Details of the Target

General Information of Target

Target ID LDTP00950
Target Name Dynamin-like 120 kDa protein, mitochondrial (OPA1)
Gene Name OPA1
Gene ID 4976
Synonyms
KIAA0567; Dynamin-like 120 kDa protein, mitochondrial; EC 3.6.5.5; Optic atrophy protein 1) [Cleaved into: Dynamin-like 120 kDa protein, form S1]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
DFFTSGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKEN
KELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAG
KTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALR
HEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFS
ISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPS
RIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT
TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNE
ILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQW
TDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAED
SLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKN
RTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQV
YRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTN
TEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
Subcellular location
Mitochondrion inner membrane
Function
Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes. Plays a role in remodeling cristae and the release of cytochrome c during apoptosis. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Plays a role in mitochondrial genome maintenance.; [Dynamin-like 120 kDa protein, form S1]: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.; [Isoform 4]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane.; [Isoform 5]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane.
TTD ID
T88404
Uniprot ID
O60313
DrugMap ID
TTTU49Q
Ensemble ID
ENST00000361150.6
HGNC ID
HGNC:8140
ChEMBL ID
CHEMBL4105705

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
ONAyne
 Probe Info  		K228(0.62)  LDD0274  [3]
STPyne
 Probe Info  		K204(0.70); K228(10.00); K253(7.33); K328(10.00)  LDD0277  [3]
DBIA
 Probe Info  		C841(1.51)  LDD3310  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
AHL-Pu-1
 Probe Info  		C801(2.25)  LDD0169  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C801(0.00); C874(0.00); C375(0.00); C551(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C801(0.00); C786(0.00)  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C801(0.00); C551(0.00); C874(0.00); C375(0.00)  LDD0037  [8]
BTD
 Probe Info  		N.A.  LDD0004  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
WYneO
 Probe Info  		C786(0.00); C375(0.00)  LDD0022  [10]
aHNE
 Probe Info  		N.A.  LDD0001  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
ENE
 Probe Info  		C375(0.00); C856(0.00)  LDD0006  [10]
IPM
 Probe Info  		C786(0.00); C551(0.00)  LDD0005  [10]
TFBX
 Probe Info  		C856(0.00); C375(0.00); C801(0.00); C786(0.00)  LDD0148  [13]
VSF
 Probe Info  		C375(0.00); C786(0.00); C801(0.00)  LDD0007  [10]
Phosphinate-6
 Probe Info  		C786(0.00); C375(0.00); C856(0.00); C874(0.00)  LDD0018  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
Acrolein
 Probe Info  		C786(0.00); H727(0.00); C551(0.00); C375(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C786(0.00); H727(0.00); C375(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C375(0.00); C786(0.00); C801(0.00); C853(0.00)  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		12.00  LDD0443  [18]
NAIA_5
 Probe Info  		C801(0.00); C375(0.00); C786(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 43 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		9.06  LDD1728  [19]
C040
 Probe Info  		10.13  LDD1740  [19]
C041
 Probe Info  		6.68  LDD1741  [19]
C055
 Probe Info  		12.13  LDD1752  [19]
C056
 Probe Info  		20.39  LDD1753  [19]
C091
 Probe Info  		10.85  LDD1782  [19]
C106
 Probe Info  		25.11  LDD1793  [19]
C108
 Probe Info  		9.92  LDD1795  [19]
C112
 Probe Info  		26.54  LDD1799  [19]
C134
 Probe Info  		28.25  LDD1816  [19]
C141
 Probe Info  		9.38  LDD1823  [19]
C159
 Probe Info  		11.24  LDD1839  [19]
C160
 Probe Info  		8.28  LDD1840  [19]
C201
 Probe Info  		25.11  LDD1877  [19]
C218
 Probe Info  		12.73  LDD1892  [19]
C220
 Probe Info  		13.45  LDD1894  [19]
C228
 Probe Info  		15.35  LDD1901  [19]
C231
 Probe Info  		12.38  LDD1904  [19]
C246
 Probe Info  		13.83  LDD1919  [19]
C265
 Probe Info  		19.29  LDD1936  [19]
C277
 Probe Info  		8.88  LDD1947  [19]
C282
 Probe Info  		32.22  LDD1952  [19]
C289
 Probe Info  		26.54  LDD1959  [19]
C296
 Probe Info  		12.73  LDD1966  [19]
C310
 Probe Info  		8.00  LDD1977  [19]
C343
 Probe Info  		18.25  LDD2005  [19]
C349
 Probe Info  		13.36  LDD2010  [19]
C350
 Probe Info  		38.05  LDD2011  [19]
C355
 Probe Info  		25.63  LDD2016  [19]
C362
 Probe Info  		35.26  LDD2023  [19]
C364
 Probe Info  		15.14  LDD2025  [19]
C388
 Probe Info  		55.72  LDD2047  [19]
C390
 Probe Info  		31.78  LDD2049  [19]
C403
 Probe Info  		17.39  LDD2061  [19]
C407
 Probe Info  		12.73  LDD2064  [19]
FFF probe11
 Probe Info  		20.00  LDD0471  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe15
 Probe Info  		12.13  LDD0478  [20]
FFF probe2
 Probe Info  		20.00  LDD0463  [20]
FFF probe3
 Probe Info  		18.25  LDD0464  [20]
JN0003
 Probe Info  		16.53  LDD0469  [20]
OEA-DA
 Probe Info  		13.37  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C786(0.87)  LDD2142  [22]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C801(1.04); C786(1.05)  LDD2112  [22]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C801(0.96); C786(0.84); C856(0.93)  LDD2117  [22]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C786(1.56)  LDD2152  [22]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C786(0.85)  LDD2103  [22]
 LDCM0025  4SU-RNA DM93 C786(2.59)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C801(2.25)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C786(0.97); C801(0.94); C375(0.96); C435(1.18)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C786(0.97); C801(1.06); C375(1.01); C435(1.18)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C786(0.98); C801(1.06); C375(1.06); C435(1.07)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C786(0.96); C801(1.03); C375(1.05); C435(1.29)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C786(1.01); C801(1.03); C435(0.99); C551(0.94)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C786(0.98); C801(1.06); C375(0.92); C435(0.97)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C786(0.99); C801(1.02); C375(0.92); C435(1.02)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C786(0.94); C801(1.02); C375(1.09); C435(1.11)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C786(1.02); C801(1.17); C375(0.90); C435(0.95)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C786(0.91); C801(1.02); C375(0.99); C435(1.11)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C786(0.99); C801(1.00); C375(1.02); C435(0.85)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C786(0.98); C801(1.02); C375(0.97); C435(1.12)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C786(0.98); C801(1.03); C435(1.06); C551(0.98)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C786(1.02); C801(1.03); C375(0.96); C435(0.92)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C786(0.94); C801(1.07); C375(1.00); C435(1.21)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C786(0.99); C801(1.15); C375(0.95); C435(0.96)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C786(0.98); C801(1.09); C375(1.02); C435(0.95)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C786(1.02); C801(1.09); C375(1.01); C435(1.03)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C786(0.97); C801(0.92); C375(0.97); C435(1.45)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C786(1.00); C801(1.04); C375(0.97); C435(1.00)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C786(1.05); C801(1.07); C375(1.04); C435(1.18)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C786(1.00); C801(1.08); C435(1.02); C551(1.00)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C786(1.00); C801(1.13); C375(0.99); C435(0.93)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C786(0.97); C801(1.10); C375(0.94); C435(0.99)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C786(0.92); C801(1.12); C375(0.99); C435(0.96)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C786(0.95); C801(1.02); C375(1.12); C435(1.18)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C786(1.00); C801(1.04); C375(1.10); C435(1.11)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C786(0.98); C801(0.94); C375(1.09); C435(1.06)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C786(0.98); C801(1.03); C375(1.04); C435(1.26)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C786(0.93); C801(1.05); C435(1.02); C551(0.99)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C786(0.98); C801(1.14); C375(0.99); C435(0.95)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C786(0.99); C801(1.02); C375(1.05); C435(1.60)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C786(0.92); C801(1.00); C375(0.99); C435(0.95)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C786(0.97); C801(1.12); C375(0.96); C435(1.14)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C786(0.98); C801(1.03); C375(1.04); C435(1.09)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C786(0.98); C801(1.04); C375(1.04); C435(0.99)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C786(0.98); C801(0.95); C375(1.03); C435(0.76)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C786(1.02); C801(0.94); C375(0.95); C435(1.07)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C786(0.95); C801(1.05); C435(1.06); C551(0.92)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C786(1.00); C801(1.14); C375(1.02); C435(1.10)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C786(0.91); C801(1.08); C375(1.10); C435(1.00)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C786(1.01); C801(1.25); C375(0.95); C435(1.04)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C786(0.98); C801(0.98); C375(0.97); C435(1.17)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C786(0.93); C801(1.04); C375(1.01); C435(1.18)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C786(0.96); C801(1.02); C375(1.02); C435(1.01)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C786(0.96); C801(0.99); C375(1.03); C435(0.88)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C786(0.96); C801(1.04); C375(1.01); C435(1.04)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C786(0.98); C801(1.13); C435(1.12); C551(0.95)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C786(1.00); C801(1.16); C375(0.96); C435(0.97)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C786(0.96); C801(1.07); C375(0.97); C435(0.93)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C786(0.92); C801(1.05); C375(0.94); C435(0.95)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C786(0.94); C801(0.87); C375(0.99); C435(1.12)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C786(0.99); C801(0.94); C375(0.98); C435(1.10)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C786(1.00); C801(0.97); C435(1.31); C551(0.93)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C786(0.99); C801(0.93); C375(1.06); C435(1.38)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C786(1.04); C801(0.95); C375(1.01); C435(1.10)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C786(1.00); C801(0.95); C435(1.19); C551(0.96)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C786(0.98); C801(1.02); C375(0.94); C435(1.07)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C786(0.92); C801(0.95); C375(1.00); C435(1.41)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C786(0.96); C801(1.04); C375(0.94); C435(1.02)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C786(0.93); C801(1.01); C375(0.94); C435(0.89)  LDD1569  [23]
 LDCM0520  AKOS000195272 MDA-MB-231 C786(0.90)  LDD2113  [22]
 LDCM0248  AKOS034007472 HEK-293T C786(1.03); C801(1.06); C375(0.99); C435(1.00)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C786(0.99); C801(1.13); C375(0.92); C435(0.98)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C786(0.94); C801(1.09); C375(0.94); C435(0.94)  LDD1514  [23]
 LDCM0108  Chloroacetamide HeLa C375(0.00); C786(0.00); C435(0.00); C551(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C786(1.18); C786(0.90); C786(0.81); C801(0.76)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C786(0.89); C801(1.07); C375(0.93); C435(1.56)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C786(1.03); C801(0.94); C435(0.74); C551(1.01)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C786(0.98); C801(0.98); C375(0.95); C435(1.12)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C786(1.01); C801(1.08); C375(0.93); C435(1.17)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C786(0.96); C801(0.88); C375(0.91); C435(0.96)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C786(0.92); C801(1.22); C375(0.94); C435(1.17)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C786(0.96); C801(1.05); C375(0.92); C435(0.90)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C786(0.96); C801(1.14); C375(0.96); C435(1.14)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C786(0.97); C801(0.88); C375(0.97); C435(0.88)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C786(0.94); C801(1.03); C375(0.93); C435(1.13)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C786(1.01); C801(1.15); C375(1.01); C435(0.84)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C786(1.04); C801(1.13); C375(0.90); C435(0.95)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C786(0.98); C801(1.15); C375(0.94); C435(0.95)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C786(0.99); C801(0.95); C375(0.92); C435(0.96)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C786(0.96); C801(1.00); C375(0.87); C435(1.10)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C786(1.09); C801(1.09); C375(0.99); C435(1.48)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C786(0.95); C801(1.05); C375(0.95); C435(1.00)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C786(1.03); C801(0.92); C375(0.94); C435(0.87)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C786(0.94); C801(1.17); C375(1.02); C435(1.06)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C786(0.96); C801(1.06); C375(0.91); C435(0.74)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C786(0.92); C801(1.10); C375(0.95); C435(1.18)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C786(0.98); C801(0.89); C375(0.95); C435(1.09)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C786(0.91); C801(0.98); C375(0.98); C435(1.19)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C786(0.91); C801(1.12); C375(0.82); C435(0.68)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C786(0.92); C801(1.07); C375(0.93); C435(0.90)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C786(0.92); C801(1.10); C375(0.90); C435(1.05)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C786(0.99); C801(0.97); C375(0.95); C435(1.02)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C786(0.87); C801(1.01); C375(0.87); C435(1.24)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C786(1.01); C801(1.13); C375(0.89); C435(0.99)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C786(0.95); C801(1.19); C375(0.93); C435(1.11)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C786(0.97); C801(0.90); C375(0.95); C435(1.05)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C786(0.94); C801(0.96); C375(0.92); C435(1.26)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C786(0.97); C801(0.96); C375(0.98); C435(0.89)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C786(1.03); C801(1.18); C375(0.96); C435(1.01)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C786(1.04); C801(1.07); C375(1.00); C435(1.16)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C786(0.80); C801(0.95); C375(0.92); C435(1.18)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C786(1.00); C801(1.14); C375(0.97); C435(0.89)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C786(0.95); C801(1.09); C375(0.95); C435(0.99)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C786(0.94); C801(1.10); C375(1.13); C435(0.97)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C786(1.09); C801(1.15); C375(1.14); C435(0.92)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C786(1.01); C801(0.94); C375(1.05); C435(0.98)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C786(1.01); C801(1.09); C375(1.14); C435(0.80)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C786(1.12); C801(1.05); C375(0.93); C435(0.65)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C786(1.07); C801(1.11); C435(0.80); C551(1.08)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C786(1.03); C801(1.14); C375(1.03); C435(1.01)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C786(0.94); C801(1.22); C375(0.98); C435(0.66)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C786(0.91); C801(0.89); C375(1.00); C435(1.03)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C786(0.96); C801(1.06); C375(0.99); C435(0.90)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C786(0.93); C801(1.20); C375(1.02); C435(1.17)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C786(0.97); C801(1.14); C375(0.97); C435(0.86)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C786(0.97); C801(1.07); C375(1.02); C435(0.87)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C786(0.84); C801(1.03); C375(0.97); C435(1.10)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C786(0.93); C801(1.08); C375(1.06); C435(0.92)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C786(1.06); C801(1.14); C375(0.99); C435(0.81)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C786(1.03); C801(1.16); C375(1.08); C435(0.85)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C786(1.00); C801(1.07); C375(0.90); C435(0.54)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C786(1.06); C801(1.14); C435(0.84); C551(1.00)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C786(0.99); C801(1.12); C375(0.98); C435(0.85)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C786(0.93); C801(1.07); C375(0.96); C435(0.61)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C786(0.94); C801(1.01); C375(0.99); C435(1.21)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C786(1.01); C801(1.09); C375(0.97); C435(1.02)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C786(0.99); C801(1.03); C375(0.96); C435(0.88)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C786(0.98); C801(1.13); C375(0.97); C435(0.83)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C786(1.12); C801(1.08); C375(1.00); C435(0.96)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C786(0.98); C801(1.07); C375(1.12); C435(0.77)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C786(1.02); C801(1.11); C375(1.04); C435(0.93)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C786(1.01); C801(1.04); C375(1.02); C435(0.82)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C786(1.13); C801(1.09); C375(0.94); C435(0.66)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C786(1.07); C801(1.07); C435(0.87); C551(0.94)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C786(1.04); C801(1.16); C375(0.92); C435(0.97)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C786(0.94); C801(0.94); C375(0.96); C435(0.63)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C786(0.88); C801(0.98); C375(0.99); C435(0.98)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C786(0.98); C801(1.09); C375(0.96); C435(1.06)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C786(0.93); C801(0.97); C375(1.00); C435(0.91)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C786(0.95); C801(1.04); C375(0.93); C435(0.80)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C786(0.97); C801(1.19); C375(0.88); C435(0.98)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C786(0.86); C801(1.07); C375(0.96); C435(1.06)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C786(0.99); C801(1.07); C375(0.97); C435(0.99)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C786(0.99); C801(1.04); C375(1.08); C435(1.06)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C786(1.08); C801(0.96); C375(0.91); C435(0.80)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C786(0.98); C801(1.08); C435(0.84); C551(1.03)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C786(0.97); C801(1.32); C375(0.95); C435(0.93)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C786(0.94); C801(0.92); C375(1.07); C435(1.11)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C786(0.93); C801(0.93); C375(0.95); C435(0.70)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C786(0.92); C801(1.06); C375(0.97); C435(1.27)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C786(0.96); C801(1.06); C375(1.05); C435(1.14)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C786(0.91); C801(1.10); C375(1.01); C435(1.07)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C786(0.91); C801(0.98); C375(0.90); C435(0.72)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C786(0.97); C801(1.14); C375(0.95); C435(1.03)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C786(0.92); C801(1.01); C375(1.10); C435(1.00)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C786(1.01); C801(1.01); C375(1.07); C435(1.00)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C786(1.01); C801(1.12); C375(1.07); C435(0.94)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C786(1.05); C801(1.02); C375(0.97); C435(0.86)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C786(1.06); C801(1.07); C375(1.15); C435(1.00)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C786(1.02); C801(1.16); C435(0.88); C551(1.02)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C786(1.03); C801(1.20); C375(1.01); C435(0.89)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C786(0.95); C801(1.10); C375(1.00); C435(0.69)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C786(0.94); C801(0.99); C375(0.94); C435(2.76)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C786(1.03); C801(0.92); C375(0.98); C435(1.00)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C786(0.98); C801(1.11); C375(0.94); C435(1.01)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C786(0.98); C801(1.03); C375(0.93); C435(0.85)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C786(0.93); C801(1.10); C375(1.08); C435(1.03)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C786(0.96); C801(1.15); C375(1.06); C435(0.98)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C786(0.96); C801(0.81); C375(0.83); C435(0.68)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C786(0.98); C801(1.08); C375(1.06); C435(0.82)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C786(1.02); C801(1.13); C375(0.99); C435(0.70)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C786(0.99); C801(1.10); C435(0.84); C551(1.00)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C786(0.99); C801(1.08); C375(0.96); C435(0.98)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C786(0.93); C801(1.05); C375(0.96); C435(0.53)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C786(0.91); C801(1.06); C375(1.00); C435(2.09)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C786(0.92); C801(0.80); C375(0.97); C435(1.05)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C786(0.91); C801(1.01); C375(0.95); C435(1.30)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C786(0.97); C801(1.01); C375(0.95); C435(0.96)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C786(0.93); C801(1.10); C375(0.96); C435(1.15)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C786(1.01); C801(1.13); C375(1.00); C435(0.78)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C786(0.87); C801(0.85); C375(0.96); C435(1.27)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C786(0.95); C801(1.08); C375(0.99); C435(0.98)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C786(0.96); C801(0.91); C375(1.02); C435(0.83)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C786(1.01); C801(1.04); C375(0.93); C435(0.75)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C786(1.01); C801(1.03); C435(0.94); C551(0.98)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C786(1.26); C801(0.92); C375(0.83); C435(1.17)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C786(0.94); C801(0.91); C375(0.90); C435(0.71)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C786(1.02); C801(0.94); C375(0.88); C435(1.25)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C786(1.00); C801(0.92); C375(1.06); C435(0.92)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C786(1.00); C801(0.99); C375(0.99); C435(1.18)  LDD1697  [23]
 LDCM0495  E2913 HEK-293T C786(0.89); C801(0.92); C375(1.05); C435(1.06)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C786(3.68); C375(1.61); C801(1.14)  LDD1702  [22]
 LDCM0625  F8 Ramos C786(1.55); C375(1.46); C801(1.59)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C786(1.36); C375(1.26); C801(0.86)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C786(0.18); C375(1.17); C801(0.44)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C786(0.82); C375(1.06); C801(1.10)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C786(0.97); C375(1.07); C801(1.22)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C786(0.86); C375(0.89); C801(0.78)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C786(0.95); C375(0.94); C801(1.26)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C786(0.85); C375(0.95); C801(1.15)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C786(1.03); C375(1.09); C801(1.30)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C786(1.12); C375(0.95); C801(1.43)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C786(0.76); C375(0.69); C801(1.04)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C786(1.35); C375(1.13); C801(1.10)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C786(0.78); C375(0.87); C801(0.94)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C786(1.71); C375(1.61); C801(1.09)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C786(0.89); C801(0.96); C375(0.99); C435(1.34)  LDD1671  [23]
 LDCM0596  Fragment38 Ramos C786(0.98); C375(0.76); C801(1.13)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C786(1.06); C375(0.85); C801(1.01)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C786(0.95); C801(0.94); C375(0.99); C435(0.88)  LDD1631  [23]
 LDCM0610  Fragment52 Ramos C786(1.02); C375(1.33); C801(0.92)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C786(1.19); C375(1.08); C801(0.90)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C786(1.81); C375(0.97); C801(0.96)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C786(1.10); C375(1.13); C801(0.91)  LDD2188  [24]
 LDCM0015  HNE MDA-MB-231 C786(1.16)  LDD0346  [24]
 LDCM0107  IAA HeLa H458(0.00); H957(0.00); H224(0.00); H336(0.00)  LDD0221  [16]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 HEK-293T C786(0.93); C801(0.92); C375(0.89); C435(1.15)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C786(1.03); C801(1.06); C375(0.96); C435(1.03)  LDD1497  [23]
 LDCM0024  KB05 COLO792 C841(1.51)  LDD3310  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C786(1.03)  LDD2102  [22]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C786(0.33)  LDD2121  [22]
 LDCM0109  NEM HeLa H957(0.00); H727(0.00); H458(0.00); H337(0.00)  LDD0223  [16]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C786(0.98)  LDD2090  [22]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C786(0.83)  LDD2092  [22]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C786(0.89)  LDD2093  [22]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C786(1.16)  LDD2094  [22]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C786(1.30)  LDD2096  [22]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C786(1.19)  LDD2097  [22]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C786(0.85); C375(0.58)  LDD2098  [22]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C786(0.99); C853(1.09)  LDD2099  [22]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C786(0.97)  LDD2100  [22]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C786(0.76)  LDD2104  [22]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C801(1.09); C786(1.10); C375(0.76)  LDD2107  [22]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C786(0.93)  LDD2108  [22]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C801(1.02); C786(0.95); C856(1.10); C853(1.04)  LDD2109  [22]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C786(2.02)  LDD2110  [22]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C786(1.72)  LDD2111  [22]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C801(0.96); C786(0.74)  LDD2114  [22]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C786(0.52)  LDD2115  [22]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C786(1.21)  LDD2116  [22]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C786(1.76)  LDD2118  [22]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C786(2.57)  LDD2119  [22]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C786(0.69)  LDD2120  [22]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C786(2.24)  LDD2122  [22]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C786(0.74); C856(1.04); C853(0.66)  LDD2123  [22]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C786(1.10)  LDD2124  [22]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C786(0.98)  LDD2125  [22]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C786(1.23)  LDD2126  [22]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C786(1.01)  LDD2127  [22]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C786(0.69)  LDD2128  [22]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C801(1.00); C786(0.88)  LDD2129  [22]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C786(0.60)  LDD2133  [22]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C786(0.55)  LDD2134  [22]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C786(0.90)  LDD2135  [22]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C786(1.43); C853(0.61)  LDD2136  [22]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C786(1.08); C853(0.66)  LDD2137  [22]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C853(2.82); C786(2.07)  LDD1700  [22]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C801(1.51); C786(0.83); C375(0.66)  LDD2140  [22]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C786(0.94)  LDD2141  [22]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C801(2.32); C786(5.74)  LDD2144  [22]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C786(0.98); C853(1.15)  LDD2146  [22]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C786(1.01)  LDD2147  [22]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C786(0.68)  LDD2148  [22]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C786(1.43)  LDD2149  [22]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C786(2.00)  LDD2151  [22]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C801(1.52); C786(1.57)  LDD2153  [22]
 LDCM0627  NUDT7-COV-1 HEK-293T C786(0.63)  LDD2206  [25]
 LDCM0628  OTUB2-COV-1 HEK-293T C786(0.46)  LDD2207  [25]
 LDCM0131  RA190 MM1.R C375(1.20)  LDD0304  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) Sirtuin family Q9NTG7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.