Details of the Target
General Information of Target
Target ID | LDTP00486 | |||||
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Target Name | Cytochrome b-c1 complex subunit 8 (UQCRQ) | |||||
Gene Name | UQCRQ | |||||
Gene ID | 27089 | |||||
Synonyms |
Cytochrome b-c1 complex subunit 8; Complex III subunit 8; Complex III subunit VIII; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
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3D Structure | ||||||
Sequence |
MGREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIY
TWGTEEFERSKRKNPAAYENDK |
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Target Bioclass |
Enzyme
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Family |
UQCRQ/QCR8 family
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Subcellular location |
Mitochondrion inner membrane
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Function |
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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TH211 Probe Info |
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Y27(5.43) | LDD0260 | [1] | |
C-Sul Probe Info |
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6.95 | LDD0066 | [2] | |
ONAyne Probe Info |
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K73(9.09) | LDD0274 | [3] | |
STPyne Probe Info |
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K33(10.00) | LDD0277 | [3] | |
SAHA-CA-4PAP Probe Info |
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5.00 | LDD0269 | [4] | |
OSF Probe Info |
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N.A. | LDD0029 | [5] | |
Acrolein Probe Info |
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N.A. | LDD0217 | [6] | |
Crotonaldehyde Probe Info |
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N.A. | LDD0219 | [6] |
PAL-AfBPP Probe
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Drug(s) Related To This Target
Investigative
References