Details of the Target

General Information of Target

Target ID LDTP05006
Target Name Ras-related protein Rab-1A (RAB1A)
Gene Name RAB1A
Gene ID 5861
Synonyms
RAB1; Ras-related protein Rab-1A; EC 3.6.5.2; YPT1-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI
KLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKL
LVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGA
TAGGAEKSNVKIQSTPVKQSGGGCC
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Golgi apparatus
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Required to modulate the compacted morphology of the Golgi. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
Uniprot ID
P62820
Ensemble ID
ENST00000398529.7
HGNC ID
HGNC:9758
ChEMBL ID
CHEMBL3879826

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.P178S .
MFE319 SNV: p.S20P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.52  LDD0402  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
C-Sul
 Probe Info  		2.20  LDD0066  [3]
TH211
 Probe Info  		Y112(20.00)  LDD0257  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
AZ-9
 Probe Info  		E54(1.09)  LDD2208  [6]
OPA-S-S-alkyne
 Probe Info  		K61(2.00)  LDD3494  [7]
Probe 1
 Probe Info  		Y80(213.95); Y136(98.83)  LDD3495  [8]
BTD
 Probe Info  		C126(1.30)  LDD1700  [9]
HHS-475
 Probe Info  		Y112(1.03)  LDD0264  [10]
DBIA
 Probe Info  		C205(1.20)  LDD0531  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		K58(0.00); K191(0.00); K61(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [14]
ATP probe
 Probe Info  		K132(0.00); K187(0.00)  LDD0035  [16]
IPM
 Probe Info  		C126(0.00); C26(0.00)  LDD0025  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
TFBX
 Probe Info  		C26(0.00); C126(0.00)  LDD0027  [17]
WYneC
 Probe Info  		N.A.  LDD0014  [18]
WYneN
 Probe Info  		C126(0.00); C26(0.00)  LDD0021  [18]
NHS
 Probe Info  		K191(0.00); K61(0.00); K187(0.00)  LDD0010  [18]
PF-06672131
 Probe Info  		N.A.  LDD0152  [19]
SF
 Probe Info  		Y81(0.00); Y112(0.00); Y80(0.00)  LDD0028  [20]
STPyne
 Probe Info  		K191(0.00); K61(0.00)  LDD0009  [18]
Phosphinate-6
 Probe Info  		C26(0.00); C126(0.00)  LDD0018  [21]
Acrolein
 Probe Info  		N.A.  LDD0217  [22]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [22]
AOyne
 Probe Info  		4.70  LDD0443  [23]
MPP-AC
 Probe Info  		N.A.  LDD0428  [24]
NAIA_5
 Probe Info  		C126(0.00); C26(0.00)  LDD2223  [25]
HHS-465
 Probe Info  		N.A.  LDD2240  [26]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C092
 Probe Info  		18.51  LDD1783  [27]
C094
 Probe Info  		32.00  LDD1785  [27]
C187
 Probe Info  		99.73  LDD1865  [27]
C191
 Probe Info  		99.73  LDD1868  [27]
C193
 Probe Info  		60.55  LDD1869  [27]
C228
 Probe Info  		15.56  LDD1901  [27]
C231
 Probe Info  		13.18  LDD1904  [27]
C232
 Probe Info  		41.36  LDD1905  [27]
C235
 Probe Info  		31.56  LDD1908  [27]
C289
 Probe Info  		26.54  LDD1959  [27]
C310
 Probe Info  		7.67  LDD1977  [27]
C362
 Probe Info  		26.17  LDD2023  [27]
FFF probe11
 Probe Info  		6.90  LDD0471  [28]
FFF probe13
 Probe Info  		10.67  LDD0475  [28]
FFF probe14
 Probe Info  		12.10  LDD0477  [28]
FFF probe2
 Probe Info  		13.02  LDD0463  [28]
FFF probe3
 Probe Info  		20.00  LDD0464  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [29]
Staurosporine capture compound
 Probe Info  		2.14  LDD0083  [30]
OEA-DA
 Probe Info  		4.32  LDD0046  [31]
STS-1
 Probe Info  		N.A.  LDD0068  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C126(0.61)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C126(0.70)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C126(0.69)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C126(0.86)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C126(0.75)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C126(1.19)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C126(1.02)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C126(0.51)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C126(0.67)  LDD2131  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C126(3.09)  LDD0372  [33]
 LDCM0214  AC1 HCT 116 C205(1.20)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C204(0.91); C205(1.79)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C204(1.01)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C204(1.12)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C204(0.97)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C204(1.12)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C204(1.10)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C204(1.13)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C204(1.01)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C204(1.32)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C204(0.85)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C204(0.90)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C204(0.81); C205(1.53)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C204(0.90)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C204(0.87)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C204(1.16)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C205(0.92)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C205(1.69)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C205(1.24)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C205(1.54)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C205(1.20)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C205(1.02)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C205(1.39)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C204(0.95); C205(1.09)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C205(1.18)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C205(1.12)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C205(1.03)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C205(1.03)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C205(1.01)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C205(1.13)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C205(1.59)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C205(1.35)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C205(1.22)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C205(0.90)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C205(1.08)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C205(0.88)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C205(0.78)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C205(0.92)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C205(1.22)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C205(1.12)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C205(1.23)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C205(1.02)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C205(0.81)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C205(1.30)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C204(0.97); C205(1.19)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C205(1.41)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C205(0.99)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C205(1.15)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C204(1.18)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C204(1.45)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C204(1.22)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C204(1.54)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C204(1.86)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C204(2.05)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C204(1.57)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C204(1.06); C205(1.09)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C204(1.28)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C204(1.20)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C204(1.42)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C204(2.34)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C204(1.68)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C204(1.60)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C204(1.42)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C204(1.42)  LDD2161  [11]
 LDCM0277  AC18 HEK-293T C126(1.27)  LDD1516  [34]
 LDCM0278  AC19 HEK-293T C126(1.11)  LDD1517  [34]
 LDCM0279  AC2 HCT 116 C205(1.10)  LDD0596  [11]
 LDCM0281  AC21 HEK-293T C126(0.96)  LDD1520  [34]
 LDCM0282  AC22 HEK-293T C126(1.01)  LDD1521  [34]
 LDCM0283  AC23 HEK-293T C126(0.96)  LDD1522  [34]
 LDCM0284  AC24 HEK-293T C126(0.88)  LDD1523  [34]
 LDCM0285  AC25 HEK-293T C205(1.21)  LDD0883  [11]
 LDCM0286  AC26 HEK-293T C205(1.31)  LDD0884  [11]
 LDCM0287  AC27 HEK-293T C205(1.19)  LDD0885  [11]
 LDCM0288  AC28 HEK-293T C205(1.25)  LDD0886  [11]
 LDCM0289  AC29 HEK-293T C205(1.23)  LDD0887  [11]
 LDCM0290  AC3 HCT 116 C205(1.19)  LDD0607  [11]
 LDCM0291  AC30 HEK-293T C205(1.19)  LDD0889  [11]
 LDCM0292  AC31 HEK-293T C205(0.95)  LDD0890  [11]
 LDCM0293  AC32 HEK-293T C205(1.26)  LDD0891  [11]
 LDCM0294  AC33 HEK-293T C205(1.23)  LDD0892  [11]
 LDCM0295  AC34 HEK-293T C205(1.27)  LDD0893  [11]
 LDCM0296  AC35 HEK-293T C126(0.98)  LDD1535  [34]
 LDCM0298  AC37 HEK-293T C126(1.01)  LDD1537  [34]
 LDCM0299  AC38 HEK-293T C126(1.00)  LDD1538  [34]
 LDCM0300  AC39 HEK-293T C126(0.77)  LDD1539  [34]
 LDCM0301  AC4 HCT 116 C205(1.35)  LDD0618  [11]
 LDCM0302  AC40 HEK-293T C126(0.83)  LDD1541  [34]
 LDCM0304  AC42 HEK-293T C126(1.35)  LDD1543  [34]
 LDCM0305  AC43 HEK-293T C126(0.91)  LDD1544  [34]
 LDCM0307  AC45 HEK-293T C126(1.05)  LDD1546  [34]
 LDCM0308  AC46 HCT 116 C205(0.90)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C205(0.80)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C205(1.19)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C205(1.41)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C205(1.29)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C205(1.50)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C205(0.85)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C205(0.80)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C205(1.49)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C205(1.27)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C205(1.49)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C205(1.63)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C205(1.51)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C205(1.33)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C205(1.36)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C205(1.02); C204(1.07)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C205(1.33)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C205(1.49)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C205(1.60)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C205(1.18)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C205(1.76)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C205(1.35)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C205(1.19)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C205(1.63)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C204(1.28)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C204(1.19)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C205(0.98); C204(1.09)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C204(1.67)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C204(1.12)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C204(1.48)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C204(1.37)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C204(1.01)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C204(1.34)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C204(1.26)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C204(0.98)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C204(1.10)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C204(1.42)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C205(0.98); C204(1.01)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C204(0.83)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C204(1.48)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C204(1.13)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C205(1.19)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C205(1.38)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C205(1.49)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C205(1.14)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C205(1.16)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C205(1.18)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C205(1.17)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C205(1.35)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C205(1.01)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C205(1.24)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C205(1.32)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C205(0.96)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C205(1.29)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C205(0.95)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C205(1.44)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C204(2.40)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C204(0.89)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C126(0.33)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C126(0.71)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C204(0.97); C205(1.11)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C204(0.94); C205(1.08)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C204(1.13); C205(2.08)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.58  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C204(1.08)  LDD2171  [11]
 LDCM0498  BS-3668 MDA-MB-231 C126(0.45)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C126(0.47)  LDD2227  [25]
 LDCM0368  CL10 HEK-293T C126(0.24)  LDD1572  [34]
 LDCM0369  CL100 HCT 116 C205(1.07)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C205(1.01); C204(1.06)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C204(1.00); C205(1.10)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C204(0.74); C205(1.01)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C204(0.84); C205(0.92)  LDD0690  [11]
 LDCM0377  CL108 HEK-293T C126(1.20)  LDD1581  [34]
 LDCM0379  CL11 HEK-293T C126(0.11)  LDD1583  [34]
 LDCM0382  CL112 HEK-293T C205(1.43)  LDD0980  [11]
 LDCM0383  CL113 HEK-293T C205(1.28)  LDD0981  [11]
 LDCM0384  CL114 HEK-293T C205(1.84)  LDD0982  [11]
 LDCM0385  CL115 HEK-293T C205(1.49)  LDD0983  [11]
 LDCM0386  CL116 HEK-293T C205(1.47)  LDD0984  [11]
 LDCM0390  CL12 HEK-293T C126(0.13)  LDD1594  [34]
 LDCM0391  CL120 HEK-293T C126(1.28)  LDD1595  [34]
 LDCM0392  CL121 HCT 116 C205(0.52)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C205(1.12)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C205(1.34)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C205(0.95)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C205(0.93)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C205(0.96)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C205(0.79)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C205(1.51)  LDD0716  [11]
 LDCM0403  CL16 HCT 116 C204(0.96)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C204(0.12)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C204(0.86)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C204(2.14)  LDD0723  [11]
 LDCM0408  CL20 HCT 116 C204(1.15)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C204(1.05)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C204(0.87)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C204(0.89)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C204(1.04)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C204(0.96)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C204(1.20)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C204(0.94)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C204(1.02)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C204(1.10)  LDD0734  [11]
 LDCM0419  CL30 HCT 116 C204(1.03)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C204(1.04); C205(0.84)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C204(1.04); C205(0.84)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C204(1.27); C205(1.01)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C204(1.21); C205(0.95)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C204(1.13); C205(1.05)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C204(0.95); C205(1.08)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C204(1.00); C205(0.96)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C204(1.35); C205(0.86)  LDD0745  [11]
 LDCM0429  CL4 HEK-293T C126(0.96)  LDD1633  [34]
 LDCM0430  CL40 HCT 116 C204(1.00); C205(0.59)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C204(1.12); C205(0.70)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C204(0.67); C205(0.66)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C204(0.95); C205(0.73)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C204(0.87); C205(0.78)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C204(0.97); C205(0.88)  LDD0752  [11]
 LDCM0436  CL46 HEK-293T C205(1.34)  LDD1034  [11]
 LDCM0437  CL47 HEK-293T C205(1.16)  LDD1035  [11]
 LDCM0438  CL48 HEK-293T C205(1.20)  LDD1036  [11]
 LDCM0439  CL49 HEK-293T C205(1.11)  LDD1037  [11]
 LDCM0441  CL50 HEK-293T C205(1.44)  LDD1039  [11]
 LDCM0442  CL51 HEK-293T C205(1.19)  LDD1040  [11]
 LDCM0443  CL52 HEK-293T C205(0.89)  LDD1041  [11]
 LDCM0444  CL53 HEK-293T C205(0.99)  LDD1042  [11]
 LDCM0445  CL54 HEK-293T C205(1.23)  LDD1043  [11]
 LDCM0446  CL55 HEK-293T C205(1.27)  LDD1044  [11]
 LDCM0447  CL56 HEK-293T C205(1.14)  LDD1045  [11]
 LDCM0448  CL57 HEK-293T C205(1.18)  LDD1046  [11]
 LDCM0449  CL58 HEK-293T C205(0.95)  LDD1047  [11]
 LDCM0450  CL59 HEK-293T C205(1.35)  LDD1048  [11]
 LDCM0451  CL6 HEK-293T C126(0.58)  LDD1654  [34]
 LDCM0452  CL60 HEK-293T C205(1.55)  LDD1050  [11]
 LDCM0453  CL61 HCT 116 C205(0.68)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C205(1.30)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C205(1.01)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C205(0.70)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C205(0.66)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C205(1.19)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C205(0.93)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C205(1.31)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C205(0.84)  LDD0778  [11]
 LDCM0462  CL7 HEK-293T C126(0.42)  LDD1665  [34]
 LDCM0463  CL70 HCT 116 C205(0.77)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C205(1.23)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C205(1.18)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C205(1.12)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C205(1.04)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C205(1.03)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C205(1.01)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C205(1.02)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C205(1.30)  LDD0789  [11]
 LDCM0474  CL80 HCT 116 C205(0.99)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C205(1.02)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C205(1.14)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C205(1.04)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C205(1.28)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C205(1.03)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C205(0.81)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C205(0.95)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C205(1.38)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C205(1.98)  LDD0800  [11]
 LDCM0484  CL9 HEK-293T C126(0.25)  LDD1687  [34]
 LDCM0485  CL90 HCT 116 C205(0.35)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C205(1.13)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C205(1.00)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C205(1.08)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C205(1.26)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C205(1.09)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C205(1.11)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C205(0.94)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C205(1.20)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C205(1.27)  LDD0811  [11]
 LDCM0625  F8 Ramos C126(0.89)  LDD2187  [35]
 LDCM0572  Fragment10 Ramos C126(0.80)  LDD2189  [35]
 LDCM0573  Fragment11 Ramos C126(0.01)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C126(0.79)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C126(0.99)  LDD2192  [35]
 LDCM0576  Fragment14 Ramos C126(1.16)  LDD2193  [35]
 LDCM0579  Fragment20 Ramos C126(0.71)  LDD2194  [35]
 LDCM0580  Fragment21 Ramos C126(0.81)  LDD2195  [35]
 LDCM0582  Fragment23 Ramos C126(0.45)  LDD2196  [35]
 LDCM0578  Fragment27 Ramos C126(0.95)  LDD2197  [35]
 LDCM0586  Fragment28 Ramos C126(0.64)  LDD2198  [35]
 LDCM0588  Fragment30 Ramos C126(1.14)  LDD2199  [35]
 LDCM0589  Fragment31 Ramos C126(1.09)  LDD2200  [35]
 LDCM0590  Fragment32 Ramos C126(0.98)  LDD2201  [35]
 LDCM0468  Fragment33 HCT 116 C205(1.01)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C126(1.08)  LDD2203  [35]
 LDCM0566  Fragment4 Ramos C126(0.88)  LDD2184  [35]
 LDCM0427  Fragment51 HCT 116 C204(0.92); C205(1.26)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C126(1.05)  LDD2204  [35]
 LDCM0614  Fragment56 Ramos C126(1.14)  LDD2205  [35]
 LDCM0569  Fragment7 Ramos C126(0.75)  LDD2186  [35]
 LDCM0571  Fragment9 Ramos C126(0.69)  LDD2188  [35]
 LDCM0116  HHS-0101 DM93 Y112(1.03)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y112(1.06)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y112(0.98)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y112(1.25)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y112(0.82)  LDD0268  [10]
 LDCM0022  KB02 HEK-293T C26(1.05)  LDD1492  [34]
 LDCM0023  KB03 HEK-293T C26(0.91)  LDD1497  [34]
 LDCM0024  KB05 HEK-293T C26(0.94)  LDD1502  [34]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C126(1.20)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C126(0.54)  LDD2121  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C126(0.48)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C126(1.53)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C126(0.98)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C126(0.95)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C126(1.49)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C126(0.29)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C126(0.78)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C126(0.63)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C126(0.78)  LDD2099  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C126(0.93)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C126(0.80)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C126(1.65)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C126(0.79)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C126(0.82)  LDD2107  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C126(0.72)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C126(2.14)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C126(0.86)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C126(1.04)  LDD2114  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C126(0.43)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C126(0.80)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C126(2.21)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C126(0.95)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C126(0.40)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C126(0.80)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C126(0.38)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C126(0.68)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C126(0.86)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C126(1.10)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C126(0.90)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C126(0.62)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C126(0.50)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C126(0.95)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C126(1.17)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C126(0.94)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C126(1.30)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C126(0.60)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C126(0.45)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C126(1.11)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C126(3.40)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C126(0.72)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C126(3.11)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C126(0.56)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C126(0.47)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C126(0.38)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C126(0.42)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C126(1.55)  LDD2153  [9]
 LDCM0019  Staurosporine Hep-G2 2.14  LDD0083  [30]
 LDCM0021  THZ1 HCT 116 C204(1.08)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inositol polyphosphate 5-phosphatase OCRL (OCRL) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q01968
Serine/threonine-protein kinase mTOR (MTOR) PI3/PI4-kinase family P42345
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide exchange factor MSS4 (RABIF) DSS4/MSS4 family P47224
Rab GDP dissociation inhibitor alpha (GDI1) Rab GDI family P31150
Rab GDP dissociation inhibitor beta (GDI2) Rab GDI family P50395
Regulatory-associated protein of mTOR (RPTOR) WD repeat RAPTOR family Q8N122

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
31 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
32 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
33 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578