Details of the Target

General Information of Target

Target ID LDTP18087
Target Name Dephospho-CoA kinase domain-containing protein (DCAKD)
Gene Name DCAKD
Gene ID 79877
Synonyms
Dephospho-CoA kinase domain-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVPPRRHRGAGRPGVLSSSPPFRLRSAKFSGIALEDLRRALKTRLQMVCVFVMNRMNSQN
SGFTQRRRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFII
WKPWRQQCTRGLRGKHAAFFADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDLPSEKPES
TNIDTEKTPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPVKEQESILKTVGKLTATQV
AKISFFFCFVWFLANLSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSK
LLAVILSIGGVVLVNLAGSEKPAGRDTVGSIWSLAGAMLYAVYIVMIKRKVDREDKLDIP
MFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLMCIIINGLIGTVLSEFLWLWGCF
LTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIVTLLCHYNNWDPV
MVGIRRIFAFICRKHRIQRVPEDSEQCESLISMHSVSQEDGAS
Target Bioclass
Enzyme
Family
CoaE family
Uniprot ID
Q8WVC6
Ensemble ID
ENST00000310604.9
HGNC ID
HGNC:26238

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN18 SNV: p.K97E DBIA    Probe Info 
MDAMB453 SNV: p.G42R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K168(10.00)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
DBIA
 Probe Info  		C135(0.97)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
Ox-W18
 Probe Info  		N.A.  LDD2175  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 71 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.70  LDD1714  [8]
C022
 Probe Info  		9.99  LDD1728  [8]
C040
 Probe Info  		11.47  LDD1740  [8]
C049
 Probe Info  		5.54  LDD1747  [8]
C055
 Probe Info  		15.89  LDD1752  [8]
C056
 Probe Info  		25.11  LDD1753  [8]
C063
 Probe Info  		12.13  LDD1760  [8]
C070
 Probe Info  		8.75  LDD1766  [8]
C091
 Probe Info  		16.34  LDD1782  [8]
C092
 Probe Info  		24.42  LDD1783  [8]
C094
 Probe Info  		40.79  LDD1785  [8]
C095
 Probe Info  		5.39  LDD1786  [8]
C100
 Probe Info  		7.41  LDD1789  [8]
C106
 Probe Info  		24.76  LDD1793  [8]
C107
 Probe Info  		5.70  LDD1794  [8]
C112
 Probe Info  		29.04  LDD1799  [8]
C134
 Probe Info  		27.10  LDD1816  [8]
C143
 Probe Info  		15.56  LDD1825  [8]
C153
 Probe Info  		16.34  LDD1834  [8]
C158
 Probe Info  		9.51  LDD1838  [8]
C159
 Probe Info  		8.17  LDD1839  [8]
C160
 Probe Info  		7.52  LDD1840  [8]
C161
 Probe Info  		12.04  LDD1841  [8]
C169
 Probe Info  		23.26  LDD1849  [8]
C201
 Probe Info  		39.67  LDD1877  [8]
C206
 Probe Info  		17.03  LDD1881  [8]
C210
 Probe Info  		45.57  LDD1884  [8]
C218
 Probe Info  		17.27  LDD1892  [8]
C219
 Probe Info  		4.92  LDD1893  [8]
C220
 Probe Info  		20.53  LDD1894  [8]
C228
 Probe Info  		28.05  LDD1901  [8]
C231
 Probe Info  		25.81  LDD1904  [8]
C232
 Probe Info  		34.06  LDD1905  [8]
C233
 Probe Info  		9.19  LDD1906  [8]
C234
 Probe Info  		5.43  LDD1907  [8]
C235
 Probe Info  		29.24  LDD1908  [8]
C238
 Probe Info  		13.64  LDD1911  [8]
C246
 Probe Info  		16.68  LDD1919  [8]
C277
 Probe Info  		10.48  LDD1947  [8]
C285
 Probe Info  		22.63  LDD1955  [8]
C289
 Probe Info  		29.04  LDD1959  [8]
C293
 Probe Info  		23.75  LDD1963  [8]
C296
 Probe Info  		15.45  LDD1966  [8]
C299
 Probe Info  		6.41  LDD1968  [8]
C310
 Probe Info  		12.64  LDD1977  [8]
C339
 Probe Info  		5.90  LDD2002  [8]
C343
 Probe Info  		12.21  LDD2005  [8]
C348
 Probe Info  		9.92  LDD2009  [8]
C349
 Probe Info  		18.64  LDD2010  [8]
C350
 Probe Info  		54.57  LDD2011  [8]
C355
 Probe Info  		23.75  LDD2016  [8]
C362
 Probe Info  		68.59  LDD2023  [8]
C363
 Probe Info  		17.27  LDD2024  [8]
C364
 Probe Info  		16.56  LDD2025  [8]
C366
 Probe Info  		9.51  LDD2027  [8]
C367
 Probe Info  		4.96  LDD2028  [8]
C376
 Probe Info  		6.73  LDD2036  [8]
C382
 Probe Info  		9.71  LDD2041  [8]
C388
 Probe Info  		80.45  LDD2047  [8]
C390
 Probe Info  		53.82  LDD2049  [8]
C403
 Probe Info  		18.13  LDD2061  [8]
C407
 Probe Info  		17.88  LDD2064  [8]
C429
 Probe Info  		12.47  LDD2084  [8]
C431
 Probe Info  		16.11  LDD2086  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]
FFF probe2
 Probe Info  		20.00  LDD0463  [9]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
OEA-DA
 Probe Info  		19.23  LDD0046  [10]
STS-1
 Probe Info  		N.A.  LDD0068  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C135(1.02)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C135(0.97)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C135(1.05)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C135(0.91)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C135(0.99)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C135(1.04)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C135(1.39)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C135(1.08)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C135(1.22)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C135(1.15)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C135(1.41)  LDD1509  [12]
 LDCM0227  AC110 HEK-293T C135(1.04)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C135(0.95)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C135(1.04)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C135(0.83)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C135(0.90)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C135(0.99)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C135(0.70)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C135(0.78)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C135(0.90)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C135(0.80)  LDD0834  [3]
 LDCM0238  AC120 HEK-293T C135(0.70)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C135(0.76)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C135(0.67)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C135(0.74)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C135(0.80)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C135(0.75)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C135(0.73)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C135(0.75)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C135(1.12)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C135(0.84)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C135(0.82)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C135(0.93)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C135(1.01)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C135(0.87)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C135(0.96)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C135(0.91)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C135(0.92)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C135(0.90)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C135(0.92)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C135(0.87)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C135(1.05)  LDD1512  [12]
 LDCM0260  AC140 HEK-293T C135(0.94)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C135(0.91)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C135(0.94)  LDD0860  [3]
 LDCM0276  AC17 HCT 116 C135(0.81)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C135(0.74)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C135(0.90)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C135(1.04)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C135(0.83)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C135(0.94)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C135(0.92)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C135(1.05)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C135(0.90)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C135(0.96)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C135(1.25)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C135(0.86)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C135(1.18)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C135(1.68)  LDD1529  [12]
 LDCM0291  AC30 HCT 116 C135(1.11)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C135(1.11)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C135(1.22)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C135(1.37)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C135(1.07)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C135(0.72)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C135(0.73)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C135(1.07)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C135(1.29)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C135(0.97)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C135(0.90)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C135(0.79)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C135(1.01)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C135(1.36)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C135(1.15)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C135(1.61)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C135(1.14)  LDD1547  [12]
 LDCM0310  AC48 HEK-293T C135(1.10)  LDD1549  [12]
 LDCM0314  AC51 HEK-293T C135(1.52)  LDD1553  [12]
 LDCM0317  AC54 HEK-293T C135(1.42)  LDD1556  [12]
 LDCM0319  AC56 HEK-293T C135(1.15)  LDD1558  [12]
 LDCM0322  AC59 HEK-293T C135(1.24)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C135(1.34)  LDD1562  [12]
 LDCM0326  AC62 HEK-293T C135(1.42)  LDD1565  [12]
 LDCM0328  AC64 HEK-293T C135(0.93)  LDD1567  [12]
 LDCM0345  AC8 HEK-293T C135(1.13)  LDD1569  [12]
 LDCM0349  AC83 HEK-293T C135(1.12)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C135(0.77)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C135(0.84)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C135(0.90)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C135(0.81)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C135(0.82)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C135(0.85)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C135(0.96)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C135(0.90)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C135(0.81)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C135(0.82)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C135(1.00)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C135(0.74)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C135(0.91)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C135(0.87)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C135(1.16)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C135(1.17)  LDD0964  [3]
 LDCM0275  AKOS034007705 HEK-293T C135(1.14)  LDD1514  [12]
 LDCM0020  ARS-1620 HCC44 C135(0.97)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C135(0.84)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C135(0.93)  LDD0685  [3]
 LDCM0370  CL101 HEK-293T C135(1.00)  LDD1574  [12]
 LDCM0372  CL103 HEK-293T C135(1.04)  LDD1576  [12]
 LDCM0374  CL105 HCT 116 C135(1.01)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C135(1.16)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C135(1.05)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C135(1.26)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C135(0.89)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C135(0.99)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C135(1.19)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C135(0.99)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C135(0.78)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C135(0.88)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C135(0.95)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C135(0.99)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C135(1.21)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C135(1.11)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C135(1.36)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C135(0.89)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C135(1.34)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C135(1.13)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C135(0.98)  LDD1596  [12]
 LDCM0394  CL123 HEK-293T C135(1.25)  LDD1598  [12]
 LDCM0396  CL125 HEK-293T C135(1.10)  LDD1600  [12]
 LDCM0398  CL127 HEK-293T C135(0.75)  LDD1602  [12]
 LDCM0400  CL13 HCT 116 C135(0.92)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C135(1.05)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C135(1.20)  LDD0719  [3]
 LDCM0406  CL19 HEK-293T C135(1.41)  LDD1610  [12]
 LDCM0407  CL2 HCT 116 C135(0.89)  LDD0724  [3]
 LDCM0410  CL22 HEK-293T C135(1.88)  LDD1614  [12]
 LDCM0412  CL24 HEK-293T C135(1.32)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C135(0.91)  LDD1617  [12]
 LDCM0415  CL27 HEK-293T C135(0.83)  LDD1619  [12]
 LDCM0418  CL3 HCT 116 C135(1.00)  LDD0735  [3]
 LDCM0420  CL31 HEK-293T C135(1.67)  LDD1624  [12]
 LDCM0423  CL34 HEK-293T C135(2.14)  LDD1627  [12]
 LDCM0425  CL36 HEK-293T C135(1.30)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C135(0.80)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C135(1.18)  LDD1632  [12]
 LDCM0429  CL4 HCT 116 C135(0.86)  LDD0746  [3]
 LDCM0433  CL43 HEK-293T C135(1.62)  LDD1637  [12]
 LDCM0436  CL46 HEK-293T C135(2.39)  LDD1640  [12]
 LDCM0438  CL48 HEK-293T C135(1.44)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C135(0.87)  LDD1643  [12]
 LDCM0440  CL5 HCT 116 C135(1.08)  LDD0757  [3]
 LDCM0446  CL55 HEK-293T C135(1.72)  LDD1649  [12]
 LDCM0449  CL58 HEK-293T C135(1.67)  LDD1652  [12]
 LDCM0451  CL6 HCT 116 C135(1.21)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C135(1.48)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C135(0.92)  LDD1656  [12]
 LDCM0455  CL63 HEK-293T C135(0.82)  LDD1658  [12]
 LDCM0459  CL67 HEK-293T C135(1.47)  LDD1662  [12]
 LDCM0462  CL7 HCT 116 C135(1.30)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C135(2.18)  LDD1666  [12]
 LDCM0465  CL72 HEK-293T C135(1.23)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C135(0.85)  LDD1669  [12]
 LDCM0472  CL79 HEK-293T C135(1.13)  LDD1675  [12]
 LDCM0473  CL8 HCT 116 C135(0.89)  LDD0790  [3]
 LDCM0476  CL82 HEK-293T C135(2.52)  LDD1679  [12]
 LDCM0478  CL84 HEK-293T C135(1.23)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C135(0.80)  LDD1682  [12]
 LDCM0481  CL87 HEK-293T C135(0.89)  LDD1684  [12]
 LDCM0484  CL9 HCT 116 C135(0.89)  LDD0801  [3]
 LDCM0486  CL91 HEK-293T C135(1.55)  LDD1689  [12]
 LDCM0489  CL94 HEK-293T C135(1.70)  LDD1692  [12]
 LDCM0491  CL96 HEK-293T C135(1.34)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C135(1.00)  LDD1695  [12]
 LDCM0494  CL99 HEK-293T C135(1.15)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C135(0.94)  LDD1698  [12]
 LDCM0576  Fragment14 Ramos C135(1.59)  LDD2193  [13]
 LDCM0468  Fragment33 HEK-293T C135(0.83)  LDD1671  [12]
 LDCM0566  Fragment4 Ramos C135(0.86)  LDD2184  [13]
 LDCM0569  Fragment7 Ramos C135(0.68)  LDD2186  [13]
 LDCM0022  KB02 HCT 116 C135(1.26)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C135(2.05)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C135(0.67)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C135(1.03)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C135(0.58)  LDD2207  [14]

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD001377 , PXD005252
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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