Details of the Target

General Information of Target

Target ID LDTP12056
Target Name Thiol S-methyltransferase TMT1A (TMT1A)
Gene Name TMT1A
Gene ID 25840
Synonyms
METTL7A; Thiol S-methyltransferase TMT1A; EC 2.1.1.9; Methyltransferase-like protein 7A; N6-adenosine-methyltransferase TMT1A; EC 2.1.1.348; Protein AAM-B; Thiol methyltransferase 1A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPDLASQRHSESFPSVNSRPNVILPGREGRREGLPPGGGTRGSLVPTRPVPPSPAPLGT
SPYSWSRSGPGRGGGAGSSRVPRGVPGPAVCAPGSLLHHASPTQTMAAADGSLFDNPRTF
SRRPPAQASRQAKATKRKYQASSEAPPAKRRNETSFLPAKKTSVKETQRTFKGNAQKMFS
PKKHSVSTSDRNQEERQCIKTSSLFKNNPDIPELHRPVVKQVQEKVFTSAAFHELGLHPH
LISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCIPVVQSLQAMESKI
QRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINIL
ISTPGRLVDHIKSTKNIHFSRLRWLVFDEADRILDLGFEKDITVILNAVNAECQKRQNVL
LSATLTEGVTRLADISLHDPVSISVLDKSHDQLNPKDKAVQEVCPPPAGDKLDSFAIPES
LKQHVTVVPSKLRLVCLAAFILQKCKFEEDQKMVVFFSSCELVEFHYSLFLQTLLSSSGA
PASGQLPSASMRLKFLRLHGGMEQEERTAVFQEFSHSRRGVLLCTDVAARGLDLPQVTWI
VQYNAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLASHKINVSEIKMEDILC
VLTRDDCFKGKRWGAQKSHAVGPQEIRERATVLQTVFEDYVHSSERRVSWAKKALQSFIQ
AYATYPRELKHIFHVRSLHLGHVAKSFGLRDAPRNLSALTRKKRKAHVKRPDLHKKTQSK
HSLAEILRSEYSSGMEADIAKVKKQNAPGEPGGRPLQHSLQPTPCFGRGKTLKWRKTQKG
VQRDSKTSQKV
Target Bioclass
Enzyme
Family
Methyltransferase superfamily
Subcellular location
Lipid droplet
Function
Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface. Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival. Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles.; (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.
Uniprot ID
Q9H8H3
Ensemble ID
ENST00000332160.5
HGNC ID
HGNC:24550

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [1]
STPyne
 Probe Info  		K105(7.78); K109(5.72)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K210(1.36)  LDD3494  [3]
P11
 Probe Info  		20.00  LDD0201  [4]
DBIA
 Probe Info  		C79(1.48)  LDD0080  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
Acrolein
 Probe Info  		C79(0.00); C96(0.00)  LDD0217  [10]
Crotonaldehyde
 Probe Info  		C79(0.00); C96(0.00)  LDD0219  [10]
Methacrolein
 Probe Info  		C96(0.00); C79(0.00)  LDD0218  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C79(0.00); C96(0.00); C92(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C220
 Probe Info  		43.41  LDD1894  [14]
C246
 Probe Info  		14.32  LDD1919  [14]
C307
 Probe Info  		15.24  LDD1975  [14]
C310
 Probe Info  		12.73  LDD1977  [14]
C423
 Probe Info  		8.06  LDD2078  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe14
 Probe Info  		20.00  LDD0477  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]
JN0003
 Probe Info  		20.00  LDD0484  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [16]
AEA-DA
 Probe Info  		8.40  LDD0333  [17]
OEA-DA
 Probe Info  		20.00  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C79(1.52)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C79(1.08)  LDD0813  [5]
 LDCM0216  AC100 HCT 116 C79(0.85)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C79(0.75)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C79(1.04)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C79(0.85)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C79(0.89)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C79(0.81)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C79(0.74)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C79(0.88)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C79(1.00)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C79(0.74)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C79(1.01)  LDD0824  [5]
 LDCM0227  AC110 HCT 116 C79(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C79(0.79)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C79(0.85)  LDD0546  [5]
 LDCM0230  AC113 HEK-293T C79(0.94)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C79(1.06)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C79(0.97)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C79(0.88)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C79(1.13)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C79(1.01)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C79(0.98)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C79(1.12)  LDD0835  [5]
 LDCM0238  AC120 HEK-293T C79(0.97)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C79(1.06)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C79(1.07)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C79(0.88)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C79(1.11)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C79(1.30)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C79(1.06)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C79(0.96)  LDD0843  [5]
 LDCM0259  AC14 HEK-293T C79(1.17)  LDD0857  [5]
 LDCM0270  AC15 HEK-293T C79(1.53)  LDD0868  [5]
 LDCM0276  AC17 HEK-293T C79(2.03)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C79(1.63)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C79(1.25)  LDD0876  [5]
 LDCM0279  AC2 HCT 116 C79(1.61)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C79(1.53)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C79(1.64)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C79(1.37)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C79(1.54)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C79(1.08)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C79(1.00)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C79(0.93)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C79(1.07)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C79(1.98)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C79(1.25)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C79(1.53)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C79(1.06)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C79(0.90)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C79(0.94)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C79(1.19)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C79(0.89)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C92(1.02); C96(1.04); C79(0.90); C148(1.04)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C92(1.02); C96(1.13); C79(0.94); C148(0.93)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C92(1.06); C96(1.10); C79(1.01); C148(1.09)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C92(1.12); C96(1.01); C79(0.92); C148(0.92)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C92(1.08); C96(1.03); C79(0.88); C148(0.97)  LDD1539  [18]
 LDCM0301  AC4 HCT 116 C79(1.73)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C92(1.07); C96(0.99); C79(0.92); C148(1.08)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C92(1.05); C96(1.08); C79(1.06); C148(1.08)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C92(1.02); C96(0.84); C79(0.93); C148(1.00)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C92(1.02); C96(0.96); C79(0.92); C148(0.83)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C92(0.99); C96(1.13); C79(0.97); C148(1.04)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C92(1.03); C96(1.04); C79(0.97); C148(1.00)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C79(0.98)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C79(1.26)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C79(1.49)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C79(1.21)  LDD0909  [5]
 LDCM0312  AC5 HCT 116 C79(1.82)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C79(1.35)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C79(1.56)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C79(1.31)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C79(1.22)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C79(1.65)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C79(1.48)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C79(0.94)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C79(0.97)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C79(0.75)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C79(1.05)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C79(0.77)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C79(1.75)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C79(1.50)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C79(0.67)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C79(1.17)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C79(0.94)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C79(1.21)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C79(0.75)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C79(1.05)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C79(1.09)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C79(1.16)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C79(1.16)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C79(1.24)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C79(1.16)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C79(1.62)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C79(1.51)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C79(1.17)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C79(1.18)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C79(0.99)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C79(1.07)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C79(1.19)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C79(1.15)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C79(1.10)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C79(1.14)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C79(1.16)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C79(1.25)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C79(1.06)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C79(1.13)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C79(1.16)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C79(1.25)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C79(1.04)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C79(1.19)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C79(1.40)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C79(1.39)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C79(1.14)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C79(1.12)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C79(1.25)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C79(1.21)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C79(1.04)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C79(1.14)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C79(1.78)  LDD0962  [5]
 LDCM0365  AC98 HCT 116 C79(0.89)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C79(0.73)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C79(1.08)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C79(1.90)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C79(1.42)  LDD0873  [5]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [4]
 LDCM0108  Chloroacetamide HeLa C79(0.00); C96(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C79(1.87)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C79(0.95)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C79(2.51)  LDD0966  [5]
 LDCM0369  CL100 HCT 116 C79(1.65)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C79(1.67)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C79(1.66)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C79(1.36)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C79(1.38)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C79(1.28)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C79(1.44)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C79(1.35)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C79(1.63)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C79(1.20)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C79(2.14)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C79(1.37)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C79(1.13)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C79(1.25)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C79(0.97)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C79(1.51)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C79(1.19)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C79(1.10)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C92(1.02); C96(1.04); C79(0.88); C148(0.99)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C92(1.06); C96(1.03); C79(0.87); C148(0.97)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C92(1.06); C96(1.02); C79(1.03); C148(0.82)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C79(0.94)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C92(1.03); C96(0.98); C79(0.97); C148(0.88)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C79(1.70)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C79(1.10)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C79(2.15)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C79(1.29)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C79(1.10)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C79(1.47)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C79(1.05)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C79(0.52)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C79(0.99)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C79(1.09)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C79(1.94)  LDD1000  [5]
 LDCM0403  CL16 HCT 116 C79(1.19)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C79(1.07)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C79(1.12)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C79(1.33)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C79(0.89)  LDD1005  [5]
 LDCM0408  CL20 HCT 116 C79(1.17)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C79(1.29)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C79(1.83)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C79(1.16)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C79(1.30)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C79(1.31)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C79(1.32)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C79(1.06)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C79(1.24)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C79(1.35)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C79(1.07)  LDD1016  [5]
 LDCM0419  CL30 HCT 116 C79(1.08)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C79(1.21)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C79(1.21)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C79(2.66)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C79(1.50)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C79(1.30)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C79(1.28)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C79(1.43)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C79(2.76)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C79(0.95)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C79(1.65)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C79(2.15)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C79(2.16)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C79(2.97)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C79(1.31)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C79(2.88)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C79(1.03)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C79(0.97)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C79(0.78)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C79(1.17)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C79(1.05)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C79(1.60)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C79(1.34)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C79(0.68)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C79(1.67)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C79(1.29)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C79(1.13)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C79(0.88)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C79(1.46)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C79(1.33)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C79(1.35)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C79(1.28)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C79(1.79)  LDD1050  [5]
 LDCM0453  CL61 HCT 116 C79(1.06)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C79(1.24)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C79(1.18)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C79(1.44)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C79(1.23)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C79(1.56)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C79(1.42)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C79(1.33)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C79(1.14)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C79(1.20)  LDD1060  [5]
 LDCM0463  CL70 HCT 116 C79(1.30)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C79(1.28)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C79(1.28)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C79(1.37)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C79(1.28)  LDD0784  [5]
 LDCM0469  CL76 HEK-293T C79(1.36)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C79(1.41)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C79(1.39)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C79(1.34)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C79(1.15)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C79(1.31)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C79(1.27)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C79(1.08)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C79(1.28)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C79(1.40)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C79(1.49)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C79(1.62)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C79(1.30)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C79(1.49)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C79(1.28)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C79(1.11)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C79(1.77)  LDD1083  [5]
 LDCM0486  CL91 HCT 116 C79(1.06)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C79(1.02)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C79(1.03)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C79(1.13)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C79(1.15)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C79(1.22)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C79(1.93)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C79(1.66)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C79(1.65)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C92(1.01); C96(1.08); C79(0.92); C148(0.85)  LDD1698  [18]
 LDCM0625  F8 Ramos C96(2.00); C79(1.04); C92(1.33)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C96(1.01); C79(2.39); C92(1.28)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C96(0.01); C79(0.04); C92(0.00)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C96(1.42); C79(2.04); C92(1.51)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C96(0.91); C79(1.27); C92(1.01)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C96(1.62); C79(1.65); C92(1.76)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C96(1.75); C79(2.68); C92(2.60)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C96(0.94); C79(1.17); C92(1.08)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C96(0.68); C79(1.03); C92(1.03)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C96(0.91); C79(0.99); C92(0.96)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C96(0.90); C79(1.44); C92(0.73)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C96(1.06); C79(0.81); C92(0.96)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C96(0.79); C79(0.70); C92(0.91)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C96(0.97); C79(1.10); C92(0.83)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C79(1.24)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C96(0.98); C79(0.91); C92(0.95)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C96(1.31); C79(1.67); C92(1.30)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C79(1.29)  LDD1025  [5]
 LDCM0610  Fragment52 Ramos C96(0.97); C79(0.79); C92(1.15)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C96(1.23); C79(0.66); C92(1.07)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C96(1.40); C79(1.38); C92(1.43)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C96(3.36); C79(5.63); C92(2.93)  LDD2188  [19]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HCT 116 C79(1.48)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C79(2.40)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C79(1.47)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0225  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C79(0.61)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C96(0.76); C79(0.50)  LDD2207  [20]
 LDCM0131  RA190 MM1.R C79(1.43); C96(1.41)  LDD0304  [21]
 LDCM0136  SR-4559 HEK-293T 8.40  LDD0333  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3) Complex I 30 kDa subunit family O75489
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.