Details of the Target

General Information of Target

Target ID LDTP01770
Target Name NADH-cytochrome b5 reductase 3 (CYB5R3)
Gene Name CYB5R3
Gene ID 1727
Synonyms
DIA1; NADH-cytochrome b5 reductase 3; B5R; Cytochrome b5 reductase; EC 1.6.2.2; Diaphorase-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAQLSTLGHMVLFPVWFLYSLLMKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRF
RFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPK
FPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAG
GTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLD
RAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFV
F
Target Bioclass
Enzyme
Family
Flavoprotein pyridine nucleotide cytochrome reductase family
Subcellular location
Cytoplasm; Endoplasmic reticulum membrane
Function Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.
Uniprot ID
P00387
Ensemble ID
ENST00000352397.10
HGNC ID
HGNC:2873
ChEMBL ID
CHEMBL2146

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.R84P .
KYSE410 Substitution: p.P122F DBIA    Probe Info 
KYSE510 SNV: p.Q135E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		5.68  LDD0244  [1]
N1
 Probe Info  		100.00  LDD0242  [1]
TH211
 Probe Info  		Y94(20.00); Y151(14.40); Y248(10.49)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
OPA-S-S-alkyne
 Probe Info  		K164(1.79); K42(3.81)  LDD3494  [5]
DBIA
 Probe Info  		C237(1.32)  LDD3310  [6]
BTD
 Probe Info  		C204(0.96)  LDD2101  [7]
AHL-Pu-1
 Probe Info  		C204(2.41)  LDD0170  [8]
HHS-475
 Probe Info  		Y80(0.56)  LDD0264  [9]
HHS-465
 Probe Info  		Y80(7.13)  LDD2237  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
m-APA
 Probe Info  		N.A.  LDD2232  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
ATP probe
 Probe Info  		N.A.  LDD0035  [15]
1d-yne
 Probe Info  		N.A.  LDD0356  [16]
IPM
 Probe Info  		N.A.  LDD2156  [17]
NHS
 Probe Info  		K42(0.00); K120(0.00)  LDD0010  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		H55(0.00); C204(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
MPP-AC
 Probe Info  		N.A.  LDD0428  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [22]
TER-AC
 Probe Info  		N.A.  LDD0426  [21]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		6.36  LDD1740  [23]
C285
 Probe Info  		19.29  LDD1955  [23]
C293
 Probe Info  		22.16  LDD1963  [23]
C388
 Probe Info  		36.76  LDD2047  [23]
C403
 Probe Info  		14.62  LDD2061  [23]
FFF probe11
 Probe Info  		17.83  LDD0471  [24]
FFF probe12
 Probe Info  		12.14  LDD0473  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [24]
FFF probe14
 Probe Info  		12.56  LDD0477  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		17.77  LDD0464  [24]
FFF probe4
 Probe Info  		20.00  LDD0466  [24]
FFF probe9
 Probe Info  		13.63  LDD0470  [24]
JN0003
 Probe Info  		20.00  LDD0469  [24]
STS-1
 Probe Info  		N.A.  LDD0136  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
A-DA
 Probe Info  		2.28  LDD0143  [27]
OEA-DA
 Probe Info  		7.12  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C204(0.93)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C204(1.76)  LDD2117  [7]
 LDCM0025  4SU-RNA DM93 C204(2.41)  LDD0170  [8]
 LDCM0214  AC1 HEK-293T C204(0.97)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C204(1.05); C274(1.07); C284(1.11)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C204(1.09); C274(0.99)  LDD1509  [29]
 LDCM0237  AC12 HEK-293T C204(1.07); C274(1.18); C284(0.94)  LDD1510  [29]
 LDCM0259  AC14 HEK-293T C204(1.07); C284(0.99)  LDD1512  [29]
 LDCM0270  AC15 HEK-293T C204(1.08); C274(0.85); C284(2.26)  LDD1513  [29]
 LDCM0276  AC17 HEK-293T C204(1.01)  LDD1515  [29]
 LDCM0277  AC18 HEK-293T C204(1.00); C274(0.99); C284(0.91)  LDD1516  [29]
 LDCM0278  AC19 HEK-293T C204(0.96); C274(0.88)  LDD1517  [29]
 LDCM0279  AC2 HEK-293T C204(0.98); C274(1.06); C284(1.36)  LDD1518  [29]
 LDCM0280  AC20 HEK-293T C204(1.03); C274(1.18); C284(0.91)  LDD1519  [29]
 LDCM0281  AC21 HEK-293T C204(1.01); C274(1.08)  LDD1520  [29]
 LDCM0282  AC22 HEK-293T C204(1.10); C284(1.35)  LDD1521  [29]
 LDCM0283  AC23 HEK-293T C204(1.03); C274(1.00); C284(1.47)  LDD1522  [29]
 LDCM0284  AC24 HEK-293T C204(1.10); C274(0.98)  LDD1523  [29]
 LDCM0285  AC25 HEK-293T C204(0.98)  LDD1524  [29]
 LDCM0286  AC26 HEK-293T C204(1.04); C274(0.94); C284(1.16)  LDD1525  [29]
 LDCM0287  AC27 HEK-293T C204(1.10); C274(1.07)  LDD1526  [29]
 LDCM0288  AC28 HEK-293T C204(1.08); C274(1.24); C284(0.95)  LDD1527  [29]
 LDCM0289  AC29 HEK-293T C204(0.98); C274(1.09)  LDD1528  [29]
 LDCM0290  AC3 HEK-293T C204(1.12); C274(1.09)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C204(1.10); C284(1.00)  LDD1530  [29]
 LDCM0292  AC31 HEK-293T C204(1.10); C274(1.18); C284(1.23)  LDD1531  [29]
 LDCM0293  AC32 HEK-293T C204(0.97); C274(1.02)  LDD1532  [29]
 LDCM0294  AC33 HEK-293T C204(1.01)  LDD1533  [29]
 LDCM0295  AC34 HEK-293T C204(1.01); C274(0.98); C284(0.90)  LDD1534  [29]
 LDCM0296  AC35 HEK-293T C204(1.04); C274(1.22)  LDD1535  [29]
 LDCM0297  AC36 HEK-293T C204(1.05); C274(0.92); C284(0.97)  LDD1536  [29]
 LDCM0298  AC37 HEK-293T C204(1.05); C274(1.07)  LDD1537  [29]
 LDCM0299  AC38 HEK-293T C204(1.09); C284(1.37)  LDD1538  [29]
 LDCM0300  AC39 HEK-293T C204(1.02); C274(1.21); C284(1.22)  LDD1539  [29]
 LDCM0301  AC4 HEK-293T C204(1.16); C274(1.38); C284(0.82)  LDD1540  [29]
 LDCM0302  AC40 HEK-293T C204(1.00); C274(1.07)  LDD1541  [29]
 LDCM0303  AC41 HEK-293T C204(1.00)  LDD1542  [29]
 LDCM0304  AC42 HEK-293T C204(1.08); C274(0.86); C284(1.09)  LDD1543  [29]
 LDCM0305  AC43 HEK-293T C204(1.09); C274(1.03)  LDD1544  [29]
 LDCM0306  AC44 HEK-293T C204(1.04); C274(1.07); C284(1.01)  LDD1545  [29]
 LDCM0307  AC45 HEK-293T C204(0.95); C274(1.14)  LDD1546  [29]
 LDCM0308  AC46 HEK-293T C204(1.10); C284(1.19)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C204(0.97); C274(1.28); C284(0.96)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C204(1.07); C274(0.95)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C204(1.03)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C204(1.01); C274(1.04)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C204(1.05); C274(1.01); C284(1.30)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C204(1.20); C274(0.95)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C204(1.02); C274(1.03); C284(1.03)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C204(0.93); C274(1.08)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C204(1.04); C284(0.88)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C204(1.00); C274(1.03); C284(1.08)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C204(1.00); C274(1.07)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C204(0.99)  LDD1559  [29]
 LDCM0321  AC58 HEK-293T C204(1.10); C274(1.13); C284(1.03)  LDD1560  [29]
 LDCM0322  AC59 HEK-293T C204(1.19); C274(1.14)  LDD1561  [29]
 LDCM0323  AC6 HEK-293T C204(0.97); C284(1.22)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C204(1.02); C274(1.32); C284(0.85)  LDD1563  [29]
 LDCM0325  AC61 HEK-293T C204(1.04); C274(1.21)  LDD1564  [29]
 LDCM0326  AC62 HEK-293T C204(0.97); C284(1.18)  LDD1565  [29]
 LDCM0327  AC63 HEK-293T C204(1.04); C274(1.05); C284(1.21)  LDD1566  [29]
 LDCM0328  AC64 HEK-293T C204(1.15); C274(0.99)  LDD1567  [29]
 LDCM0334  AC7 HEK-293T C204(1.04); C274(0.92); C284(1.17)  LDD1568  [29]
 LDCM0345  AC8 HEK-293T C204(1.02); C274(1.07)  LDD1569  [29]
 LDCM0248  AKOS034007472 HEK-293T C204(1.03); C274(0.99)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C204(0.96)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C204(1.15); C274(1.01)  LDD1514  [29]
 LDCM0083  Avasimibe A-549 2.28  LDD0143  [27]
 LDCM0108  Chloroacetamide HeLa C204(0.00); H55(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C204(1.01); C274(1.00)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C204(0.92); C284(0.90)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C204(1.00); C274(0.93); C284(1.00)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C204(1.00); C274(1.05)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C204(1.01); C274(0.80)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C204(0.97); C274(1.00)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C204(1.12); C274(0.99); C284(0.73)  LDD1577  [29]
 LDCM0374  CL105 HEK-293T C204(1.03); C274(1.00)  LDD1578  [29]
 LDCM0375  CL106 HEK-293T C204(1.10); C274(1.03)  LDD1579  [29]
 LDCM0376  CL107 HEK-293T C204(0.98); C274(0.97)  LDD1580  [29]
 LDCM0377  CL108 HEK-293T C204(1.03); C274(1.01); C284(0.99)  LDD1581  [29]
 LDCM0378  CL109 HEK-293T C204(0.99); C274(0.97)  LDD1582  [29]
 LDCM0379  CL11 HEK-293T C204(1.06); C274(1.20); C284(0.83)  LDD1583  [29]
 LDCM0380  CL110 HEK-293T C204(1.00); C274(0.94)  LDD1584  [29]
 LDCM0381  CL111 HEK-293T C204(0.92); C274(0.77)  LDD1585  [29]
 LDCM0382  CL112 HEK-293T C204(1.08); C274(1.04); C284(0.96)  LDD1586  [29]
 LDCM0383  CL113 HEK-293T C204(1.00); C274(1.20)  LDD1587  [29]
 LDCM0384  CL114 HEK-293T C204(0.99); C274(0.88)  LDD1588  [29]
 LDCM0385  CL115 HEK-293T C204(1.04); C274(0.85)  LDD1589  [29]
 LDCM0386  CL116 HEK-293T C204(1.03); C274(1.01); C284(1.01)  LDD1590  [29]
 LDCM0387  CL117 HEK-293T C204(1.03); C274(1.15)  LDD1591  [29]
 LDCM0388  CL118 HEK-293T C204(1.06); C274(1.08)  LDD1592  [29]
 LDCM0389  CL119 HEK-293T C204(1.10); C274(1.05)  LDD1593  [29]
 LDCM0390  CL12 HEK-293T C204(1.02); C274(0.94)  LDD1594  [29]
 LDCM0391  CL120 HEK-293T C204(1.00); C274(1.11); C284(0.84)  LDD1595  [29]
 LDCM0392  CL121 HEK-293T C204(0.96); C274(1.02)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C204(0.96); C274(0.95)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C204(1.02); C274(0.85)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C204(0.95); C274(1.09); C284(0.97)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C204(1.11); C274(0.96)  LDD1600  [29]
 LDCM0397  CL126 HEK-293T C204(1.09); C274(1.14)  LDD1601  [29]
 LDCM0398  CL127 HEK-293T C204(1.02); C274(0.88)  LDD1602  [29]
 LDCM0399  CL128 HEK-293T C204(0.99); C274(1.05); C284(1.17)  LDD1603  [29]
 LDCM0400  CL13 HEK-293T C204(0.84); C274(0.92)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C204(1.11); C274(0.89)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C204(0.90); C274(0.69)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C204(1.01); C274(1.02); C284(1.02)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C204(0.80)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C204(1.14); C274(0.99); C284(0.95)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C204(1.08); C274(1.02)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C204(0.89); C274(1.00)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C204(0.99); C274(0.97); C284(1.61)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C204(1.00); C274(1.06)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C204(1.10); C284(1.51)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C204(1.15); C274(1.12); C284(1.55)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C204(1.00); C274(1.15)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C204(1.03); C274(0.99)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C204(1.05); C274(0.93)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C204(0.89); C274(0.92)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C204(0.91); C274(0.91); C284(0.83)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C204(0.96)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C204(0.95); C274(0.95)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C204(1.00); C274(0.97); C284(1.08)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C204(0.93); C274(0.96)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C204(1.01); C274(0.96); C284(0.85)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C204(0.91); C274(0.73)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C204(1.01); C284(1.24)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C204(1.10); C274(0.84); C284(1.92)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C204(1.14); C274(0.89)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C204(1.05); C274(1.24)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C204(0.93); C274(0.87)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C204(0.90); C274(0.83); C284(1.26)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C204(0.99); C274(1.03); C284(0.93)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C204(1.00)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C204(1.08); C274(0.99); C284(1.31)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C204(1.15); C274(0.87)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C204(1.05); C274(0.89); C284(1.33)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C204(0.93); C274(0.84)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C204(1.14); C284(0.90)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C204(1.04); C274(0.95); C284(1.36)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C204(1.12); C274(0.86)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C204(1.18); C274(1.44)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C204(0.94)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C204(1.02); C274(0.98)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C204(0.87); C274(1.18); C284(0.82)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C204(0.95)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C204(1.10); C274(1.05); C284(1.01)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C204(1.19); C274(1.09)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C204(1.08); C274(0.84); C284(1.12)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C204(1.03); C274(0.97)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C204(1.11); C284(1.25)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C204(1.13); C274(0.97); C284(1.03)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C204(1.03); C274(0.89); C284(1.02)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C204(1.06); C274(1.06)  LDD1655  [29]
 LDCM0453  CL61 HEK-293T C204(0.99); C274(1.26)  LDD1656  [29]
 LDCM0454  CL62 HEK-293T C204(1.06); C274(1.08)  LDD1657  [29]
 LDCM0455  CL63 HEK-293T C204(1.06); C274(0.86)  LDD1658  [29]
 LDCM0456  CL64 HEK-293T C204(1.05); C274(0.99); C284(0.91)  LDD1659  [29]
 LDCM0457  CL65 HEK-293T C204(0.98)  LDD1660  [29]
 LDCM0458  CL66 HEK-293T C204(1.07); C274(0.83); C284(0.90)  LDD1661  [29]
 LDCM0459  CL67 HEK-293T C204(1.13); C274(1.09)  LDD1662  [29]
 LDCM0460  CL68 HEK-293T C204(1.08); C274(1.09); C284(0.90)  LDD1663  [29]
 LDCM0461  CL69 HEK-293T C204(1.02); C274(0.98)  LDD1664  [29]
 LDCM0462  CL7 HEK-293T C204(1.02); C274(1.07)  LDD1665  [29]
 LDCM0463  CL70 HEK-293T C204(1.25); C284(1.01)  LDD1666  [29]
 LDCM0464  CL71 HEK-293T C204(1.02); C274(0.89); C284(0.97)  LDD1667  [29]
 LDCM0465  CL72 HEK-293T C204(0.94); C274(0.92)  LDD1668  [29]
 LDCM0466  CL73 HEK-293T C204(1.08); C274(1.02)  LDD1669  [29]
 LDCM0467  CL74 HEK-293T C204(1.13); C274(0.93)  LDD1670  [29]
 LDCM0469  CL76 HEK-293T C204(1.08); C274(1.08); C284(0.94)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C204(0.96)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C204(1.13); C274(0.89); C284(0.97)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C204(1.13); C274(1.11)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C204(0.89); C274(0.83); C284(0.74)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C204(1.09); C274(0.98); C284(0.97)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C204(1.03); C274(0.94)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C204(1.22); C284(1.32)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C204(1.12); C274(1.04); C284(1.37)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C204(1.08); C274(0.73)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C204(1.06); C274(1.08)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C204(1.05); C274(1.12)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C204(1.01); C274(0.90)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C204(1.07); C274(1.26); C284(1.20)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C204(1.00)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C204(1.09); C274(1.04)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C204(0.95); C274(0.70); C284(0.87)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C204(1.14); C274(1.14)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C204(0.99); C274(1.22); C284(0.96)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C204(1.04); C274(0.96)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C204(1.11); C284(0.63)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C204(0.88); C274(0.80); C284(0.88)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C204(1.05); C274(0.91)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C204(0.96); C274(1.05)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C204(1.04); C274(0.98)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C204(1.01); C274(0.91)  LDD1697  [29]
 LDCM0495  E2913 HEK-293T C204(0.92); C274(0.81)  LDD1698  [29]
 LDCM0468  Fragment33 HEK-293T C204(1.06); C274(1.01)  LDD1671  [29]
 LDCM0427  Fragment51 HEK-293T C204(1.00); C274(1.11)  LDD1631  [29]
 LDCM0116  HHS-0101 DM93 Y80(0.56)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y80(0.64)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y80(0.26)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y80(0.36)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y80(0.83)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C204(1.00); C274(0.87)  LDD1492  [29]
 LDCM0023  KB03 HEK-293T C204(0.97); C274(0.91)  LDD1497  [29]
 LDCM0024  KB05 COLO792 C237(1.32)  LDD3310  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [20]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C204(0.96)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C204(0.61)  LDD2104  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C204(0.89)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C204(1.22)  LDD2107  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C204(0.70)  LDD2114  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C204(1.77)  LDD2123  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C204(1.13)  LDD2127  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C204(1.78)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C204(2.01)  LDD2137  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C204(1.08)  LDD2141  [7]
 LDCM0084  Ro 48-8071 A-549 2.01  LDD0145  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) Lipase family P54315
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG8) ALG6/ALG8 glucosyltransferase family Q9BVK2
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) Chondroitin N-acetylgalactosaminyltransferase family Q8N6G5
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
Ceramide synthase 4 (CERS4) . Q9HA82
Transporter and channel
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Stomatin (STOM) Band 7/mec-2 family P27105
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Protein cornichon homolog 1 (CNIH1) Cornichon family O95406
Hemoglobin subunit alpha (HBA1; HBA2) Globin family P69905
Lysosomal-associated transmembrane protein 5 (LAPTM5) LAPTM4/LAPTM5 transporter family Q13571
Major facilitator superfamily domain-containing protein 6 (MFSD6) MFSD6 family Q6ZSS7
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Ninjurin-1 (NINJ1) Ninjurin family Q92982
Probable UDP-sugar transporter protein SLC35A4 (SLC35A4) Nucleotide-sugar transporter family Q96G79
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) Nucleotide-sugar transporter family Q8TB61
Na(+)/dicarboxylate cotransporter 3 (SLC13A3) SLC13A/DASS transporter family Q8WWT9
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
Vacuole membrane protein 1 (VMP1) VMP1 family Q96GC9
Transmembrane protein 60 (TMEM60) . Q9H2L4
Transmembrane protein 79 (TMEM79) . Q9BSE2
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Metabotropic glutamate receptor 2 (GRM2) G-protein coupled receptor 3 family Q14416
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) . O14798
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Protein FAM3C (FAM3C) FAM3 family Q92520
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Gastrin (GAST) Gastrin/cholecystokinin family P01350
Neuronal vesicle trafficking-associated protein 1 (NSG1) NSG family P42857
Nurim (NRM) Nurim family Q8IXM6
NXPE family member 3 (NXPE3) NXPE family Q969Y0
ORM1-like protein 2 (ORMDL2) ORM family Q53FV1
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Transmembrane protein 115 (TMEM115) TMEM115 family Q12893
Asialoglycoprotein receptor 1 (ASGR1) . P07306
Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4) . O75427
Transmembrane protein 51 (TMEM51) . Q9NW97
WAP four-disulfide core domain protein 2 (WFDC2) . Q14508

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Flavin Adenine Dinucleotide Small molecular drug DB03147
Nadh Small molecular drug DB00157
Copper . DB09130

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
28 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402