General Information of Target

Target ID LDTP00486
Target Name Cytochrome b-c1 complex subunit 8 (UQCRQ)
Gene Name UQCRQ
Gene ID 27089
Synonyms
Cytochrome b-c1 complex subunit 8; Complex III subunit 8; Complex III subunit VIII; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIY
TWGTEEFERSKRKNPAAYENDK
Target Bioclass
Enzyme
Family
UQCRQ/QCR8 family
Subcellular location
Mitochondrion inner membrane
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Uniprot ID
O14949
Ensemble ID
ENST00000378665.1
HGNC ID
HGNC:29594

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info 
Y27(5.43)  LDD0260  [1]
C-Sul
 Probe Info 
6.95  LDD0066  [2]
ONAyne
 Probe Info 
K73(9.09)  LDD0274  [3]
STPyne
 Probe Info 
K33(10.00)  LDD0277  [3]
SAHA-CA-4PAP
 Probe Info 
5.00  LDD0269  [4]
OSF
 Probe Info 
N.A.  LDD0029  [5]
Acrolein
 Probe Info 
N.A.  LDD0217  [6]
Crotonaldehyde
 Probe Info 
N.A.  LDD0219  [6]
PAL-AfBPP Probe
Click To Hide/Show 140 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info 
7.21  LDD1714  [7]
C007
 Probe Info 
5.28  LDD1716  [7]
C017
 Probe Info 
6.73  LDD1725  [7]
C022
 Probe Info 
26.91  LDD1728  [7]
C026
 Probe Info 
5.70  LDD1732  [7]
C039
 Probe Info 
5.31  LDD1739  [7]
C040
 Probe Info 
41.64  LDD1740  [7]
C041
 Probe Info 
18.64  LDD1741  [7]
C049
 Probe Info 
12.04  LDD1747  [7]
C053
 Probe Info 
11.16  LDD1751  [7]
C055
 Probe Info 
63.12  LDD1752  [7]
C056
 Probe Info 
96.34  LDD1753  [7]
C059
 Probe Info 
6.36  LDD1756  [7]
C063
 Probe Info 
36.00  LDD1760  [7]
C064
 Probe Info 
12.30  LDD1761  [7]
C067
 Probe Info 
6.63  LDD1763  [7]
C070
 Probe Info 
25.63  LDD1766  [7]
C072
 Probe Info 
18.25  LDD1768  [7]
C082
 Probe Info 
9.19  LDD1774  [7]
C085
 Probe Info 
8.40  LDD1777  [7]
C087
 Probe Info 
14.12  LDD1779  [7]
C091
 Probe Info 
40.50  LDD1782  [7]
C092
 Probe Info 
81.01  LDD1783  [7]
C094
 Probe Info 
95.01  LDD1785  [7]
C095
 Probe Info 
9.51  LDD1786  [7]
C100
 Probe Info 
10.70  LDD1789  [7]
C106
 Probe Info 
86.82  LDD1793  [7]
C107
 Probe Info 
16.68  LDD1794  [7]
C108
 Probe Info 
24.93  LDD1795  [7]
C112
 Probe Info 
99.73  LDD1799  [7]
C129
 Probe Info 
7.01  LDD1811  [7]
C130
 Probe Info 
17.63  LDD1812  [7]
C134
 Probe Info 
99.73  LDD1816  [7]
C135
 Probe Info 
31.34  LDD1817  [7]
C139
 Probe Info 
23.75  LDD1821  [7]
C140
 Probe Info 
9.78  LDD1822  [7]
C141
 Probe Info 
15.67  LDD1823  [7]
C143
 Probe Info 
99.73  LDD1825  [7]
C153
 Probe Info 
36.76  LDD1834  [7]
C159
 Probe Info 
23.75  LDD1839  [7]
C160
 Probe Info 
24.93  LDD1840  [7]
C161
 Probe Info 
59.30  LDD1841  [7]
C163
 Probe Info 
9.85  LDD1843  [7]
C165
 Probe Info 
15.56  LDD1845  [7]
C166
 Probe Info 
11.96  LDD1846  [7]
C169
 Probe Info 
82.71  LDD1849  [7]
C178
 Probe Info 
26.54  LDD1857  [7]
C186
 Probe Info 
14.62  LDD1864  [7]
C194
 Probe Info 
25.28  LDD1870  [7]
C196
 Probe Info 
24.25  LDD1872  [7]
C198
 Probe Info 
22.01  LDD1874  [7]
C201
 Probe Info 
99.73  LDD1877  [7]
C206
 Probe Info 
99.73  LDD1881  [7]
C207
 Probe Info 
51.63  LDD1882  [7]
C210
 Probe Info 
99.73  LDD1884  [7]
C218
 Probe Info 
31.34  LDD1892  [7]
C219
 Probe Info 
7.46  LDD1893  [7]
C220
 Probe Info 
41.64  LDD1894  [7]
C225
 Probe Info 
9.19  LDD1898  [7]
C226
 Probe Info 
9.32  LDD1899  [7]
C228
 Probe Info 
57.28  LDD1901  [7]
C229
 Probe Info 
13.64  LDD1902  [7]
C231
 Probe Info 
84.45  LDD1904  [7]
C232
 Probe Info 
99.73  LDD1905  [7]
C233
 Probe Info 
23.75  LDD1906  [7]
C234
 Probe Info 
15.67  LDD1907  [7]
C235
 Probe Info 
87.43  LDD1908  [7]
C238
 Probe Info 
56.89  LDD1911  [7]
C240
 Probe Info 
14.83  LDD1913  [7]
C243
 Probe Info 
29.45  LDD1916  [7]
C244
 Probe Info 
16.91  LDD1917  [7]
C246
 Probe Info 
50.21  LDD1919  [7]
C249
 Probe Info 
14.72  LDD1922  [7]
C252
 Probe Info 
31.12  LDD1925  [7]
C264
 Probe Info 
41.36  LDD1935  [7]
C265
 Probe Info 
30.70  LDD1936  [7]
C270
 Probe Info 
11.39  LDD1940  [7]
C273
 Probe Info 
14.32  LDD1943  [7]
C277
 Probe Info 
17.39  LDD1947  [7]
C278
 Probe Info 
99.73  LDD1948  [7]
C280
 Probe Info 
15.89  LDD1950  [7]
C282
 Probe Info 
75.58  LDD1952  [7]
C284
 Probe Info 
67.65  LDD1954  [7]
C285
 Probe Info 
92.41  LDD1955  [7]
C287
 Probe Info 
30.06  LDD1957  [7]
C288
 Probe Info 
22.01  LDD1958  [7]
C289
 Probe Info 
99.73  LDD1959  [7]
C290
 Probe Info 
6.92  LDD1960  [7]
C293
 Probe Info 
54.95  LDD1963  [7]
C296
 Probe Info 
24.93  LDD1966  [7]
C299
 Probe Info 
17.27  LDD1968  [7]
C304
 Probe Info 
8.06  LDD1973  [7]
C305
 Probe Info 
22.32  LDD1974  [7]
C310
 Probe Info 
23.75  LDD1977  [7]
C313
 Probe Info 
14.83  LDD1980  [7]
C314
 Probe Info 
21.26  LDD1981  [7]
C322
 Probe Info 
10.41  LDD1988  [7]
C326
 Probe Info 
12.38  LDD1990  [7]
C338
 Probe Info 
15.56  LDD2001  [7]
C339
 Probe Info 
12.21  LDD2002  [7]
C343
 Probe Info 
37.27  LDD2005  [7]
C346
 Probe Info 
11.47  LDD2007  [7]
C348
 Probe Info 
20.11  LDD2009  [7]
C349
 Probe Info 
47.18  LDD2010  [7]
C350
 Probe Info 
99.73  LDD2011  [7]
C353
 Probe Info 
7.16  LDD2014  [7]
C354
 Probe Info 
8.40  LDD2015  [7]
C355
 Probe Info 
39.95  LDD2016  [7]
C356
 Probe Info 
13.09  LDD2017  [7]
C357
 Probe Info 
6.36  LDD2018  [7]
C373
 Probe Info 
5.46  LDD2033  [7]
C376
 Probe Info 
16.80  LDD2036  [7]
C378
 Probe Info 
8.94  LDD2037  [7]
C380
 Probe Info 
6.73  LDD2039  [7]
C382
 Probe Info 
26.54  LDD2041  [7]
C383
 Probe Info 
11.88  LDD2042  [7]
C386
 Probe Info 
8.63  LDD2045  [7]
C388
 Probe Info 
99.73  LDD2047  [7]
C390
 Probe Info 
99.73  LDD2049  [7]
C391
 Probe Info 
23.10  LDD2050  [7]
C399
 Probe Info 
12.30  LDD2058  [7]
C403
 Probe Info 
60.13  LDD2061  [7]
C405
 Probe Info 
5.28  LDD2063  [7]
C407
 Probe Info 
40.79  LDD2064  [7]
C409
 Probe Info 
5.50  LDD2066  [7]
C413
 Probe Info 
19.70  LDD2069  [7]
C419
 Probe Info 
12.30  LDD2074  [7]
C420
 Probe Info 
10.56  LDD2075  [7]
C424
 Probe Info 
8.94  LDD2079  [7]
C426
 Probe Info 
22.01  LDD2081  [7]
C429
 Probe Info 
28.44  LDD2084  [7]
C431
 Probe Info 
63.56  LDD2086  [7]
FFF probe11
 Probe Info 
20.00  LDD0471  [8]
FFF probe13
 Probe Info 
20.00  LDD0475  [8]
FFF probe14
 Probe Info 
20.00  LDD0477  [8]
FFF probe15
 Probe Info 
7.54  LDD0478  [8]
FFF probe2
 Probe Info 
20.00  LDD0463  [8]
FFF probe3
 Probe Info 
17.49  LDD0464  [8]
BD-F
 Probe Info 
L58(0.00); T61(0.00); I59(0.00); F56(0.00)  LDD0024  [9]
OEA-DA
 Probe Info 
7.57  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0096  SAHA K562 5.00  LDD0269  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-nonyl-4-quinolinol 1-oxide Small molecular drug DB08453
6-hydroxy-5-undecyl-47-benzothiazoledione Small molecular drug DB04799
Ubiquinone Q2 Small molecular drug DB08690
(5s)-3-anilino-5-(24-difluorophenyl)-5-methyl-13-oxazolidine-24-dione . DB07763
(S)-famoxadone . DB07778
2-hexyloxy-6-hydroxymethyl-tetrahydro-pyran-345-triol . DB04141
Azoxystrobin . DB07401
Methyl (2z)-3-methoxy-2-{2-[(E)-2-phenylvinyl]Phenyl}Acrylate . DB08330

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570