Details of the Target

General Information of Target

Target ID LDTP04120
Target Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A)
Gene Name STT3A
Gene ID 3703
Synonyms
ITM1; TMC; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Oligosaccharyl transferase subunit STT3A; STT3-A; EC 2.4.99.18; B5; Integral membrane protein 1; Transmembrane protein TMC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKFGFLRLSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRTTRFL
AEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFFHITIDIRNVCVFLA
PLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPGYISRSVAGSYDNEGIAIFCMLLTY
YMWIKAVKTGSICWAAKCALAYFYMVSSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAY
CTVYCLGTILSMQISFVGFQPVLSSEHMAAFGVFGLCQIHAFVDYLRSKLNPQQFEVLFR
SVISLVGFVLLTVGALLMLTGKISPWTGRFYSLLDPSYAKNNIPIIASVSEHQPTTWSSY
YFDLQLLVFMFPVGLYYCFSNLSDARIFIIMYGVTSMYFSAVMVRLMLVLAPVMCILSGI
GVSQVLSTYMKNLDISRPDKKSKKQQDSTYPIKNEVASGMILVMAFFLITYTFHSTWVTS
EAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMSWWDYGYQITAMANRTI
LVDNNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMV
RIGGSTDTGKHIKENDYYTPTGEFRVDREGSPVLLNCLMYKMCYYRFGQVYTEAKRPPGF
DRVRNAEIGNKDFELDVLEEAYTTEHWLVRIYKVKDLDNRGLSRT
Target Bioclass
Enzyme
Family
STT3 family
Subcellular location
Endoplasmic reticulum
Function
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.
Uniprot ID
P46977
Ensemble ID
ENST00000392708.9
HGNC ID
HGNC:6172

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.F371C DBIA    Probe Info 
CCK81 SNV: p.V262A .
COLO320 SNV: p.E653K .
DEL SNV: p.H222P .
MDAMB231 SNV: p.M523L .
NALM6 SNV: p.R499K .
NCIH1155 SNV: p.R506Ter .
NCIH2286 SNV: p.E455K .
SKMEL5 SNV: p.G307R .
SNGM SNV: p.P79H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.41  LDD0197  [1]
CHEMBL5175495
 Probe Info  		11.42  LDD0196  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y331(7.28)  LDD0260  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
STPyne
 Probe Info  		K3(6.90); K440(5.41); K610(3.65); K655(10.00)  LDD0277  [6]
ONAyne
 Probe Info  		K610(6.90)  LDD0275  [6]
Probe 1
 Probe Info  		Y618(25.45); Y651(38.22)  LDD3495  [7]
BTD
 Probe Info  		C193(1.58)  LDD2090  [8]
Acrolein
 Probe Info  		N.A.  LDD0221  [9]
DBIA
 Probe Info  		C637(1.07)  LDD0078  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
IPM
 Probe Info  		C193(0.00); C637(0.00)  LDD0005  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
W1
 Probe Info  		C193(0.00); C637(0.00)  LDD0236  [16]
AOyne
 Probe Info  		11.90  LDD0443  [17]
TPP-AC
 Probe Info  		N.A.  LDD0427  [18]
PAL-AfBPP Probe
Click To Hide/Show 73 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.50  LDD1725  [19]
C022
 Probe Info  		9.85  LDD1728  [19]
C040
 Probe Info  		11.79  LDD1740  [19]
C056
 Probe Info  		21.41  LDD1753  [19]
C063
 Probe Info  		13.64  LDD1760  [19]
C070
 Probe Info  		13.27  LDD1766  [19]
C082
 Probe Info  		5.70  LDD1774  [19]
C091
 Probe Info  		25.46  LDD1782  [19]
C092
 Probe Info  		56.10  LDD1783  [19]
C094
 Probe Info  		52.35  LDD1785  [19]
C095
 Probe Info  		5.10  LDD1786  [19]
C100
 Probe Info  		5.17  LDD1789  [19]
C107
 Probe Info  		5.74  LDD1794  [19]
C112
 Probe Info  		25.46  LDD1799  [19]
C134
 Probe Info  		36.50  LDD1816  [19]
C141
 Probe Info  		12.13  LDD1823  [19]
C143
 Probe Info  		22.47  LDD1825  [19]
C159
 Probe Info  		8.69  LDD1839  [19]
C161
 Probe Info  		19.56  LDD1841  [19]
C166
 Probe Info  		7.94  LDD1846  [19]
C169
 Probe Info  		21.26  LDD1849  [19]
C187
 Probe Info  		17.39  LDD1865  [19]
C201
 Probe Info  		47.50  LDD1877  [19]
C210
 Probe Info  		41.36  LDD1884  [19]
C218
 Probe Info  		20.97  LDD1892  [19]
C219
 Probe Info  		7.78  LDD1893  [19]
C220
 Probe Info  		15.78  LDD1894  [19]
C225
 Probe Info  		5.50  LDD1898  [19]
C228
 Probe Info  		19.29  LDD1901  [19]
C229
 Probe Info  		13.18  LDD1902  [19]
C231
 Probe Info  		31.78  LDD1904  [19]
C233
 Probe Info  		11.08  LDD1906  [19]
C235
 Probe Info  		34.06  LDD1908  [19]
C246
 Probe Info  		18.38  LDD1919  [19]
C264
 Probe Info  		16.34  LDD1935  [19]
C273
 Probe Info  		5.39  LDD1943  [19]
C277
 Probe Info  		8.17  LDD1947  [19]
C287
 Probe Info  		10.34  LDD1957  [19]
C289
 Probe Info  		36.76  LDD1959  [19]
C293
 Probe Info  		17.15  LDD1963  [19]
C296
 Probe Info  		14.62  LDD1966  [19]
C299
 Probe Info  		5.74  LDD1968  [19]
C339
 Probe Info  		5.82  LDD2002  [19]
C343
 Probe Info  		11.55  LDD2005  [19]
C348
 Probe Info  		11.79  LDD2009  [19]
C349
 Probe Info  		21.11  LDD2010  [19]
C350
 Probe Info  		29.24  LDD2011  [19]
C362
 Probe Info  		63.12  LDD2023  [19]
C363
 Probe Info  		16.45  LDD2024  [19]
C364
 Probe Info  		17.63  LDD2025  [19]
C366
 Probe Info  		7.06  LDD2027  [19]
C382
 Probe Info  		11.16  LDD2041  [19]
C388
 Probe Info  		45.57  LDD2047  [19]
C390
 Probe Info  		26.91  LDD2049  [19]
C403
 Probe Info  		22.01  LDD2061  [19]
C407
 Probe Info  		17.15  LDD2064  [19]
C426
 Probe Info  		12.82  LDD2081  [19]
C429
 Probe Info  		11.16  LDD2084  [19]
C433
 Probe Info  		6.68  LDD2088  [19]
FFF probe11
 Probe Info  		20.00  LDD0471  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe15
 Probe Info  		7.16  LDD0478  [20]
FFF probe2
 Probe Info  		17.37  LDD0463  [20]
FFF probe3
 Probe Info  		15.72  LDD0464  [20]
FFF probe4
 Probe Info  		13.08  LDD0466  [20]
FFF probe6
 Probe Info  		6.54  LDD0467  [20]
FFF probe9
 Probe Info  		12.03  LDD0470  [20]
JN0003
 Probe Info  		20.00  LDD0469  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]
A-DA
 Probe Info  		2.01  LDD0145  [22]
Alk-rapa
 Probe Info  		3.81  LDD0213  [23]
OEA-DA
 Probe Info  		7.45  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C193(0.78)  LDD2117  [8]
 LDCM0214  AC1 HCT 116 C193(1.04)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C193(0.91)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C193(0.88)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C193(0.86)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C193(0.92)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C193(0.62)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C193(0.73)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C193(0.83)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C193(0.67)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C193(1.00)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C193(0.83)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C193(0.80)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C193(0.96)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C193(0.73)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C193(0.71)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C193(0.64)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C193(1.16)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C193(1.07)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C193(1.04)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C193(1.13)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C193(1.26)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C193(1.07)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C193(1.03)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C193(1.06)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C193(0.98)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C193(1.36)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C193(1.06)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C193(1.15)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C193(1.24)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C193(1.03)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C193(1.03)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C193(1.07)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C193(1.52); C637(1.22)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C193(1.65); C637(1.07)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C193(1.33); C637(1.60)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C193(1.27); C637(1.10)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C193(1.21); C637(1.05)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C193(1.17); C637(1.27)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C193(1.07); C637(0.97)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C193(1.14); C637(0.88)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C193(1.05); C637(0.89)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C193(1.09); C637(1.06)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C193(0.97); C637(0.76)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C193(0.91); C637(0.85)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C193(1.05)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C193(0.89); C637(0.82)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C193(0.88); C637(0.87)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C193(1.03); C637(1.01)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C193(0.95)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C193(0.79)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C193(0.80)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C193(0.71)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C193(0.75)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C193(0.74)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C193(0.68)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C193(1.07)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C193(0.84)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C193(1.01)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C193(0.75)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C193(0.70)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C193(0.78)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C193(0.71)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C193(0.89)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C193(0.94)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C193(0.93)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C193(0.56)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C193(0.94)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C193(1.04)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C193(0.81)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C193(0.92)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C193(0.86)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C193(1.09)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C193(1.02)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C193(1.13); C637(1.19)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C193(0.93); C637(1.10)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C193(0.80); C637(0.94)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C637(0.90); C193(1.08)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C193(0.82); C637(0.83)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C193(1.41)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C637(0.86); C193(0.94)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C193(1.02); C637(1.08)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C193(0.76); C637(0.90)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C193(0.77); C637(0.87)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C193(0.77); C637(0.80)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C193(1.06)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C193(1.04)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C193(1.23)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C193(1.03)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C193(0.82)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C193(1.30)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C193(1.18)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C193(0.98)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C193(0.92)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C193(0.84)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C193(0.99)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C193(0.93)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C193(0.83)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C193(0.93)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C193(0.73)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C193(0.65)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C193(1.47)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C193(0.76)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C193(0.84)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C193(0.92)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C193(0.73)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C193(0.82)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C193(0.65)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C193(0.58)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C637(1.11); C193(1.47)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C637(1.03); C193(1.20)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C637(0.90); C193(1.25)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C193(0.86)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C637(1.02); C193(1.17)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C637(0.99); C193(1.34)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C637(0.99); C193(1.39)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C637(1.12); C193(1.37)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C637(0.93); C193(1.47)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C193(0.96); C637(1.12)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C637(1.19); C193(1.22)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C637(0.66); C193(1.09)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C637(0.67); C193(0.98)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C637(0.68); C193(1.00)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C193(1.31)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C637(0.81); C193(0.98)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C637(0.72); C193(1.11)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C637(0.68); C193(0.97)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C193(0.73); C637(0.79)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C637(0.81); C193(0.93)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C637(0.73); C193(0.89)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C637(0.72); C193(1.20)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C637(0.52); C193(0.92)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C637(0.66); C193(0.92)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C637(0.57); C193(1.02)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C193(1.01)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C637(0.69); C193(1.07)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C637(0.63); C193(1.10)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C637(0.42); C193(0.84)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C193(0.67); C637(0.98)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C193(0.67); C637(0.92)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C193(0.74); C637(1.02)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C637(0.71); C193(1.15)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C637(0.71); C193(0.86)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C637(0.68); C193(0.85)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C637(0.73); C193(0.84)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C637(0.61); C193(1.00)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C193(0.72); C637(0.98)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C193(0.79); C637(1.00)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C193(0.88); C637(0.90)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C193(0.85); C637(1.18)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C637(0.59); C193(0.90)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C193(0.80); C637(1.16)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C637(0.72); C193(0.76)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C193(0.61)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C193(0.84)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C193(1.06)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C193(1.04)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C193(1.04)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C193(0.84)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C637(1.07)  LDD0078  [10]
 LDCM0199  BPK-21 T cell C193(20.00)  LDD0530  [25]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C193(0.93); C637(1.08)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C637(1.47); C193(1.51)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C193(1.04)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C193(1.03)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C193(1.31)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C193(1.36)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C193(1.35)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C193(0.78)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C193(1.13)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C193(0.61)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C193(1.19)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C193(0.98)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C637(1.07); C193(1.20)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C193(1.08)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C193(0.95)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C637(0.94); C193(1.08)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C193(0.78); C637(0.95)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C637(0.86); C193(1.18)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C193(0.73); C637(0.86)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C193(0.69); C637(0.86)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C193(0.72)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C193(0.96)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C193(0.92)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C193(1.10); C637(1.46)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C193(0.93)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C193(0.73)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C193(0.87)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C193(2.23)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C193(0.75)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C637(1.10); C193(1.17)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C637(1.23); C193(1.64)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C637(1.11); C193(1.20)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C637(0.92); C193(1.06)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C193(1.15); C637(1.29)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C193(1.23); C637(1.42)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C637(1.15); C193(1.28)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C193(0.91)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C193(1.29)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C193(1.08)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C193(1.06)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C193(1.03); C637(1.08)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C193(1.09)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C193(2.49)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C193(1.09)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C193(1.06)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C193(1.39)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C193(1.68)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C193(1.06)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C193(1.11)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C193(1.23)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C193(1.39)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C193(1.18); C637(1.31)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C193(1.64)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C193(0.96); C637(0.79)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C193(0.69); C637(0.92)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C193(1.54); C637(0.77)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C193(0.90); C637(0.41)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C193(0.94); C637(0.39)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C193(1.00); C637(0.57)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C193(0.97); C637(0.33)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C193(0.78); C637(0.41)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C193(3.12); C637(1.03)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C193(0.87); C637(0.56)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C193(0.85); C637(0.59)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C193(0.92); C637(0.18)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C193(0.76); C637(0.29)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C193(1.22); C637(0.50)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C193(0.98); C637(0.35)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C193(1.36); C637(1.10)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C193(1.08); C637(1.30)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C193(1.32); C637(1.45)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C193(1.35); C637(0.97)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C193(1.07); C637(1.16)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C193(1.42); C637(1.14)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C193(1.43); C637(1.16)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C193(1.23); C637(1.21)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C193(1.35); C637(1.09)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C193(2.02); C637(0.98)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C193(1.35); C637(1.23)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C193(1.11); C637(1.25)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C193(1.34); C637(1.27)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C193(1.28); C637(1.26)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C193(1.36); C637(1.07)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C193(1.46); C637(1.41)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C193(1.23); C637(1.05)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C193(1.27)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C193(1.23)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C193(0.89)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C193(1.05)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C193(2.89)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C193(0.94)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C193(1.15)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C193(2.36)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C193(1.07)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C193(1.52); C637(1.46)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C193(1.88)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C193(1.35)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C193(1.75)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C193(1.30)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C193(1.49)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C193(1.29)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C193(1.34)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C193(1.22)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C193(0.93)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C193(1.39); C637(0.94)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C193(1.02)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C193(1.15)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C193(1.78)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C193(1.48)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C193(1.25)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C193(1.02)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C193(1.11)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C193(1.14)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C193(1.14)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C193(1.12)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C193(0.92); C637(1.17)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C193(2.38)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C193(0.96)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C193(1.31)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C193(1.42)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C193(1.04)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C193(1.45)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C193(1.41)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C193(1.89)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C193(1.01)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C193(1.20)  LDD0811  [10]
 LDCM0093  CY-5 Bcap37 2.84  LDD0253  [26]
 LDCM0495  E2913 HEK-293T C637(1.11); C193(0.97)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C193(39.09)  LDD1702  [8]
 LDCM0625  F8 Ramos C637(0.89)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C637(1.42)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C637(0.38); C193(0.64)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C637(1.88)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C637(1.18); C193(0.81)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C637(1.95)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C637(2.95)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C637(0.99)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C637(0.91)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C637(0.92); C193(1.04)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C637(0.86)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C637(1.13)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C637(1.07)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C637(1.20)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C193(1.57)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C637(1.34)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C637(1.10)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C193(1.00); C637(0.18)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C637(1.44); C193(0.67)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C637(0.82); C193(1.07)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C637(1.15)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C637(1.96)  LDD2188  [28]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 HCT 116 C193(4.65)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C193(7.16)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C193(10.39)  LDD0082  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C193(1.58)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C193(1.14)  LDD2092  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C193(1.48)  LDD2094  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C193(5.93)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C193(0.87)  LDD2101  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C193(0.87)  LDD2115  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C193(0.82)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C193(0.73)  LDD2125  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C193(0.94)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C193(0.85)  LDD2134  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C193(0.91)  LDD2137  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C193(1.08)  LDD2148  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C193(2.03)  LDD2153  [8]
 LDCM0131  RA190 MM1.R C193(2.15); C637(1.79)  LDD0304  [29]
 LDCM0090  Rapamycin JHH-7 3.81  LDD0213  [23]
 LDCM0084  Ro 48-8071 A-549 2.01  LDD0145  [22]
 LDCM0021  THZ1 HCT 116 C193(0.98); C637(0.89)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Protein O-mannose kinase (POMK) Ser/Thr protein kinase family Q9H5K3
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) TKL Ser/Thr protein kinase family O43187
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Wolframin (WFS1) . O76024
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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