Details of the Target

General Information of Target

Target ID LDTP02602
Target Name Histidine--tRNA ligase, cytoplasmic (HARS1)
Gene Name HARS1
Gene ID 3035
Synonyms
HARS; HRS; Histidine--tRNA ligase, cytoplasmic; EC 6.1.1.21; Histidyl-tRNA synthetase; HisRS
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK
GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ
GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG
NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK
LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG
DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG
GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL
LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS
VTSREEVDVRREDLVEEIKRRTGQPLCIC
Target Bioclass
Enzyme
Family
Class-II aminoacyl-tRNA synthetase family
Subcellular location
Cytoplasm
Function Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.
Uniprot ID
P12081
Ensemble ID
ENST00000307633.7
HGNC ID
HGNC:4816
ChEMBL ID
CHEMBL4002

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.R19P DBIA    Probe Info 
AN3CA SNV: p.A2T DBIA    Probe Info 
IGR1 SNV: p.P134S DBIA    Probe Info 
LN18 SNV: p.V96A .
LNCaP clone FGC SNV: p.T102A DBIA    Probe Info 
VMRCRCW SNV: p.Q14P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.69  LDD0402  [1]
AZ-5
 Probe Info  		10.00  LDD0394  [2]
AZ-9
 Probe Info  		4.12  LDD0393  [2]
TH211
 Probe Info  		Y172(18.05)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K12(8.33)  LDD0274  [5]
Probe 1
 Probe Info  		Y442(30.18)  LDD3495  [6]
BTD
 Probe Info  		C235(1.74)  LDD1700  [7]
DA-P3
 Probe Info  		9.75  LDD0182  [8]
AHL-Pu-1
 Probe Info  		C509(3.01)  LDD0169  [9]
HHS-475
 Probe Info  		Y172(0.77); Y168(0.82)  LDD0264  [10]
IPM
 Probe Info  		C235(1.05)  LDD1701  [7]
DBIA
 Probe Info  		C507(1.15); C235(0.90)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		K42(0.00); K418(0.00); K419(0.00); K243(0.00)  LDD0199  [13]
1d-yne
 Probe Info  		N.A.  LDD0358  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C224(0.00); C196(0.00); C379(0.00); C455(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C224(0.00); C196(0.00); C455(0.00); C235(0.00)  LDD0037  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		C509(0.00); C507(0.00)  LDD0027  [19]
NHS
 Probe Info  		K75(0.00); K42(0.00)  LDD0010  [20]
PF-06672131
 Probe Info  		C507(0.00); C509(0.00)  LDD0017  [21]
SF
 Probe Info  		N.A.  LDD0028  [22]
STPyne
 Probe Info  		K418(0.00); K42(0.00)  LDD0009  [20]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K42(0.00); K288(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		C235(0.00); C224(0.00)  LDD0217  [24]
Methacrolein
 Probe Info  		N.A.  LDD0218  [24]
AOyne
 Probe Info  		6.10  LDD0443  [25]
MPP-AC
 Probe Info  		N.A.  LDD0428  [26]
NAIA_5
 Probe Info  		C379(0.00); C224(0.00); C196(0.00); C455(0.00)  LDD2223  [18]
TER-AC
 Probe Info  		N.A.  LDD0426  [26]
TPP-AC
 Probe Info  		N.A.  LDD0427  [26]
HHS-465
 Probe Info  		N.A.  LDD2240  [27]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		14.27  LDD0471  [28]
FFF probe13
 Probe Info  		20.00  LDD0475  [28]
FFF probe14
 Probe Info  		20.00  LDD0477  [28]
FFF probe15
 Probe Info  		16.55  LDD0478  [28]
FFF probe2
 Probe Info  		17.44  LDD0463  [28]
FFF probe3
 Probe Info  		8.53  LDD0464  [28]
FFF probe4
 Probe Info  		16.83  LDD0466  [28]
FFF probe7
 Probe Info  		20.00  LDD0483  [28]
JN0003
 Probe Info  		19.61  LDD0469  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [29]
OEA-DA
 Probe Info  		15.42  LDD0046  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C235(0.60)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C235(0.81)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C235(0.77)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C235(1.03)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C235(1.16); C379(1.31)  LDD2117  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C235(0.30)  LDD2132  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C509(3.01)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C174(0.96); C191(0.96); C379(0.95); C507(1.00)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C235(0.80); C507(1.04); C509(0.76)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C224(1.58); C235(1.84); C379(0.86); C507(0.96)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C224(0.76); C235(0.90); C379(0.78); C507(1.03)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C224(0.78); C235(0.85); C379(0.65); C507(0.96)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C224(0.38); C235(0.58); C379(0.44); C507(1.25)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C224(0.58); C235(0.74); C379(0.56); C507(1.01)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C224(0.53); C235(0.74); C379(0.54); C507(1.15)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C224(0.51); C235(0.79); C379(0.54); C507(1.18)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C224(1.17); C235(1.52); C379(0.41); C507(1.15)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C224(0.81); C235(1.08); C379(0.63); C507(0.90)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C224(0.70); C235(0.82); C379(0.58); C507(1.10)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C235(0.85); C507(0.99); C509(0.68)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C224(0.73); C235(0.89); C379(0.58); C507(0.94)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C224(0.73); C235(0.90); C379(0.56); C507(0.93)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C224(0.94); C235(1.24); C379(0.44); C507(1.11)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C507(1.01)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C507(1.22)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C507(1.30)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C507(1.26)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C507(1.11)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C507(1.04)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C507(1.15)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C235(1.01); C507(0.86); C509(0.60)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C507(1.00)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C507(1.08)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C507(1.19)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C507(1.00)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C507(1.04)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C507(1.18)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C507(1.21)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C507(1.28)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C235(0.49); C507(1.47); C509(1.39)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C235(1.04); C507(1.14); C509(1.20)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C235(0.83); C507(1.38); C509(1.30)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C235(1.07); C507(1.18); C509(1.17)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C235(1.12); C507(1.18); C509(1.22)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C235(0.98); C507(1.24); C509(1.23)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C235(1.17); C507(1.47); C509(1.34)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C235(0.87); C507(1.49); C509(1.34)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C235(1.06); C507(1.13); C509(1.15)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C235(1.30); C507(1.08); C509(1.08)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C235(1.19); C507(1.38); C509(1.38)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C235(1.12); C507(1.32); C509(1.30)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C235(1.06); C507(0.98); C509(0.84)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C235(1.11); C507(1.49); C509(1.43)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C235(1.04); C507(1.38); C509(1.42)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C235(1.14); C507(1.21); C509(1.22)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C379(1.03); C507(1.23); C509(1.13)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C379(0.75); C509(1.47); C507(1.67)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C379(1.04); C509(1.15); C507(1.20)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C379(1.06); C507(1.53); C509(1.64)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C379(0.65); C507(1.52); C509(1.56)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C379(0.37); C509(1.88); C507(2.19)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C379(0.70); C509(1.65); C507(1.75)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C509(0.79); C235(0.88); C507(0.98)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C509(1.14); C507(1.19); C379(1.26)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C379(1.13); C509(1.24); C507(1.31)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C379(0.55); C509(1.32); C507(1.41)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C379(0.29); C507(2.18); C509(2.21)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C379(0.76); C507(1.53); C509(1.42)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C379(0.80); C507(1.38); C509(1.33)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C379(1.09); C507(1.14); C509(1.26)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C379(0.85); C507(1.27); C509(1.10)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C507(1.14); C174(1.18); C191(1.18)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C174(0.99); C191(0.99); C507(1.24)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C507(1.17); C174(1.45); C191(1.45)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C509(0.93); C379(1.01); C507(1.06); C174(1.11)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C507(1.12); C174(1.70); C191(1.70)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C507(1.16); C174(1.19); C191(1.19)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C507(1.06); C174(1.27); C191(1.27)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C507(1.26); C174(1.39); C191(1.39)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C507(1.07); C174(1.16); C191(1.16)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C507(1.08); C509(1.08)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C507(1.30); C509(1.31)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C507(1.24); C509(1.44)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C507(1.18); C509(1.25)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C509(1.22); C507(1.26)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C509(0.96); C379(1.02); C507(1.03); C174(1.07)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C507(1.27); C509(1.46)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C507(1.27); C509(1.51)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C507(1.67); C509(1.80)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C507(1.45); C509(1.73)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C507(1.44); C509(1.52)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C509(0.69); C507(0.80); C235(1.31); C379(1.90)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C509(0.78); C507(0.96); C235(1.39); C174(1.40)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C509(0.91); C507(1.00); C235(1.20); C379(1.26)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C507(0.90); C509(0.95); C379(1.36); C235(1.42)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C509(0.95); C507(0.98); C174(1.10); C191(1.10)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C174(1.01); C191(1.01); C379(1.02); C509(1.04)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C235(0.77); C174(0.78); C191(0.78); C379(1.24)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C509(0.80); C507(1.02); C235(1.10); C379(1.33)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C507(1.04); C235(1.04); C174(1.06); C191(1.06)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C509(0.96); C507(1.05); C235(1.14); C379(1.20)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C509(0.96); C379(0.96); C507(1.00); C235(1.09)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C174(0.59); C191(0.59); C235(0.81); C379(0.91)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C174(1.02); C191(1.02); C379(1.07); C507(1.12)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C224(0.89); C379(1.01); C174(1.08); C191(1.08)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C174(1.02); C191(1.02); C224(1.14); C507(1.19)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C224(0.30); C174(0.47); C191(0.47); C379(0.51)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C379(0.96); C174(1.05); C191(1.05); C509(1.06)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C224(0.31); C379(0.51); C174(0.53); C191(0.53)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C507(1.05); C174(1.27); C191(1.27); C235(1.29)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C174(0.67); C191(0.67); C224(0.93); C507(1.15)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C224(0.50); C174(0.68); C191(0.68); C379(0.72)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C224(0.58); C174(0.62); C191(0.62); C379(0.65)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C224(0.23); C379(0.43); C174(0.46); C191(0.46)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C224(0.15); C379(0.30); C235(0.39); C174(0.41)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C174(0.38); C191(0.38); C224(0.56); C235(0.92)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C174(0.30); C191(0.30); C224(0.56); C235(0.89)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C174(0.19); C191(0.19); C224(0.31); C235(0.63)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C509(0.77); C507(1.01); C235(1.08)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C174(0.41); C191(0.41); C224(0.64); C235(0.99)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C174(0.52); C191(0.52); C224(0.86); C235(1.09)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C174(0.18); C191(0.18); C224(0.33); C235(0.56)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C174(0.34); C191(0.34); C224(0.62); C235(0.95)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C174(0.19); C191(0.19); C224(0.36); C235(0.65)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C174(0.41); C191(0.41); C224(0.58); C235(1.09)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C174(0.53); C191(0.53); C224(0.79); C235(1.28)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C174(0.11); C191(0.11); C224(0.20); C235(0.43)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C224(0.86); C509(1.00); C507(1.14); C174(1.16)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C174(0.58); C191(0.58); C224(0.69); C235(0.88)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C509(0.65); C235(0.66); C507(0.97)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C224(0.28); C174(0.56); C191(0.56); C235(0.58)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C509(1.00); C224(1.01); C235(1.10); C507(1.14)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C174(0.52); C191(0.52); C224(0.57); C235(0.89)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C224(0.20); C174(0.32); C191(0.32); C235(0.40)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C224(0.24); C174(0.29); C191(0.29); C235(0.40)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C224(0.16); C174(0.25); C191(0.25); C235(0.30)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C224(0.43); C174(0.62); C191(0.62); C235(0.66)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C174(0.39); C191(0.39); C224(0.40); C235(0.63)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C174(0.37); C191(0.37); C235(1.00); C507(1.04)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C224(0.86); C235(0.93); C174(0.96); C191(0.96)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C509(0.62); C235(0.82); C507(0.93)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C224(0.59); C235(0.67); C174(0.71); C191(0.71)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C174(0.76); C191(0.76); C224(0.81); C235(0.97)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C224(0.10); C174(0.22); C191(0.22); C235(0.24)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C174(0.32); C191(0.32); C235(0.56); C509(1.32)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C174(0.42); C191(0.42); C235(0.75); C509(1.14)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C174(0.66); C191(0.66); C509(1.01); C235(1.01)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C174(0.77); C191(0.77); C235(1.09); C507(1.30)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C174(0.80); C191(0.80); C507(1.07); C235(1.11)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C174(0.90); C191(0.90); C235(0.98); C507(1.14)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C174(0.52); C191(0.52); C235(0.80); C509(1.35)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C507(1.08); C509(1.22); C235(1.29); C174(1.80)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C174(0.24); C191(0.24); C235(0.41); C509(1.40)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C174(0.33); C191(0.33); C235(0.52); C509(1.27)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C174(0.78); C191(0.78); C235(0.95); C507(1.05)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C174(0.68); C191(0.68); C509(1.02); C235(1.05)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C174(0.78); C191(0.78); C235(1.05); C509(1.11)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C174(0.68); C191(0.68); C235(0.81); C509(1.21)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C174(0.41); C191(0.41); C235(0.66); C509(1.38)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C224(0.07); C379(0.12); C235(0.14); C509(1.52)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C379(0.70); C224(0.73); C235(0.80); C507(0.92)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C235(0.38)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C235(0.74)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C235(0.90); C507(0.85); C509(0.64)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C509(0.67); C235(0.96); C507(0.99)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C235(0.49); C509(1.39); C507(1.47)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.47  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C507(1.15); C235(0.90)  LDD0078  [11]
 LDCM0102  BDHI 8 Jurkat C196(23.58)  LDD0204  [31]
 LDCM0498  BS-3668 MDA-MB-231 C235(0.64)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C235(0.00); C224(0.00)  LDD0222  [24]
 LDCM0367  CL1 HCT 116 C224(0.83); C509(1.19); C507(1.25); C174(1.84)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C174(0.73); C191(0.73); C224(0.78); C507(1.62)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C379(0.93); C174(0.97); C191(0.97); C507(1.16)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C235(0.92); C507(1.11); C509(1.13)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C509(0.71); C235(1.01); C507(1.01)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C235(0.71); C509(0.75); C507(0.95)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C509(0.76); C235(0.94); C507(1.01)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C174(1.05); C191(1.05); C507(1.28)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C174(0.74); C191(0.74); C507(1.61)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C174(0.73); C191(0.73); C507(1.59)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C174(0.62); C191(0.62); C507(1.47)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C174(1.16); C191(1.16); C507(1.36)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C174(0.36); C191(0.36); C224(0.58); C507(1.66)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C174(0.85); C191(0.85); C507(1.56)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C174(1.02); C191(1.02); C507(1.31)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C507(1.01); C509(1.04)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C507(1.42); C509(1.54)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C509(1.35); C507(1.40)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C507(1.17); C509(1.24)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C507(1.20); C509(1.22)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C174(0.41); C191(0.41); C235(0.48); C379(0.64)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C509(0.92); C507(1.03); C235(1.11); C174(1.23)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C174(0.77); C191(0.77); C235(0.89); C509(0.96)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C174(0.33); C191(0.33); C224(0.52); C507(1.53)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C509(0.88); C507(0.97); C235(1.10); C174(1.34)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C174(0.77); C191(0.77); C379(0.83); C224(0.89)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C174(0.79); C191(0.79); C224(0.83); C379(1.07)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C174(0.81); C191(0.81); C224(0.92); C379(0.94)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C224(0.37); C379(0.57); C174(0.57); C191(0.57)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C174(0.60); C191(0.60); C509(1.00); C224(1.07)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C174(0.56); C191(0.56); C224(0.70); C235(0.94)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C174(0.55); C191(0.55); C224(0.86); C235(1.07)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C174(0.21); C191(0.21); C224(0.44); C235(0.71)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C224(0.87); C174(0.91); C191(0.91); C507(1.11)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C224(0.94); C507(1.31); C509(1.40); C174(2.35)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C224(0.66); C174(1.14); C191(1.14); C507(1.46)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C174(0.82); C191(0.82); C224(0.90); C507(1.24)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C224(0.94); C174(1.04); C191(1.04); C507(1.44)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C174(0.99); C191(0.99); C224(1.05); C507(1.23)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C224(0.91); C174(0.99); C191(0.99); C507(1.23)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C224(0.82); C174(0.93); C191(0.93); C509(1.09)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C174(0.49); C191(0.49); C224(0.55); C507(1.57)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C174(0.39); C191(0.39); C224(0.42); C507(1.56)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C174(0.18); C191(0.18); C224(0.22); C507(2.49)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C224(0.67); C174(0.73); C191(0.73); C507(1.21)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C174(0.34); C191(0.34); C224(0.39); C507(1.46)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C174(0.36); C191(0.36); C224(0.39); C507(1.53)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C174(0.77); C191(0.77); C224(0.72); C507(1.33)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C174(0.94); C191(0.94); C224(0.85); C507(1.32)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C174(0.76); C191(0.76); C224(0.68); C507(1.53)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C174(0.52); C191(0.52); C224(0.64); C507(1.41)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C174(1.20); C191(1.20); C224(0.91); C507(1.05)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C174(0.84); C191(0.84); C224(0.77); C507(1.20)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C224(0.86); C235(0.93); C507(1.31)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C224(1.05); C235(1.01); C507(1.28); C509(1.10)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C224(0.98); C235(0.99); C507(1.52); C509(1.28)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C224(0.42); C235(0.95); C507(1.79); C509(1.19)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C224(0.38); C235(0.83); C507(1.93); C509(1.23)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C224(0.53); C235(0.80); C507(1.69); C509(1.09)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C224(0.35); C235(0.75); C507(2.12); C509(1.14)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C224(0.48); C235(0.74); C507(1.86); C509(1.26)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C174(1.97); C191(1.97); C224(0.97); C507(1.26)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C224(0.61); C235(0.74); C507(1.85); C509(1.38)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C224(0.60); C235(0.62); C507(1.59); C509(1.16)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C224(0.18); C235(0.55); C507(3.57); C509(1.09)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C224(0.29); C235(0.78); C507(1.86); C509(1.15)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C224(0.70); C235(0.83); C507(1.52); C509(1.19)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C224(0.43); C235(1.08); C507(1.74); C509(1.06)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C507(1.01)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C507(0.92)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C507(0.97)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C507(1.07)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C174(1.07); C191(1.07); C224(0.92); C507(1.07)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C507(1.07)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C507(1.07)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C507(1.09)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C507(1.03)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C507(1.05)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C507(1.02)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C507(1.05)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C507(1.13)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C507(1.07)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C507(1.00)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C174(0.70); C191(0.70); C224(0.93); C507(1.17)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C507(1.00)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C224(0.92); C507(1.19); C509(0.92)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C224(0.89); C507(1.02); C509(1.12)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C224(0.90); C507(1.26); C509(1.46)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C224(0.68); C507(1.35); C509(1.04)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C224(0.84); C507(1.11); C509(1.38)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C224(0.35); C507(1.44); C509(1.16)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C224(0.63); C507(1.21); C509(1.25)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C224(0.96); C507(1.26); C509(0.92)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C224(1.12); C507(1.22); C509(1.21)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C174(0.71); C191(0.71); C224(0.76); C507(1.14)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C224(0.81); C507(1.19); C509(1.05)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C224(0.72); C507(1.28); C509(1.01)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C224(0.90); C507(1.01); C509(1.35)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C224(0.86); C507(1.12); C509(1.02)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C224(0.72); C507(1.27); C509(1.21)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C174(1.24); C191(1.24); C224(0.88); C235(1.26)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C174(0.85); C191(0.85); C224(0.95); C235(1.19)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C174(0.86); C191(0.86); C224(0.99); C235(1.37)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C174(0.41); C191(0.41); C224(0.42); C235(0.81)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C174(0.27); C191(0.27); C224(0.47); C507(1.45)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C174(1.34); C191(1.34); C224(1.52); C235(1.22)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C174(1.00); C191(1.00); C224(0.78); C235(1.00)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C174(0.21); C191(0.21); C224(0.22); C235(0.56)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C174(0.29); C191(0.29); C224(0.29); C235(0.74)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C174(0.18); C191(0.18); C224(0.16); C235(0.45)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C174(1.05); C191(1.05); C224(0.77); C235(1.19)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C174(0.90); C191(0.90); C224(1.01); C235(1.39)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C174(0.81); C191(0.81); C224(1.00); C235(1.12)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C174(0.33); C191(0.33); C224(0.31); C235(0.84)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C174(0.13); C191(0.13); C224(0.13); C235(0.42)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C174(1.06); C191(1.06); C224(0.92); C507(1.13)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C174(1.41); C191(1.41); C224(1.03); C235(1.09)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C174(1.06); C191(1.06); C379(0.89); C507(1.19)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C174(0.85); C191(0.85); C379(0.88); C507(1.21)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C174(0.88); C191(0.88); C379(1.05); C507(0.95)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C174(1.16); C191(1.16); C379(0.89); C507(1.20)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C174(1.04); C191(1.04); C379(0.92); C507(1.27)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C174(1.00); C191(1.00); C379(0.83); C507(1.26)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C174(0.97); C191(0.97); C379(1.02); C507(1.36)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C174(1.09); C191(1.09); C379(1.03); C507(1.15)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C174(1.08); C191(1.08); C379(1.08); C507(1.09)  LDD0811  [11]
 LDCM0189  Compound 16 HEK-293T 24.46  LDD0492  [28]
 LDCM0185  Compound 17 HEK-293T 12.93  LDD0504  [28]
 LDCM0184  Compound 20 HEK-293T 14.56  LDD0503  [28]
 LDCM0191  Compound 21 HEK-293T 7.15  LDD0493  [28]
 LDCM0186  Compound 31 HEK-293T 6.56  LDD0506  [28]
 LDCM0187  Compound 32 HEK-293T 15.80  LDD0507  [28]
 LDCM0188  Compound 33 HEK-293T 7.80  LDD0505  [28]
 LDCM0190  Compound 34 HEK-293T 11.54  LDD0497  [28]
 LDCM0192  Compound 35 HEK-293T 5.36  LDD0491  [28]
 LDCM0193  Compound 36 HEK-293T 3.45  LDD0511  [28]
 LDCM0195  Compound 38 HEK-293T 7.19  LDD0499  [28]
 LDCM0196  Compound 39 HEK-293T 7.07  LDD0496  [28]
 LDCM0197  Compound 40 HEK-293T 6.51  LDD0495  [28]
 LDCM0495  E2913 HEK-293T C235(1.00); C379(0.95); C455(0.96); C224(0.96)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C235(0.69)  LDD1702  [7]
 LDCM0031  Epigallocatechin gallate HEK-293T 20.04  LDD0183  [8]
 LDCM0572  Fragment10 Ramos C235(0.56)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C235(2.22)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C235(0.84)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C235(0.80)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C235(1.09)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C235(0.69)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C235(1.00)  LDD2195  [33]
 LDCM0588  Fragment30 Ramos C235(1.45)  LDD2199  [33]
 LDCM0590  Fragment32 Ramos C235(0.69)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C224(0.79); C507(1.35); C509(1.14)  LDD0785  [11]
 LDCM0427  Fragment51 HCT 116 C224(0.21); C235(0.88); C507(2.47); C509(1.10)  LDD0744  [11]
 LDCM0569  Fragment7 Ramos C235(0.80)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C235(0.71)  LDD2188  [33]
 LDCM0116  HHS-0101 DM93 Y172(0.77); Y168(0.82)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y172(0.74); Y168(0.80)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y168(0.84); Y172(0.90)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y168(1.95); Y172(2.37)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y168(5.59); Y172(13.28)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C507(2.58)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C507(2.18)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C507(2.80)  LDD0082  [11]
 LDCM0030  Luteolin HEK-293T 9.75  LDD0182  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C235(1.24)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C235(0.76); C379(0.75)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C235(0.74)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C235(1.35); C379(1.27)  LDD2090  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C235(0.97); C379(1.32)  LDD2093  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C235(0.68)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C235(1.05)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C235(1.01); C379(0.95)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C235(0.51)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C235(0.76); C379(0.97)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C235(0.47)  LDD2104  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C235(0.89)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C235(0.51)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C235(0.50)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C379(1.07)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C235(0.44)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C235(0.31)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C235(0.32)  LDD2118  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C235(0.83); C379(0.98)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C235(0.26)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C235(0.74); C379(1.10)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C235(0.27)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C235(0.78); C379(0.96)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C235(0.96); C379(1.10)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C235(0.60)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C235(1.21)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C235(0.69)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C235(0.60)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C235(0.99); C379(1.17)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C235(0.97); C379(1.00)  LDD2136  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C235(1.74)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C235(0.86)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C235(0.75)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C235(0.78); C379(0.95)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C235(1.62); C379(2.04)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C235(2.91); C379(1.04)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C235(0.84); C379(0.86)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C235(2.47); C379(1.19)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C235(0.58); C379(0.52)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C235(0.45)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C235(0.13)  LDD2151  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C507(0.12)  LDD2206  [34]
 LDCM0032  Oleacein HEK-293T 5.38  LDD0184  [8]
 LDCM0021  THZ1 HCT 116 C507(1.01)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histidine--tRNA ligase, cytoplasmic (HARS1) Class-II aminoacyl-tRNA synthetase family P12081

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Histidine Small molecular drug DB00117

References

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2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
27 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.