Details of the Target

General Information of Target

Target ID LDTP01366
Target Name Flotillin-1 (FLOT1)
Gene Name FLOT1
Gene ID 10211
Synonyms
Flotillin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI
YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
HKPLRTA
Target Bioclass
Transporter and channel
Family
Band 7/mec-2 family, Flotillin subfamily
Subcellular location
Cell membrane
Function May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
Uniprot ID
O75955
Ensemble ID
ENST00000376389.8
HGNC ID
HGNC:3757
ChEMBL ID
CHEMBL5209841

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.P20S .
CAL120 Deletion: p.R261_Q263del DBIA    Probe Info 
HCT15 SNV: p.L380P .
JURKAT SNV: p.A273T .
NCIH1155 SNV: p.E312K .
SHP77 SNV: p.C34Y .
SNGM SNV: p.Y149H DBIA    Probe Info 
SW1271 Deletion: p.Q353GfsTer14 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		100.00  LDD0244  [1]
STPyne
 Probe Info  		K166(10.00); K422(9.79)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K54(0.74); K285(1.67); K184(1.83); K246(2.54)  LDD3494  [3]
Probe 1
 Probe Info  		Y223(21.85)  LDD3495  [4]
DBIA
 Probe Info  		C85(2.12); C34(2.57)  LDD3310  [5]
BTD
 Probe Info  		C34(1.74)  LDD2141  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C85(0.00); C34(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
1d-yne
 Probe Info  		N.A.  LDD0356  [11]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Acrolein
 Probe Info  		H98(0.00); C34(0.00); H155(0.00)  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
AOyne
 Probe Info  		9.90  LDD0443  [14]
NAIA_5
 Probe Info  		C85(0.00); C34(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		6.68  LDD1728  [16]
C040
 Probe Info  		7.94  LDD1740  [16]
C112
 Probe Info  		19.70  LDD1799  [16]
C170
 Probe Info  		7.36  LDD1850  [16]
C201
 Probe Info  		25.63  LDD1877  [16]
C220
 Probe Info  		12.38  LDD1894  [16]
C310
 Probe Info  		8.11  LDD1977  [16]
C339
 Probe Info  		7.16  LDD2002  [16]
C354
 Probe Info  		7.57  LDD2015  [16]
C407
 Probe Info  		12.73  LDD2064  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe12
 Probe Info  		20.00  LDD0473  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe15
 Probe Info  		20.00  LDD0478  [17]
FFF probe2
 Probe Info  		18.37  LDD0463  [17]
FFF probe4
 Probe Info  		20.00  LDD0466  [17]
JN0003
 Probe Info  		20.00  LDD0469  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C34(0.97); C85(1.05); C5(1.27)  LDD1507  [18]
 LDCM0215  AC10 PaTu 8988t C17(0.71); C5(0.71)  LDD1094  [19]
 LDCM0226  AC11 PaTu 8988t C17(0.64); C5(0.64)  LDD1105  [19]
 LDCM0230  AC113 PaTu 8988t C17(1.02); C5(1.02)  LDD1109  [19]
 LDCM0231  AC114 PaTu 8988t C17(0.84); C5(0.84)  LDD1110  [19]
 LDCM0232  AC115 PaTu 8988t C17(0.65); C5(0.65)  LDD1111  [19]
 LDCM0233  AC116 PaTu 8988t C17(0.80); C5(0.80)  LDD1112  [19]
 LDCM0234  AC117 PaTu 8988t C17(0.65); C5(0.65)  LDD1113  [19]
 LDCM0235  AC118 PaTu 8988t C17(0.95); C5(0.95)  LDD1114  [19]
 LDCM0236  AC119 PaTu 8988t C17(0.62); C5(0.62)  LDD1115  [19]
 LDCM0237  AC12 PaTu 8988t C17(0.75); C5(0.75)  LDD1116  [19]
 LDCM0238  AC120 PaTu 8988t C17(1.97); C5(1.97)  LDD1117  [19]
 LDCM0239  AC121 PaTu 8988t C17(0.96); C5(0.96)  LDD1118  [19]
 LDCM0240  AC122 PaTu 8988t C17(1.74); C5(1.74)  LDD1119  [19]
 LDCM0241  AC123 PaTu 8988t C17(1.77); C5(1.77)  LDD1120  [19]
 LDCM0242  AC124 PaTu 8988t C17(1.31); C5(1.31)  LDD1121  [19]
 LDCM0243  AC125 PaTu 8988t C17(1.55); C5(1.55)  LDD1122  [19]
 LDCM0244  AC126 PaTu 8988t C17(1.78); C5(1.78)  LDD1123  [19]
 LDCM0245  AC127 PaTu 8988t C17(1.36); C5(1.36)  LDD1124  [19]
 LDCM0246  AC128 PaTu 8988t C17(1.70); C5(1.70)  LDD1125  [19]
 LDCM0247  AC129 PaTu 8988t C17(1.53); C5(1.53)  LDD1126  [19]
 LDCM0249  AC130 PaTu 8988t C17(1.78); C5(1.78)  LDD1128  [19]
 LDCM0250  AC131 PaTu 8988t C17(1.03); C5(1.03)  LDD1129  [19]
 LDCM0251  AC132 PaTu 8988t C17(0.72); C5(0.72)  LDD1130  [19]
 LDCM0252  AC133 PaTu 8988t C17(0.77); C5(0.77)  LDD1131  [19]
 LDCM0253  AC134 PaTu 8988t C17(1.06); C5(1.06)  LDD1132  [19]
 LDCM0254  AC135 PaTu 8988t C17(0.82); C5(0.82)  LDD1133  [19]
 LDCM0255  AC136 PaTu 8988t C17(0.75); C5(0.75)  LDD1134  [19]
 LDCM0256  AC137 PaTu 8988t C17(0.67); C5(0.67)  LDD1135  [19]
 LDCM0257  AC138 PaTu 8988t C17(2.18); C5(2.18)  LDD1136  [19]
 LDCM0258  AC139 PaTu 8988t C17(0.76); C5(0.76)  LDD1137  [19]
 LDCM0259  AC14 PaTu 8988t C17(1.24); C5(1.24)  LDD1138  [19]
 LDCM0260  AC140 PaTu 8988t C17(0.87); C5(0.87)  LDD1139  [19]
 LDCM0261  AC141 PaTu 8988t C17(1.60); C5(1.60)  LDD1140  [19]
 LDCM0262  AC142 PaTu 8988t C17(1.26); C5(1.26)  LDD1141  [19]
 LDCM0263  AC143 PaTu 8988t C85(0.90); C17(0.83); C5(0.83)  LDD1142  [19]
 LDCM0264  AC144 PaTu 8988t C85(0.88); C17(0.60); C5(0.60)  LDD1143  [19]
 LDCM0265  AC145 PaTu 8988t C85(0.84); C17(1.12); C5(1.12)  LDD1144  [19]
 LDCM0266  AC146 PaTu 8988t C85(0.96); C17(0.75); C5(0.75)  LDD1145  [19]
 LDCM0267  AC147 PaTu 8988t C85(0.87); C17(1.08); C5(1.08)  LDD1146  [19]
 LDCM0268  AC148 PaTu 8988t C85(0.83); C17(0.77); C5(0.77)  LDD1147  [19]
 LDCM0269  AC149 PaTu 8988t C85(0.74); C17(0.46); C5(0.46)  LDD1148  [19]
 LDCM0270  AC15 PaTu 8988t C17(0.97); C5(0.97)  LDD1149  [19]
 LDCM0271  AC150 PaTu 8988t C85(0.78); C17(0.73); C5(0.73)  LDD1150  [19]
 LDCM0272  AC151 PaTu 8988t C85(0.79); C17(0.72); C5(0.72)  LDD1151  [19]
 LDCM0273  AC152 PaTu 8988t C85(0.88); C17(0.45); C5(0.45)  LDD1152  [19]
 LDCM0274  AC153 PaTu 8988t C85(0.87); C17(0.64); C5(0.64)  LDD1153  [19]
 LDCM0621  AC154 PaTu 8988t C85(0.90); C17(0.60); C5(0.60)  LDD2166  [19]
 LDCM0622  AC155 PaTu 8988t C85(0.80); C17(0.60); C5(0.60)  LDD2167  [19]
 LDCM0623  AC156 PaTu 8988t C85(0.82); C17(0.59); C5(0.59)  LDD2168  [19]
 LDCM0624  AC157 PaTu 8988t C85(0.83); C17(0.88); C5(0.88)  LDD2169  [19]
 LDCM0276  AC17 HEK-293T C34(0.99); C85(1.02); C5(1.02)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C34(1.01); C85(0.98)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C34(1.04); C85(0.96); C5(1.03)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C34(1.05); C85(1.08)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C34(0.98); C85(1.00); C5(0.92)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C34(1.03); C85(0.96); C5(1.14)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C34(0.96); C85(1.03); C5(1.11)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C34(1.04); C85(0.95); C5(1.32)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C34(0.99); C5(0.75)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C34(1.01); C85(1.02); C5(1.03)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C34(1.02); C85(0.95)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C34(1.01); C85(0.97); C5(0.93)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C34(1.04); C85(0.95); C5(0.99)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C34(1.01); C85(1.02); C5(1.06)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C34(0.97); C85(1.09); C5(0.92)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C34(1.00); C85(1.00); C5(0.70)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C34(1.01); C85(1.03); C5(0.91)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C34(1.06); C5(0.97)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C34(0.99); C85(1.04); C5(1.03)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C34(1.04); C85(1.03)  LDD1534  [18]
 LDCM0296  AC35 PaTu 8988t C85(0.87); C17(0.37); C5(0.37)  LDD1175  [19]
 LDCM0297  AC36 PaTu 8988t C85(0.78); C17(0.48); C5(0.48)  LDD1176  [19]
 LDCM0298  AC37 PaTu 8988t C85(0.88); C17(0.27); C5(0.27)  LDD1177  [19]
 LDCM0299  AC38 PaTu 8988t C85(0.93); C17(0.32); C5(0.32)  LDD1178  [19]
 LDCM0300  AC39 PaTu 8988t C85(0.81); C17(0.55); C5(0.55)  LDD1179  [19]
 LDCM0301  AC4 HEK-293T C34(1.01); C85(1.02); C5(1.01)  LDD1540  [18]
 LDCM0302  AC40 PaTu 8988t C85(0.82); C17(0.43); C5(0.43)  LDD1181  [19]
 LDCM0303  AC41 PaTu 8988t C85(0.84); C17(0.45); C5(0.45)  LDD1182  [19]
 LDCM0304  AC42 PaTu 8988t C85(1.20); C17(0.29); C5(0.29)  LDD1183  [19]
 LDCM0305  AC43 PaTu 8988t C85(0.81); C17(0.49); C5(0.49)  LDD1184  [19]
 LDCM0306  AC44 PaTu 8988t C85(0.98); C17(0.32); C5(0.32)  LDD1185  [19]
 LDCM0307  AC45 PaTu 8988t C85(0.85); C17(0.39); C5(0.39)  LDD1186  [19]
 LDCM0308  AC46 PaTu 8988t C85(1.12); C17(1.35); C5(1.35)  LDD1187  [19]
 LDCM0309  AC47 PaTu 8988t C85(0.89); C17(1.03); C5(1.03)  LDD1188  [19]
 LDCM0310  AC48 PaTu 8988t C85(0.81); C17(0.64); C5(0.64)  LDD1189  [19]
 LDCM0311  AC49 PaTu 8988t C85(0.96); C17(0.91); C5(0.91)  LDD1190  [19]
 LDCM0312  AC5 HEK-293T C34(0.96); C85(0.98); C5(1.04)  LDD1551  [18]
 LDCM0313  AC50 PaTu 8988t C85(1.00); C17(0.82); C5(0.82)  LDD1192  [19]
 LDCM0314  AC51 PaTu 8988t C85(0.91); C17(0.88); C5(0.88)  LDD1193  [19]
 LDCM0315  AC52 PaTu 8988t C85(0.85); C17(0.65); C5(0.65)  LDD1194  [19]
 LDCM0316  AC53 PaTu 8988t C85(0.89); C17(0.80); C5(0.80)  LDD1195  [19]
 LDCM0317  AC54 PaTu 8988t C85(0.83); C17(0.64); C5(0.64)  LDD1196  [19]
 LDCM0318  AC55 PaTu 8988t C85(0.91); C17(0.91); C5(0.91)  LDD1197  [19]
 LDCM0319  AC56 PaTu 8988t C85(0.94); C17(0.82); C5(0.82)  LDD1198  [19]
 LDCM0320  AC57 HEK-293T C34(1.02); C85(1.05); C5(1.06)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C34(1.10); C85(1.08)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C34(0.99); C85(1.04); C5(1.01)  LDD1561  [18]
 LDCM0323  AC6 PaTu 8988t C17(0.85); C5(0.85)  LDD1202  [19]
 LDCM0324  AC60 HEK-293T C34(0.97); C85(1.04); C5(0.98)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C34(1.01); C85(1.10); C5(1.20)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C34(0.98); C85(1.07); C5(1.06)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C34(1.03); C85(1.00); C5(1.06)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C34(1.12); C5(0.84)  LDD1567  [18]
 LDCM0332  AC68 PaTu 8988t C17(0.84); C5(0.84)  LDD1211  [19]
 LDCM0333  AC69 PaTu 8988t C17(0.81); C5(0.81)  LDD1212  [19]
 LDCM0334  AC7 PaTu 8988t C17(0.67); C5(0.67)  LDD1213  [19]
 LDCM0335  AC70 PaTu 8988t C17(0.91); C5(0.91)  LDD1214  [19]
 LDCM0336  AC71 PaTu 8988t C17(0.91); C5(0.91)  LDD1215  [19]
 LDCM0337  AC72 PaTu 8988t C17(0.79); C5(0.79)  LDD1216  [19]
 LDCM0338  AC73 PaTu 8988t C17(0.97); C5(0.97)  LDD1217  [19]
 LDCM0339  AC74 PaTu 8988t C17(1.07); C5(1.07)  LDD1218  [19]
 LDCM0340  AC75 PaTu 8988t C17(0.77); C5(0.77)  LDD1219  [19]
 LDCM0341  AC76 PaTu 8988t C17(0.73); C5(0.73)  LDD1220  [19]
 LDCM0342  AC77 PaTu 8988t C17(0.90); C5(0.90)  LDD1221  [19]
 LDCM0343  AC78 PaTu 8988t C17(0.47); C5(0.47)  LDD1222  [19]
 LDCM0344  AC79 PaTu 8988t C17(0.90); C5(0.90)  LDD1223  [19]
 LDCM0345  AC8 PaTu 8988t C17(1.00); C5(1.00)  LDD1224  [19]
 LDCM0346  AC80 PaTu 8988t C17(1.21); C5(1.21)  LDD1225  [19]
 LDCM0347  AC81 PaTu 8988t C17(0.85); C5(0.85)  LDD1226  [19]
 LDCM0348  AC82 PaTu 8988t C17(0.76); C5(0.76)  LDD1227  [19]
 LDCM0248  AKOS034007472 PaTu 8988t C17(0.92); C5(0.92)  LDD1127  [19]
 LDCM0356  AKOS034007680 PaTu 8988t C17(0.62); C5(0.62)  LDD1235  [19]
 LDCM0275  AKOS034007705 PaTu 8988t C17(0.68); C5(0.68)  LDD1154  [19]
 LDCM0108  Chloroacetamide HeLa C34(0.00); C85(0.00); H421(0.00); H107(0.00)  LDD0222  [13]
 LDCM0367  CL1 PaTu 8988t C17(0.83); C5(0.83)  LDD1246  [19]
 LDCM0368  CL10 PaTu 8988t C17(0.43); C5(0.43)  LDD1247  [19]
 LDCM0369  CL100 HEK-293T C34(1.06); C85(0.96)  LDD1573  [18]
 LDCM0370  CL101 PaTu 8988t C17(0.60); C5(0.60)  LDD1249  [19]
 LDCM0371  CL102 PaTu 8988t C17(0.91); C5(0.91)  LDD1250  [19]
 LDCM0372  CL103 PaTu 8988t C17(0.78); C5(0.78)  LDD1251  [19]
 LDCM0373  CL104 PaTu 8988t C17(0.53); C5(0.53)  LDD1252  [19]
 LDCM0374  CL105 HEK-293T C34(1.02); C85(0.99); C5(0.99)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C34(1.00); C85(1.02); C5(1.18)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C34(0.99); C85(0.92)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C34(1.00); C85(0.98)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C34(1.10); C85(0.99); C5(1.13)  LDD1582  [18]
 LDCM0379  CL11 PaTu 8988t C17(0.54); C5(0.54)  LDD1258  [19]
 LDCM0380  CL110 HEK-293T C34(1.46); C85(0.90); C5(1.10)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C34(1.12); C85(0.94)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C34(1.06); C85(0.93)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C34(0.94); C85(1.01); C5(0.89)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C34(1.21); C85(0.92); C5(0.95)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C34(0.96); C85(1.00)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C34(0.97); C85(0.96)  LDD1590  [18]
 LDCM0387  CL117 PaTu 8988t C85(1.12); C17(0.44); C5(0.44)  LDD1266  [19]
 LDCM0388  CL118 PaTu 8988t C85(1.27); C17(0.37); C5(0.37)  LDD1267  [19]
 LDCM0389  CL119 PaTu 8988t C85(0.88); C17(0.55); C5(0.55)  LDD1268  [19]
 LDCM0390  CL12 PaTu 8988t C17(0.88); C5(0.88)  LDD1269  [19]
 LDCM0391  CL120 PaTu 8988t C85(0.83); C17(1.48); C5(1.48)  LDD1270  [19]
 LDCM0392  CL121 PaTu 8988t C85(0.88); C17(0.91); C5(0.91)  LDD1271  [19]
 LDCM0393  CL122 PaTu 8988t C85(1.17); C17(0.86); C5(0.86)  LDD1272  [19]
 LDCM0394  CL123 PaTu 8988t C85(0.78); C17(1.05); C5(1.05)  LDD1273  [19]
 LDCM0395  CL124 PaTu 8988t C85(0.97); C17(0.77); C5(0.77)  LDD1274  [19]
 LDCM0396  CL125 HEK-293T C34(1.00); C85(1.11); C5(0.96)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C34(1.05); C85(0.98); C5(1.16)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C34(0.92); C85(1.00)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C34(1.07); C85(1.05)  LDD1603  [18]
 LDCM0400  CL13 PaTu 8988t C17(0.51); C5(0.51)  LDD1279  [19]
 LDCM0401  CL14 PaTu 8988t C17(0.76); C5(0.76)  LDD1280  [19]
 LDCM0402  CL15 PaTu 8988t C17(0.88); C5(0.88)  LDD1281  [19]
 LDCM0403  CL16 PaTu 8988t C17(0.88); C5(0.88)  LDD1282  [19]
 LDCM0404  CL17 PaTu 8988t C17(0.83); C5(0.83)  LDD1283  [19]
 LDCM0405  CL18 PaTu 8988t C17(0.69); C5(0.69)  LDD1284  [19]
 LDCM0406  CL19 PaTu 8988t C17(1.05); C5(1.05)  LDD1285  [19]
 LDCM0407  CL2 PaTu 8988t C17(0.91); C5(0.91)  LDD1286  [19]
 LDCM0408  CL20 PaTu 8988t C17(0.83); C5(0.83)  LDD1287  [19]
 LDCM0409  CL21 PaTu 8988t C17(0.76); C5(0.76)  LDD1288  [19]
 LDCM0410  CL22 PaTu 8988t C17(0.75); C5(0.75)  LDD1289  [19]
 LDCM0411  CL23 PaTu 8988t C17(0.60); C5(0.60)  LDD1290  [19]
 LDCM0412  CL24 PaTu 8988t C17(0.69); C5(0.69)  LDD1291  [19]
 LDCM0413  CL25 PaTu 8988t C17(0.66); C5(0.66)  LDD1292  [19]
 LDCM0414  CL26 PaTu 8988t C17(0.53); C5(0.53)  LDD1293  [19]
 LDCM0415  CL27 PaTu 8988t C17(1.02); C5(1.02)  LDD1294  [19]
 LDCM0416  CL28 PaTu 8988t C17(0.50); C5(0.50)  LDD1295  [19]
 LDCM0417  CL29 PaTu 8988t C17(0.52); C5(0.52)  LDD1296  [19]
 LDCM0418  CL3 PaTu 8988t C17(0.53); C5(0.53)  LDD1297  [19]
 LDCM0419  CL30 PaTu 8988t C17(0.83); C5(0.83)  LDD1298  [19]
 LDCM0420  CL31 PaTu 8988t C85(1.07)  LDD1299  [19]
 LDCM0421  CL32 PaTu 8988t C85(1.11)  LDD1300  [19]
 LDCM0422  CL33 PaTu 8988t C85(0.93)  LDD1301  [19]
 LDCM0423  CL34 PaTu 8988t C85(0.84)  LDD1302  [19]
 LDCM0424  CL35 PaTu 8988t C85(1.02)  LDD1303  [19]
 LDCM0425  CL36 PaTu 8988t C85(0.26)  LDD1304  [19]
 LDCM0426  CL37 PaTu 8988t C85(1.34)  LDD1305  [19]
 LDCM0428  CL39 PaTu 8988t C85(1.27)  LDD1307  [19]
 LDCM0429  CL4 PaTu 8988t C17(0.56); C5(0.56)  LDD1308  [19]
 LDCM0430  CL40 PaTu 8988t C85(1.25)  LDD1309  [19]
 LDCM0431  CL41 PaTu 8988t C85(1.37)  LDD1310  [19]
 LDCM0432  CL42 PaTu 8988t C85(1.49)  LDD1311  [19]
 LDCM0433  CL43 PaTu 8988t C85(0.97)  LDD1312  [19]
 LDCM0434  CL44 PaTu 8988t C85(1.22)  LDD1313  [19]
 LDCM0435  CL45 PaTu 8988t C85(1.06)  LDD1314  [19]
 LDCM0436  CL46 PaTu 8988t C85(0.75); C17(0.77); C5(0.77)  LDD1315  [19]
 LDCM0437  CL47 PaTu 8988t C85(0.69); C17(0.71); C5(0.71)  LDD1316  [19]
 LDCM0438  CL48 PaTu 8988t C85(0.59); C17(0.86); C5(0.86)  LDD1317  [19]
 LDCM0439  CL49 PaTu 8988t C85(0.54); C17(1.05); C5(1.05)  LDD1318  [19]
 LDCM0440  CL5 PaTu 8988t C17(0.45); C5(0.45)  LDD1319  [19]
 LDCM0441  CL50 PaTu 8988t C85(0.83); C17(0.85); C5(0.85)  LDD1320  [19]
 LDCM0442  CL51 PaTu 8988t C85(0.75); C17(0.75); C5(0.75)  LDD1321  [19]
 LDCM0443  CL52 PaTu 8988t C85(0.67); C17(0.92); C5(0.92)  LDD1322  [19]
 LDCM0444  CL53 PaTu 8988t C85(0.50); C17(0.58); C5(0.58)  LDD1323  [19]
 LDCM0445  CL54 PaTu 8988t C85(0.59); C17(0.60); C5(0.60)  LDD1324  [19]
 LDCM0446  CL55 PaTu 8988t C85(0.72); C17(0.88); C5(0.88)  LDD1325  [19]
 LDCM0447  CL56 PaTu 8988t C85(0.82); C17(0.48); C5(0.48)  LDD1326  [19]
 LDCM0448  CL57 PaTu 8988t C85(0.61); C17(0.78); C5(0.78)  LDD1327  [19]
 LDCM0449  CL58 PaTu 8988t C85(0.63); C17(0.76); C5(0.76)  LDD1328  [19]
 LDCM0450  CL59 PaTu 8988t C85(0.98); C17(0.94); C5(0.94)  LDD1329  [19]
 LDCM0451  CL6 PaTu 8988t C17(0.73); C5(0.73)  LDD1330  [19]
 LDCM0452  CL60 PaTu 8988t C85(0.77); C17(0.76); C5(0.76)  LDD1331  [19]
 LDCM0453  CL61 HEK-293T C34(0.94); C85(1.16); C5(1.05)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C34(0.98); C85(1.01); C5(1.28)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C34(1.04); C85(1.02)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C34(1.38); C85(0.95)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C34(0.99); C85(1.06); C5(0.93)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C34(1.04); C85(1.02)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C34(1.12); C85(1.12); C5(1.04)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C34(1.04); C85(1.08); C5(1.15)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C34(1.29); C85(1.08); C5(1.03)  LDD1664  [18]
 LDCM0462  CL7 PaTu 8988t C17(0.66); C5(0.66)  LDD1341  [19]
 LDCM0463  CL70 HEK-293T C34(1.18); C85(1.24); C5(0.70)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C34(1.13); C85(1.09); C5(0.91)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C34(1.20); C5(0.63)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C34(1.12); C85(1.09); C5(1.30)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C34(1.01); C85(1.05); C5(0.88)  LDD1670  [18]
 LDCM0469  CL76 PaTu 8988t C85(1.10); C17(0.57); C5(0.57)  LDD1348  [19]
 LDCM0470  CL77 PaTu 8988t C85(0.76); C17(0.70); C5(0.70)  LDD1349  [19]
 LDCM0471  CL78 PaTu 8988t C85(0.81); C17(0.56); C5(0.56)  LDD1350  [19]
 LDCM0472  CL79 PaTu 8988t C85(1.19); C17(0.64); C5(0.64)  LDD1351  [19]
 LDCM0473  CL8 PaTu 8988t C17(0.66); C5(0.66)  LDD1352  [19]
 LDCM0474  CL80 PaTu 8988t C85(0.86); C17(0.46); C5(0.46)  LDD1353  [19]
 LDCM0475  CL81 PaTu 8988t C85(1.06); C17(0.50); C5(0.50)  LDD1354  [19]
 LDCM0476  CL82 PaTu 8988t C85(0.96); C17(0.64); C5(0.64)  LDD1355  [19]
 LDCM0477  CL83 PaTu 8988t C85(0.82); C17(0.73); C5(0.73)  LDD1356  [19]
 LDCM0478  CL84 PaTu 8988t C85(1.16); C17(0.55); C5(0.55)  LDD1357  [19]
 LDCM0479  CL85 PaTu 8988t C85(1.06); C17(0.67); C5(0.67)  LDD1358  [19]
 LDCM0480  CL86 PaTu 8988t C85(0.80); C17(0.65); C5(0.65)  LDD1359  [19]
 LDCM0481  CL87 PaTu 8988t C85(0.87); C17(0.48); C5(0.48)  LDD1360  [19]
 LDCM0482  CL88 PaTu 8988t C85(0.81); C17(0.44); C5(0.44)  LDD1361  [19]
 LDCM0483  CL89 PaTu 8988t C85(0.79); C17(0.53); C5(0.53)  LDD1362  [19]
 LDCM0484  CL9 PaTu 8988t C17(0.61); C5(0.61)  LDD1363  [19]
 LDCM0485  CL90 PaTu 8988t C85(1.12); C17(0.56); C5(0.56)  LDD1364  [19]
 LDCM0486  CL91 HEK-293T C34(1.02); C85(1.07); C5(1.05)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C34(1.19); C85(0.97); C5(1.13)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C34(1.34); C85(1.11); C5(1.20)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C34(1.11); C85(1.10); C5(0.77)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C34(1.48); C85(0.91); C5(0.94)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C34(1.43); C5(0.79)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C34(1.09); C85(0.96); C5(1.06)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C34(1.07); C85(1.00); C5(1.04)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C34(1.02); C85(0.97)  LDD1697  [18]
 LDCM0185  Compound 17 HEK-293T 6.31  LDD0512  [17]
 LDCM0495  E2913 HEK-293T C34(0.94); C85(0.97)  LDD1698  [18]
 LDCM0625  F8 Ramos C34(1.17)  LDD2187  [20]
 LDCM0573  Fragment11 Ramos C34(0.44)  LDD2190  [20]
 LDCM0575  Fragment13 Ramos C34(0.98)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C34(2.13)  LDD2193  [20]
 LDCM0580  Fragment21 Ramos C34(1.48)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C34(1.13)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C34(0.73)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C34(0.75)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C34(0.71)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C34(0.74)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C34(1.09)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C34(0.98); C85(1.01)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C34(0.56)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C34(1.87)  LDD2184  [20]
 LDCM0427  Fragment51 PaTu 8988t C85(0.98)  LDD1306  [19]
 LDCM0610  Fragment52 Ramos C34(0.99)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C34(0.73)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C34(1.01)  LDD2186  [20]
 LDCM0107  IAA HeLa H107(0.00); H59(0.00); C34(0.00); H155(0.00)  LDD0221  [13]
 LDCM0022  KB02 T cell-activated C5(5.96)  LDD1704  [21]
 LDCM0023  KB03 22RV1 C85(2.37); C34(5.10)  LDD2660  [5]
 LDCM0024  KB05 COLO792 C85(2.12); C34(2.57)  LDD3310  [5]
 LDCM0109  NEM HeLa H98(0.00); H155(0.00); H421(0.00)  LDD0223  [13]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C34(1.74)  LDD2141  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Flotillin-2 (FLOT2) Band 7/mec-2 family Q14254
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Epithelial membrane protein 3 (EMP3) PMP-22/EMP/MP20 family P54852
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.