Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name CY-1  Probe Info 
Probe concentration 50 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name CY-5  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast carcinoma [ICD-11:2C60]
Model Name Human breast carcinoma cells (Bcap37)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02333  Glutathione S-transferase P (GSTP1) 17.0
 LDTP03103  Glutathione S-transferase Mu 3 (GSTM3) 10.4
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 8.7
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 2.8
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06676  Centrosome and spindle pole-associated protein 1 (CSPP1) 19.4
 LDTP05382  A-kinase anchor protein 12 (AKAP12) 5.8

References

1 Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery". J Med Chem. 2021 Nov 11;64(21):15582-15592. doi: 10.1021/acs.jmedchem.0c02024. Epub 2021 Oct 8.