Details of the Target

General Information of Target

Target ID LDTP00235
Target Name Membrane-associated progesterone receptor component 1 (PGRMC1)
Gene Name PGRMC1
Gene ID 10857
Synonyms
HPR6.6; PGRMC; Membrane-associated progesterone receptor component 1; mPR; Dap1; IZA
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDD
EPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRD
ASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVY
SDEEEPKDESARKND
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Cytochrome b5 family, MAPR subfamily
Subcellular location
Microsome membrane
Function
Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization.
TTD ID
T17814
Uniprot ID
O00264
DrugMap ID
TTY3LAZ
Ensemble ID
ENST00000217971.8
HGNC ID
HGNC:16090
ChEMBL ID
CHEMBL4105706

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBPP2
 Probe Info  		4.01  LDD0318  [2]
CHEMBL5175495
 Probe Info  		10.44  LDD0196  [3]
TG42
 Probe Info  		4.34  LDD0326  [4]
TH211
 Probe Info  		Y113(11.67); Y164(20.00)  LDD0260  [5]
FBP2
 Probe Info  		4.04  LDD0317  [2]
TH216
 Probe Info  		Y113(13.34)  LDD0259  [5]
STPyne
 Probe Info  		K102(7.65); K105(6.03); K96(10.00)  LDD0277  [6]
BTD
 Probe Info  		C129(3.25)  LDD1699  [7]
AZ-9
 Probe Info  		D131(10.00); E110(10.00)  LDD2209  [8]
ONAyne
 Probe Info  		K102(0.00); K105(0.00)  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K105(2.63); K102(5.04)  LDD3494  [9]
Probe 1
 Probe Info  		Y113(38.51)  LDD3495  [10]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [11]
THZ1-DTB
 Probe Info  		C129(1.12); C129(1.06)  LDD0460  [11]
AHL-Pu-1
 Probe Info  		C129(3.56)  LDD0169  [12]
HPAP
 Probe Info  		3.59  LDD0062  [13]
HHS-475
 Probe Info  		Y113(0.08)  LDD0264  [14]
HHS-465
 Probe Info  		Y113(10.00)  LDD2237  [15]
Acrolein
 Probe Info  		N.A.  LDD0221  [16]
DBIA
 Probe Info  		C129(0.98)  LDD1507  [17]
ATP probe
 Probe Info  		K105(0.00); K102(0.00); K169(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [19]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [19]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [19]
IPM
 Probe Info  		N.A.  LDD0025  [20]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
NAIA_4
 Probe Info  		N.A.  LDD2226  [21]
WYneC
 Probe Info  		N.A.  LDD0014  [22]
WYneO
 Probe Info  		N.A.  LDD0022  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [23]
ENE
 Probe Info  		N.A.  LDD0006  [22]
NHS
 Probe Info  		N.A.  LDD0010  [22]
OSF
 Probe Info  		N.A.  LDD0029  [24]
PF-06672131
 Probe Info  		N.A.  LDD0017  [25]
SF
 Probe Info  		Y113(0.00); Y164(0.00); K102(0.00)  LDD0028  [24]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
1c-yne
 Probe Info  		K105(0.00); K163(0.00)  LDD0228  [23]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
W1
 Probe Info  		N.A.  LDD0236  [27]
AOyne
 Probe Info  		14.50  LDD0443  [28]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]
TER-AC
 Probe Info  		N.A.  LDD0426  [29]
HHS-482
 Probe Info  		Y113(0.58)  LDD2239  [15]
PAL-AfBPP Probe
Click To Hide/Show 108 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.52  LDD1714  [30]
C022
 Probe Info  		8.17  LDD1728  [30]
C040
 Probe Info  		24.08  LDD1740  [30]
C041
 Probe Info  		6.11  LDD1741  [30]
C053
 Probe Info  		7.01  LDD1751  [30]
C055
 Probe Info  		14.93  LDD1752  [30]
C056
 Probe Info  		31.56  LDD1753  [30]
C063
 Probe Info  		21.86  LDD1760  [30]
C070
 Probe Info  		10.41  LDD1766  [30]
C082
 Probe Info  		5.46  LDD1774  [30]
C087
 Probe Info  		8.22  LDD1779  [30]
C091
 Probe Info  		18.51  LDD1782  [30]
C092
 Probe Info  		35.02  LDD1783  [30]
C094
 Probe Info  		41.36  LDD1785  [30]
C095
 Probe Info  		7.11  LDD1786  [30]
C100
 Probe Info  		8.94  LDD1789  [30]
C106
 Probe Info  		30.70  LDD1793  [30]
C107
 Probe Info  		6.06  LDD1794  [30]
C108
 Probe Info  		9.06  LDD1795  [30]
C112
 Probe Info  		47.18  LDD1799  [30]
C134
 Probe Info  		39.40  LDD1816  [30]
C135
 Probe Info  		11.47  LDD1817  [30]
C141
 Probe Info  		10.70  LDD1823  [30]
C143
 Probe Info  		20.11  LDD1825  [30]
C153
 Probe Info  		28.84  LDD1834  [30]
C158
 Probe Info  		9.45  LDD1838  [30]
C159
 Probe Info  		10.06  LDD1839  [30]
C160
 Probe Info  		8.00  LDD1840  [30]
C161
 Probe Info  		16.80  LDD1841  [30]
C165
 Probe Info  		13.74  LDD1845  [30]
C169
 Probe Info  		34.06  LDD1849  [30]
C187
 Probe Info  		23.59  LDD1865  [30]
C191
 Probe Info  		11.63  LDD1868  [30]
C193
 Probe Info  		6.15  LDD1869  [30]
C196
 Probe Info  		13.93  LDD1872  [30]
C198
 Probe Info  		12.13  LDD1874  [30]
C201
 Probe Info  		48.17  LDD1877  [30]
C206
 Probe Info  		20.82  LDD1881  [30]
C210
 Probe Info  		54.95  LDD1884  [30]
C218
 Probe Info  		26.91  LDD1892  [30]
C219
 Probe Info  		5.17  LDD1893  [30]
C220
 Probe Info  		26.91  LDD1894  [30]
C226
 Probe Info  		9.99  LDD1899  [30]
C228
 Probe Info  		31.56  LDD1901  [30]
C231
 Probe Info  		22.63  LDD1904  [30]
C232
 Probe Info  		35.51  LDD1905  [30]
C234
 Probe Info  		6.63  LDD1907  [30]
C235
 Probe Info  		25.63  LDD1908  [30]
C238
 Probe Info  		16.00  LDD1911  [30]
C243
 Probe Info  		10.93  LDD1916  [30]
C246
 Probe Info  		14.72  LDD1919  [30]
C252
 Probe Info  		11.96  LDD1925  [30]
C264
 Probe Info  		21.26  LDD1935  [30]
C266
 Probe Info  		8.34  LDD1937  [30]
C278
 Probe Info  		74.03  LDD1948  [30]
C282
 Probe Info  		19.84  LDD1952  [30]
C284
 Probe Info  		99.73  LDD1954  [30]
C285
 Probe Info  		32.00  LDD1955  [30]
C287
 Probe Info  		9.32  LDD1957  [30]
C288
 Probe Info  		6.87  LDD1958  [30]
C289
 Probe Info  		49.87  LDD1959  [30]
C293
 Probe Info  		18.64  LDD1963  [30]
C296
 Probe Info  		15.56  LDD1966  [30]
C299
 Probe Info  		8.69  LDD1968  [30]
C305
 Probe Info  		38.32  LDD1974  [30]
C310
 Probe Info  		8.57  LDD1977  [30]
C313
 Probe Info  		14.32  LDD1980  [30]
C314
 Probe Info  		35.75  LDD1981  [30]
C322
 Probe Info  		8.17  LDD1988  [30]
C326
 Probe Info  		7.84  LDD1990  [30]
C338
 Probe Info  		11.55  LDD2001  [30]
C339
 Probe Info  		5.70  LDD2002  [30]
C343
 Probe Info  		15.03  LDD2005  [30]
C348
 Probe Info  		15.56  LDD2009  [30]
C349
 Probe Info  		33.36  LDD2010  [30]
C350
 Probe Info  		77.71  LDD2011  [30]
C353
 Probe Info  		9.06  LDD2014  [30]
C355
 Probe Info  		33.13  LDD2016  [30]
C356
 Probe Info  		8.00  LDD2017  [30]
C362
 Probe Info  		99.73  LDD2023  [30]
C363
 Probe Info  		52.71  LDD2024  [30]
C364
 Probe Info  		29.86  LDD2025  [30]
C366
 Probe Info  		6.36  LDD2027  [30]
C382
 Probe Info  		9.32  LDD2041  [30]
C388
 Probe Info  		84.45  LDD2047  [30]
C390
 Probe Info  		47.84  LDD2049  [30]
C391
 Probe Info  		12.38  LDD2050  [30]
C403
 Probe Info  		18.77  LDD2061  [30]
C407
 Probe Info  		30.48  LDD2064  [30]
C413
 Probe Info  		30.48  LDD2069  [30]
C420
 Probe Info  		13.00  LDD2075  [30]
C424
 Probe Info  		7.46  LDD2079  [30]
C426
 Probe Info  		14.93  LDD2081  [30]
C429
 Probe Info  		12.82  LDD2084  [30]
C431
 Probe Info  		21.71  LDD2086  [30]
FFF probe11
 Probe Info  		20.00  LDD0471  [31]
FFF probe12
 Probe Info  		5.57  LDD0473  [31]
FFF probe13
 Probe Info  		20.00  LDD0475  [31]
FFF probe14
 Probe Info  		16.71  LDD0477  [31]
FFF probe2
 Probe Info  		20.00  LDD0463  [31]
FFF probe3
 Probe Info  		18.00  LDD0464  [31]
FFF probe4
 Probe Info  		14.82  LDD0466  [31]
FFF probe9
 Probe Info  		5.00  LDD0470  [31]
JN0003
 Probe Info  		20.00  LDD0469  [31]
STS-2
 Probe Info  		N.A.  LDD0138  [32]
BD-F
 Probe Info  		Q50(0.00); A52(0.00); D49(0.00); G48(0.00)  LDD0024  [33]
LD-F
 Probe Info  		P51(0.00); D49(0.00); D56(0.00)  LDD0015  [33]
OEA-DA
 Probe Info  		13.67  LDD0046  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C129(0.80)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C129(0.82)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C129(0.73)  LDD2095  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C129(1.33)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C129(0.84)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C129(0.75)  LDD2132  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C129(3.56)  LDD0169  [12]
 LDCM0214  AC1 HEK-293T C129(0.98)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C129(0.91)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C129(0.98)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C129(0.95)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C129(0.93)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C129(0.96)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C129(1.09)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C129(1.01)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C129(0.93)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C129(0.96)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C129(1.05)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C129(1.01)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C129(1.02)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C129(1.07)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C129(1.04)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C129(1.00)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C129(0.89)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C129(0.96)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C129(0.93)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C129(0.91)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C129(0.95)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C129(0.88)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C129(0.95)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C129(1.02)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C129(1.11)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C129(0.99)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C129(1.04)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C129(1.07)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C129(0.88)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C129(0.95)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C129(0.99)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C129(0.91)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C129(0.98)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C129(1.09)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C129(0.88)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C129(1.04)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C129(1.01)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C129(0.89)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C129(0.90)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C129(0.94)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C129(1.04)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C129(1.05)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C129(1.00)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C129(0.93)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C129(1.01)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C129(1.10)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C129(1.06)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C129(1.03)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C129(1.06)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C129(1.04)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C129(1.01)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C129(0.98)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C129(1.02)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C129(0.89)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C129(1.00)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C129(0.92)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C129(0.99)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C129(0.98)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C129(0.97)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C129(0.93)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C129(0.91)  LDD1569  [17]
 LDCM0545  Acetamide MDA-MB-231 C129(0.95)  LDD2138  [7]
 LDCM0248  AKOS034007472 HEK-293T C129(0.98)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C129(0.97)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C129(0.96)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 11.98  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C129(0.93)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C129(0.00); H166(0.00); H165(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C129(7.29); C129(0.88)  LDD2227  [21]
 LDCM0367  CL1 HEK-293T C129(0.89)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C129(0.68)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C129(1.01)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C129(0.97)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C129(0.86)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C129(1.06)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C129(0.92)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C129(1.02)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C129(1.00)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C129(1.10)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C129(1.05)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C129(0.98)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C129(0.76)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C129(0.83)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C129(0.92)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C129(0.86)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C129(1.04)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C129(0.84)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C129(0.92)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C129(1.07)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C129(1.07)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C129(0.93)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C129(0.93)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C129(0.83)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C129(0.98)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C129(1.09)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C129(1.06)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C129(0.96)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C129(0.95)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C129(0.98)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C129(1.02)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C129(1.04)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C129(1.05)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C129(0.94)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C129(0.93)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C129(0.89)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C129(0.97)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C129(0.55)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C129(0.84)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C129(0.96)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C129(0.93)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C129(0.97)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C129(0.82)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C129(0.80)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C129(0.86)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C129(0.86)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C129(1.09)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C129(1.12)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C129(1.06)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C129(0.97)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C129(0.96)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C129(0.84)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C129(0.93)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C129(0.92)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C129(0.91)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C129(0.78)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C129(0.87)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C129(0.91)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C129(0.91)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C129(1.12)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C129(1.17)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C129(0.90)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C129(1.11)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C129(0.93)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C129(0.93)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C129(0.97)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C129(0.82)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C129(0.89)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C129(0.88)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C129(0.89)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C129(1.03)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C129(0.99)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C129(0.85)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C129(1.07)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C129(0.92)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C129(0.82)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C129(0.79)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C129(0.89)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C129(0.85)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C129(0.75)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C129(0.80)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C129(0.84)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C129(0.71)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C129(0.98)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C129(1.11)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C129(1.03)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C129(1.06)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C129(0.87)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C129(1.05)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C129(0.97)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C129(0.90)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C129(0.92)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C129(0.91)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C129(0.90)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C129(0.91)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C129(0.84)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C129(1.11)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C129(0.94)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C129(0.97)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C129(0.96)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C129(0.78)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C129(0.84)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C129(0.89)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C129(0.62)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C129(0.84)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C129(0.93)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C129(0.78)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C129(0.79)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C129(0.81)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C129(1.07)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C129(1.07)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C129(1.03)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C129(1.02)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C129(1.00)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C129(0.72)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C129(0.78)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C129(0.96)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C129(0.96)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C129(0.80)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C129(0.84)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C129(0.75)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C129(0.83)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C129(0.93)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C129(0.91)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C129(0.97)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C129(1.13)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C129(0.93)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C129(1.08)  LDD1631  [17]
 LDCM0116  HHS-0101 DM93 Y113(0.08)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y113(1.23)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y113(0.24)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y113(0.11)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y113(0.10)  LDD0268  [14]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [11]
 LDCM0023  KB03 MDA-MB-231 C129(5.43)  LDD1701  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C129(0.75)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0226  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C129(1.11)  LDD2089  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C129(1.72)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C129(1.42)  LDD2094  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C129(1.17)  LDD2097  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C129(1.14)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C129(0.92)  LDD2104  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C129(0.41)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C129(0.71)  LDD2108  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C129(1.48)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C129(0.71)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C129(0.61)  LDD2115  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C129(1.26)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C129(0.82)  LDD2133  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C129(1.43)  LDD2135  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C129(2.55)  LDD1700  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C129(0.71)  LDD2141  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C129(2.97)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C129(1.87)  LDD2145  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C129(0.83)  LDD2150  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C129(1.95)  LDD2153  [7]
 LDCM0014  Panhematin HEK-293T 3.59  LDD0062  [13]
 LDCM0021  THZ1 HeLa S3 C129(1.12); C129(1.06)  LDD0460  [11]
 LDCM0111  W14 Hep-G2 C129(3.16)  LDD0238  [27]
 LDCM0113  W17 Hep-G2 C129(2.46)  LDD0240  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase GET3 (GET3) ArsA ATPase family O43681
Ferrochelatase, mitochondrial (FECH) Ferrochelatase family P22830
NADPH--cytochrome P450 reductase (POR) NADPH--cytochrome P450 reductase family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family P16435
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (KCNE5) Potassium channel KCNE family Q9UJ90
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) . P49069
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endothelial zinc finger protein induced by tumor necrosis factor alpha (ZNF71) Krueppel C2H2-type zinc-finger protein family Q9NQZ8
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-defensin 124 (DEFB124) Beta-defensin family Q8NES8
Coiled-coil domain-containing protein 134 (CCDC134) CCDC134 family Q9H6E4
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1) WD repeat CIA1 family O76071
Bcl-2-interacting killer (BIK) . Q13323
Protein KASH5 (KASH5) . Q8N6L0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dextromethorphan Small molecular drug DB00514
Nortriptyline Small molecular drug DB00540
Sertraline Small molecular drug DB01104

References

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2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
30 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
33 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
34 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570