Details of the Target

General Information of Target

Target ID LDTP04892
Target Name Ras-related protein Rab-2A (RAB2A)
Gene Name RAB2A
Gene ID 5862
Synonyms
RAB2; Ras-related protein Rab-2A; EC 3.6.5.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIW
DTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNK
SDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINN
EANGIKIGPQHAATNATHAGNQGGQQAGGGCC
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi.
Uniprot ID
P61019
Ensemble ID
ENST00000262646.12
HGNC ID
HGNC:9763
ChEMBL ID
CHEMBL4105893

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE410 SNV: p.S74L .
SKOV3 SNV: p.Y9H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.14  LDD0402  [1]
STPyne
 Probe Info  		K165(8.91); K56(6.53)  LDD0277  [2]
AZ-9
 Probe Info  		E66(0.76); E173(1.12)  LDD2208  [3]
IPM
 Probe Info  		C21(3.40)  LDD2230  [4]
OPA-S-S-alkyne
 Probe Info  		K130(1.45); K131(1.70)  LDD3494  [5]
MCL-4
 Probe Info  		7.00  LDD0049  [6]
HPAP
 Probe Info  		3.72  LDD0062  [7]
DBIA
 Probe Info  		C21(0.83); C212(0.91)  LDD0531  [8]
5E-2FA
 Probe Info  		H141(0.00); H35(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K29(0.00); K53(0.00); K56(0.00)  LDD0199  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
Ox-W18
 Probe Info  		N.A.  LDD2175  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		C21(0.00); H141(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
MPP-AC
 Probe Info  		N.A.  LDD0428  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
TER-AC
 Probe Info  		N.A.  LDD0426  [16]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		2.05  LDD0398  [18]
C040
 Probe Info  		7.46  LDD1740  [19]
C228
 Probe Info  		16.45  LDD1901  [19]
C232
 Probe Info  		38.85  LDD1905  [19]
C235
 Probe Info  		28.25  LDD1908  [19]
C349
 Probe Info  		8.51  LDD2010  [19]
C362
 Probe Info  		27.47  LDD2023  [19]
FFF probe11
 Probe Info  		15.44  LDD0471  [20]
FFF probe13
 Probe Info  		17.09  LDD0475  [20]
FFF probe14
 Probe Info  		14.68  LDD0477  [20]
FFF probe2
 Probe Info  		13.30  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
JN0003
 Probe Info  		20.00  LDD0469  [20]
OEA-DA
 Probe Info  		4.75  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C21(0.83); C212(0.91)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C21(1.08)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C21(0.68)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C21(0.66)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C21(0.69)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C21(0.67)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C21(0.72)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C21(0.66)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C21(0.70)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C21(0.73)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C21(0.73)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C21(0.71)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C21(1.05)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C21(0.76)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C21(0.65)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C21(0.71)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C212(1.20)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C212(1.08)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C212(0.95)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C212(1.09)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C212(1.09)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C212(1.35)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C212(1.18)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C21(1.13)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C212(1.02)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C212(1.23)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C212(1.33)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C212(1.04)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C212(0.72)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C212(1.23)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C212(1.23)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C212(0.86)  LDD0562  [8]
 LDCM0259  AC14 HCT 116 C21(1.09)  LDD0576  [8]
 LDCM0270  AC15 HCT 116 C21(1.07)  LDD0587  [8]
 LDCM0276  AC17 HCT 116 C21(1.05); C212(1.21)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C212(1.19); C21(1.33)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C212(1.37); C21(1.49)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C21(1.04); C212(1.14)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C212(1.14); C21(1.24)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C21(1.02); C212(1.29)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C21(1.03); C212(1.22)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C21(1.04); C212(1.45)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C212(0.81); C21(1.22)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C21(1.02)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C21(0.99)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C21(1.08)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C21(0.96)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C21(0.97)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C21(0.94); C212(0.96)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C21(1.03)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C21(0.98)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C21(0.94)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C21(0.92)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C21(0.94)  LDD0612  [8]
 LDCM0301  AC4 HCT 116 C212(0.83); C21(0.93)  LDD0618  [8]
 LDCM0308  AC46 HCT 116 C21(1.05); C212(2.57)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C21(0.94); C212(1.69)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C21(0.81); C212(1.66)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C21(0.70); C212(1.23)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C21(0.87); C212(0.90)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C21(0.80); C212(1.93)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C21(0.90); C212(1.56)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C21(0.80); C212(2.05)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C21(0.92); C212(1.73)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C21(0.79); C212(0.94)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C21(0.74); C212(0.99)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C21(0.62); C212(0.96)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C212(0.70)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C212(0.77)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C212(0.92)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C21(1.06)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C212(1.13)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C212(0.66)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C212(0.92)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C212(1.10)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C212(0.88)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C212(1.03)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C212(0.66)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C212(0.93)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C21(1.05)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C21(1.01)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C21(1.07)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C21(0.96)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C21(1.18)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C21(1.06)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C21(0.89)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C21(1.08)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C21(0.88)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C21(1.53)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C21(1.39)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C21(1.00)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C21(1.33)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C21(1.10)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C21(1.11)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C21(1.30)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C21(0.58)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C212(1.05)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C212(1.54)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C212(1.68)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C212(1.26)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C212(1.23)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C212(1.03)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C212(1.12)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C212(1.53)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C212(1.34)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C212(1.43)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C212(1.57)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C212(1.81)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C212(1.36)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C212(2.33)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C212(1.22)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C21(0.28)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C21(0.76)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C21(1.19)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C21(1.13)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C21(1.02)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.36  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H141(0.00); C21(0.00); H96(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C212(0.92); C21(0.93)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C212(0.82); C21(0.86)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C21(0.90); C212(1.15)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C21(1.12)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C21(1.14)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C21(0.99)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C21(1.02)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C212(0.91); C21(1.20)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C21(0.94); C212(1.13)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C21(1.05); C212(1.15)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C212(0.79); C21(1.15)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C212(0.84); C21(1.05)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C212(0.69); C21(0.87)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C212(0.70); C21(1.14)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C21(1.06); C212(1.17)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C21(1.06)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C21(0.94)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C21(0.85)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C21(0.97)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C21(1.05)  LDD0703  [8]
 LDCM0390  CL12 HCT 116 C21(0.85); C212(0.86)  LDD0707  [8]
 LDCM0392  CL121 HCT 116 C21(0.75); C212(1.54)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C21(0.90); C212(2.18)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C21(0.95); C212(2.12)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C21(0.94); C212(1.21)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C212(0.85)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C212(0.97)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C212(0.78)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C212(0.78)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C21(0.90); C212(0.93)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C212(0.78); C21(0.91)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C21(0.56); C212(0.95)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C21(0.93)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C21(0.89)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C21(0.87)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C21(1.02)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C212(0.91); C21(1.13)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C21(0.99)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C21(0.86)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C21(0.70)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C21(1.09)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C21(0.95)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C21(1.09)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C21(1.05)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C21(1.09)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C21(0.98)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C21(1.08)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C21(1.06); C212(0.69)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C21(1.13)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C21(0.81)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C21(0.72)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C21(0.73)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C21(0.65)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C21(0.67)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C21(0.80)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C21(0.70)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C21(0.79)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C21(1.00); C212(0.93)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C21(0.81)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C21(0.86)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C21(0.49)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C21(0.59)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C21(0.64)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C21(0.62)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C21(1.14)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C21(1.13)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C21(1.03)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C21(1.05)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C21(1.00); C212(1.03)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C21(1.05)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C21(1.08)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C21(1.14)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C21(0.92)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C21(0.99)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C21(1.05)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C21(1.06)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C21(1.05)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C21(1.11)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C21(1.02)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C21(0.86); C212(1.52)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C21(1.01)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C21(1.00)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C21(1.01)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C21(1.03)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C21(0.96)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C21(1.06)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C21(1.02)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C21(0.96)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C21(0.88)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C21(0.82)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C21(0.99); C212(1.48)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C21(0.97)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C21(0.96)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C21(1.03)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C21(0.95)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C21(0.91)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C21(0.83)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C21(0.75)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C21(0.89)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C21(0.89)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C21(0.89); C212(0.81)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C21(0.82)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C21(0.88)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C21(0.78)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C21(0.89)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C21(0.70)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C21(0.94)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C21(1.00)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C21(0.93)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C21(0.84)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C21(0.58)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C21(0.96); C212(1.69)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C21(0.83)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C21(0.91); C212(1.49)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C21(0.86); C212(1.20)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C21(0.83); C212(1.02)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C21(0.87); C212(0.89)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C21(0.86); C212(1.57)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C21(0.89); C212(1.42)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C21(0.95); C212(1.23)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C21(1.00); C212(1.14)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C21(0.97); C212(1.05)  LDD0811  [8]
 LDCM0468  Fragment33 HCT 116 C21(1.00)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C21(0.57)  LDD0744  [8]
 LDCM0107  IAA HeLa H96(0.00); H141(0.00)  LDD0221  [15]
 LDCM0006  Micheliolide M9-ENL1 7.00  LDD0049  [6]
 LDCM0109  NEM HeLa H141(0.00); H96(0.00)  LDD0223  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C21(0.17)  LDD2207  [22]
 LDCM0014  Panhematin HEK-293T 3.72  LDD0062  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AMSH-like protease (STAMBPL1) Peptidase M67C family Q96FJ0
E3 ubiquitin-protein ligase TRIM7 (TRIM7) TRIM/RBCC family Q9C029
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 70, mitochondrial (TMEM70) TMEM70 family Q9BUB7
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin-45 (BLZF1) . Q9H2G9
Transcription cofactor HES-6 (HES6) . Q96HZ4
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cofilin-2 (CFL2) Actin-binding proteins ADF family Q9Y281
Protein FAM114A2 (FAM114A2) FAM114 family Q9NRY5
Protein NOXP20 (FAM114A1) FAM114 family Q8IWE2
Golgi-associated RAB2 interactor protein 4 (GARIN4) GARIN family Q8IYT1
Golgi-associated RAB2 interactor protein 6 (GARIN6) GARIN family Q8NEG0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
FERM domain-containing protein 1 (FRMD1) . Q8N878
Islet cell autoantigen 1 (ICA1) . Q05084
TBC1 domain family member 25 (TBC1D25) . Q3MII6

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.