Details of the Target

General Information of Target

Target ID LDTP03212
Target Name Splicing factor, proline- and glutamine-rich (SFPQ)
Gene Name SFPQ
Gene ID 6421
Synonyms
PSF; Splicing factor, proline- and glutamine-rich; 100 kDa DNA-pairing protein; hPOMp100; DNA-binding p52/p100 complex, 100 kDa subunit; Polypyrimidine tract-binding protein-associated-splicing factor; PSF; PTB-associated-splicing factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPI
PPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPG
VGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQ
AGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGE
PRGGRQHHPPYHQQHHQGPPPGGPGGRSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLF
VGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTPMRGR
QLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFAS
KPAARKAFERCSEGVFLLTTTPRPVIVEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRF
AQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLRQDLM
RRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRM
GYMDPRERDMRMGGGGAMNMGDPYGSGGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGS
DMRTERFGQGGAGPVGGQGPRGMGPGTPAGYGRGREEYEGPNKKPRF
Target Bioclass
Transcription factor
Subcellular location
Nucleus speckle
Function
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator. Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Required for the assembly of nuclear speckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Uniprot ID
P23246
Ensemble ID
ENST00000357214.6
HGNC ID
HGNC:10774

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R581C DBIA    Probe Info 
HCT116 SNV: p.P155L DBIA    Probe Info 
HT115 SNV: p.A400V .
IM95 SNV: p.P213S .
JURKAT SNV: p.P35S Compound 10    Probe Info 
MINO SNV: p.P61T .
NCIH1155 SNV: p.S521N .
NCIH2286 Substitution: p.R376F .
RT112 SNV: p.E351Q .
SKNSH SNV: p.G23C .
SW1573 SNV: p.P56T .
TOV21G SNV: p.A134D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		10.00  LDD0452  [1]
P2
 Probe Info  		10.00  LDD0449  [1]
P8
 Probe Info  		1.51  LDD0451  [1]
A-EBA
 Probe Info  		2.88  LDD0215  [2]
ILS-1
 Probe Info  		2.01; 2.40  LDD0415  [3]
Jackson_1
 Probe Info  		20.00  LDD0122  [4]
CY-1
 Probe Info  		100.00  LDD0243  [5]
TH211
 Probe Info  		Y597(20.00); Y602(20.00); Y698(20.00); Y293(14.73)  LDD0257  [6]
TH214
 Probe Info  		Y527(20.00)  LDD0258  [6]
TH216
 Probe Info  		Y527(5.86)  LDD0259  [6]
ONAyne
 Probe Info  		K472(0.00); K561(0.00); K413(0.00); K421(0.00)  LDD0273  [7]
Probe 1
 Probe Info  		Y320(45.30); Y470(213.23); Y488(9.65); Y527(9.53)  LDD3495  [8]
BTD
 Probe Info  		C431(0.32)  LDD2100  [9]
HHS-475
 Probe Info  		Y624(0.80); Y488(2.41); Y381(4.33)  LDD0264  [10]
DBIA
 Probe Info  		C431(1.16)  LDD0531  [11]
5E-2FA
 Probe Info  		H528(0.00); H483(0.00); H369(0.00); H553(0.00)  LDD2235  [12]
AMP probe
 Probe Info  		N.A.  LDD0200  [13]
ATP probe
 Probe Info  		K421(0.00); K332(0.00); K466(0.00); K314(0.00)  LDD0199  [13]
m-APA
 Probe Info  		H528(0.00); H483(0.00); H369(0.00); H553(0.00)  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [14]
ATP probe
 Probe Info  		K338(0.00); K232(0.00); K319(0.00); K472(0.00)  LDD0035  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
1d-yne
 Probe Info  		N.A.  LDD0356  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
IPM
 Probe Info  		N.A.  LDD0147  [18]
NHS
 Probe Info  		K314(0.00); K421(0.00); K319(0.00); K208(0.00)  LDD0010  [21]
SF
 Probe Info  		K703(0.00); Y527(0.00); Y490(0.00); Y488(0.00)  LDD0028  [22]
STPyne
 Probe Info  		K279(0.00); K330(0.00); K421(0.00); K291(0.00)  LDD0009  [21]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [23]
Ox-W18
 Probe Info  		N.A.  LDD2175  [24]
1c-yne
 Probe Info  		K516(0.00); K349(0.00); K462(0.00); K559(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		H528(0.00); H483(0.00); H553(0.00); H530(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		H483(0.00); H553(0.00); H369(0.00)  LDD0219  [25]
NAIA_5
 Probe Info  		C297(0.00); C431(0.00)  LDD2223  [26]
HHS-465
 Probe Info  		K421(0.00); K518(0.00); K630(0.00); Y624(0.00)  LDD2240  [27]
HHS-482
 Probe Info  		Y381(0.88); Y488(0.81); Y527(0.74); Y597(0.89)  LDD2239  [28]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		15.24  LDD1713  [29]
C063
 Probe Info  		12.13  LDD1760  [29]
C210
 Probe Info  		43.11  LDD1884  [29]
C403
 Probe Info  		18.90  LDD2061  [29]
FFF probe11
 Probe Info  		6.54  LDD0471  [30]
FFF probe12
 Probe Info  		5.12  LDD0473  [30]
FFF probe13
 Probe Info  		19.88  LDD0475  [30]
FFF probe14
 Probe Info  		12.55  LDD0477  [30]
FFF probe2
 Probe Info  		8.53  LDD0463  [30]
FFF probe3
 Probe Info  		14.64  LDD0464  [30]
FFF probe4
 Probe Info  		12.42  LDD0466  [30]
JN0003
 Probe Info  		14.00  LDD0469  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
BD-F
 Probe Info  		E389(0.00); E385(0.00)  LDD0024  [32]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [33]
DA-2
 Probe Info  		N.A.  LDD0071  [34]
OEA-DA
 Probe Info  		3.70  LDD0046  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C431(1.16)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C431(1.02)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C431(0.94)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C431(0.76)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C431(0.83)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C431(0.77)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C431(0.94)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C431(0.88)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C431(0.84)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C431(0.80)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C431(0.78)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C431(0.76)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C431(1.01)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C431(0.76)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C431(0.71)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C431(0.60)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C431(1.00)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C431(0.99)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C431(1.01)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C431(0.98)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C431(0.92)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C431(1.02)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C431(1.04)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C431(1.28)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C431(1.06)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C431(1.13)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C431(1.12)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C431(0.94)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C431(1.21)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C431(1.08)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C431(1.32)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C431(1.24)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C431(0.63)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C431(0.69)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C431(0.70)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C431(0.65)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C431(0.71)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C431(1.18)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C431(0.91)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C431(0.87)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C431(0.82)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C431(0.58)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C431(1.05)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C431(0.74)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C431(1.32)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C431(1.03)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C431(0.76)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C431(0.65)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C431(0.67)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C431(1.23)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C431(1.49)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C431(0.76)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C431(1.43)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C431(0.93)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C431(0.80)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C431(1.54)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C431(0.92)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C431(0.88)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C431(0.92)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C431(0.56)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C431(0.93)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C431(0.63)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C431(0.90)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C431(0.69)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C431(1.23)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C431(1.14)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C431(0.93)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C431(0.93)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C431(0.83)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C431(1.36)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C431(1.09)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C431(0.93)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C431(0.85)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C431(1.11)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C431(1.30)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C431(1.43)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C431(1.33)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C431(1.21)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C431(1.24)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C431(1.25)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C431(1.36)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C431(1.56)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C431(1.31)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C431(1.27)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C431(0.83)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C431(0.80)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C431(0.91)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C431(0.96)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C431(0.94)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C431(1.53)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C431(0.85)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C431(0.77)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C431(0.70)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C431(0.73)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C431(0.90)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C431(0.78)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C431(0.80)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C431(0.85)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C431(0.91)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C431(1.05)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C431(1.35)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C431(0.90)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C431(0.87)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C431(0.98)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C431(1.00)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C431(0.98)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C431(0.88)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C431(0.87)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C431(1.44)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C431(1.51)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C431(0.80)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C431(0.85)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C431(0.90)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C431(2.30)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C431(0.96)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C431(0.80)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C431(1.10)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C431(1.16)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C431(1.51)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C431(0.82)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C431(1.14)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C431(1.34)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C431(1.08)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C431(1.30)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C431(1.70)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C431(1.34)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C431(1.15)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C431(1.46)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C431(1.25)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C431(1.78)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C431(1.15)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C431(1.20)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C431(1.26)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C431(1.06)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C431(1.66)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C431(1.21)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C431(1.28)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C431(0.66)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C431(0.77)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C431(0.61)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C431(0.70)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C431(0.98)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C431(0.75)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C431(0.80)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C431(1.09)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C431(0.81)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C431(0.93)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C431(0.86)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C431(0.77)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C431(1.00)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C431(0.98)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C431(0.76)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C431(0.77)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C431(0.75)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C431(1.06)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C431(1.10)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C431(1.21)  LDD0592  [11]
 LDCM0108  Chloroacetamide HeLa H528(0.00); H530(0.00); H553(0.00); H230(0.00)  LDD0222  [25]
 LDCM0367  CL1 HCT 116 C431(0.75)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C431(0.91)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C431(1.08)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C431(1.02)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C431(1.07)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C431(1.37)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C431(1.10)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C431(1.23)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C431(1.30)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C431(1.29)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C431(1.53)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C431(1.12)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C431(0.89)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C431(1.08)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C431(0.79)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C431(1.28)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C431(1.29)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C431(1.17)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C431(1.31)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C431(1.53)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C431(0.83)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C431(0.85)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C431(0.70)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C431(0.99)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C431(0.79)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C431(0.76)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C431(1.25)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C431(0.96)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C431(0.95)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C431(1.11)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C431(1.41)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C431(1.04)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C431(1.02)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C431(1.18)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C431(0.92)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C431(0.76)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C431(0.88)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C431(0.85)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C431(1.10)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C431(1.08)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C431(1.00)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C431(0.96)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C431(1.16)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C431(1.15)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C431(0.89)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C431(1.01)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C431(0.81)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C431(0.75)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C431(1.08)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C431(1.08)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C431(1.21)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C431(1.14)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C431(1.05)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C431(0.94)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C431(0.84)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C431(0.84)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C431(1.07)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C431(0.92)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C431(1.04)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C431(1.03)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C431(0.90)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C431(0.75)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C431(0.70)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C431(0.87)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C431(0.96)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C431(0.85)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C431(1.14)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C431(1.02)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C431(0.76)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C431(0.97)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C431(0.95)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C431(1.27)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C431(1.01)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C431(1.26)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C431(1.12)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C431(0.74)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C431(1.01)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C431(1.15)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C431(1.04)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C431(1.15)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C431(1.32)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C431(1.14)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C431(1.39)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C431(1.15)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C431(1.26)  LDD0769  [11]
 LDCM0453  CL61 HEK-293T C431(1.03)  LDD1656  [36]
 LDCM0454  CL62 HEK-293T C431(1.13)  LDD1657  [36]
 LDCM0455  CL63 HEK-293T C431(1.15)  LDD1658  [36]
 LDCM0456  CL64 HEK-293T C431(1.04)  LDD1659  [36]
 LDCM0457  CL65 HEK-293T C431(1.05)  LDD1660  [36]
 LDCM0458  CL66 HEK-293T C431(1.00)  LDD1661  [36]
 LDCM0459  CL67 HEK-293T C431(1.06)  LDD1662  [36]
 LDCM0460  CL68 HEK-293T C431(1.16)  LDD1663  [36]
 LDCM0461  CL69 HEK-293T C431(1.16)  LDD1664  [36]
 LDCM0462  CL7 HCT 116 C431(1.12)  LDD0779  [11]
 LDCM0463  CL70 HEK-293T C431(1.15)  LDD1666  [36]
 LDCM0464  CL71 HEK-293T C431(1.04)  LDD1667  [36]
 LDCM0465  CL72 HEK-293T C431(1.04)  LDD1668  [36]
 LDCM0466  CL73 HEK-293T C431(0.92)  LDD1669  [36]
 LDCM0467  CL74 HEK-293T C431(1.12)  LDD1670  [36]
 LDCM0469  CL76 HCT 116 C431(0.92)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C431(0.96)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C431(1.03)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C431(1.08)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C431(1.39)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C431(1.23)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C431(1.22)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C431(1.16)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C431(1.14)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C431(0.93)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C431(1.06)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C431(1.00)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C431(1.07)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C431(1.12)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C431(1.13)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C431(0.75)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C431(1.00)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C431(0.84)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C431(1.22)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C431(1.46)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C431(1.15)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C431(0.96)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C431(1.06)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C431(0.93)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C431(0.82)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C431(1.04)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C431(1.17)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C431(0.51)  LDD1702  [9]
 LDCM0468  Fragment33 HEK-293T C431(1.09)  LDD1671  [36]
 LDCM0427  Fragment51 HCT 116 C431(0.83)  LDD0744  [11]
 LDCM0116  HHS-0101 DM93 Y624(0.80); Y488(2.41); Y381(4.33)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y624(0.66); Y698(0.96); Y381(3.27); Y488(3.32)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y624(0.39); Y381(4.10)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y624(0.77); Y698(1.14); Y381(3.70); Y488(4.45)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y698(0.44); Y624(0.63); Y381(2.33); Y488(3.70)  LDD0268  [10]
 LDCM0107  IAA HeLa H530(0.00); H528(0.00); H553(0.00); H483(0.00)  LDD0221  [25]
 LDCM0022  KB02 HEK-293T C431(0.88)  LDD1492  [36]
 LDCM0023  KB03 HEK-293T C431(0.97)  LDD1497  [36]
 LDCM0024  KB05 MV4-11 C431(1.63)  LDD3338  [37]
 LDCM0109  NEM HeLa H528(0.00); H483(0.00); H530(0.00); H553(0.00)  LDD0223  [25]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C431(0.32)  LDD2100  [9]
 LDCM0131  RA190 MM1.R C431(1.18)  LDD0304  [38]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-tyrosine kinase 6 (PTK6) Tyr protein kinase family Q13882
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte nuclear factor 4-alpha (HNF4A) Nuclear hormone receptor family P41235
Non-POU domain-containing octamer-binding protein (NONO) . Q15233
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thyroid hormone receptor-associated protein 3 (THRAP3) BCLAF1/THRAP3 family Q9Y2W1
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Paired amphipathic helix protein Sin3a (SIN3A) . Q96ST3
Polypyrimidine tract-binding protein 1 (PTBP1) . P26599

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Copper . DB09130

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
28 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
29 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
32 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
33 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
34 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
35 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
36 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
37 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
38 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.