); C453(1.43)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C380(0.30); C453(0.98); C268(1.59)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C380(0.40); C268(0.65); C453(1.13)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C268(0.55); C453(1.25); C380(1.62)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C268(0.49); C380(0.50); C453(1.01)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C268(0.40); C380(0.83); C453(1.00)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C268(0.27); C380(0.33); C453(1.04)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C453(0.99)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C453(1.26)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C453(1.22)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C453(0.78); C268(0.93); C410(0.96)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C453(1.42)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C453(0.96)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C453(1.07)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C453(1.29)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C453(1.38)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C453(1.22)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C453(1.33)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C453(1.43)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C268(0.60); C380(0.66); C453(0.97)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C268(0.52); C453(0.90); C380(1.15)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C453(0.50); C410(0.84); C268(0.92)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C268(0.32); C453(0.75); C380(1.22)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C268(0.75); C453(0.81); C380(1.53)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C268(0.59); C380(0.70); C453(0.76)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C453(0.78); C268(0.39); C380(0.72)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C268(0.37); C453(0.87); C380(1.14)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C268(0.33); C380(0.75); C453(0.91)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C268(0.42); C453(0.83)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C268(0.45); C380(0.70); C453(1.32)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C268(0.83); C453(0.91); C380(1.12)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C268(0.77); C453(0.86); C380(0.95)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C410(0.64); C453(0.76); C268(0.91)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C268(0.43); C453(0.85); C380(3.31)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C453(0.77); C268(0.93); C380(1.08)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C268(0.16); C453(0.81); C380(0.88)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C380(0.35); C410(0.50); C453(1.01)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C380(0.36); C410(0.46); C453(1.01)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C410(0.66); C380(0.77); C453(0.82)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C380(0.75); C453(0.85); C410(1.02)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C453(0.74); C410(0.90); C380(1.05)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C380(0.62); C453(0.82); C410(0.90)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C380(0.45); C410(0.77); C453(0.88)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C453(0.65); C380(1.08); C410(1.51)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C380(0.35); C410(0.53); C453(1.06)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C380(0.41); C410(0.61); C453(0.63)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C410(0.69); C380(0.69); C453(0.82)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C410(0.66); C453(0.68); C380(0.70)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C380(0.68); C453(0.81); C410(0.99)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C380(0.61); C410(0.81); C453(0.82)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C380(0.42); C410(0.54); C453(0.83)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C380(0.42); C410(0.86); C453(1.15)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C410(0.86); C453(1.01); C380(1.02)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C380(0.49)  LDD2138  [32]
 LDCM0520  AKOS000195272 MDA-MB-231 C380(0.84); C410(0.63)  LDD2113  [32]
 LDCM0248  AKOS034007472 HCT 116 C453(0.42); C268(0.83); C410(0.95)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C453(0.45); C268(0.77); C410(0.87)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C410(0.38); C453(0.74); C268(1.03)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 9.73  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C453(0.87)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C410(0.78)  LDD2091  [32]
 LDCM0630  CCW28-3 231MFP C453(2.11); C268(1.17)  LDD2214  [33]
 LDCM0108  Chloroacetamide HeLa C154(0.00); C410(0.00); C453(0.00); C268(0.00)  LDD0222  [24]
 LDCM0367  CL1 HCT 116 C380(0.76); C453(1.31)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C453(0.93); C380(1.00)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C453(0.74)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C453(0.70); C410(0.80); C268(0.96)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C453(0.46); C268(0.85); C410(1.22)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C453(0.57); C410(0.83); C268(0.85)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C453(0.69); C268(0.71); C410(0.88)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C410(0.70); C453(0.82); C380(1.20)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C410(0.30); C453(0.77); C380(1.13)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C410(0.41); C453(0.75); C380(1.35)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C410(0.30); C453(0.86); C380(1.20)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C410(0.73); C380(1.33); C453(1.57)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C380(0.97); C453(1.48)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C410(0.43); C453(1.07); C380(1.56)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C410(0.76); C380(1.27); C453(1.49)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C453(0.71); C380(0.88)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C380(0.81); C453(1.25)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C380(0.40); C453(1.17)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C380(0.88); C453(1.09)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C453(0.74); C380(0.97)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C410(0.48); C380(0.55); C453(0.64)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C380(0.92); C453(0.96); C410(0.97)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C410(0.59); C453(0.85); C380(1.32)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C380(0.68); C453(1.77)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C380(0.88); C453(0.91); C410(1.14)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C380(0.59); C268(0.67); C453(1.09)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C268(0.55); C380(0.62); C453(0.76)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C380(0.33); C268(0.51); C453(1.13)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C380(0.44); C268(0.50); C453(0.99)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C453(1.07)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C453(1.22)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C453(1.01)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C453(1.29)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C380(0.69); C453(1.31)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C380(1.01); C453(1.57)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C380(1.47); C453(1.55)  LDD0719  [10]
 LDCM0403  CL16 HEK-293T C268(1.00); C410(1.12); C445(1.21); C453(1.05)  LDD1001  [10]
 LDCM0404  CL17 HCT 116 C453(1.24)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C453(0.83)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C453(1.02)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C380(1.09); C453(1.20)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C453(1.67)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C453(1.08)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C453(1.42)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C453(0.92)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C453(0.92)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C453(0.86)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C453(0.92)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C453(0.82)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C453(0.87)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C453(1.97)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C453(1.29); C380(1.19)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C453(0.84)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C453(1.08); C268(0.79); C380(1.10)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C453(1.05); C268(0.50); C380(1.03)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C453(1.90); C268(0.72); C380(0.86)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C453(1.24); C268(0.34); C380(0.63)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C453(1.60); C268(0.39); C380(0.99)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C453(1.57); C268(0.48); C380(0.56)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C453(4.46); C268(0.38); C380(0.62)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C453(1.87); C268(0.53); C380(1.48)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C453(1.48); C380(0.85)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C453(1.79); C268(0.41); C380(1.22)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C453(1.41); C268(0.58); C380(1.03)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C453(1.21); C268(0.22); C380(0.84)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C453(2.33); C268(0.43); C380(1.54)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C453(1.73); C268(0.45); C380(1.30)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C453(1.17); C268(0.32); C380(1.46)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C453(1.86); C380(0.63)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C453(2.15); C380(0.87)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C453(1.99); C380(0.67)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C453(2.80); C380(0.75)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C453(1.41); C380(0.88)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C453(1.66); C380(1.02)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C453(1.60); C380(1.34)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C453(1.27); C380(1.01)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C453(3.82); C380(0.75)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C453(3.70); C380(0.60)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C453(2.46); C380(0.87)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C453(1.52); C380(1.15)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C453(1.62); C380(0.65)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C453(2.10); C380(1.00)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C453(1.47); C380(0.88)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C453(1.43); C380(1.33)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C453(1.82); C380(0.67)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C453(0.97)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C453(0.95)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C453(1.08)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C453(1.02)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C453(1.10)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C453(0.92)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C453(1.27)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C453(2.16)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C453(1.35)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C453(0.88); C380(0.79)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C453(1.51)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C453(1.40)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C453(1.66)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C453(2.13)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C453(1.85)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C453(0.85)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C453(1.39)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C453(0.85)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C453(1.06)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C453(1.28); C380(0.90)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C453(0.80)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C453(0.85)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C453(0.90)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C453(1.12)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C453(0.97)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C453(1.16)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C453(1.19)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C453(1.19)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C453(1.14)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C453(0.76)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C453(1.35); C380(1.14)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C453(1.38)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C453(1.03)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C453(1.77)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C453(1.10)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C453(0.92)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C453(1.20)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C453(1.04)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C453(1.15)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C453(0.74)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C453(0.74)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C380(0.92); C410(0.99); C69(1.04); C453(1.00)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C410(11.90); C268(3.66); C154(1.94)  LDD1702  [32]
 LDCM0175  Ethacrynic acid HeLa C453(0.78)  LDD2210  [9]
 LDCM0625  F8 Ramos C410(0.37); C154(0.52); C380(0.39); C268(0.53)  LDD2187  [35]
 LDCM0572  Fragment10 Ramos C410(0.64); C154(0.61); C380(0.37); C268(0.41)  LDD2189  [35]
 LDCM0573  Fragment11 Ramos C410(0.11); C154(0.32); C380(0.05)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C410(0.66); C154(0.52); C380(0.25); C268(0.29)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C410(0.85); C154(0.90); C380(0.69); C268(0.55)  LDD2192  [35]
 LDCM0576  Fragment14 Ramos C410(0.23); C154(0.36); C380(0.16); C268(0.28)  LDD2193  [35]
 LDCM0579  Fragment20 Ramos C410(0.66); C154(0.68); C380(0.33); C268(0.27)  LDD2194  [35]
 LDCM0580  Fragment21 Ramos C410(0.57); C154(1.14); C380(0.74); C268(0.32)  LDD2195  [35]
 LDCM0582  Fragment23 Ramos C410(1.02); C154(1.30); C380(0.55); C268(0.62)  LDD2196  [35]
 LDCM0578  Fragment27 Ramos C410(0.81); C154(1.30); C380(0.93); C268(0.65)  LDD2197  [35]
 LDCM0586  Fragment28 Ramos C410(0.75); C154(0.67); C380(0.47); C268(1.07)  LDD2198  [35]
 LDCM0588  Fragment30 Ramos C410(0.93); C154(0.83); C380(0.81); C268(0.45)  LDD2199  [35]
 LDCM0589  Fragment31 Ramos C410(0.44); C154(0.63); C380(0.40); C268(0.32)  LDD2200  [35]
 LDCM0590  Fragment32 Ramos C410(0.59); C154(0.58); C380(0.28); C268(0.43)  LDD2201  [35]
 LDCM0468  Fragment33 HCT 116 C453(0.97)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C410(0.49); C154(0.53); C380(0.50); C268(0.40)  LDD2203  [35]
 LDCM0566  Fragment4 Ramos C410(0.77); C154(0.90); C380(0.59); C268(0.66)  LDD2184  [35]
 LDCM0427  Fragment51 HCT 116 C453(1.77); C268(0.28); C380(2.06)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C410(1.00); C154(0.53); C380(0.76); C268(0.63)  LDD2204  [35]
 LDCM0614  Fragment56 Ramos C410(1.13); C154(0.78); C380(0.77); C268(0.62)  LDD2205  [35]
 LDCM0569  Fragment7 Ramos C410(0.47); C154(0.66); C380(0.26); C268(0.61)  LDD2186  [35]
 LDCM0571  Fragment9 Ramos C410(0.61); C154(0.58); C380(0.28); C268(0.35)  LDD2188  [35]
 LDCM0107  IAA HeLa C154(0.00); C410(0.00); H402(0.00); C380(0.00)  LDD0221  [24]
 LDCM0179  JZ128 PC-3 C453(0.00); C410(0.00)  LDD0462  [8]
 LDCM0022  KB02 HCT 116 C453(1.58)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C453(1.02)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C453(1.24)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C410(0.92)  LDD2102  [32]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C380(0.87)  LDD2121  [32]
 LDCM0109  NEM HeLa C410(0.00); C453(0.00); H402(0.00); H223(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C380(0.86); C154(1.02)  LDD2089  [32]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C410(0.99)  LDD2092  [32]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C410(1.21)  LDD2093  [32]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C410(0.90)  LDD2096  [32]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C410(1.08)  LDD2097  [32]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C410(1.13)  LDD2098  [32]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C380(1.07); C410(1.08)  LDD2099  [32]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C380(0.73); C410(1.19)  LDD2100  [32]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C380(0.91); C410(1.00)  LDD2101  [32]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C410(0.79)  LDD2104  [32]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C410(1.19)  LDD2105  [32]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C380(1.17)  LDD2107  [32]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C380(0.90)  LDD2108  [32]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C410(1.20)  LDD2109  [32]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C380(1.43); C410(1.24)  LDD2111  [32]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C380(0.78); C410(0.64)  LDD2114  [32]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C410(0.49)  LDD2118  [32]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C380(1.73); C410(2.25)  LDD2119  [32]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C410(0.67)  LDD2120  [32]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C380(0.35)  LDD2122  [32]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C410(1.31)  LDD2123  [32]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C380(0.51); C410(0.48)  LDD2124  [32]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C380(0.96); C410(1.04)  LDD2125  [32]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C410(0.51)  LDD2126  [32]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C410(0.99)  LDD2127  [32]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C410(0.74)  LDD2128  [32]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C380(1.31); C410(1.47)  LDD2129  [32]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C380(0.39); C410(0.49)  LDD2133  [32]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C410(0.50)  LDD2134  [32]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C380(1.00); C410(1.34)  LDD2135  [32]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C380(1.19); C410(1.40)  LDD2136  [32]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C380(0.96); C410(1.05)  LDD2137  [32]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C410(1.01)  LDD1700  [32]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C380(0.95); C410(0.98)  LDD2140  [32]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C380(0.81); C410(0.90)  LDD2141  [32]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C410(0.80)  LDD2143  [32]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C410(1.30)  LDD2144  [32]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C410(1.13)  LDD2147  [32]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C410(0.51)  LDD2148  [32]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C380(0.42)  LDD2150  [32]
 LDCM0627  NUDT7-COV-1 HEK-293T C453(0.88)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C410(1.26); C380(0.57); C453(0.49); C453(0.32)  LDD2207  [36]
 LDCM0131  RA190 MM1.R C268(1.44); C453(1.40); C154(1.34); C380(1.17)  LDD0304  [37]
 LDCM0021  THZ1 HCT 116 C380(1.05); C453(0.96); C268(1.00)  LDD2173  [10]
 LDCM0111  W14 Hep-G2 W401(0.69)  LDD0238  [3]
 LDCM0112  W16 Hep-G2 C453(0.56)  LDD0239  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Zinc-regulated GTPase metalloprotein activator 1A (ZNG1A) SIMIBI class G3E GTPase family Q9BRT8
Sulfotransferase 1B1 (SULT1B1) Sulfotransferase 1 family O43704
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Phosphatidylinositol transfer protein alpha isoform (PITPNA) PtdIns transfer protein family Q00169
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 232 (ZNF232) Krueppel C2H2-type zinc-finger protein family Q9UNY5
Zinc finger protein 513 (ZNF513) Krueppel C2H2-type zinc-finger protein family Q8N8E2
T-box transcription factor TBX6 (TBX6) . O95947
THAP domain-containing protein 3 (THAP3) . Q8WTV1
Transcription factor SOX-14 (SOX14) . O95416
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-J-like protein (CCNJL) Cyclin family, Cyclin J subfamily Q8IV13
Translation initiation factor eIF2B subunit delta (EIF2B4) EIF-2B alpha/beta/delta subunits family Q9UI10
UL16-binding protein 3 (ULBP3) MHC class I family Q9BZM4
Prefoldin subunit 2 (PFDN2) Prefoldin subunit beta family Q9UHV9
Rho GDP-dissociation inhibitor 2 (ARHGDIB) Rho GDI family P52566
UPF0449 protein C19orf25 (C19orf25) UPF0449 family Q9UFG5
Vasculin-like protein 1 (GPBP1L1) Vasculin family Q9HC44
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
COMM domain-containing protein 10 (COMMD10) . Q9Y6G5
Elongation factor 1-gamma (EEF1G) . P26641
Spindlin interactor and repressor of chromatin-binding protein (SPINDOC) . Q9BUA3
Uncharacterized protein C2orf15 (C2orf15) . Q8WU43

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-nonyl-4-quinolinol 1-oxide Small molecular drug DB08453
6-hydroxy-5-undecyl-47-benzothiazoledione Small molecular drug DB04799
Ubiquinone Q2 Small molecular drug DB08690
(5s)-3-anilino-5-(24-difluorophenyl)-5-methyl-13-oxazolidine-24-dione . DB07763
(S)-famoxadone . DB07778
2-hexyloxy-6-hydroxymethyl-tetrahydro-pyran-345-triol . DB04141
Azoxystrobin . DB07401
Methyl (2z)-3-methoxy-2-{2-[(E)-2-phenylvinyl]Phenyl}Acrylate . DB08330
Myxothiazol . DB04741

References

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Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
32 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
33 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD044402
35 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.