Details of the Target

General Information of Target

Target ID LDTP04356
Target Name Emerin (EMD)
Gene Name EMD
Gene ID 2010
Synonyms
EDMD; STA; Emerin
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRLSPPSSSAASSYS
FSDLNSTRGDADMYDLPKKEDALLYQSKGYNDDYYEESYFTTRTYGEPESAGPSRAVRQS
VTSFPDADAFHHQVHDDDLLSSSEEECKDRERPMYGRDSAYQSITHYRPVSASRSSLDLS
YYPTSSSTSFMSSSSSSSSWLTRRAIRPENRAPGAGLGQDRQVPLWGQLLLFLVFVIVLF
FIYHFMQAEEGNPF
Target Bioclass
Other
Subcellular location
Nucleus inner membrane
Function
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.
Uniprot ID
P50402
Ensemble ID
ENST00000369842.9
HGNC ID
HGNC:3331

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y85(11.54); Y161(16.21); Y19(10.73)  LDD0260  [2]
FBP2
 Probe Info  		2.22  LDD0323  [3]
AZ-9
 Probe Info  		E97(10.00)  LDD2208  [4]
Probe 1
 Probe Info  		Y41(12.67); Y74(14.80); Y85(18.76); Y94(28.41)  LDD3495  [5]
DBIA
 Probe Info  		C147(1.31)  LDD3323  [6]
P12
 Probe Info  		8.97  LDD0202  [7]
DA-P3
 Probe Info  		5.12  LDD0180  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
1d-yne
 Probe Info  		N.A.  LDD0356  [13]
IPM
 Probe Info  		N.A.  LDD0147  [14]
NHS
 Probe Info  		K79(0.00); K37(0.00)  LDD0010  [15]
OSF
 Probe Info  		N.A.  LDD0029  [16]
SF
 Probe Info  		Y41(0.00); Y59(0.00); Y167(0.00); Y85(0.00)  LDD0028  [16]
STPyne
 Probe Info  		K79(0.00); K37(0.00)  LDD0009  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [17]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Acrolein
 Probe Info  		H23(0.00); C147(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		H166(0.00); H23(0.00)  LDD0219  [18]
AOyne
 Probe Info  		14.30  LDD0443  [19]
PAL-AfBPP Probe
Click To Hide/Show 65 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		4.06  LDD0398  [20]
C022
 Probe Info  		8.11  LDD1728  [21]
C027
 Probe Info  		7.94  LDD1733  [21]
C040
 Probe Info  		14.83  LDD1740  [21]
C041
 Probe Info  		5.62  LDD1741  [21]
C056
 Probe Info  		16.80  LDD1753  [21]
C063
 Probe Info  		12.55  LDD1760  [21]
C070
 Probe Info  		8.94  LDD1766  [21]
C087
 Probe Info  		7.52  LDD1779  [21]
C091
 Probe Info  		14.83  LDD1782  [21]
C092
 Probe Info  		21.86  LDD1783  [21]
C094
 Probe Info  		31.56  LDD1785  [21]
C106
 Probe Info  		19.56  LDD1793  [21]
C112
 Probe Info  		20.53  LDD1799  [21]
C134
 Probe Info  		27.67  LDD1816  [21]
C153
 Probe Info  		16.00  LDD1834  [21]
C159
 Probe Info  		7.94  LDD1839  [21]
C161
 Probe Info  		12.91  LDD1841  [21]
C165
 Probe Info  		13.00  LDD1845  [21]
C169
 Probe Info  		26.17  LDD1849  [21]
C187
 Probe Info  		26.17  LDD1865  [21]
C191
 Probe Info  		20.53  LDD1868  [21]
C193
 Probe Info  		7.21  LDD1869  [21]
C196
 Probe Info  		10.48  LDD1872  [21]
C198
 Probe Info  		9.99  LDD1874  [21]
C201
 Probe Info  		28.84  LDD1877  [21]
C206
 Probe Info  		16.00  LDD1881  [21]
C218
 Probe Info  		16.00  LDD1892  [21]
C220
 Probe Info  		13.74  LDD1894  [21]
C228
 Probe Info  		22.78  LDD1901  [21]
C231
 Probe Info  		13.93  LDD1904  [21]
C232
 Probe Info  		39.95  LDD1905  [21]
C235
 Probe Info  		21.71  LDD1908  [21]
C238
 Probe Info  		11.96  LDD1911  [21]
C289
 Probe Info  		32.22  LDD1959  [21]
C314
 Probe Info  		11.24  LDD1981  [21]
C348
 Probe Info  		12.82  LDD2009  [21]
C349
 Probe Info  		14.32  LDD2010  [21]
C350
 Probe Info  		37.27  LDD2011  [21]
C353
 Probe Info  		6.28  LDD2014  [21]
C355
 Probe Info  		22.94  LDD2016  [21]
C362
 Probe Info  		49.87  LDD2023  [21]
C363
 Probe Info  		16.56  LDD2024  [21]
C364
 Probe Info  		16.56  LDD2025  [21]
C388
 Probe Info  		75.06  LDD2047  [21]
C390
 Probe Info  		40.79  LDD2049  [21]
C391
 Probe Info  		13.09  LDD2050  [21]
C403
 Probe Info  		17.75  LDD2061  [21]
C407
 Probe Info  		17.63  LDD2064  [21]
C420
 Probe Info  		10.27  LDD2075  [21]
C431
 Probe Info  		16.00  LDD2086  [21]
FFF probe11
 Probe Info  		20.00  LDD0471  [22]
FFF probe13
 Probe Info  		19.99  LDD0475  [22]
FFF probe14
 Probe Info  		13.11  LDD0477  [22]
FFF probe2
 Probe Info  		17.95  LDD0463  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
FFF probe4
 Probe Info  		20.00  LDD0466  [22]
FFF probe6
 Probe Info  		5.34  LDD0467  [22]
FFF probe9
 Probe Info  		6.06  LDD0470  [22]
JN0003
 Probe Info  		20.00  LDD0469  [22]
STS-1
 Probe Info  		N.A.  LDD0136  [23]
STS-2
 Probe Info  		N.A.  LDD0138  [23]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [24]
BD-F
 Probe Info  		N.A.  LDD0024  [25]
OEA-DA
 Probe Info  		13.67  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C147(1.04)  LDD1507  [27]
 LDCM0215  AC10 HEK-293T C147(1.07)  LDD1508  [27]
 LDCM0226  AC11 HEK-293T C147(0.85)  LDD1509  [27]
 LDCM0237  AC12 HEK-293T C147(1.09)  LDD1510  [27]
 LDCM0259  AC14 HEK-293T C147(1.14)  LDD1512  [27]
 LDCM0270  AC15 HEK-293T C147(1.35)  LDD1513  [27]
 LDCM0276  AC17 HEK-293T C147(1.11)  LDD1515  [27]
 LDCM0277  AC18 HEK-293T C147(1.01)  LDD1516  [27]
 LDCM0278  AC19 HEK-293T C147(1.70)  LDD1517  [27]
 LDCM0279  AC2 HEK-293T C147(0.98)  LDD1518  [27]
 LDCM0280  AC20 HEK-293T C147(1.15)  LDD1519  [27]
 LDCM0282  AC22 HEK-293T C147(1.15)  LDD1521  [27]
 LDCM0283  AC23 HEK-293T C147(1.46)  LDD1522  [27]
 LDCM0284  AC24 HEK-293T C147(1.13)  LDD1523  [27]
 LDCM0285  AC25 HEK-293T C147(1.04)  LDD1524  [27]
 LDCM0286  AC26 HEK-293T C147(1.09)  LDD1525  [27]
 LDCM0287  AC27 HEK-293T C147(1.12)  LDD1526  [27]
 LDCM0288  AC28 HEK-293T C147(1.20)  LDD1527  [27]
 LDCM0290  AC3 HEK-293T C147(1.15)  LDD1529  [27]
 LDCM0291  AC30 HEK-293T C147(1.07)  LDD1530  [27]
 LDCM0292  AC31 HEK-293T C147(1.23)  LDD1531  [27]
 LDCM0293  AC32 HEK-293T C147(1.29)  LDD1532  [27]
 LDCM0294  AC33 HEK-293T C147(1.05)  LDD1533  [27]
 LDCM0295  AC34 HEK-293T C147(1.06)  LDD1534  [27]
 LDCM0296  AC35 HEK-293T C147(1.04)  LDD1535  [27]
 LDCM0297  AC36 HEK-293T C147(1.00)  LDD1536  [27]
 LDCM0299  AC38 HEK-293T C147(1.01)  LDD1538  [27]
 LDCM0300  AC39 HEK-293T C147(0.93)  LDD1539  [27]
 LDCM0301  AC4 HEK-293T C147(1.05)  LDD1540  [27]
 LDCM0302  AC40 HEK-293T C147(1.19)  LDD1541  [27]
 LDCM0303  AC41 HEK-293T C147(0.99)  LDD1542  [27]
 LDCM0304  AC42 HEK-293T C147(0.99)  LDD1543  [27]
 LDCM0305  AC43 HEK-293T C147(1.16)  LDD1544  [27]
 LDCM0306  AC44 HEK-293T C147(1.07)  LDD1545  [27]
 LDCM0308  AC46 HEK-293T C147(1.22)  LDD1547  [27]
 LDCM0309  AC47 HEK-293T C147(1.60)  LDD1548  [27]
 LDCM0310  AC48 HEK-293T C147(1.09)  LDD1549  [27]
 LDCM0311  AC49 HEK-293T C147(1.09)  LDD1550  [27]
 LDCM0313  AC50 HEK-293T C147(1.07)  LDD1552  [27]
 LDCM0314  AC51 HEK-293T C147(0.90)  LDD1553  [27]
 LDCM0315  AC52 HEK-293T C147(1.06)  LDD1554  [27]
 LDCM0317  AC54 HEK-293T C147(1.07)  LDD1556  [27]
 LDCM0318  AC55 HEK-293T C147(1.09)  LDD1557  [27]
 LDCM0319  AC56 HEK-293T C147(1.02)  LDD1558  [27]
 LDCM0320  AC57 HEK-293T C147(1.00)  LDD1559  [27]
 LDCM0321  AC58 HEK-293T C147(1.01)  LDD1560  [27]
 LDCM0322  AC59 HEK-293T C147(0.82)  LDD1561  [27]
 LDCM0323  AC6 HEK-293T C147(1.23)  LDD1562  [27]
 LDCM0324  AC60 HEK-293T C147(1.07)  LDD1563  [27]
 LDCM0326  AC62 HEK-293T C147(1.07)  LDD1565  [27]
 LDCM0327  AC63 HEK-293T C147(0.97)  LDD1566  [27]
 LDCM0328  AC64 HEK-293T C147(1.04)  LDD1567  [27]
 LDCM0334  AC7 HEK-293T C147(0.96)  LDD1568  [27]
 LDCM0345  AC8 HEK-293T C147(1.00)  LDD1569  [27]
 LDCM0356  AKOS034007680 HEK-293T C147(1.07)  LDD1570  [27]
 LDCM0275  AKOS034007705 HEK-293T C147(0.98)  LDD1514  [27]
 LDCM0156  Aniline NCI-H1299 14.25  LDD0403  [1]
 LDCM0088  C45 HEK-293T 8.97  LDD0202  [7]
 LDCM0087  Capsaicin HEK-293T 7.34  LDD0185  [8]
 LDCM0108  Chloroacetamide HeLa H166(0.00); H23(0.00)  LDD0222  [18]
 LDCM0367  CL1 HEK-293T C147(1.08)  LDD1571  [27]
 LDCM0368  CL10 HEK-293T C147(1.15)  LDD1572  [27]
 LDCM0369  CL100 HEK-293T C147(1.21)  LDD1573  [27]
 LDCM0370  CL101 HEK-293T C147(1.08)  LDD1574  [27]
 LDCM0371  CL102 HEK-293T C147(0.96)  LDD1575  [27]
 LDCM0372  CL103 HEK-293T C147(1.08)  LDD1576  [27]
 LDCM0373  CL104 HEK-293T C147(0.91)  LDD1577  [27]
 LDCM0374  CL105 HEK-293T C147(1.04)  LDD1578  [27]
 LDCM0375  CL106 HEK-293T C147(1.16)  LDD1579  [27]
 LDCM0376  CL107 HEK-293T C147(0.97)  LDD1580  [27]
 LDCM0377  CL108 HEK-293T C147(1.09)  LDD1581  [27]
 LDCM0378  CL109 HEK-293T C147(0.96)  LDD1582  [27]
 LDCM0379  CL11 HEK-293T C147(1.13)  LDD1583  [27]
 LDCM0380  CL110 HEK-293T C147(1.08)  LDD1584  [27]
 LDCM0381  CL111 HEK-293T C147(1.12)  LDD1585  [27]
 LDCM0382  CL112 HEK-293T C147(1.27)  LDD1586  [27]
 LDCM0383  CL113 HEK-293T C147(1.04)  LDD1587  [27]
 LDCM0384  CL114 HEK-293T C147(0.95)  LDD1588  [27]
 LDCM0385  CL115 HEK-293T C147(1.07)  LDD1589  [27]
 LDCM0386  CL116 HEK-293T C147(1.02)  LDD1590  [27]
 LDCM0387  CL117 HEK-293T C147(1.11)  LDD1591  [27]
 LDCM0388  CL118 HEK-293T C147(1.04)  LDD1592  [27]
 LDCM0389  CL119 HEK-293T C147(1.17)  LDD1593  [27]
 LDCM0390  CL12 HEK-293T C147(0.83)  LDD1594  [27]
 LDCM0391  CL120 HEK-293T C147(0.91)  LDD1595  [27]
 LDCM0392  CL121 HEK-293T C147(1.06)  LDD1596  [27]
 LDCM0393  CL122 HEK-293T C147(1.04)  LDD1597  [27]
 LDCM0394  CL123 HEK-293T C147(0.94)  LDD1598  [27]
 LDCM0395  CL124 HEK-293T C147(1.14)  LDD1599  [27]
 LDCM0396  CL125 HEK-293T C147(0.98)  LDD1600  [27]
 LDCM0397  CL126 HEK-293T C147(0.94)  LDD1601  [27]
 LDCM0398  CL127 HEK-293T C147(0.94)  LDD1602  [27]
 LDCM0399  CL128 HEK-293T C147(0.90)  LDD1603  [27]
 LDCM0400  CL13 HEK-293T C147(1.23)  LDD1604  [27]
 LDCM0401  CL14 HEK-293T C147(1.14)  LDD1605  [27]
 LDCM0402  CL15 HEK-293T C147(1.21)  LDD1606  [27]
 LDCM0403  CL16 HEK-293T C147(1.06)  LDD1607  [27]
 LDCM0404  CL17 HEK-293T C147(1.11)  LDD1608  [27]
 LDCM0405  CL18 HEK-293T C147(1.18)  LDD1609  [27]
 LDCM0406  CL19 HEK-293T C147(1.08)  LDD1610  [27]
 LDCM0407  CL2 HEK-293T C147(1.03)  LDD1611  [27]
 LDCM0408  CL20 HEK-293T C147(1.17)  LDD1612  [27]
 LDCM0410  CL22 HEK-293T C147(1.16)  LDD1614  [27]
 LDCM0411  CL23 HEK-293T C147(1.09)  LDD1615  [27]
 LDCM0412  CL24 HEK-293T C147(0.90)  LDD1616  [27]
 LDCM0413  CL25 HEK-293T C147(0.98)  LDD1617  [27]
 LDCM0414  CL26 HEK-293T C147(1.17)  LDD1618  [27]
 LDCM0415  CL27 HEK-293T C147(1.24)  LDD1619  [27]
 LDCM0416  CL28 HEK-293T C147(1.22)  LDD1620  [27]
 LDCM0417  CL29 HEK-293T C147(1.06)  LDD1621  [27]
 LDCM0418  CL3 HEK-293T C147(1.08)  LDD1622  [27]
 LDCM0419  CL30 HEK-293T C147(1.14)  LDD1623  [27]
 LDCM0420  CL31 HEK-293T C147(0.92)  LDD1624  [27]
 LDCM0421  CL32 HEK-293T C147(1.04)  LDD1625  [27]
 LDCM0423  CL34 HEK-293T C147(0.89)  LDD1627  [27]
 LDCM0424  CL35 HEK-293T C147(1.25)  LDD1628  [27]
 LDCM0425  CL36 HEK-293T C147(0.97)  LDD1629  [27]
 LDCM0426  CL37 HEK-293T C147(1.13)  LDD1630  [27]
 LDCM0428  CL39 HEK-293T C147(1.16)  LDD1632  [27]
 LDCM0429  CL4 HEK-293T C147(1.30)  LDD1633  [27]
 LDCM0430  CL40 HEK-293T C147(1.52)  LDD1634  [27]
 LDCM0431  CL41 HEK-293T C147(1.04)  LDD1635  [27]
 LDCM0432  CL42 HEK-293T C147(0.99)  LDD1636  [27]
 LDCM0433  CL43 HEK-293T C147(1.22)  LDD1637  [27]
 LDCM0434  CL44 HEK-293T C147(1.16)  LDD1638  [27]
 LDCM0436  CL46 HEK-293T C147(1.07)  LDD1640  [27]
 LDCM0437  CL47 HEK-293T C147(1.20)  LDD1641  [27]
 LDCM0438  CL48 HEK-293T C147(0.90)  LDD1642  [27]
 LDCM0439  CL49 HEK-293T C147(1.06)  LDD1643  [27]
 LDCM0440  CL5 HEK-293T C147(1.08)  LDD1644  [27]
 LDCM0441  CL50 HEK-293T C147(1.06)  LDD1645  [27]
 LDCM0443  CL52 HEK-293T C147(1.13)  LDD1646  [27]
 LDCM0444  CL53 HEK-293T C147(1.02)  LDD1647  [27]
 LDCM0445  CL54 HEK-293T C147(1.12)  LDD1648  [27]
 LDCM0446  CL55 HEK-293T C147(1.05)  LDD1649  [27]
 LDCM0447  CL56 HEK-293T C147(1.07)  LDD1650  [27]
 LDCM0449  CL58 HEK-293T C147(1.00)  LDD1652  [27]
 LDCM0450  CL59 HEK-293T C147(1.15)  LDD1653  [27]
 LDCM0451  CL6 HEK-293T C147(1.01)  LDD1654  [27]
 LDCM0452  CL60 HEK-293T C147(0.94)  LDD1655  [27]
 LDCM0453  CL61 HEK-293T C147(1.14)  LDD1656  [27]
 LDCM0454  CL62 HEK-293T C147(1.00)  LDD1657  [27]
 LDCM0455  CL63 HEK-293T C147(1.11)  LDD1658  [27]
 LDCM0456  CL64 HEK-293T C147(1.26)  LDD1659  [27]
 LDCM0457  CL65 HEK-293T C147(1.13)  LDD1660  [27]
 LDCM0458  CL66 HEK-293T C147(1.17)  LDD1661  [27]
 LDCM0459  CL67 HEK-293T C147(1.36)  LDD1662  [27]
 LDCM0460  CL68 HEK-293T C147(1.13)  LDD1663  [27]
 LDCM0462  CL7 HEK-293T C147(0.86)  LDD1665  [27]
 LDCM0463  CL70 HEK-293T C147(1.10)  LDD1666  [27]
 LDCM0464  CL71 HEK-293T C147(0.98)  LDD1667  [27]
 LDCM0465  CL72 HEK-293T C147(0.97)  LDD1668  [27]
 LDCM0466  CL73 HEK-293T C147(0.96)  LDD1669  [27]
 LDCM0467  CL74 HEK-293T C147(0.99)  LDD1670  [27]
 LDCM0469  CL76 HEK-293T C147(1.25)  LDD1672  [27]
 LDCM0470  CL77 HEK-293T C147(1.06)  LDD1673  [27]
 LDCM0471  CL78 HEK-293T C147(1.20)  LDD1674  [27]
 LDCM0472  CL79 HEK-293T C147(0.94)  LDD1675  [27]
 LDCM0473  CL8 HEK-293T C147(1.06)  LDD1676  [27]
 LDCM0474  CL80 HEK-293T C147(0.98)  LDD1677  [27]
 LDCM0476  CL82 HEK-293T C147(0.99)  LDD1679  [27]
 LDCM0477  CL83 HEK-293T C147(1.19)  LDD1680  [27]
 LDCM0478  CL84 HEK-293T C147(0.84)  LDD1681  [27]
 LDCM0479  CL85 HEK-293T C147(1.09)  LDD1682  [27]
 LDCM0480  CL86 HEK-293T C147(1.05)  LDD1683  [27]
 LDCM0481  CL87 HEK-293T C147(1.31)  LDD1684  [27]
 LDCM0482  CL88 HEK-293T C147(1.12)  LDD1685  [27]
 LDCM0483  CL89 HEK-293T C147(1.01)  LDD1686  [27]
 LDCM0485  CL90 HEK-293T C147(0.99)  LDD1688  [27]
 LDCM0486  CL91 HEK-293T C147(0.96)  LDD1689  [27]
 LDCM0487  CL92 HEK-293T C147(0.96)  LDD1690  [27]
 LDCM0489  CL94 HEK-293T C147(1.19)  LDD1692  [27]
 LDCM0490  CL95 HEK-293T C147(1.21)  LDD1693  [27]
 LDCM0491  CL96 HEK-293T C147(0.93)  LDD1694  [27]
 LDCM0492  CL97 HEK-293T C147(1.04)  LDD1695  [27]
 LDCM0493  CL98 HEK-293T C147(1.19)  LDD1696  [27]
 LDCM0494  CL99 HEK-293T C147(1.18)  LDD1697  [27]
 LDCM0028  Dobutamine HEK-293T 5.12  LDD0180  [8]
 LDCM0495  E2913 HEK-293T C147(1.26)  LDD1698  [27]
 LDCM0468  Fragment33 HEK-293T C147(1.03)  LDD1671  [27]
 LDCM0427  Fragment51 HEK-293T C147(1.11)  LDD1631  [27]
 LDCM0107  IAA HeLa H23(0.00); H166(0.00)  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C147(1.00)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C147(1.01)  LDD1497  [27]
 LDCM0024  KB05 SKMEL24 C147(1.31)  LDD3323  [6]
 LDCM0109  NEM HeLa H166(0.00); H23(0.00)  LDD0223  [18]
 LDCM0029  Quercetin HEK-293T 7.24  LDD0181  [8]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin, cytoplasmic 1 (ACTB) Actin family P60709
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
Ribonuclease H1 (RNASEH1) RNase H family O60930
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
Ceramide synthase 4 (CERS4) . Q9HA82
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
ATP-sensitive inward rectifier potassium channel 12 (KCNJ12) Inward rectifier-type potassium channel family Q14500
Inward rectifier potassium channel 18 (KCNJ18) Inward rectifier-type potassium channel family B7U540
ATP-sensitive inward rectifier potassium channel 8 (KCNJ8) Inward rectifier-type potassium channel (TC 1.A.2.1) family Q15842
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
SUN domain-containing protein 2 (SUN2) . Q9UH99
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 174 (TMEM174) . Q8WUU8
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 1 homolog (ZFP1) Krueppel C2H2-type zinc-finger protein family Q6P2D0
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 232 (ZNF232) Krueppel C2H2-type zinc-finger protein family Q9UNY5
Zinc finger protein 329 (ZNF329) Krueppel C2H2-type zinc-finger protein family Q86UD4
Zinc finger protein 341 (ZNF341) Krueppel C2H2-type zinc-finger protein family Q9BYN7
Zinc finger protein 398 (ZNF398) Krueppel C2H2-type zinc-finger protein family Q8TD17
Zinc finger protein 549 (ZNF549) Krueppel C2H2-type zinc-finger protein family Q6P9A3
Zinc finger protein 64 (ZFP64) Krueppel C2H2-type zinc-finger protein family Q9NTW7
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Homeobox protein MOX-1 (MEOX1) . P50221
Homeobox protein MOX-2 (MEOX2) . P50222
Transcription factor 23 (TCF23) . Q7RTU1
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Erythroid membrane-associated protein (ERMAP) BTN/MOG family Q96PL5
Myeloid cell surface antigen CD33 (CD33) SIGLEC (sialic acid binding Ig-like lectin) family P20138
Other
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Barrier-to-autointegration factor (BANF1) BAF family O75531
Bcl-2-associated transcription factor 1 (BCLAF1) BCLAF1/THRAP3 family Q9NYF8
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Bystin (BYSL) Bystin family Q13895
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Endophilin-A1 (SH3GL2) Endophilin family Q99962
Activator of basal transcription 1 (ABT1) ESF2/ABP1 family Q9ULW3
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Protein INCA1 (INCA1) INCA family Q0VD86
Prelamin-A/C (LMNA) Intermediate filament family P02545
Large ribosomal subunit protein mL45 (MRPL45) Mitochondrion-specific ribosomal protein mL45 family Q9BRJ2
Transcription termination factor 4, mitochondrial (MTERF4) MTERF family Q7Z6M4
Neural proliferation differentiation and control protein 1 (NPDC1) NPDC1/cab-1 family Q9NQX5
Ankyrin repeat domain-containing protein SOWAHB (SOWAHB) SOWAH family A6NEL2
Transmembrane protein 200A (TMEM200A) TMEM200 family Q86VY9
Transmembrane protein 43 (TMEM43) TMEM43 family Q9BTV4
Ankyrin repeat and SAM domain-containing protein 6 (ANKS6) . Q68DC2
Arginine vasopressin-induced protein 1 (AVPI1) . Q5T686
C-type lectin domain family 14 member A (CLEC14A) . Q86T13
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 33 (CCDC33) . Q8N5R6
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
GRAM domain-containing protein 2A (GRAMD2A) . Q8IUY3
Heat shock factor 2-binding protein (HSF2BP) . O75031
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
Leucine zipper protein 4 (LUZP4) . Q9P127
Protein KASH5 (KASH5) . Q8N6L0
Protein PIMREG (PIMREG) . Q9BSJ6
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228
Transmembrane protein 52B (TMEM52B) . Q4KMG9
Transmembrane protein 80 (TMEM80) . Q96HE8
Uncharacterized protein CXorf66 (CXorf66) . Q5JRM2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
25 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402