Details of the Target

General Information of Target

Target ID LDTP01525
Target Name Mitochondrial proton/calcium exchanger protein (LETM1)
Gene Name LETM1
Gene ID 3954
Synonyms
Mitochondrial proton/calcium exchanger protein; Electroneutral mitochondrial K(+)/H(+)exchanger; KHE; Leucine zipper-EF-hand-containing transmembrane protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP
VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV
EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF
ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP
SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA
MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH
REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI
TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE
ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV
KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV
EEKEKAKEKAEKEVAEVKS
Target Bioclass
Transporter and channel
Family
LETM1 family
Subcellular location
Mitochondrion inner membrane
Function
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Functions also as an electroneutral mitochondrial proton/potassium exchanger. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization.
Uniprot ID
O95202
Ensemble ID
ENST00000302787.3
HGNC ID
HGNC:6556

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.K729T DBIA    Probe Info 
CAL51 SNV: p.G99Ter .
ECC2 SNV: p.R194Q DBIA    Probe Info 
EFO27 SNV: p.R249M DBIA    Probe Info 
HCT15 SNV: p.S281N; p.Q449R; p.E490D .
HEC1 SNV: p.A674S DBIA    Probe Info 
IGR1 SNV: p.A464V DBIA    Probe Info 
IGROV1 SNV: p.A673V DBIA    Probe Info 
JURKAT SNV: p.Q486Ter Compound 10    Probe Info 
LS123 Substitution: p.T192P DBIA    Probe Info 
MFE319 SNV: p.I82M .
MOLT4 SNV: p.P530S; p.V691M IA-alkyne    Probe Info 
P31FUJ SNV: p.E533G DBIA    Probe Info 
RL952 SNV: p.V96M .
TE11 SNV: p.L17F DBIA    Probe Info 
TOV21G SNV: p.S703Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
HDSF-alk
 Probe Info  		1.73  LDD0197  [2]
W1
 Probe Info  		33.50  LDD0235  [3]
TH211
 Probe Info  		Y598(20.00); Y165(20.00); Y141(5.01)  LDD0260  [4]
C-Sul
 Probe Info  		3.75  LDD0066  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
Probe 1
 Probe Info  		Y579(15.24)  LDD3495  [7]
BTD
 Probe Info  		C379(1.09)  LDD2090  [8]
Jackson_14
 Probe Info  		2.13  LDD0123  [9]
DBIA
 Probe Info  		C552(1.61)  LDD0080  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C379(0.00); C330(0.00); C552(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C330(0.00); C379(0.00); C552(0.00)  LDD0036  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C379(0.00); C330(0.00); C552(0.00); C203(0.00)  LDD0037  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneO
 Probe Info  		C379(0.00); C552(0.00)  LDD0022  [15]
Compound 10
 Probe Info  		C330(0.00); C379(0.00)  LDD2216  [16]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		K150(0.00); K679(0.00); K360(0.00); K284(0.00)  LDD0010  [15]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
1c-yne
 Probe Info  		K493(0.00); K434(0.00); K360(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C552(0.00); C330(0.00)  LDD0217  [18]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
AOyne
 Probe Info  		5.60  LDD0443  [19]
NAIA_5
 Probe Info  		C552(0.00); C330(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 80 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		10.27  LDD1728  [21]
C040
 Probe Info  		12.30  LDD1740  [21]
C055
 Probe Info  		19.84  LDD1752  [21]
C056
 Probe Info  		21.71  LDD1753  [21]
C063
 Probe Info  		11.08  LDD1760  [21]
C070
 Probe Info  		20.39  LDD1766  [21]
C082
 Probe Info  		5.21  LDD1774  [21]
C091
 Probe Info  		15.35  LDD1782  [21]
C094
 Probe Info  		31.78  LDD1785  [21]
C100
 Probe Info  		5.46  LDD1789  [21]
C106
 Probe Info  		19.84  LDD1793  [21]
C107
 Probe Info  		9.32  LDD1794  [21]
C112
 Probe Info  		31.34  LDD1799  [21]
C134
 Probe Info  		25.81  LDD1816  [21]
C141
 Probe Info  		12.38  LDD1823  [21]
C143
 Probe Info  		14.72  LDD1825  [21]
C153
 Probe Info  		18.38  LDD1834  [21]
C161
 Probe Info  		11.47  LDD1841  [21]
C163
 Probe Info  		9.71  LDD1843  [21]
C178
 Probe Info  		15.78  LDD1857  [21]
C187
 Probe Info  		18.25  LDD1865  [21]
C194
 Probe Info  		8.51  LDD1870  [21]
C196
 Probe Info  		9.85  LDD1872  [21]
C201
 Probe Info  		80.45  LDD1877  [21]
C206
 Probe Info  		18.77  LDD1881  [21]
C210
 Probe Info  		55.33  LDD1884  [21]
C218
 Probe Info  		18.25  LDD1892  [21]
C219
 Probe Info  		8.88  LDD1893  [21]
C220
 Probe Info  		18.64  LDD1894  [21]
C225
 Probe Info  		5.54  LDD1898  [21]
C228
 Probe Info  		21.26  LDD1901  [21]
C231
 Probe Info  		44.94  LDD1904  [21]
C233
 Probe Info  		10.93  LDD1906  [21]
C235
 Probe Info  		28.05  LDD1908  [21]
C238
 Probe Info  		17.63  LDD1911  [21]
C240
 Probe Info  		8.69  LDD1913  [21]
C246
 Probe Info  		19.84  LDD1919  [21]
C264
 Probe Info  		16.68  LDD1935  [21]
C273
 Probe Info  		5.03  LDD1943  [21]
C285
 Probe Info  		27.28  LDD1955  [21]
C287
 Probe Info  		18.25  LDD1957  [21]
C289
 Probe Info  		28.44  LDD1959  [21]
C296
 Probe Info  		31.78  LDD1966  [21]
C299
 Probe Info  		7.31  LDD1968  [21]
C310
 Probe Info  		11.47  LDD1977  [21]
C313
 Probe Info  		14.62  LDD1980  [21]
C314
 Probe Info  		19.29  LDD1981  [21]
C339
 Probe Info  		6.15  LDD2002  [21]
C343
 Probe Info  		18.64  LDD2005  [21]
C348
 Probe Info  		9.85  LDD2009  [21]
C349
 Probe Info  		18.77  LDD2010  [21]
C350
 Probe Info  		60.13  LDD2011  [21]
C356
 Probe Info  		11.08  LDD2017  [21]
C357
 Probe Info  		5.13  LDD2018  [21]
C362
 Probe Info  		76.11  LDD2023  [21]
C363
 Probe Info  		20.82  LDD2024  [21]
C364
 Probe Info  		24.59  LDD2025  [21]
C366
 Probe Info  		6.77  LDD2027  [21]
C367
 Probe Info  		5.10  LDD2028  [21]
C388
 Probe Info  		45.89  LDD2047  [21]
C390
 Probe Info  		26.17  LDD2049  [21]
C403
 Probe Info  		14.03  LDD2061  [21]
C407
 Probe Info  		11.16  LDD2064  [21]
C413
 Probe Info  		14.03  LDD2069  [21]
C426
 Probe Info  		17.88  LDD2081  [21]
FFF probe11
 Probe Info  		20.00  LDD0471  [22]
FFF probe12
 Probe Info  		20.00  LDD0473  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe15
 Probe Info  		6.52  LDD0478  [22]
FFF probe2
 Probe Info  		20.00  LDD0463  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
FFF probe4
 Probe Info  		15.15  LDD0466  [22]
FFF probe6
 Probe Info  		16.31  LDD0467  [22]
JN0003
 Probe Info  		20.00  LDD0469  [22]
STS-1
 Probe Info  		N.A.  LDD0136  [23]
STS-2
 Probe Info  		N.A.  LDD0138  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]
Diazir
 Probe Info  		N.A.  LDD0011  [15]
OEA-DA
 Probe Info  		8.71  LDD0046  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C379(0.63)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C379(0.52)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C379(1.00)  LDD2117  [8]
 LDCM0025  4SU-RNA HEK-293T C379(2.09)  LDD0371  [26]
 LDCM0214  AC1 HCT 116 C379(0.64); C552(1.01)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C203(0.93); C379(1.21); C552(1.32)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C379(1.21); C552(1.07)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C379(0.98); C552(0.98)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C379(1.23); C552(0.96)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C379(1.19); C552(1.21)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C379(1.32); C552(1.04)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C379(1.05); C552(1.16)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C379(1.04); C552(1.27)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C379(1.03); C552(1.17)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C379(1.07); C552(1.00)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C379(0.99); C552(0.87)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C203(0.88); C379(1.27); C552(1.52)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C379(1.03); C552(0.93)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C379(1.08); C552(0.89)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C379(1.04); C552(1.00)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C379(1.17); C552(1.00)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C379(1.14); C552(1.12)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C379(1.03); C552(1.19)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C379(1.31); C552(1.16)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C379(1.28); C552(1.15)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C379(1.25); C552(1.04)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C379(1.40); C552(1.29)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C203(0.86); C379(1.43); C552(1.19)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C379(1.02); C552(1.11)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C379(1.00); C552(1.01)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C379(1.12); C552(1.15)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C379(0.74); C552(1.04)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C379(1.20); C552(0.95)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C379(1.18); C552(1.10)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C379(1.41); C552(1.28)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C379(1.15); C552(1.35)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C379(1.10); C552(0.91)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C379(1.39); C552(0.69)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C379(1.00); C552(0.93)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C379(1.23); C552(0.68)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C379(1.08); C552(0.79)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C379(1.22); C552(0.83)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C379(1.12); C552(0.87)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C379(1.07); C552(0.90)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C379(1.15); C552(0.79)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C379(0.91); C552(0.75)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C379(0.80); C552(0.82)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C379(0.82); C552(0.82)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C203(0.91); C379(1.72); C552(1.11)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C379(0.77); C552(0.87)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C379(0.81); C552(0.88)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C379(1.28); C552(0.70)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C552(1.15)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C552(1.30)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C552(1.06)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C552(1.14)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C552(1.25)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C552(1.61)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C552(1.34)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C203(0.90); C552(1.23); C379(1.56)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C552(0.96)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C552(1.04)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C552(1.24)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C552(1.74)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C552(1.12)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C552(1.19)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C552(0.96)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C552(0.97)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C379(0.93); C552(0.98)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C379(1.09); C552(1.15)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C552(0.94); C379(1.00)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C379(0.65); C552(1.01)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C552(0.88); C379(0.89)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C379(1.05); C552(1.35)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C552(0.93); C379(1.05)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C552(0.96); C379(0.97)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C552(0.80); C379(1.01)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C379(0.78); C552(1.66)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C379(0.75); C552(1.64)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C379(0.83); C552(1.86)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C379(0.65); C552(1.88)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C379(0.69); C552(1.67)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C379(0.62); C552(0.98)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C379(0.58); C552(1.86)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C379(0.60); C552(1.60)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C379(0.55); C552(1.75)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C379(0.62); C552(2.15)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C379(0.82); C552(2.19)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C552(0.83); C203(1.02); C379(1.43)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C203(0.86); C552(0.96); C379(1.36)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C552(1.03); C203(1.13); C379(1.15)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C203(0.88); C552(0.99); C379(1.08)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C203(0.85); C379(1.04); C552(1.16)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C379(0.49); C552(1.01)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C379(0.90); C203(0.92); C552(1.10)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C379(1.03); C552(1.11); C203(1.62)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C379(0.92); C552(1.08); C203(1.09)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C379(0.91); C552(1.44); C203(2.43)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C379(0.92); C203(1.08); C552(1.15)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C379(0.91); C203(1.18); C552(1.33)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C552(1.31); C379(1.41)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C552(1.02); C379(1.19)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C552(0.94); C379(1.52)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C552(1.15); C379(1.73)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C379(0.47); C552(0.94)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C552(0.93); C379(2.30)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C552(0.95); C379(1.43)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C379(0.96); C552(1.25)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C379(0.71); C552(1.20)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C379(0.91); C552(0.96)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C379(0.95); C552(1.69)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C379(0.80); C552(1.28)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C379(0.55); C203(1.17); C552(1.21)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C379(0.57); C203(1.13); C552(1.45)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C379(0.59); C203(1.01); C552(1.29)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C203(0.80); C379(1.18); C552(1.26)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C379(0.54); C203(0.91); C552(1.20)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C379(0.69); C203(1.29); C552(1.37)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C379(0.51); C203(1.06); C552(1.19)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C379(0.55); C552(1.06); C203(1.21)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C379(0.50); C552(1.23); C203(1.31)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C379(0.56); C552(1.05); C203(1.40)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C379(0.60); C552(1.02); C203(1.16)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C379(0.53); C552(0.96); C203(1.33)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C379(0.87); C552(1.10)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C552(1.18); C379(1.30)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C203(0.89); C379(1.03); C552(1.07)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C379(1.14); C552(1.32)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C552(1.08); C379(1.12)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C379(0.96); C552(1.49)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C379(0.77); C552(1.79)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C379(1.00); C552(1.43)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C379(0.78); C552(2.00)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C379(0.93); C552(1.29)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C379(0.79); C552(1.28)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C379(1.04); C552(1.23)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C379(1.07); C552(1.18)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C203(0.85); C552(1.24); C379(1.30)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C379(0.78); C552(1.17)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C552(1.06); C379(1.19)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C379(0.95); C552(1.93)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C379(0.98); C203(1.12); C552(1.85)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C379(0.93); C203(0.98); C552(1.80)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C379(1.09); C203(1.33); C552(1.43)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C379(1.19); C203(1.26); C552(1.40)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C379(1.14); C552(1.21); C203(1.25)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C379(1.14); C552(1.33); C203(1.42)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C379(0.91); C203(1.49); C552(1.58)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C379(1.20); C552(1.47); C203(1.50)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C379(0.96); C203(1.38); C552(1.59)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C379(1.18); C203(1.44); C552(1.72)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C203(0.97); C552(1.42); C379(1.47)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C552(1.09); C203(1.11); C379(1.77)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C379(1.13); C203(1.15); C552(1.41)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C203(0.89); C379(1.42); C552(1.60)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C379(1.05); C203(1.31); C552(1.52)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C379(1.05); C552(1.74)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C552(0.98); C379(1.15)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C203(1.04); C379(1.17); C552(1.03)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C203(0.86); C379(0.90); C552(1.23)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C203(0.96); C379(1.56); C552(2.32)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.56  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C552(1.08)  LDD2171  [10]
 LDCM0108  Chloroacetamide HeLa C552(0.00); C330(0.00); C379(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C203(0.91); C552(1.13); C379(1.21)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C203(0.92); C379(0.95); C552(1.07)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C379(0.60); C552(1.05)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C203(0.83); C552(1.34); C379(1.67)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C203(0.87); C552(1.01); C379(1.63)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C203(0.82); C552(0.97); C379(1.86)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C203(0.88); C552(1.08); C379(1.83)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C379(1.09); C552(1.35)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C379(1.09); C552(1.54)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C379(1.11); C552(1.27)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C379(1.14); C552(1.54)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C379(1.00); C552(1.03)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C552(0.87); C379(0.88); C203(1.01)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C379(1.01); C552(1.23)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C552(0.95); C379(0.99)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C379(0.76); C552(1.11)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C379(0.73); C552(1.70)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C379(0.54); C552(1.66)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C379(0.73); C552(1.69)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C379(0.53); C552(1.95)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C379(0.96); C203(1.07); C552(1.65)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C379(1.04); C552(1.08); C203(1.30)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C379(0.96); C552(1.28); C203(1.43)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C379(0.87); C203(0.96); C552(1.24)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C379(1.04); C552(1.19); C203(1.43)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C379(0.44); C552(1.46)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C379(0.74); C552(1.25)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C379(0.55); C552(1.16)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C379(0.58); C552(1.19)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C379(0.76); C552(0.90); C203(1.34)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C379(0.68); C552(0.95); C203(1.24)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C379(0.72); C552(0.89); C203(0.98)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C379(0.55); C203(1.22); C552(1.35)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C203(0.92); C552(0.93); C379(1.16)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C203(0.91); C552(0.96); C379(1.13)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C552(0.74); C203(0.92); C379(1.12)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C379(0.82); C203(0.98); C552(1.03)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C203(0.95); C379(1.09); C552(1.19)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C203(0.88); C552(1.22); C379(1.27)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C203(0.92); C379(1.00); C552(1.09)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C203(0.92); C552(1.22); C379(1.25)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C379(0.81); C203(0.91); C552(1.41)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C379(0.86); C203(0.94); C552(1.00)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C379(0.75); C552(0.92); C203(1.08)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C379(0.93); C203(0.94); C552(1.03)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C379(0.84); C203(0.99); C552(1.00)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C203(0.96); C379(0.98); C552(0.86)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C203(0.97); C379(0.88); C552(1.05)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C203(1.07); C379(0.95); C552(1.04)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C203(1.02); C379(0.91); C552(1.11)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C203(1.12); C379(0.88); C552(1.11)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C203(0.77); C379(1.08); C552(0.94)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C203(1.00); C379(0.84); C552(1.17)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C379(1.30); C552(1.11)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C379(1.17); C552(1.23)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C379(1.03); C552(1.13)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C379(0.92); C552(1.52)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C379(1.22); C552(1.46)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C379(1.12); C552(1.56)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C379(1.13); C552(1.79)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C379(0.97); C552(1.54)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C203(0.84); C379(0.92); C552(0.91)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C379(0.78); C552(1.44)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C379(0.95); C552(1.39)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C379(1.09); C552(2.41)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C379(1.15); C552(2.15)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C379(1.06); C552(1.98)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C379(1.00); C552(1.69)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C203(1.03); C379(0.92); C552(0.88)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C203(0.87); C379(0.90); C552(0.89)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C203(0.83); C379(1.08); C552(0.87)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C203(1.08); C379(1.19); C552(1.01)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C203(1.19); C379(1.09); C552(0.98)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C203(0.85); C379(0.96); C552(0.81)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C203(1.05); C379(1.05); C552(0.95)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C203(0.73); C379(0.96); C552(1.10)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C203(0.77); C379(0.86); C552(0.87)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C203(0.72); C379(1.06); C552(0.83)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C203(0.77); C379(0.96); C552(0.83)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C203(0.76); C379(0.85); C552(0.87)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C203(0.85); C379(0.88); C552(0.81)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C203(0.80); C379(1.11); C552(0.77)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C203(0.90); C379(1.03); C552(0.97)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C203(0.90); C379(1.03); C552(1.05)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C203(0.95); C379(0.99); C552(0.94)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C203(1.13); C379(1.51); C552(1.09)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C203(0.98); C379(1.02); C552(1.05)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C203(1.02); C379(1.08); C552(1.05)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C203(0.89); C379(1.29); C552(1.21)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C203(1.25); C379(1.30); C552(0.84)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C203(0.99); C379(1.30); C552(1.69)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C203(1.08); C379(1.42); C552(1.26)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C203(1.08); C379(1.59); C552(1.16)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C203(1.07); C379(1.26); C552(1.12)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C203(1.05); C379(1.00); C552(1.05)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C203(1.03); C379(1.48); C552(1.15)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C203(0.99); C379(1.31); C552(1.22)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C203(1.15); C379(1.25); C552(1.24)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C203(1.11); C379(1.46); C552(1.06)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C203(1.03); C379(1.18); C552(1.21)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C379(0.97)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C379(0.93)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C379(0.80)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C379(0.78)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C203(1.09); C379(0.90); C552(0.96)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C379(1.42)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C379(0.86)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C379(0.77)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C379(0.68)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C379(0.69)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C379(0.77)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C379(0.85)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C379(0.81)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C379(0.61)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C379(0.69)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C203(0.96); C379(1.04); C552(1.10)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C379(1.67)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C379(0.70); C552(1.11)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C379(0.87); C552(1.04)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C379(0.95); C552(1.14)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C379(0.82); C552(1.00)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C379(0.64); C552(1.20)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C379(0.74); C552(1.14)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C379(0.73); C552(0.89)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C379(0.70); C552(1.11)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C379(0.62); C552(1.09)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C379(0.95); C552(1.03); C330(1.02); C203(1.08)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C379(1.97); C552(1.12); C330(1.12)  LDD1702  [8]
 LDCM0625  F8 Ramos C203(0.75); C379(1.21); C330(0.61)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C203(0.58); C379(0.98); C330(0.67)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C203(1.10); C379(0.05); C330(1.59)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C203(0.69); C379(1.00); C330(0.41)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C203(0.92); C379(1.06); C330(0.59)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C203(0.53); C379(0.95); C330(1.14)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C203(0.52); C379(1.22); C330(0.32)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C203(0.91); C379(0.84); C330(0.55)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C203(1.11); C379(0.56); C330(0.84)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C203(0.95); C379(0.86); C330(0.38)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C203(0.61); C379(0.92); C330(0.09)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C203(1.18); C379(1.16); C330(0.38)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C203(0.75); C379(0.67); C330(0.29)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C203(0.51); C379(0.79); C330(0.52)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C203(0.90); C379(1.61); C552(1.43)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C203(0.78); C379(0.90); C330(0.44)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C203(0.72); C379(1.07); C330(0.65)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C379(0.89); C552(2.09)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C203(1.05); C379(1.26); C330(1.30)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C203(1.18); C379(1.53); C330(1.23)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C203(0.57); C379(0.99); C330(0.24)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C203(0.71); C379(0.93); C330(0.38)  LDD2188  [28]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C552(1.61)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C552(1.24)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C552(1.53)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C379(0.67)  LDD2102  [8]
 LDCM0109  NEM HeLa N.A.  LDD0224  [18]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C379(1.09)  LDD2090  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C379(0.70)  LDD2100  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C379(0.61)  LDD2104  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C379(0.56)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C379(0.83); C552(1.06)  LDD2107  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C379(1.14)  LDD2110  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C379(0.82)  LDD2123  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C379(0.88); C552(1.15)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C379(1.01); C552(1.70)  LDD2137  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C379(0.55)  LDD2141  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C379(0.49)  LDD2148  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C379(0.93)  LDD2206  [29]
 LDCM0131  RA190 MM1.R C552(1.12)  LDD0304  [30]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.13  LDD0123  [9]
 LDCM0021  THZ1 HCT 116 C552(1.08)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66

References

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3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
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8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
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11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
26 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.