Details of the Target

General Information of Target

Target ID LDTP01613
Target Name Sphingosine-1-phosphate lyase 1 (SGPL1)
Gene Name SGPL1
Gene ID 8879
Synonyms
KIAA1252; Sphingosine-1-phosphate lyase 1; S1PL; SP-lyase 1; SPL 1; hSPL; EC 4.1.2.27; Sphingosine-1-phosphate aldolase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
LSSVFLDSLYSTDTVTQGSQMNGSPKPH
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Group II decarboxylase family, Sphingosine-1-phosphate lyase subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance.
TTD ID
T01575
Uniprot ID
O95470
DrugMap ID
TT618Q2
Ensemble ID
ENST00000373202.8
HGNC ID
HGNC:10817
ChEMBL ID
CHEMBL3286061

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.23  LDD0197  [1]
C-Sul
 Probe Info  		3.87  LDD0066  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
ONAyne
 Probe Info  		K353(5.97)  LDD0275  [4]
IPM
 Probe Info  		C285(0.00); C34(0.00)  LDD0241  [5]
Probe 1
 Probe Info  		Y354(47.30); Y356(44.37)  LDD3495  [6]
DBIA
 Probe Info  		C34(3.42)  LDD3313  [7]
HPAP
 Probe Info  		4.36  LDD0062  [8]
Acrolein
 Probe Info  		N.A.  LDD0223  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
W1
 Probe Info  		N.A.  LDD0236  [5]
AOyne
 Probe Info  		13.80  LDD0443  [14]
NAIA_5
 Probe Info  		C34(0.00); C285(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 121 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		9.45  LDD1714  [16]
C007
 Probe Info  		6.23  LDD1716  [16]
C017
 Probe Info  		5.58  LDD1725  [16]
C022
 Probe Info  		14.22  LDD1728  [16]
C027
 Probe Info  		21.86  LDD1733  [16]
C040
 Probe Info  		15.14  LDD1740  [16]
C041
 Probe Info  		8.63  LDD1741  [16]
C044
 Probe Info  		6.11  LDD1743  [16]
C049
 Probe Info  		7.01  LDD1747  [16]
C055
 Probe Info  		17.75  LDD1752  [16]
C056
 Probe Info  		39.95  LDD1753  [16]
C063
 Probe Info  		18.00  LDD1760  [16]
C064
 Probe Info  		7.31  LDD1761  [16]
C067
 Probe Info  		5.62  LDD1763  [16]
C070
 Probe Info  		16.11  LDD1766  [16]
C072
 Probe Info  		9.00  LDD1768  [16]
C082
 Probe Info  		12.73  LDD1774  [16]
C091
 Probe Info  		25.28  LDD1782  [16]
C092
 Probe Info  		29.86  LDD1783  [16]
C094
 Probe Info  		56.89  LDD1785  [16]
C095
 Probe Info  		5.03  LDD1786  [16]
C100
 Probe Info  		7.11  LDD1789  [16]
C106
 Probe Info  		28.25  LDD1793  [16]
C107
 Probe Info  		10.20  LDD1794  [16]
C108
 Probe Info  		19.03  LDD1795  [16]
C112
 Probe Info  		22.94  LDD1799  [16]
C129
 Probe Info  		7.06  LDD1811  [16]
C130
 Probe Info  		9.99  LDD1812  [16]
C134
 Probe Info  		35.51  LDD1816  [16]
C135
 Probe Info  		11.47  LDD1817  [16]
C139
 Probe Info  		18.00  LDD1821  [16]
C140
 Probe Info  		7.73  LDD1822  [16]
C141
 Probe Info  		13.45  LDD1823  [16]
C143
 Probe Info  		22.01  LDD1825  [16]
C153
 Probe Info  		22.16  LDD1834  [16]
C159
 Probe Info  		8.63  LDD1839  [16]
C160
 Probe Info  		9.58  LDD1840  [16]
C161
 Probe Info  		15.78  LDD1841  [16]
C163
 Probe Info  		6.06  LDD1843  [16]
C165
 Probe Info  		13.36  LDD1845  [16]
C169
 Probe Info  		42.22  LDD1849  [16]
C178
 Probe Info  		17.75  LDD1857  [16]
C183
 Probe Info  		5.03  LDD1861  [16]
C186
 Probe Info  		19.84  LDD1864  [16]
C201
 Probe Info  		86.22  LDD1877  [16]
C206
 Probe Info  		30.70  LDD1881  [16]
C207
 Probe Info  		18.00  LDD1882  [16]
C210
 Probe Info  		57.68  LDD1884  [16]
C211
 Probe Info  		11.71  LDD1885  [16]
C213
 Probe Info  		14.72  LDD1887  [16]
C218
 Probe Info  		21.71  LDD1892  [16]
C219
 Probe Info  		8.17  LDD1893  [16]
C220
 Probe Info  		25.63  LDD1894  [16]
C225
 Probe Info  		6.87  LDD1898  [16]
C226
 Probe Info  		6.73  LDD1899  [16]
C228
 Probe Info  		32.90  LDD1901  [16]
C229
 Probe Info  		8.22  LDD1902  [16]
C231
 Probe Info  		27.10  LDD1904  [16]
C233
 Probe Info  		11.88  LDD1906  [16]
C234
 Probe Info  		7.21  LDD1907  [16]
C235
 Probe Info  		29.24  LDD1908  [16]
C238
 Probe Info  		18.00  LDD1911  [16]
C240
 Probe Info  		9.58  LDD1913  [16]
C243
 Probe Info  		12.82  LDD1916  [16]
C246
 Probe Info  		20.68  LDD1919  [16]
C252
 Probe Info  		10.06  LDD1925  [16]
C264
 Probe Info  		33.36  LDD1935  [16]
C265
 Probe Info  		15.45  LDD1936  [16]
C270
 Probe Info  		7.21  LDD1940  [16]
C273
 Probe Info  		5.06  LDD1943  [16]
C277
 Probe Info  		14.62  LDD1947  [16]
C282
 Probe Info  		20.53  LDD1952  [16]
C285
 Probe Info  		26.54  LDD1955  [16]
C287
 Probe Info  		14.12  LDD1957  [16]
C288
 Probe Info  		9.85  LDD1958  [16]
C289
 Probe Info  		37.01  LDD1959  [16]
C293
 Probe Info  		25.11  LDD1963  [16]
C296
 Probe Info  		13.45  LDD1966  [16]
C299
 Probe Info  		12.04  LDD1968  [16]
C307
 Probe Info  		6.96  LDD1975  [16]
C310
 Probe Info  		7.67  LDD1977  [16]
C314
 Probe Info  		19.84  LDD1981  [16]
C326
 Probe Info  		7.31  LDD1990  [16]
C339
 Probe Info  		7.52  LDD2002  [16]
C343
 Probe Info  		25.81  LDD2005  [16]
C348
 Probe Info  		15.56  LDD2009  [16]
C349
 Probe Info  		33.82  LDD2010  [16]
C350
 Probe Info  		56.89  LDD2011  [16]
C353
 Probe Info  		6.02  LDD2014  [16]
C355
 Probe Info  		31.34  LDD2016  [16]
C356
 Probe Info  		13.55  LDD2017  [16]
C357
 Probe Info  		7.36  LDD2018  [16]
C362
 Probe Info  		60.55  LDD2023  [16]
C363
 Probe Info  		21.71  LDD2024  [16]
C364
 Probe Info  		19.70  LDD2025  [16]
C366
 Probe Info  		8.69  LDD2027  [16]
C367
 Probe Info  		5.74  LDD2028  [16]
C376
 Probe Info  		9.78  LDD2036  [16]
C378
 Probe Info  		6.06  LDD2037  [16]
C380
 Probe Info  		5.43  LDD2039  [16]
C382
 Probe Info  		10.85  LDD2041  [16]
C386
 Probe Info  		8.57  LDD2045  [16]
C388
 Probe Info  		63.12  LDD2047  [16]
C390
 Probe Info  		53.45  LDD2049  [16]
C403
 Probe Info  		14.72  LDD2061  [16]
C407
 Probe Info  		20.39  LDD2064  [16]
C409
 Probe Info  		7.31  LDD2066  [16]
C419
 Probe Info  		13.00  LDD2074  [16]
C424
 Probe Info  		8.34  LDD2079  [16]
C426
 Probe Info  		15.56  LDD2081  [16]
C429
 Probe Info  		13.64  LDD2084  [16]
C431
 Probe Info  		20.11  LDD2086  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe15
 Probe Info  		20.00  LDD0478  [17]
FFF probe2
 Probe Info  		20.00  LDD0463  [17]
FFF probe3
 Probe Info  		20.00  LDD0464  [17]
JN0003
 Probe Info  		20.00  LDD0469  [17]
A-DA
 Probe Info  		2.99  LDD0145  [18]
OEA-DA
 Probe Info  		20.00  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C34(1.01); C404(0.85); C486(1.02); C285(0.96)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C34(0.95); C486(0.81); C285(1.00)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C404(1.05); C486(0.85); C285(1.15)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C34(0.99); C404(0.96); C486(0.83); C285(1.06)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C34(1.12); C404(1.14); C486(0.96); C285(1.08)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C34(1.05); C404(1.01); C486(1.11); C285(1.08)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C34(1.03); C404(0.91); C486(0.89); C285(1.05)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C34(0.95); C486(0.83); C285(0.90)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C404(1.03); C486(0.67); C285(1.08)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C34(0.89); C486(0.75); C285(0.91)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C34(0.97); C404(1.03); C486(0.85); C285(0.98)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C34(0.95); C404(0.98); C486(1.04); C285(1.07)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C34(1.06); C404(0.98); C486(0.84); C285(1.05)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C34(0.94); C404(1.37); C486(0.99); C285(1.08)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C34(0.78); C404(1.05); C486(1.15); C285(0.88)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C34(1.04); C404(0.93); C486(0.81); C285(0.97)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C34(0.97); C486(0.86); C285(0.97)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C404(1.17); C486(0.90); C285(1.13)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C34(1.00); C404(0.99); C486(0.71); C285(1.05)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C34(0.99); C404(0.97); C486(0.83); C285(1.16)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C404(0.74); C486(0.89); C285(1.05)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C34(0.91); C404(0.93); C486(1.03); C285(0.94)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C34(1.01); C404(1.07); C486(0.92); C285(1.17)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C34(1.13); C404(0.93); C486(1.08); C285(1.04)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C34(1.00); C404(1.01); C486(0.99); C285(1.00)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C34(0.89); C486(0.89); C285(1.02)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C404(0.80); C486(0.76); C285(1.07)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C34(0.93); C404(0.94); C486(1.04); C285(1.03)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C34(0.86); C404(1.10); C486(1.07); C285(0.83)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C34(0.95); C404(0.96); C486(0.97); C285(1.02)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C34(0.98); C404(1.22); C486(1.00); C285(1.07)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C34(1.00); C404(1.00); C486(0.84); C285(1.00)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C34(1.10); C404(0.99); C486(1.20); C285(0.98)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C34(1.03); C404(1.05); C486(1.10); C285(0.98)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C34(0.91); C486(0.92); C285(0.75)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C404(1.10); C486(0.85); C285(1.07)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C34(0.93); C404(0.91); C486(0.76); C285(0.99)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C34(0.93); C404(0.97); C486(1.07); C285(0.99)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C34(0.94); C404(0.99); C486(0.91); C285(1.05)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C34(1.01); C404(1.01); C486(1.00); C285(1.10)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C34(1.03); C404(1.16); C486(1.55); C285(1.09)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C34(1.09); C404(1.00); C486(1.29); C285(1.02)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C34(0.96); C404(0.98); C486(0.98); C285(1.00)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C34(0.89); C486(0.80); C285(0.99)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C404(0.89); C486(0.72); C285(1.13)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C34(0.97); C404(1.03); C486(0.79); C285(0.95)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C34(0.89); C404(0.96); C486(0.96); C285(0.94)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C34(1.00); C404(0.97); C486(0.92); C285(1.20)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C34(1.02); C404(1.09); C486(1.01); C285(1.16)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C34(0.95); C404(0.93); C486(1.07); C285(0.95)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C34(1.03); C404(0.87); C486(0.98); C285(0.92)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C34(0.93); C486(1.09); C285(0.88)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C404(0.99); C486(0.85); C285(1.07)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C34(0.99); C404(1.01); C486(0.82); C285(1.01)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C34(1.04); C404(1.09); C486(1.09); C285(0.95)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C34(0.89); C404(1.04); C486(0.87); C285(0.86)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C34(0.98); C404(1.00); C486(0.94); C285(1.02)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C34(0.99); C404(1.15); C486(0.88); C285(1.03)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C34(0.95); C404(1.10); C486(1.03); C285(0.97)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C34(0.99); C404(1.28); C486(1.18); C285(1.07)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C34(1.02); C404(1.13); C486(1.83); C285(1.01)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C34(0.84); C404(1.07); C486(1.00); C285(0.88)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C34(1.05); C404(1.08); C486(0.80); C285(0.99)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C34(1.17); C404(1.14); C486(1.21); C285(1.01)  LDD1514  [20]
 LDCM0367  CL1 HEK-293T C34(1.18); C404(1.37); C486(0.98); C285(1.13)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C34(1.11); C404(1.96); C486(0.75); C285(1.10)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C34(1.06); C404(1.08); C486(0.77); C285(1.18)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C34(1.05); C404(1.06); C486(1.12); C285(1.03)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C34(1.13); C486(0.74); C285(0.89)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C34(1.15); C404(0.98); C486(0.93); C285(0.93)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C34(1.05); C404(1.29); C486(0.77); C285(1.20)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C34(1.04); C404(1.07); C486(1.25); C285(0.96)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C34(1.05); C486(0.90); C285(1.01)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C34(1.10); C404(1.02); C486(1.11); C285(0.98)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C34(1.03); C404(1.15); C486(0.92); C285(1.14)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C34(1.10); C404(1.17); C486(0.98); C285(1.06)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C34(0.87); C404(2.43); C486(0.90); C285(1.06)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C34(1.10); C486(0.11); C285(0.97)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C34(1.13); C404(1.03); C486(2.01); C285(0.91)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C34(1.03); C404(0.98); C486(0.83); C285(1.19)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C34(1.06); C404(1.02); C486(1.07); C285(1.14)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C34(1.14); C486(0.75); C285(1.55)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C34(1.15); C404(1.02); C486(0.84); C285(1.06)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C34(0.99); C404(1.15); C486(0.75); C285(1.13)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C34(1.02); C404(0.98); C486(0.90); C285(1.19)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C34(1.06); C486(1.02); C285(1.21)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C34(1.13); C404(1.11); C486(0.87); C285(0.98)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C34(0.84); C404(1.89); C486(0.98); C285(0.90)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C34(1.06); C404(0.99); C486(0.86); C285(1.26)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C34(1.02); C404(0.99); C486(1.27); C285(1.06)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C34(1.10); C486(0.88); C285(1.22)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C34(1.20); C404(1.33); C486(1.04); C285(0.99)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C34(1.07); C404(1.13); C486(0.73); C285(1.26)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C34(1.01); C404(1.05); C486(1.04); C285(0.98)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C34(1.02); C486(0.87); C285(0.91)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C34(1.07); C404(1.19); C486(0.87); C285(0.91)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C34(0.96); C404(0.97); C486(0.87); C285(1.16)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C34(1.00); C404(1.05); C486(1.10); C285(0.99)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C34(1.06); C486(0.81); C285(0.98)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C34(1.15); C404(1.48); C486(0.65); C285(1.08)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C34(0.95); C404(1.52); C486(1.03); C285(1.43)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C34(1.05); C404(1.23); C486(0.89); C285(1.01)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C34(0.85); C486(1.01); C285(0.96)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C404(1.22); C486(0.89); C285(1.25)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C34(0.96); C486(0.97); C285(0.84)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C34(0.85); C404(1.52); C486(0.93); C285(1.17)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C34(0.72); C404(1.92); C486(0.33); C285(1.07)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C34(0.76); C404(1.75); C486(0.97); C285(1.02)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C34(0.79); C404(2.24); C486(0.94); C285(1.12)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C34(0.73); C404(1.93); C486(1.35); C285(0.87)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C34(1.18); C404(1.12); C486(0.87); C285(1.06)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C34(1.01); C486(1.05); C285(1.16)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C34(1.07); C404(0.98); C486(0.98); C285(0.98)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C34(0.98); C404(1.06); C486(0.80); C285(1.27)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C34(0.93); C404(0.89); C486(0.96); C285(1.02)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C34(1.09); C404(1.46); C486(0.76); C285(1.12)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C34(0.87); C486(0.83); C285(1.18)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C404(1.02); C486(1.09); C285(1.13)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C34(0.84); C404(1.20); C486(0.85); C285(1.09)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C34(1.00); C404(1.58); C486(0.78); C285(0.93)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C34(0.76); C404(1.55); C486(0.84); C285(1.00)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C34(0.81); C404(1.87); C486(1.02); C285(1.14)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C34(0.72); C404(1.47); C486(0.97); C285(0.94)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C34(1.09); C404(1.06); C486(0.99); C285(1.03)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C34(1.01); C404(1.10); C486(0.89); C285(0.99)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C34(0.98); C404(1.20); C486(0.82); C285(1.24)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C34(0.95); C404(1.17); C486(0.87); C285(1.19)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C34(0.95); C404(0.85); C486(0.79); C285(0.89)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C34(0.74); C486(0.74); C285(0.91)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C404(1.09); C486(1.08); C285(1.11)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C34(0.83); C404(1.48); C486(0.92); C285(0.97)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C34(0.73); C404(1.21); C486(0.81); C285(1.01)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C34(0.79); C404(1.47); C486(0.83); C285(0.99)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C34(0.77); C404(1.66); C486(0.86); C285(1.14)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C34(0.76); C404(1.47); C486(1.06); C285(0.91)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C34(1.08); C404(0.97); C486(1.17); C285(1.10)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C34(0.91); C404(0.99); C486(1.00); C285(1.03)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C34(1.11); C486(1.10); C285(0.93)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C34(1.00); C404(1.22); C486(0.89); C285(1.22)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C34(1.05); C404(1.10); C486(0.72); C285(1.07)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C34(0.88); C486(0.82); C285(1.25)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C404(1.13); C486(0.96); C285(1.10)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C34(0.85); C404(1.28); C486(0.92); C285(0.86)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C34(0.74); C404(1.31); C486(1.03); C285(1.08)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C34(0.83); C404(1.44); C486(1.07); C285(1.14)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C34(0.82); C404(2.01); C486(0.80); C285(1.20)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C34(0.85); C486(0.89); C285(0.96)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C34(0.71); C404(1.37); C486(1.18); C285(0.92)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C34(1.14); C404(1.08); C486(1.07); C285(1.05)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C34(1.01); C486(0.99); C285(0.77)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C34(1.02); C404(1.14); C486(1.25); C285(0.99)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C34(1.07); C404(1.29); C486(0.84); C285(1.26)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C34(0.98); C404(1.01); C486(1.08); C285(1.00)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C34(0.79); C486(1.34); C285(1.21)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C404(1.06); C486(0.68); C285(1.11)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C34(0.81); C404(1.25); C486(0.97); C285(0.97)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C34(0.71); C404(1.32); C486(0.91); C285(1.04)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C404(1.27); C486(0.81); C285(1.18)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C34(0.81); C404(1.21); C486(0.96); C285(1.11)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C34(0.81); C404(2.16); C486(0.59); C285(1.21)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C34(0.75); C404(1.31); C486(1.32); C285(0.87)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C34(1.11); C404(1.12); C486(0.87); C285(1.00)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C34(1.00); C486(0.97); C285(0.90)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C34(0.94); C404(1.05); C486(0.83); C285(1.14)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C34(1.03); C404(1.01); C486(0.74); C285(0.99)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C34(0.82); C486(0.93); C285(1.20)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C404(1.03); C486(0.83); C285(1.09)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C34(1.20); C404(2.28); C486(0.86); C285(0.94)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C34(0.86); C404(1.17); C486(0.79); C285(1.03)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C34(0.73); C404(1.17); C486(0.80); C285(1.10)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C34(0.76); C404(1.24); C486(0.84); C285(1.03)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C34(0.81); C404(1.99); C486(0.72); C285(1.10)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C34(0.76); C404(1.44); C486(0.84); C285(0.89)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C34(1.22); C404(1.19); C486(0.93); C285(1.15)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C34(1.06); C486(0.71); C285(0.88)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C34(1.08); C404(1.31); C486(0.73); C285(1.04)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C34(0.97); C404(1.03); C486(0.84); C285(1.06)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C34(0.99); C404(1.08); C486(0.74); C285(0.88)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C34(0.75); C404(1.53); C486(0.92); C285(0.94)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C34(1.14); C486(0.87); C285(0.88)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C404(1.66); C486(0.74); C285(1.15)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C34(0.84); C404(1.14); C486(0.89); C285(0.92)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C34(0.78); C404(1.53); C486(0.99); C285(1.11)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C34(0.80); C404(1.23); C486(1.00); C285(1.01)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C34(1.00); C404(2.13); C486(0.94); C285(1.06)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C34(0.83); C404(1.27); C486(1.09); C285(0.88)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C34(1.02); C404(0.99); C486(0.97); C285(1.09)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C34(1.08); C486(1.00); C285(1.00)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C34(1.07); C404(1.01); C486(0.83); C285(1.06)  LDD1697  [20]
 LDCM0185  Compound 17 HEK-293T 8.73  LDD0512  [17]
 LDCM0191  Compound 21 HEK-293T 6.31  LDD0508  [17]
 LDCM0190  Compound 34 HEK-293T 10.42  LDD0510  [17]
 LDCM0192  Compound 35 HEK-293T 7.14  LDD0509  [17]
 LDCM0193  Compound 36 HEK-293T 7.55  LDD0511  [17]
 LDCM0495  E2913 HEK-293T C34(1.12); C404(1.01); C486(0.85); C285(1.26)  LDD1698  [20]
 LDCM0468  Fragment33 HEK-293T C34(1.08); C404(1.21); C486(0.95); C285(1.00)  LDD1671  [20]
 LDCM0427  Fragment51 HEK-293T C34(0.99); C486(0.80); C285(0.76)  LDD1631  [20]
 LDCM0022  KB02 HEK-293T C285(1.04); C486(1.11); C34(1.01)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C285(1.03); C486(0.97); C34(0.92)  LDD1497  [20]
 LDCM0024  KB05 Hs 936.T C34(3.42)  LDD3313  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0014  Panhematin HEK-293T 4.36  LDD0062  [8]
 LDCM0084  Ro 48-8071 A-549 2.99  LDD0145  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Phospholipid phosphatase 4 (PLPP4) PA-phosphatase related phosphoesterase family Q5VZY2
Inactive ribonuclease-like protein 10 (RNASE10) Pancreatic ribonuclease family Q5GAN6
Fatty acid 2-hydroxylase (FA2H) Sterol desaturase family Q7L5A8
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) . Q9NX47
Transporter and channel
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
Interferon-induced transmembrane protein 3 (IFITM3) CD225/Dispanin family Q01628
Statherin (STATH) Histatin/statherin family P02808
Major facilitator superfamily domain-containing protein 6 (MFSD6) MFSD6 family Q6ZSS7
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Aquaporin-9 (AQP9) MIP/aquaporin (TC 1.A.8) family O43315
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Secretory carrier-associated membrane protein 5 (SCAMP5) SCAMP family Q8TAC9
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Syntaxin-4 (STX4) Syntaxin family Q12846
Transmembrane protein 176A (TMEM176A) TMEM176 family Q96HP8
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Proteolipid protein 2 (PLP2) . Q04941
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane progestin receptor gamma (PAQR5) ADIPOR family Q9NXK6
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ephrin-A5 (EFNA5) Ephrin family P52803
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Tetraspanin-4 (TSPAN4) Tetraspanin (TM4SF) family O14817
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Protein unc-50 homolog (UNC50) Unc-50 family Q53HI1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyridoxal Phosphate Small molecular drug DB00114
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lx2931 Small molecular drug D09ZWH
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid24809814c31 Small molecular drug D0S5OU
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lx-2932 Small molecular drug D01FLN

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
19 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402