Details of the Target

General Information of Target

Target ID LDTP00562
Target Name Membrane-associated progesterone receptor component 2 (PGRMC2)
Gene Name PGRMC2
Gene ID 10424
Synonyms
DG6; PMBP; Membrane-associated progesterone receptor component 2; Progesterone membrane-binding protein; Steroid receptor protein DG6
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVAL
VALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRIL
LAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQM
ESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD
Target Bioclass
Transporter and channel
Family
Cytochrome b5 family, MAPR subfamily
Subcellular location
Membrane
Function
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1.
Uniprot ID
O15173
Ensemble ID
ENST00000296425.10
HGNC ID
HGNC:16089

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.A68V .
SNU1 SNV: p.G6V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBPP2
 Probe Info  		6.29  LDD0318  [2]
TH211
 Probe Info  		Y143(17.66)  LDD0260  [3]
FBP2
 Probe Info  		2.01  LDD0323  [2]
TH216
 Probe Info  		Y143(20.00)  LDD0259  [3]
STPyne
 Probe Info  		K135(7.94); K193(3.01)  LDD0277  [4]
AZ-9
 Probe Info  		E88(10.00); E89(10.00); E185(1.51)  LDD2208  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
DBIA
 Probe Info  		C183(1.26)  LDD3310  [6]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [7]
THZ1-DTB
 Probe Info  		C159(1.02)  LDD0460  [7]
BTD
 Probe Info  		C159(1.15)  LDD2090  [8]
AHL-Pu-1
 Probe Info  		C159(2.25)  LDD0171  [9]
HPAP
 Probe Info  		3.61  LDD0062  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
IPM
 Probe Info  		N.A.  LDD0005  [17]
SF
 Probe Info  		Y196(0.00); Y143(0.00)  LDD0028  [18]
TFBX
 Probe Info  		N.A.  LDD0148  [19]
AOyne
 Probe Info  		13.40  LDD0443  [20]
MPP-AC
 Probe Info  		N.A.  LDD0428  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [21]
TPP-AC
 Probe Info  		N.A.  LDD0427  [21]
PAL-AfBPP Probe
Click To Hide/Show 161 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		1.53  LDD0374  [22]
ILS-1 PP
 Probe Info  		2.45  LDD0417  [23]
C004
 Probe Info  		8.82  LDD1714  [24]
C017
 Probe Info  		11.71  LDD1725  [24]
C022
 Probe Info  		20.68  LDD1728  [24]
C026
 Probe Info  		7.11  LDD1732  [24]
C027
 Probe Info  		6.82  LDD1733  [24]
C040
 Probe Info  		17.39  LDD1740  [24]
C041
 Probe Info  		9.45  LDD1741  [24]
C049
 Probe Info  		8.51  LDD1747  [24]
C053
 Probe Info  		7.01  LDD1751  [24]
C055
 Probe Info  		29.24  LDD1752  [24]
C056
 Probe Info  		64.89  LDD1753  [24]
C063
 Probe Info  		29.65  LDD1760  [24]
C067
 Probe Info  		4.92  LDD1763  [24]
C070
 Probe Info  		21.11  LDD1766  [24]
C072
 Probe Info  		9.71  LDD1768  [24]
C082
 Probe Info  		13.18  LDD1774  [24]
C085
 Probe Info  		5.62  LDD1777  [24]
C087
 Probe Info  		12.30  LDD1779  [24]
C091
 Probe Info  		32.00  LDD1782  [24]
C092
 Probe Info  		38.05  LDD1783  [24]
C094
 Probe Info  		51.98  LDD1785  [24]
C095
 Probe Info  		7.31  LDD1786  [24]
C100
 Probe Info  		7.06  LDD1789  [24]
C106
 Probe Info  		44.94  LDD1793  [24]
C107
 Probe Info  		9.45  LDD1794  [24]
C108
 Probe Info  		13.36  LDD1795  [24]
C112
 Probe Info  		78.25  LDD1799  [24]
C129
 Probe Info  		19.03  LDD1811  [24]
C130
 Probe Info  		10.20  LDD1812  [24]
C134
 Probe Info  		39.40  LDD1816  [24]
C135
 Probe Info  		17.39  LDD1817  [24]
C139
 Probe Info  		11.31  LDD1821  [24]
C141
 Probe Info  		35.26  LDD1823  [24]
C143
 Probe Info  		56.49  LDD1825  [24]
C145
 Probe Info  		10.41  LDD1827  [24]
C147
 Probe Info  		9.19  LDD1829  [24]
C153
 Probe Info  		52.35  LDD1834  [24]
C158
 Probe Info  		11.55  LDD1838  [24]
C159
 Probe Info  		22.47  LDD1839  [24]
C160
 Probe Info  		19.56  LDD1840  [24]
C161
 Probe Info  		29.04  LDD1841  [24]
C163
 Probe Info  		6.92  LDD1843  [24]
C165
 Probe Info  		12.73  LDD1845  [24]
C169
 Probe Info  		91.14  LDD1849  [24]
C173
 Probe Info  		7.01  LDD1853  [24]
C177
 Probe Info  		8.46  LDD1856  [24]
C178
 Probe Info  		44.32  LDD1857  [24]
C179
 Probe Info  		22.94  LDD1858  [24]
C183
 Probe Info  		5.35  LDD1861  [24]
C186
 Probe Info  		8.63  LDD1864  [24]
C187
 Probe Info  		30.70  LDD1865  [24]
C189
 Probe Info  		6.11  LDD1866  [24]
C191
 Probe Info  		13.09  LDD1868  [24]
C193
 Probe Info  		8.22  LDD1869  [24]
C194
 Probe Info  		18.00  LDD1870  [24]
C196
 Probe Info  		25.99  LDD1872  [24]
C197
 Probe Info  		6.87  LDD1873  [24]
C198
 Probe Info  		39.12  LDD1874  [24]
C201
 Probe Info  		99.73  LDD1877  [24]
C204
 Probe Info  		7.11  LDD1879  [24]
C205
 Probe Info  		6.45  LDD1880  [24]
C206
 Probe Info  		55.33  LDD1881  [24]
C207
 Probe Info  		26.54  LDD1882  [24]
C210
 Probe Info  		78.79  LDD1884  [24]
C213
 Probe Info  		17.15  LDD1887  [24]
C218
 Probe Info  		41.93  LDD1892  [24]
C219
 Probe Info  		10.13  LDD1893  [24]
C220
 Probe Info  		38.32  LDD1894  [24]
C225
 Probe Info  		8.40  LDD1898  [24]
C226
 Probe Info  		22.47  LDD1899  [24]
C228
 Probe Info  		40.22  LDD1901  [24]
C229
 Probe Info  		9.25  LDD1902  [24]
C231
 Probe Info  		50.91  LDD1904  [24]
C232
 Probe Info  		56.10  LDD1905  [24]
C233
 Probe Info  		13.64  LDD1906  [24]
C234
 Probe Info  		22.16  LDD1907  [24]
C235
 Probe Info  		51.27  LDD1908  [24]
C238
 Probe Info  		45.25  LDD1911  [24]
C240
 Probe Info  		12.30  LDD1913  [24]
C242
 Probe Info  		6.92  LDD1915  [24]
C252
 Probe Info  		17.88  LDD1925  [24]
C264
 Probe Info  		44.94  LDD1935  [24]
C265
 Probe Info  		22.16  LDD1936  [24]
C266
 Probe Info  		19.84  LDD1937  [24]
C270
 Probe Info  		11.16  LDD1940  [24]
C271
 Probe Info  		5.58  LDD1941  [24]
C272
 Probe Info  		5.10  LDD1942  [24]
C273
 Probe Info  		9.51  LDD1943  [24]
C277
 Probe Info  		13.93  LDD1947  [24]
C278
 Probe Info  		99.73  LDD1948  [24]
C280
 Probe Info  		10.27  LDD1950  [24]
C282
 Probe Info  		29.45  LDD1952  [24]
C284
 Probe Info  		99.73  LDD1954  [24]
C285
 Probe Info  		97.68  LDD1955  [24]
C287
 Probe Info  		31.12  LDD1957  [24]
C288
 Probe Info  		13.55  LDD1958  [24]
C289
 Probe Info  		98.36  LDD1959  [24]
C290
 Probe Info  		6.82  LDD1960  [24]
C293
 Probe Info  		31.34  LDD1963  [24]
C296
 Probe Info  		25.63  LDD1966  [24]
C299
 Probe Info  		21.11  LDD1968  [24]
C305
 Probe Info  		28.44  LDD1974  [24]
C307
 Probe Info  		6.73  LDD1975  [24]
C310
 Probe Info  		15.89  LDD1977  [24]
C313
 Probe Info  		21.86  LDD1980  [24]
C314
 Probe Info  		59.30  LDD1981  [24]
C322
 Probe Info  		14.93  LDD1988  [24]
C326
 Probe Info  		12.73  LDD1990  [24]
C338
 Probe Info  		24.93  LDD2001  [24]
C339
 Probe Info  		15.67  LDD2002  [24]
C343
 Probe Info  		32.00  LDD2005  [24]
C346
 Probe Info  		12.21  LDD2007  [24]
C347
 Probe Info  		5.28  LDD2008  [24]
C348
 Probe Info  		23.75  LDD2009  [24]
C349
 Probe Info  		45.89  LDD2010  [24]
C350
 Probe Info  		99.73  LDD2011  [24]
C353
 Probe Info  		9.92  LDD2014  [24]
C355
 Probe Info  		44.32  LDD2016  [24]
C356
 Probe Info  		13.64  LDD2017  [24]
C357
 Probe Info  		7.89  LDD2018  [24]
C361
 Probe Info  		17.03  LDD2022  [24]
C362
 Probe Info  		99.73  LDD2023  [24]
C363
 Probe Info  		99.73  LDD2024  [24]
C364
 Probe Info  		80.45  LDD2025  [24]
C366
 Probe Info  		17.15  LDD2027  [24]
C367
 Probe Info  		8.34  LDD2028  [24]
C373
 Probe Info  		16.91  LDD2033  [24]
C376
 Probe Info  		10.63  LDD2036  [24]
C378
 Probe Info  		9.58  LDD2037  [24]
C380
 Probe Info  		6.19  LDD2039  [24]
C382
 Probe Info  		20.68  LDD2041  [24]
C383
 Probe Info  		22.47  LDD2042  [24]
C388
 Probe Info  		88.65  LDD2047  [24]
C399
 Probe Info  		13.27  LDD2058  [24]
C403
 Probe Info  		37.79  LDD2061  [24]
C407
 Probe Info  		25.81  LDD2064  [24]
C413
 Probe Info  		55.72  LDD2069  [24]
C420
 Probe Info  		28.44  LDD2075  [24]
C424
 Probe Info  		13.27  LDD2079  [24]
C426
 Probe Info  		34.54  LDD2081  [24]
C428
 Probe Info  		5.43  LDD2083  [24]
C429
 Probe Info  		20.97  LDD2084  [24]
C431
 Probe Info  		39.67  LDD2086  [24]
FFF probe11
 Probe Info  		20.00  LDD0471  [25]
FFF probe12
 Probe Info  		7.06  LDD0473  [25]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe14
 Probe Info  		20.00  LDD0477  [25]
FFF probe15
 Probe Info  		11.48  LDD0478  [25]
FFF probe2
 Probe Info  		20.00  LDD0463  [25]
FFF probe3
 Probe Info  		20.00  LDD0464  [25]
FFF probe4
 Probe Info  		14.95  LDD0466  [25]
FFF probe6
 Probe Info  		11.26  LDD0467  [25]
FFF probe7
 Probe Info  		5.63  LDD0483  [25]
FFF probe9
 Probe Info  		13.82  LDD0470  [25]
JN0003
 Probe Info  		20.00  LDD0469  [25]
A-DA
 Probe Info  		2.09  LDD0145  [26]
BD-F
 Probe Info  		C159(0.00); D163(0.00)  LDD0024  [27]
OEA-DA
 Probe Info  		20.00  LDD0046  [28]
STS-1
 Probe Info  		N.A.  LDD0068  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C159(0.76)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C159(0.74)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C159(1.04)  LDD2117  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C159(2.25)  LDD0171  [9]
 LDCM0214  AC1 HEK-293T C159(0.98)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C159(0.90)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C159(0.98)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C159(0.94)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C159(0.93)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C159(0.95)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C159(1.09)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C159(1.01)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C159(0.93)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C159(0.96)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C159(1.05)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C159(1.01)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C159(1.03)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C159(1.07)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C159(1.03)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C159(0.99)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C159(0.88)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C159(0.96)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C159(0.92)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C159(0.91)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C159(0.95)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C159(0.88)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C159(0.95)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C159(1.02)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C159(1.10)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C159(0.99)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C159(1.04)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C159(1.07)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C159(0.88)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C159(0.96)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C159(0.98)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C159(0.91)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C159(0.97)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C159(1.09)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C159(0.87)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C159(1.04)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C159(1.00)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C159(0.90)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C159(0.91)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C159(0.94)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C159(1.03)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C159(1.05)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C159(1.00)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C159(0.92)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C159(1.01)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C159(1.10)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C159(1.06)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C159(1.02)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C159(1.06)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C159(1.04)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C159(1.01)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C159(0.99)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C159(1.02)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C159(0.88)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C159(1.00)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C159(0.93)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C159(0.99)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C159(0.98)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C159(0.96)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C159(0.92)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C159(0.90)  LDD1569  [30]
 LDCM0248  AKOS034007472 HEK-293T C159(0.98)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C159(0.97)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C159(0.95)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 12.34  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C159(1.03)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C159(0.89)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C159(0.69)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C159(1.01)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C159(0.97)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C159(0.87)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C159(1.05)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C159(0.92)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C159(1.03)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C159(1.00)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C159(1.10)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C159(1.05)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C159(0.98)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C159(0.75)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C159(0.84)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C159(0.92)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C159(0.86)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C159(1.04)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C159(0.84)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C159(0.92)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C159(1.07)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C159(1.07)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C159(0.93)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C159(0.93)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C159(0.83)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C159(0.98)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C159(1.09)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C159(1.06)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C159(0.96)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C159(0.95)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C159(0.98)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C159(1.02)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C159(1.04)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C159(1.05)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C159(0.95)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C159(0.93)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C159(0.89)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C159(0.97)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C159(0.56)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C159(0.84)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C159(0.96)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C159(0.93)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C159(0.97)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C159(0.82)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C159(0.80)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C159(0.85)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C159(0.85)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C159(1.10)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C159(1.12)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C159(1.06)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C159(0.97)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C159(0.97)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C159(0.84)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C159(0.92)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C159(0.92)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C159(0.91)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C159(0.78)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C159(0.87)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C159(0.90)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C159(0.90)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C159(1.12)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C159(1.17)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C159(0.90)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C159(1.11)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C159(0.93)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C159(0.93)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C159(0.97)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C159(0.82)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C159(0.89)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C159(0.87)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C159(0.89)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C159(1.03)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C159(0.99)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C159(0.85)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C159(1.08)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C159(0.92)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C159(0.82)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C159(0.77)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C159(0.89)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C159(0.85)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C159(0.75)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C159(0.80)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C159(0.83)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C159(0.71)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C159(0.98)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C159(1.11)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C159(1.04)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C159(1.06)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C159(0.87)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C159(1.05)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C159(0.97)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C159(0.90)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C159(0.92)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C159(0.92)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C159(0.90)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C159(0.92)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C159(0.83)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C159(1.11)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C159(0.95)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C159(0.97)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C159(0.96)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C159(0.78)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C159(0.83)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C159(0.89)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C159(0.62)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C159(0.83)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C159(0.93)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C159(0.77)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C159(0.79)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C159(0.81)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C159(1.07)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C159(1.07)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C159(1.03)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C159(1.02)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C159(1.00)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C159(0.72)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C159(0.78)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C159(0.96)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C159(0.96)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C159(0.80)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C159(0.84)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C159(0.75)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C159(0.82)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C159(0.93)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C159(0.91)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C159(0.97)  LDD1697  [30]
 LDCM0185  Compound 17 HEK-293T 9.95  LDD0512  [25]
 LDCM0191  Compound 21 HEK-293T 6.08  LDD0508  [25]
 LDCM0190  Compound 34 HEK-293T 11.56  LDD0510  [25]
 LDCM0192  Compound 35 HEK-293T 9.26  LDD0509  [25]
 LDCM0193  Compound 36 HEK-293T 9.39  LDD0511  [25]
 LDCM0495  E2913 HEK-293T C159(1.13)  LDD1698  [30]
 LDCM0468  Fragment33 HEK-293T C159(0.93)  LDD1671  [30]
 LDCM0427  Fragment51 HEK-293T C159(1.08)  LDD1631  [30]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [7]
 LDCM0022  KB02 HEK-293T C159(1.01)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C159(0.94)  LDD1497  [30]
 LDCM0024  KB05 COLO792 C183(1.26)  LDD3310  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C159(2.03)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C159(0.92)  LDD2121  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C159(1.15)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C159(1.03)  LDD2092  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C159(1.38)  LDD2096  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C159(0.58)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C159(0.99)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C159(0.85)  LDD2100  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C159(0.98)  LDD2104  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C159(0.87)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C159(1.05)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C159(0.52)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C159(1.03)  LDD2109  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C159(0.76)  LDD2114  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C159(0.93)  LDD2118  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C159(0.77)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C159(0.90)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C159(0.70)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C159(1.15)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C159(0.63)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C159(1.12)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C159(1.54)  LDD2128  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C159(0.41)  LDD2134  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C159(1.34)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C159(1.16)  LDD2137  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C159(1.10)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C159(0.46)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C159(1.01)  LDD2143  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C159(1.11)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C159(1.95)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C159(0.65)  LDD2148  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C159(1.65)  LDD2153  [8]
 LDCM0014  Panhematin HEK-293T 3.61  LDD0062  [10]
 LDCM0131  RA190 MM1.R C159(1.18)  LDD0304  [31]
 LDCM0084  Ro 48-8071 A-549 2.09  LDD0145  [26]
 LDCM0021  THZ1 HeLa S3 C159(1.02)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase GET3 (GET3) ArsA ATPase family O43681
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
Palmitoyltransferase ZDHHC21 (ZDHHC21) DHHC palmitoyltransferase family Q8IVQ6
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) ITPRIP family Q8IWB1
Sphingomyelin phosphodiesterase 2 (SMPD2) Neutral sphingomyelinase family O60906
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
Dehydrogenase/reductase SDR family member on chromosome X (DHRSX) Short-chain dehydrogenases/reductases (SDR) family Q8N5I4
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
Fatty acid 2-hydroxylase (FA2H) Sterol desaturase family Q7L5A8
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transmembrane reductase CYB561D2 (CYB561D2) . O14569
Transporter and channel
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid symporter 1 (SLC38A1) Amino acid/polyamine transporter 2 family Q9H2H9
Growth hormone-inducible transmembrane protein (GHITM) BI1 family Q9H3K2
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Cytochrome c oxidase assembly protein COX20, mitochondrial (COX20) COX20 family Q5RI15
Membrane-associated progesterone receptor component 1 (PGRMC1) Cytochrome b5 family O00264
Etoposide-induced protein 2.4 homolog (EI24) EI24 family O14681
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Monocarboxylate transporter 13 (SLC16A13) Monocarboxylate porter (TC 2.A.1.13) family Q7RTY0
Aquaporin-10 (AQP10) MIP/aquaporin (TC 1.A.8) family Q96PS8
Sodium/hydrogen exchanger 9B2 (SLC9B2) Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family Q86UD5
Peroxisomal membrane protein PEX16 (PEX16) Peroxin-16 family Q9Y5Y5
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Sideroflexin-1 (SFXN1) Sideroflexin family Q9H9B4
Syntaxin-3 (STX3) Syntaxin family Q13277
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Protein YIPF2 (YIPF2) YIP1 family Q9BWQ6
Zinc transporter ZIP13 (SLC39A13) ZIP transporter (TC 2.A.5) family Q96H72
Transmembrane protein 187 (TMEM187) . Q14656
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Taste receptor type 2 member 19 (TAS2R19) G-protein coupled receptor T2R family P59542
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
MAL-like protein (MALL) MAL family Q13021
Plasmolipin (PLLP) MAL family Q9Y342
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Transmembrane protein 19 (TMEM19) TMEM19 family Q96HH6
Serotransferrin (TF) Transferrin family P02787
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Complement C5 (C5) . P01031
Transmembrane protein 107 (TMEM107) . Q6UX40
UBX domain-containing protein 8 (UBXN8) . O00124

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD014175
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD025652
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402
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