Details of the Target

General Information of Target

Target ID LDTP03103
Target Name Glutathione S-transferase Mu 3 (GSTM3)
Gene Name GSTM3
Gene ID 2947
Synonyms
GST5; Glutathione S-transferase Mu 3; EC 2.5.1.18; GST class-mu 3; GSTM3-3; hGSTM3-3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLD
FPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCY
SSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLD
EFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC
Target Bioclass
Enzyme
Family
GST superfamily, Mu family
Subcellular location
Cytoplasm
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
Uniprot ID
P21266
Ensemble ID
ENST00000256594.7
HGNC ID
HGNC:4635
ChEMBL ID
CHEMBL2242

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y120(12.83); Y66(11.07); Y201(10.86); Y45(10.31)  LDD0257  [3]
STPyne
 Probe Info  		K54(7.50); K73(5.56)  LDD0277  [4]
AZ-9
 Probe Info  		E133(1.24); D205(1.28); K209(1.11); C225(1.04)  LDD2208  [5]
Probe 1
 Probe Info  		Y37(18.25); Y45(26.58); Y66(18.93); Y120(75.57)  LDD3495  [6]
AHL-Pu-1
 Probe Info  		C39(2.32)  LDD0171  [7]
HHS-465
 Probe Info  		Y120(10.00)  LDD2237  [8]
DBIA
 Probe Info  		C208(0.92); C39(0.92)  LDD0078  [9]
5E-2FA
 Probe Info  		H88(0.00); H124(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K54(0.00); K56(0.00); K35(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C178(0.00); C91(0.00); C208(0.00); C119(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C208(0.00); C3(0.00); C39(0.00)  LDD0032  [13]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [14]
IPIAA_L
 Probe Info  		C119(0.00); C39(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C208(0.00); C225(0.00); C39(0.00); C178(0.00)  LDD0037  [12]
BTD
 Probe Info  		N.A.  LDD0004  [15]
JW-RF-010
 Probe Info  		C119(0.00); C208(0.00); C178(0.00)  LDD0026  [16]
NAIA_4
 Probe Info  		C39(0.00); C208(0.00)  LDD2226  [17]
TFBX
 Probe Info  		C119(0.00); C225(0.00); C178(0.00); C39(0.00)  LDD0027  [16]
WYneN
 Probe Info  		C208(0.00); C39(0.00)  LDD0021  [15]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		N.A.  LDD0010  [15]
NPM
 Probe Info  		N.A.  LDD0016  [15]
PF-06672131
 Probe Info  		C178(0.00); C208(0.00)  LDD0152  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
Phosphinate-6
 Probe Info  		C190(0.00); C3(0.00)  LDD0018  [20]
1c-yne
 Probe Info  		K209(0.00); K128(0.00); K56(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C91(0.00); C208(0.00); C39(0.00); C119(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		C39(0.00); C119(0.00); C208(0.00); C91(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C39(0.00); C91(0.00); C208(0.00); C119(0.00)  LDD0218  [22]
W1
 Probe Info  		C225(0.00); C39(0.00); C91(0.00)  LDD0236  [23]
AOyne
 Probe Info  		15.00  LDD0443  [24]
NAIA_5
 Probe Info  		C178(0.00); C208(0.00); C91(0.00); C119(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		21.86  LDD1816  [25]
C361
 Probe Info  		25.28  LDD2022  [25]
FFF probe2
 Probe Info  		6.33  LDD0463  [26]
STS-2
 Probe Info  		N.A.  LDD0139  [27]
DA-2
 Probe Info  		N.A.  LDD0071  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C119(1.14)  LDD2112  [29]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C119(0.82)  LDD2095  [29]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C119(0.87); C208(1.00)  LDD2130  [29]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C119(1.64); C208(1.00)  LDD2117  [29]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C119(2.20)  LDD2152  [29]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C208(1.15)  LDD2132  [29]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C119(0.53)  LDD2131  [29]
 LDCM0026  4SU-RNA+native RNA DM93 C39(2.32)  LDD0171  [7]
 LDCM0214  AC1 HEK-293T C91(0.93); C39(1.29); C178(1.04); C208(0.97)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C91(0.97); C39(0.97); C119(1.12); C178(0.97)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C91(1.06); C39(0.96); C119(1.08); C178(0.99)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C91(1.06); C39(0.99); C119(1.16); C178(1.05)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C91(1.05); C39(0.95); C119(0.98); C178(1.02)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C91(1.11); C39(1.04); C119(1.14); C178(1.04)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C91(0.89); C39(1.12); C178(1.00); C208(1.03)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C91(0.82); C39(1.02); C119(0.98); C178(1.01)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C91(1.02); C39(0.92); C119(0.83); C178(0.98)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C91(0.94); C39(1.05); C119(1.09); C178(0.98)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C91(1.07); C39(0.96); C119(1.54); C178(1.02)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C91(1.07); C39(0.99); C119(0.91); C178(1.02)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C91(1.03); C39(0.95); C119(0.97); C178(1.05)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C91(1.01); C39(1.01); C119(1.15); C178(1.03)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C91(1.14); C39(1.09); C178(1.06); C208(1.04)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C91(0.89); C39(1.12); C178(1.03); C208(0.90)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C91(0.95); C39(0.98); C119(1.00); C178(1.00)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C91(1.04); C39(0.90); C119(0.95); C178(1.04)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C91(1.11); C39(1.08); C119(0.96); C178(1.07)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C91(1.07); C39(0.99); C119(0.93); C178(1.01)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C91(0.98); C39(0.98); C119(1.05); C178(0.99)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C91(0.97); C39(0.96); C119(0.86); C178(1.01)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C91(1.08); C39(0.92); C119(0.97); C178(1.05)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C91(1.13); C39(1.01); C178(1.05); C208(1.06)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C91(0.94); C39(1.19); C178(0.99); C208(1.00)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C91(0.89); C39(0.97); C119(1.10); C178(0.98)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C91(1.04); C39(0.87); C119(1.01); C178(0.97)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C91(0.99); C39(0.95); C119(1.15); C178(1.00)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C91(1.05); C39(1.07); C119(1.10); C178(1.05)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C91(1.08); C39(0.98); C119(0.99); C178(1.00)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C91(1.12); C39(1.01); C119(1.10); C178(1.00)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C91(1.02); C39(0.99); C119(1.12); C178(1.13)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C91(1.12); C39(1.52); C178(1.03); C208(1.12)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C91(0.88); C39(0.97); C178(1.04); C208(0.95)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C91(0.82); C39(1.05); C119(1.10); C178(0.98)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C91(1.04); C39(0.95); C119(1.10); C178(0.99)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C91(1.04); C39(0.99); C119(1.11); C178(1.03)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C91(1.04); C39(1.01); C119(1.05); C178(1.07)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C91(1.02); C39(1.05); C119(1.03); C178(0.98)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C91(1.25); C39(1.02); C119(1.11); C178(1.09)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C91(0.96); C39(1.11); C178(0.97); C208(1.07)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C91(0.92); C39(1.07); C178(1.02); C208(0.96)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C91(1.03); C39(1.11); C119(1.09); C178(1.15)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C91(0.89); C39(1.05); C119(1.00); C178(1.00)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C91(1.02); C39(0.93); C119(0.90); C178(0.99)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C91(0.99); C39(1.02); C119(0.94); C178(1.03)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C91(1.07); C39(0.99); C119(0.97); C178(1.05)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C91(1.05); C39(1.02); C119(0.91); C178(1.03)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C91(1.16); C39(0.98); C119(0.94); C178(0.97)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C91(1.04); C39(0.97); C178(1.03); C208(0.99)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C91(0.93); C39(0.98); C178(1.00); C208(0.96)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C91(0.88); C39(0.99); C119(0.93); C178(1.01)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C91(1.04); C39(1.04); C119(1.03); C178(0.99)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C91(0.95); C39(1.09); C119(1.03); C178(1.00)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C91(1.00); C39(1.06); C119(1.11); C178(1.03)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C91(1.00); C39(1.02); C119(0.89); C178(1.02)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C91(0.91); C39(1.08); C119(0.94); C178(1.04)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C91(1.02); C39(1.05); C119(1.18); C178(1.02)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C91(1.11); C39(1.16); C178(1.03); C208(1.00)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C91(1.13); C39(1.05); C119(1.06); C178(1.03)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C91(1.08); C39(1.11); C178(1.09); C208(1.00)  LDD1569  [30]
 LDCM0545  Acetamide MDA-MB-231 C119(0.76)  LDD2138  [29]
 LDCM0248  AKOS034007472 HEK-293T C91(1.15); C39(1.08); C119(0.98); C178(1.09)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C91(0.81); C39(1.09); C178(1.05); C208(0.98)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C91(1.08); C39(1.09); C178(1.06); C208(1.10)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 13.04  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C208(0.92); C39(0.92)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C119(0.74); C208(0.93); C91(0.65); C178(0.84)  LDD2091  [29]
 LDCM0108  Chloroacetamide HeLa C91(0.00); C208(0.00); C39(0.00); C119(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C39(2.06); C91(1.51); C91(1.41); C190(1.22)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C91(0.93); C39(0.98); C119(1.07); C178(0.96)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C91(1.41); C39(0.98); C119(1.41); C178(1.24)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C91(0.93); C39(0.99); C119(1.23); C178(1.00)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C91(0.86); C39(0.95); C119(0.95); C178(1.00)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C91(0.99); C39(0.99); C178(1.06); C208(0.88)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C91(0.97); C39(0.97); C178(1.04); C208(0.99)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C91(1.01); C39(0.99); C119(1.03); C178(1.01)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C91(0.88); C39(0.98); C119(0.98); C178(1.02)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C91(1.09); C39(0.97); C178(1.00); C208(0.87)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C91(0.94); C39(1.06); C178(1.01); C208(0.99)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C91(1.07); C39(0.98); C119(0.84); C178(0.97)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C91(0.98); C39(0.99); C119(0.96); C178(1.05)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C91(1.86); C39(0.85); C119(1.11); C178(1.20)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C91(0.91); C39(0.98); C178(0.96); C208(0.80)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C91(0.93); C39(0.95); C178(0.98); C208(1.04)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C91(0.92); C39(0.93); C119(0.97); C178(0.97)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C91(0.97); C39(0.98); C119(1.14); C178(0.96)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C91(0.93); C39(0.99); C178(1.01); C208(0.81)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C91(0.91); C39(0.98); C178(0.97); C208(0.99)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C91(1.05); C39(1.03); C119(1.05); C178(0.98)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C91(0.89); C39(1.03); C119(0.96); C178(0.99)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C91(0.98); C39(1.00); C178(1.00); C208(0.90)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C91(0.98); C39(1.04); C178(0.99); C208(0.97)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C91(0.77); C39(0.97); C178(1.11); C208(1.01)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C91(1.16); C39(1.05); C119(1.45); C178(0.98)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C91(0.92); C39(1.02); C119(1.05); C178(0.94)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C91(0.96); C39(1.00); C178(1.00); C208(0.91)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C91(0.89); C39(0.96); C178(1.04); C208(0.86)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C91(1.07); C39(1.04); C119(1.10); C178(1.02)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C91(0.92); C39(0.97); C119(0.82); C178(1.01)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C91(0.96); C39(1.07); C178(0.99); C208(0.90)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C91(0.92); C39(1.09); C178(1.02); C208(1.04)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C91(0.97); C39(1.01); C119(0.79); C178(1.01)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C91(0.92); C39(0.88); C119(0.92); C178(0.87)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C91(1.08); C39(1.06); C178(1.01); C208(0.98)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C91(0.88); C39(1.55); C178(0.91); C208(1.15)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C91(1.10); C39(0.95); C119(1.09); C178(0.99)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C91(0.86); C39(1.26); C178(1.01); C208(1.08)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C91(1.00); C39(1.08); C119(0.89); C178(0.98)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C91(1.10); C39(0.83); C119(1.11); C178(1.01)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C91(1.03); C39(0.97); C178(0.95); C208(0.89)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C91(1.14); C39(0.97); C119(1.01); C178(1.08)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C91(1.24); C39(0.89); C119(0.91); C178(1.13)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C91(1.66); C39(0.95); C119(0.95); C178(1.05)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C91(1.80); C39(0.97); C119(1.15); C178(1.07)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C91(0.68); C39(0.92); C178(1.10); C208(0.99)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C91(0.85); C39(0.89); C119(1.06); C178(1.01)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C91(1.11); C39(0.97); C178(0.95); C208(0.93)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C91(0.98); C39(1.06); C178(0.97); C208(0.92)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C91(1.07); C39(1.04); C119(1.11); C178(1.00)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C91(1.01); C39(1.09); C178(1.00); C208(0.94)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C91(0.86); C39(1.01); C178(0.93); C208(1.03)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C91(1.05); C39(1.01); C119(0.98); C178(1.00)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C91(1.06); C39(0.96); C119(0.87); C178(1.00)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C91(1.10); C39(1.00); C119(0.92); C178(1.07)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C91(1.38); C39(1.01); C119(0.90); C178(1.17)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C91(1.54); C39(0.97); C119(0.87); C178(1.06)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C91(1.68); C39(0.99); C119(1.18); C178(1.08)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C91(0.65); C39(1.02); C178(1.16); C208(0.97)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C91(0.92); C39(1.03); C119(1.04); C178(1.05)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C91(0.94); C39(1.28); C178(1.02); C208(1.03)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C91(0.98); C39(0.92); C119(0.94); C178(0.97)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C91(1.07); C39(1.02); C119(1.24); C178(1.08)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C91(0.97); C39(1.06); C178(0.97); C208(0.87)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C91(1.06); C39(1.01); C119(0.89); C178(1.05)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C91(1.14); C39(0.97); C119(0.78); C178(1.04)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C91(1.16); C39(1.07); C119(0.84); C178(1.12)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C91(1.33); C39(0.96); C119(0.90); C178(1.12)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C91(1.43); C39(1.04); C119(0.99); C178(1.13)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C91(1.57); C39(1.02); C119(1.11); C178(1.09)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C91(0.60); C39(1.12); C178(1.13); C208(1.05)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C91(0.88); C39(1.05); C119(0.99); C178(1.02)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C91(0.92); C39(1.07); C178(0.94); C208(1.11)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C91(0.97); C39(1.07); C178(0.92); C208(0.85)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C91(1.01); C39(0.96); C119(1.13); C178(1.07)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C91(0.88); C39(1.02); C178(1.03); C208(0.85)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C91(0.93); C39(0.99); C119(0.97); C178(1.03)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C91(1.16); C39(1.00); C119(0.99); C178(1.02)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C91(1.14); C39(1.00); C119(1.16); C178(1.04)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C91(1.27); C39(0.98); C119(1.08); C178(1.16)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C91(1.75); C39(0.96); C119(0.95); C178(1.03)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C91(1.75); C39(0.91); C119(1.01); C178(1.15)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C91(1.01); C39(1.07); C119(0.87); C178(1.00)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C91(0.65); C39(1.03); C178(1.10); C208(0.89)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C91(0.85); C39(0.92); C119(1.10); C178(0.95)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C91(1.02); C39(1.06); C178(0.94); C208(0.91)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C91(0.96); C39(1.00); C178(0.94); C208(1.01)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C91(0.98); C39(1.08); C119(0.98); C178(1.02)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C91(0.98); C39(1.19); C178(1.03); C208(0.98)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C91(1.00); C39(1.05); C119(1.08); C178(0.97)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C91(1.14); C39(0.94); C119(1.17); C178(1.04)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C91(1.08); C39(1.05); C119(1.14); C178(1.07)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C91(1.38); C39(1.03); C119(0.88); C178(1.10)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C91(1.02); C39(0.87); C119(1.06); C178(1.04)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C91(1.51); C39(1.00); C119(1.02); C178(1.01)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C91(1.71); C39(1.02); C119(1.09); C178(1.04)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C91(0.67); C39(1.11); C178(1.10); C208(1.01)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C91(0.89); C39(1.33); C119(1.35); C178(1.04)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C91(1.00); C39(1.12); C178(0.96); C208(0.83)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C91(0.99); C39(0.95); C119(1.01); C178(0.95)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C91(0.93); C39(1.09); C178(1.05); C208(0.97)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C91(0.95); C39(1.04); C119(0.93); C178(1.01)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C91(1.15); C39(0.99); C119(0.84); C178(1.05)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C91(0.86); C39(1.06); C119(1.07); C178(1.01)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C91(1.06); C39(0.99); C119(0.82); C178(1.06)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C91(1.34); C39(1.05); C119(0.84); C178(1.02)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C91(1.48); C39(0.96); C119(0.94); C178(1.14)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C91(1.54); C39(1.00); C119(1.03); C178(1.13)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C91(0.77); C39(1.10); C178(1.17); C208(0.93)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C91(0.90); C39(0.92); C119(0.87); C178(0.97)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C91(0.99); C39(1.16); C178(0.96); C208(0.86)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C91(0.84); C39(1.03); C178(0.94); C208(0.96)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C91(0.98); C39(1.35); C119(1.28); C178(1.01)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C91(0.94); C39(0.99); C178(0.96); C208(0.93)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C91(1.32); C39(0.94); C119(1.07); C178(1.01)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C91(0.76); C39(0.91); C119(0.95); C178(1.14)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C91(1.07); C39(1.15); C119(0.83); C178(1.02)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C91(1.05); C39(0.98); C119(1.03); C178(1.10)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C91(1.17); C39(0.93); C119(0.81); C178(1.12)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C91(1.22); C39(0.92); C119(0.96); C178(1.06)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C91(1.27); C39(0.86); C119(0.93); C178(1.10)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C91(0.87); C39(1.21); C178(1.09); C208(0.90)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C91(0.89); C39(0.91); C119(0.94); C178(1.02)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C91(1.01); C39(0.98); C178(1.00); C208(0.88)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C91(0.94); C39(0.94); C178(1.00); C208(0.97)  LDD1697  [30]
 LDCM0634  CY-0357 Hep-G2 C119(50.00); C39(4.66); C3(1.11); C225(0.99)  LDD2228  [17]
 LDCM0093  CY-5 Bcap37 10.40  LDD0253  [31]
 LDCM0495  E2913 HEK-293T C91(0.91); C39(0.94); C178(0.91); C208(0.94)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C178(5.76); C208(3.12)  LDD1702  [29]
 LDCM0468  Fragment33 HEK-293T C91(0.90); C39(1.02); C178(1.02); C208(0.91)  LDD1671  [30]
 LDCM0427  Fragment51 HEK-293T C91(0.95); C39(1.05); C178(0.99); C208(0.94)  LDD1631  [30]
 LDCM0107  IAA HeLa H88(0.00); C91(0.00); C39(0.00); C119(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C91(0.98); C39(0.99); C119(1.07); C178(1.01)  LDD1492  [30]
 LDCM0023  KB03 Jurkat C178(4.87)  LDD0315  [13]
 LDCM0024  KB05 COLO792 C208(1.17); C225(1.37)  LDD3310  [32]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C119(0.90)  LDD2121  [29]
 LDCM0109  NEM HeLa H19(0.00); H124(0.00); H88(0.00); C39(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C119(0.84); C208(0.87)  LDD2089  [29]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C119(1.05)  LDD2094  [29]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C91(1.22)  LDD2096  [29]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C119(1.04)  LDD2098  [29]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C119(1.37); C208(1.00)  LDD2099  [29]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C119(0.78)  LDD2100  [29]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C119(1.08)  LDD2104  [29]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C119(1.00)  LDD2105  [29]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C119(1.27); C208(1.08)  LDD2107  [29]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C119(0.78)  LDD2108  [29]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C119(0.98); C91(1.01)  LDD2109  [29]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C119(1.22)  LDD2111  [29]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C119(0.45); C178(0.27)  LDD2118  [29]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C119(1.51)  LDD2119  [29]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C119(0.56)  LDD2120  [29]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C119(0.33); C178(0.33)  LDD2122  [29]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C119(1.10); C208(0.92); C91(0.95); C178(1.28)  LDD2123  [29]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C119(0.22)  LDD2124  [29]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C119(1.44); C208(0.79)  LDD2125  [29]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C119(0.19); C178(0.18)  LDD2126  [29]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C119(1.47); C208(1.02); C91(1.65)  LDD2127  [29]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C119(0.41); C178(0.68)  LDD2128  [29]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C119(1.13); C208(1.09)  LDD2129  [29]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C119(1.54); C208(1.17); C91(1.68)  LDD2136  [29]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C119(1.12)  LDD2137  [29]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C119(1.57)  LDD2140  [29]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C119(1.00)  LDD2141  [29]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C119(0.40)  LDD2143  [29]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C119(1.86); C208(1.26)  LDD2144  [29]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C119(1.34); C91(1.02)  LDD2146  [29]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C119(0.94)  LDD2148  [29]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C119(0.26)  LDD2149  [29]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C119(0.64); C208(0.68)  LDD2150  [29]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C119(0.17)  LDD2151  [29]
 LDCM0627  NUDT7-COV-1 HEK-293T C3(1.11)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C208(0.43); C119(0.39); C3(0.28)  LDD2207  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutathione S-transferase Mu 3 (GSTM3) Mu family P21266
Glutathione S-transferase Mu 4 (GSTM4) Mu family Q03013
Glutathione S-transferase Mu 5 (GSTM5) Mu family P46439
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zona pellucida sperm-binding protein 4 (ZP4) ZP domain family Q12836
Clavesin-2 (CLVS2) . Q5SYC1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amitriptyline Small molecular drug DB00321
Deoxycholic Acid Small molecular drug DB03619
Glutathione Small molecular drug DB00143
Glutathione Disulfide Small molecular drug DB03310
Vitamin E Small molecular drug DB00163
Alpha-tocopherol Succinate . DB14001
D-alpha-tocopherol Acetate . DB14002

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery". J Med Chem. 2021 Nov 11;64(21):15582-15592. doi: 10.1021/acs.jmedchem.0c02024. Epub 2021 Oct 8.
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Mass spectrometry data entry: PXD047840
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