Details of the Target

General Information of Target

Target ID LDTP14200
Target Name Mitochondrial ornithine transporter 1 (SLC25A15)
Gene Name SLC25A15
Gene ID 10166
Synonyms
ORC1; ORNT1; Mitochondrial ornithine transporter 1; Solute carrier family 25 member 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ
PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP
SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA
AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ
RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG
LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM
KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK
SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN
DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ
SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ
NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE
AEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP
GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG
EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS
GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP
LDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR
GKSRSPAPPADKEAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPP
GHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEH
AKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTAL
GSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGRE
DSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGR
AISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKR
EGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELP
LAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALE
RACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPV
TTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSG
VDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALE
NRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHL
PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR
DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPI
SPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGG
TLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRP
LVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGY
HGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHL
PHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPL
YSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIE
PVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMV
KSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLE
AIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHTLTSPGGGGKA
KVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFP
YNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial ornithine-citrulline antiporter (Probable). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (Probable). Lysine and arginine are also transported by the antiport mechanism (Probable). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane.
Uniprot ID
Q9Y619
Ensemble ID
ENST00000338625.9
HGNC ID
HGNC:10985

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [1]
IPM
 Probe Info  		C23(0.00); C50(0.00)  LDD0241  [2]
EA-probe
 Probe Info  		C23(1.09); C23(1.00)  LDD2210  [3]
IA-alkyne
 Probe Info  		3.34; C125(0.38); C23(0.89)  LDD2182  [4]
DBIA
 Probe Info  		C50(2.91); C51(2.91)  LDD0080  [5]
TFBX
 Probe Info  		C51(0.00); C50(0.00)  LDD0027  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 108 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.82  LDD1711  [9]
C004
 Probe Info  		13.00  LDD1714  [9]
C022
 Probe Info  		8.00  LDD1728  [9]
C040
 Probe Info  		9.00  LDD1740  [9]
C041
 Probe Info  		14.93  LDD1741  [9]
C053
 Probe Info  		4.92  LDD1751  [9]
C055
 Probe Info  		13.93  LDD1752  [9]
C059
 Probe Info  		5.54  LDD1756  [9]
C063
 Probe Info  		13.18  LDD1760  [9]
C082
 Probe Info  		7.06  LDD1774  [9]
C085
 Probe Info  		7.21  LDD1777  [9]
C087
 Probe Info  		12.64  LDD1779  [9]
C106
 Probe Info  		24.59  LDD1793  [9]
C107
 Probe Info  		5.50  LDD1794  [9]
C108
 Probe Info  		12.64  LDD1795  [9]
C112
 Probe Info  		18.64  LDD1799  [9]
C129
 Probe Info  		6.11  LDD1811  [9]
C130
 Probe Info  		6.54  LDD1812  [9]
C139
 Probe Info  		21.56  LDD1821  [9]
C159
 Probe Info  		9.92  LDD1839  [9]
C160
 Probe Info  		18.77  LDD1840  [9]
C161
 Probe Info  		16.00  LDD1841  [9]
C165
 Probe Info  		14.52  LDD1845  [9]
C169
 Probe Info  		27.28  LDD1849  [9]
C170
 Probe Info  		7.94  LDD1850  [9]
C173
 Probe Info  		7.36  LDD1853  [9]
C178
 Probe Info  		19.16  LDD1857  [9]
C179
 Probe Info  		7.73  LDD1858  [9]
C183
 Probe Info  		5.24  LDD1861  [9]
C186
 Probe Info  		9.78  LDD1864  [9]
C191
 Probe Info  		10.48  LDD1868  [9]
C194
 Probe Info  		8.75  LDD1870  [9]
C197
 Probe Info  		5.35  LDD1873  [9]
C198
 Probe Info  		19.03  LDD1874  [9]
C201
 Probe Info  		31.12  LDD1877  [9]
C206
 Probe Info  		24.25  LDD1881  [9]
C210
 Probe Info  		41.93  LDD1884  [9]
C211
 Probe Info  		15.24  LDD1885  [9]
C213
 Probe Info  		26.72  LDD1887  [9]
C218
 Probe Info  		27.67  LDD1892  [9]
C219
 Probe Info  		6.45  LDD1893  [9]
C220
 Probe Info  		32.22  LDD1894  [9]
C226
 Probe Info  		9.19  LDD1899  [9]
C228
 Probe Info  		22.47  LDD1901  [9]
C229
 Probe Info  		7.73  LDD1902  [9]
C231
 Probe Info  		22.47  LDD1904  [9]
C232
 Probe Info  		96.34  LDD1905  [9]
C233
 Probe Info  		10.78  LDD1906  [9]
C234
 Probe Info  		16.00  LDD1907  [9]
C235
 Probe Info  		20.97  LDD1908  [9]
C238
 Probe Info  		21.86  LDD1911  [9]
C243
 Probe Info  		12.91  LDD1916  [9]
C246
 Probe Info  		15.78  LDD1919  [9]
C249
 Probe Info  		21.86  LDD1922  [9]
C252
 Probe Info  		8.28  LDD1925  [9]
C260
 Probe Info  		5.43  LDD1932  [9]
C264
 Probe Info  		20.39  LDD1935  [9]
C265
 Probe Info  		49.52  LDD1936  [9]
C266
 Probe Info  		8.34  LDD1937  [9]
C269
 Probe Info  		6.11  LDD1939  [9]
C270
 Probe Info  		8.75  LDD1940  [9]
C277
 Probe Info  		12.04  LDD1947  [9]
C282
 Probe Info  		22.94  LDD1952  [9]
C284
 Probe Info  		35.26  LDD1954  [9]
C285
 Probe Info  		22.78  LDD1955  [9]
C288
 Probe Info  		10.27  LDD1958  [9]
C289
 Probe Info  		32.00  LDD1959  [9]
C290
 Probe Info  		7.11  LDD1960  [9]
C293
 Probe Info  		37.27  LDD1963  [9]
C296
 Probe Info  		31.34  LDD1966  [9]
C299
 Probe Info  		8.57  LDD1968  [9]
C305
 Probe Info  		14.62  LDD1974  [9]
C310
 Probe Info  		14.22  LDD1977  [9]
C314
 Probe Info  		19.43  LDD1981  [9]
C322
 Probe Info  		5.62  LDD1988  [9]
C326
 Probe Info  		7.26  LDD1990  [9]
C338
 Probe Info  		21.41  LDD2001  [9]
C342
 Probe Info  		7.36  LDD2004  [9]
C343
 Probe Info  		19.97  LDD2005  [9]
C344
 Probe Info  		5.21  LDD2006  [9]
C346
 Probe Info  		14.72  LDD2007  [9]
C348
 Probe Info  		15.56  LDD2009  [9]
C349
 Probe Info  		18.90  LDD2010  [9]
C350
 Probe Info  		42.52  LDD2011  [9]
C353
 Probe Info  		9.92  LDD2014  [9]
C354
 Probe Info  		7.21  LDD2015  [9]
C356
 Probe Info  		8.46  LDD2017  [9]
C361
 Probe Info  		18.13  LDD2022  [9]
C362
 Probe Info  		70.03  LDD2023  [9]
C363
 Probe Info  		21.56  LDD2024  [9]
C364
 Probe Info  		48.17  LDD2025  [9]
C366
 Probe Info  		7.01  LDD2027  [9]
C367
 Probe Info  		6.92  LDD2028  [9]
C383
 Probe Info  		31.56  LDD2042  [9]
C403
 Probe Info  		16.11  LDD2061  [9]
C407
 Probe Info  		16.34  LDD2064  [9]
C409
 Probe Info  		5.98  LDD2066  [9]
C420
 Probe Info  		10.48  LDD2075  [9]
C426
 Probe Info  		14.93  LDD2081  [9]
C429
 Probe Info  		17.39  LDD2084  [9]
C431
 Probe Info  		22.78  LDD2086  [9]
FFF probe11
 Probe Info  		20.00  LDD0471  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [10]
FFF probe14
 Probe Info  		20.00  LDD0477  [10]
FFF probe2
 Probe Info  		20.00  LDD0463  [10]
JN0003
 Probe Info  		20.00  LDD0469  [10]
LD-F
 Probe Info  		P182(0.00); Y184(0.00)  LDD0015  [11]
OEA-DA
 Probe Info  		20.00  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C50(0.80); C51(0.80)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C50(1.15); C51(1.15)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C50(1.07); C51(1.07)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C50(0.98); C51(0.98)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C50(1.09); C51(1.09)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C50(1.06); C51(1.06)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C50(0.87); C51(0.87)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C50(0.74); C51(0.74)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C50(1.00); C51(1.00)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C50(0.84); C51(0.84)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C50(0.97); C51(0.97)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C50(1.09); C51(1.09)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C50(1.19); C51(1.19)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C50(0.72); C51(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C50(0.99); C51(0.99)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C50(0.89); C51(0.89)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C50(0.84); C51(0.84)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C50(0.75); C51(0.76)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C50(0.75); C51(0.73)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C50(0.69); C51(0.79)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C50(0.93); C51(0.79)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C50(0.76); C51(0.67)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C50(0.65); C51(0.69)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C50(1.19); C51(1.19)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C50(0.63); C51(0.68)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C50(0.93); C51(0.77)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C50(0.74); C51(0.88)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C50(0.91); C51(0.79)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C50(0.75); C51(0.74)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C50(0.70); C51(0.83)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C50(0.78); C51(0.81)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C50(0.87); C51(0.87)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C50(1.12); C51(1.12)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C50(1.28); C51(1.28)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C50(1.00); C51(1.00)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C50(1.13); C51(1.13)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C50(1.31); C51(1.31)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C50(1.06); C51(1.06)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C50(1.22); C51(1.22)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C50(1.07); C51(1.07)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C50(1.28); C51(1.28)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C50(1.08); C51(1.08)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C50(1.14); C51(1.14)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C50(1.21); C51(1.21)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C50(0.88); C51(0.88)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C50(1.25); C51(1.25)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C50(1.15); C51(1.15)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C50(1.11); C51(1.11)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C50(0.56); C51(0.56)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C50(0.62); C51(0.69)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C51(0.60); C50(0.79)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C51(0.55); C50(0.57)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C51(0.80); C50(0.89)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C50(0.46); C51(0.56)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C50(0.43); C51(0.48)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C50(1.04); C51(1.04)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C51(0.61); C50(0.76)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C50(0.66); C51(0.74)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C50(0.57); C51(0.59)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C51(0.39); C50(0.43)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C50(0.60); C51(0.66)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C50(0.60); C51(0.53)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C50(0.74); C51(0.65)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C50(0.52); C51(0.52)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C50(1.06); C51(1.06)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C50(0.89); C51(0.89)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C50(1.04); C51(1.04)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C50(1.01); C51(1.01)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C50(1.17); C51(1.17)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C50(1.09); C51(1.09)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C50(1.18); C51(1.18)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C50(1.21); C51(1.21)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C50(1.35); C51(1.35)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C50(0.76); C51(0.76)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C50(0.60); C51(0.60)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C50(0.56); C51(0.56)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C50(0.63); C51(0.63)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C50(0.64); C51(0.64)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C50(1.03); C51(1.03)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C50(0.59); C51(0.59)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C50(0.61); C51(0.61)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C50(0.50); C51(0.50)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C50(0.60); C51(0.60)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C50(0.61); C51(0.61)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C50(1.47); C51(1.47)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C50(1.03); C51(1.03)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C50(1.06); C51(1.06)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C50(1.15); C51(1.15)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C50(1.21); C51(1.21)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C50(0.91); C51(0.91)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C50(1.09); C51(1.09)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C50(1.01); C51(1.01)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C50(1.02); C51(1.02)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C50(1.05); C51(1.05)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C50(1.03); C51(1.03)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C50(1.10); C51(1.10)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C50(1.09); C51(1.09)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C50(1.01); C51(1.01)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C50(1.05); C51(1.05)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C50(1.10); C51(1.10)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C50(1.08); C51(1.08)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C50(1.22); C51(1.22)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C50(1.04); C51(1.04)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C50(1.06); C51(1.06)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C50(1.07); C51(1.07)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C50(1.08); C51(1.08)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C50(1.31); C51(1.31)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C50(1.11); C51(1.11)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C50(0.75); C51(0.75)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C50(0.71); C51(0.71)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C50(0.77); C51(0.77)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C50(0.85); C51(0.85)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C50(0.65); C51(0.65)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C50(0.67); C51(0.67)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C50(0.73); C51(0.73)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C50(0.75); C51(0.75)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C50(0.67); C51(0.67)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C50(0.78); C51(0.78)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C50(0.84); C51(0.84)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C50(0.73); C51(0.73)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C50(0.84); C51(0.84)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C50(0.80); C51(0.80)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C50(1.09); C51(1.09)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C50(0.75); C51(0.75)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C50(0.94); C51(0.94)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C50(0.86); C51(0.86)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C50(1.00); C51(1.00)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C50(1.06); C51(1.06)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C50(0.98); C51(0.98)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C50(0.94); C51(0.94)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C50(0.90); C51(0.90)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C50(0.79); C51(0.79)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C50(0.91); C51(0.91)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C50(1.03); C51(1.03)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C50(1.27); C51(1.27)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C50(0.99); C51(0.99)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C50(0.96); C51(0.96)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C50(1.01); C51(1.01)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C50(0.84); C51(0.84)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C50(0.86); C51(0.86)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C50(0.90); C51(0.90)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C50(0.85); C51(0.85)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C50(1.02); C51(1.02)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C50(0.90); C51(0.90)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C50(1.34); C51(1.34)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C50(0.95); C51(0.95)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C50(0.96); C51(0.96)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C50(0.94); C51(0.94)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C50(1.01); C51(1.01)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C50(0.89); C51(0.89)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C50(0.88); C51(0.88)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C50(0.92); C51(0.92)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C50(0.73); C51(0.73)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C50(0.86); C51(0.86)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C50(1.16); C51(1.16)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C50(1.16); C51(1.16)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C50(0.96); C51(0.96)  LDD0592  [5]
 LDCM0367  CL1 HCT 116 C50(1.47); C51(1.47)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C50(1.10); C51(1.10)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C50(0.95); C51(0.95)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C50(1.00); C51(1.00)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C50(1.07); C51(1.07)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C50(1.28); C51(1.28)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C50(1.08); C51(1.08)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C50(1.05); C51(1.05)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C50(0.92); C51(0.92)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C50(1.07); C51(1.07)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C50(1.05); C51(1.05)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C50(1.06); C51(1.06)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C50(1.25); C51(1.25)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C50(0.98); C51(0.98)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C50(1.08); C51(1.08)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C50(0.78); C51(0.78)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C50(0.60); C51(0.60)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C50(0.68); C51(0.68)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C50(0.65); C51(0.65)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C50(0.67); C51(0.67)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C50(1.24); C51(1.24)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C50(1.19); C51(1.19)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C50(1.06); C51(1.06)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C50(0.96); C51(0.96)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C50(1.17); C51(1.17)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C50(1.08); C51(1.08)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C50(0.99); C51(0.99)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C50(1.06); C51(1.06)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C50(1.08); C51(1.08)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C50(0.88); C51(0.88)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C50(0.78); C51(0.78)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C50(0.87); C51(0.87)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C50(0.77); C51(0.77)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C50(0.95); C51(0.95)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C50(1.23); C51(1.23)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C50(1.13); C51(1.13)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C50(0.75); C51(0.75)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C50(0.72); C51(0.72)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C50(0.58); C51(0.58)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C50(0.71); C51(0.71)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C50(1.49); C51(1.49)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C50(0.60); C51(0.60)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C50(0.65); C51(0.65)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C50(0.75); C51(0.75)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C50(0.65); C51(0.65)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C50(0.80); C51(0.80)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C50(0.79); C51(0.79)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C50(0.90); C51(0.90)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C50(0.75); C51(0.75)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C50(0.72); C51(0.72)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C50(0.58); C51(0.58)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C50(1.13); C51(1.13)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C50(0.87); C51(0.87)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C50(0.98); C51(1.01)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C50(0.78); C51(0.78)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C50(0.82); C51(0.82)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C50(0.86); C51(0.80)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C50(0.81); C51(0.82)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C50(0.85); C51(0.86)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C50(0.85); C51(0.82)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C50(0.88); C51(0.87)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C50(0.95); C51(0.95)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C50(0.83); C51(0.79)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C50(0.88); C51(0.87)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C50(0.85); C51(0.84)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C50(0.86); C51(0.85)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C50(0.81); C51(0.81)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C50(0.90); C51(0.90)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C50(0.80); C51(0.80)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C50(0.70); C51(0.70)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C50(0.78); C51(0.78)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C50(1.03); C51(1.03)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C50(1.13); C51(1.13)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C50(1.02); C51(1.02)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C50(0.89); C51(0.89)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C50(1.07); C51(1.07)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C50(0.63); C51(0.63)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C50(0.80); C51(0.80)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C50(1.00); C51(1.00)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C50(0.75); C51(0.75)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C50(0.67); C51(0.67)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C50(0.80); C51(0.80)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C50(0.87); C51(0.87)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C50(0.93); C51(0.93)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C50(0.77); C51(0.77)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C50(0.82); C51(0.82)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C50(0.84); C51(0.84)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C50(0.73); C51(0.73)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C50(0.76); C51(0.76)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C50(1.01); C51(1.01)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C50(0.85); C51(0.85)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C50(0.81); C51(0.81)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C50(0.70); C51(0.70)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C50(0.73); C51(0.73)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C50(1.19); C51(1.19)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C50(1.04); C51(1.04)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C50(0.89); C51(0.89)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C50(0.90); C51(0.90)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C50(0.87); C51(0.87)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C50(1.01); C51(1.01)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C50(0.82); C51(0.82)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C50(0.90); C51(0.90)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C50(0.92); C51(0.92)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C50(0.85); C51(0.85)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C50(0.97); C51(0.97)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C50(0.79); C51(0.79)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C50(0.98); C51(0.98)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C50(1.05); C51(1.05)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C50(0.92); C51(0.92)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C50(0.87); C51(0.87)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C50(0.85); C51(0.85)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C50(0.96); C51(0.96)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C50(0.92); C51(0.92)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C50(0.95); C51(0.95)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C50(0.99); C51(0.99)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C50(0.93); C51(0.93)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C50(1.07); C51(1.07)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C50(0.83); C51(0.83)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C50(1.02); C51(1.02)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C50(0.93); C51(0.93)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C50(0.84); C51(0.84)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C50(0.90); C51(0.90)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C50(0.98); C51(0.98)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C50(0.92); C51(0.92)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C50(0.86); C51(0.86)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C50(0.84); C51(0.84)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C23(1.14); C51(0.88)  LDD1698  [13]
 LDCM0175  Ethacrynic acid HeLa C23(1.09); C23(1.00)  LDD2210  [3]
 LDCM0625  F8 Ramos 1.10; C23(0.37)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos 3.03  LDD2189  [4]
 LDCM0573  Fragment11 Ramos 2.65; C23(1.18)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos 4.21  LDD2191  [4]
 LDCM0575  Fragment13 Ramos 1.23  LDD2192  [4]
 LDCM0576  Fragment14 Ramos 4.62; C23(2.17)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos 6.61; C23(0.27)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos 0.94; C23(0.63)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos 0.71; C23(0.70)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos 0.96; C23(0.29)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C125(0.42); C23(0.58)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos 1.49; C23(0.47)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos 1.64; C23(0.35)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos 2.80; C23(0.42)  LDD2201  [4]
 LDCM0468  Fragment33 HCT 116 C50(0.73); C51(0.73)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos 2.23; C23(0.24)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos 3.91; C23(1.11)  LDD2184  [4]
 LDCM0427  Fragment51 HCT 116 C50(0.81); C51(0.77)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos 1.95; C23(0.41)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos 1.21; C23(0.30)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos 2.48; C125(0.78)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos 20.00; C23(0.16)  LDD2188  [4]
 LDCM0022  KB02 HCT 116 C50(2.91); C51(2.91)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C50(2.84); C51(2.84)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C50(3.92); C51(3.92)  LDD0082  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ornithine Small molecular drug DB00129

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402