Details of the Target

General Information of Target

Target ID LDTP03775
Target Name RNA-binding protein FUS (FUS)
Gene Name FUS
Gene ID 2521
Synonyms
TLS; RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQ
SQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSS
SYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQD
QSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYE
PRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIES
VADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFS
GNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQ
QRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYD
RGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY
Target Type
Clinical trial
Target Bioclass
Other
Family
RRM TET family
Subcellular location
Nucleus
Function
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.
TTD ID
T63227
Uniprot ID
P35637
DrugMap ID
TTKGYZ9
Ensemble ID
ENST00000254108.12
HGNC ID
HGNC:4010

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.Ter527QextTer49 .
CCK81 SNV: p.G193S; p.G256R; p.G488D .
COLO320 Deletion: p.A10del .
REH SNV: p.P125H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y468(16.78); Y325(12.95)  LDD0257  [1]
TH216
 Probe Info  		Y325(16.03)  LDD0259  [1]
AZ-9
 Probe Info  		D352(0.88)  LDD2208  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
Probe 1
 Probe Info  		Y325(36.32); Y468(22.57)  LDD3495  [4]
m-APA
 Probe Info  		10.42  LDD0403  [5]
BTD
 Probe Info  		C447(1.42); C444(1.36)  LDD1700  [6]
HHS-482
 Probe Info  		Y325(1.12); Y468(0.92)  LDD0285  [7]
HHS-475
 Probe Info  		Y468(0.49); Y325(1.49)  LDD0264  [8]
HHS-465
 Probe Info  		Y325(10.00); Y468(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C444(1.85); C447(1.85); C433(1.94); C428(1.47)  LDD0080  [10]
5E-2FA
 Probe Info  		H463(0.00); H517(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K334(0.00); K316(0.00); K312(0.00); K365(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C428(0.00); C433(0.00); C444(0.00); C447(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C428(0.00); C433(0.00); C444(0.00); C447(0.00)  LDD0036  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C428(0.00); C433(0.00); C444(0.00); C447(0.00)  LDD0037  [13]
2PCA
 Probe Info  		N.A.  LDD0034  [15]
ATP probe
 Probe Info  		K312(0.00); K448(0.00); K427(0.00)  LDD0035  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [17]
IPM
 Probe Info  		N.A.  LDD0147  [18]
NHS
 Probe Info  		K334(0.00); K316(0.00)  LDD0010  [19]
OSF
 Probe Info  		N.A.  LDD0029  [20]
SF
 Probe Info  		Y468(0.00); Y325(0.00)  LDD0028  [20]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
TFBX
 Probe Info  		C447(0.00); C444(0.00)  LDD0148  [18]
Phosphinate-6
 Probe Info  		C433(0.00); C447(0.00); C428(0.00)  LDD0018  [21]
Ox-W18
 Probe Info  		N.A.  LDD2175  [22]
1c-yne
 Probe Info  		K334(0.00); K365(0.00); K348(0.00); K306(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		H463(0.00); C444(0.00); C447(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
PAL-AfBPP Probe
Click To Hide/Show 62 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.02  LDD1714  [25]
C040
 Probe Info  		7.78  LDD1740  [25]
C063
 Probe Info  		10.63  LDD1760  [25]
C087
 Probe Info  		9.78  LDD1779  [25]
C106
 Probe Info  		22.01  LDD1793  [25]
C108
 Probe Info  		10.78  LDD1795  [25]
C139
 Probe Info  		11.39  LDD1821  [25]
C145
 Probe Info  		8.28  LDD1827  [25]
C153
 Probe Info  		16.22  LDD1834  [25]
C165
 Probe Info  		22.16  LDD1845  [25]
C166
 Probe Info  		6.96  LDD1846  [25]
C187
 Probe Info  		19.29  LDD1865  [25]
C191
 Probe Info  		14.42  LDD1868  [25]
C196
 Probe Info  		12.38  LDD1872  [25]
C197
 Probe Info  		5.31  LDD1873  [25]
C198
 Probe Info  		9.71  LDD1874  [25]
C206
 Probe Info  		15.78  LDD1881  [25]
C232
 Probe Info  		64.89  LDD1905  [25]
C244
 Probe Info  		15.14  LDD1917  [25]
C246
 Probe Info  		12.21  LDD1919  [25]
C249
 Probe Info  		19.97  LDD1922  [25]
C265
 Probe Info  		15.03  LDD1936  [25]
C277
 Probe Info  		7.62  LDD1947  [25]
C284
 Probe Info  		21.11  LDD1954  [25]
C286
 Probe Info  		6.32  LDD1956  [25]
C288
 Probe Info  		6.82  LDD1958  [25]
C289
 Probe Info  		25.11  LDD1959  [25]
C293
 Probe Info  		19.03  LDD1963  [25]
C296
 Probe Info  		12.47  LDD1966  [25]
C302
 Probe Info  		5.35  LDD1971  [25]
C303
 Probe Info  		5.10  LDD1972  [25]
C305
 Probe Info  		13.93  LDD1974  [25]
C313
 Probe Info  		18.51  LDD1980  [25]
C314
 Probe Info  		15.78  LDD1981  [25]
C322
 Probe Info  		7.11  LDD1988  [25]
C326
 Probe Info  		8.28  LDD1990  [25]
C338
 Probe Info  		15.24  LDD2001  [25]
C346
 Probe Info  		13.64  LDD2007  [25]
C348
 Probe Info  		17.03  LDD2009  [25]
C349
 Probe Info  		9.13  LDD2010  [25]
C350
 Probe Info  		30.48  LDD2011  [25]
C353
 Probe Info  		8.75  LDD2014  [25]
C354
 Probe Info  		8.11  LDD2015  [25]
C355
 Probe Info  		28.44  LDD2016  [25]
C361
 Probe Info  		23.26  LDD2022  [25]
C363
 Probe Info  		19.43  LDD2024  [25]
C383
 Probe Info  		12.38  LDD2042  [25]
C391
 Probe Info  		14.12  LDD2050  [25]
C407
 Probe Info  		10.85  LDD2064  [25]
C420
 Probe Info  		11.00  LDD2075  [25]
C431
 Probe Info  		16.11  LDD2086  [25]
FFF probe11
 Probe Info  		13.62  LDD0471  [26]
FFF probe12
 Probe Info  		6.42  LDD0473  [26]
FFF probe13
 Probe Info  		18.90  LDD0475  [26]
FFF probe2
 Probe Info  		20.00  LDD0463  [26]
FFF probe3
 Probe Info  		15.59  LDD0464  [26]
FFF probe6
 Probe Info  		7.21  LDD0467  [26]
FFF probe9
 Probe Info  		5.53  LDD0470  [26]
JN0003
 Probe Info  		14.55  LDD0469  [26]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
DA-2
 Probe Info  		N.A.  LDD0071  [28]
OEA-DA
 Probe Info  		7.19  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C447(0.49); C444(0.46)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C447(0.47); C444(0.47)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C447(0.71)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C447(1.10)  LDD2152  [6]
 LDCM0214  AC1 HCT 116 C428(0.87); C433(0.57); C444(1.08); C447(1.03)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C428(0.92); C433(0.92); C444(1.23); C447(1.09)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C428(0.74); C433(0.74); C444(0.92); C447(0.91)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C428(0.88); C433(0.88); C444(0.80); C447(0.84)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C428(0.90); C433(0.90); C444(0.77); C447(0.84)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C428(1.11); C433(1.11); C444(0.98); C447(0.98)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C428(0.88); C433(0.88); C444(0.92); C447(0.83)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C428(1.00); C433(1.00); C444(0.86); C447(0.92)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C428(1.06); C433(1.06); C444(1.07); C447(1.11)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C428(1.05); C433(1.05); C444(1.01); C447(1.09)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C428(0.89); C433(0.89); C444(1.06); C447(1.00)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C428(1.04); C433(1.04); C444(0.82); C447(0.73)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C428(0.99); C433(0.99); C444(1.11); C447(1.05)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C428(0.90); C433(0.90); C444(0.93); C447(0.84)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C428(1.09); C433(1.09); C444(0.99); C447(0.97)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C428(1.02); C433(1.02); C444(0.92); C447(0.98)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C428(0.97); C433(0.87); C444(1.01); C447(1.02)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C428(0.88); C433(0.91); C444(1.30); C447(0.86)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C428(1.36); C433(1.09); C444(1.11); C447(0.73)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C428(0.94); C433(0.84); C444(1.13); C447(1.04)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C428(1.42); C433(1.12); C444(0.92); C447(0.77)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C428(0.85); C433(0.77); C444(1.01); C447(1.02)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C428(1.06); C433(0.89); C444(1.01); C447(0.83)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C428(0.95); C433(0.95); C444(0.93); C447(0.94)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C428(0.87); C433(0.76); C444(1.16); C447(1.06)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C428(1.15); C433(1.01); C444(1.00); C447(0.87)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C428(1.12); C433(0.97); C444(1.19); C447(1.01)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C428(0.98); C433(0.92); C444(1.26); C447(0.99)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C428(0.88); C433(0.83); C444(1.04); C447(0.91)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C428(1.79); C433(1.50); C444(1.07); C447(0.84)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C428(1.54); C433(1.27); C444(0.91); C447(0.79)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C428(1.53); C433(1.26); C444(1.01); C447(1.03)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C428(1.26); C433(1.26); C444(1.18); C447(1.16)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C428(0.97); C433(0.97); C444(0.89); C447(0.88)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C428(1.00); C433(1.00); C444(1.06); C447(1.04)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C428(2.16); C433(2.16); C444(0.97); C447(0.96)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C428(0.88); C433(0.88); C444(0.77); C447(0.77)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C428(0.72); C433(0.72); C444(0.96); C447(0.94)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C428(0.90); C433(0.90); C444(0.91); C447(0.91)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C428(0.89); C433(0.89); C444(0.93); C447(0.91)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C428(0.80); C433(0.80); C444(0.91); C447(0.89)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C428(0.77); C433(0.77); C444(0.83); C447(0.80)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C428(1.28); C433(1.28); C444(0.97); C447(0.95)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C428(0.99); C433(0.99); C444(0.89); C447(0.88)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C428(1.06); C433(1.06); C444(1.24); C447(1.15)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C428(0.94); C433(0.94); C444(0.92); C447(0.92)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C428(0.85); C433(0.85); C444(0.90); C447(0.88)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C428(0.81); C433(0.81); C444(0.84); C447(0.82)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C428(0.95); C433(1.00); C444(1.03); C447(1.03)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C447(1.14); C428(1.21); C444(1.22); C433(1.28)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C447(1.02); C428(1.05); C433(1.13); C444(1.37)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C447(1.08); C428(1.12); C433(1.26); C444(1.39)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C447(1.14); C428(1.30); C444(1.39); C433(1.45)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C447(1.30); C428(1.41); C433(1.55); C444(1.80)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C447(1.09); C428(1.27); C444(1.29); C433(1.40)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C428(0.95); C433(0.95); C444(1.06); C447(1.08)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C428(0.86); C447(0.94); C433(0.96); C444(0.96)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C428(0.93); C433(0.97); C447(1.03); C444(1.07)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C444(1.02); C447(1.04); C428(1.14); C433(1.16)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C447(1.37); C428(1.60); C444(1.90); C433(1.94)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C428(1.23); C433(1.35); C444(1.25); C447(1.07)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C428(1.09); C433(1.22); C444(1.20); C447(1.05)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C428(1.04); C433(1.04); C444(0.90); C447(0.92)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C428(1.37); C433(1.46); C444(1.11); C447(1.00)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C428(0.59); C447(1.31); C433(1.41); C444(1.47)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C428(0.61); C447(0.86); C433(0.94); C444(0.96)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C428(0.64); C447(1.54); C433(1.63); C444(1.67)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C433(0.55); C428(0.83); C447(0.96); C444(1.03)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C428(0.52); C447(1.20); C444(1.28); C433(1.39)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C428(0.61); C433(1.22); C444(1.41); C447(1.60)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C428(0.50); C444(1.09); C447(1.15); C433(1.56)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C428(0.57); C447(1.00); C444(1.08); C433(1.27)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C428(0.78); C447(1.33); C444(1.46); C433(1.47)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C428(1.05); C444(1.08); C433(1.21); C447(1.92)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C428(0.93); C444(1.05); C433(1.14); C447(2.13)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C428(1.05); C444(1.22); C433(1.24); C447(2.20)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C428(0.97); C444(1.14); C433(1.15); C447(2.09)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C444(1.13); C428(1.19); C433(1.38); C447(2.42)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C433(0.58); C428(0.95); C447(0.98); C444(1.02)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C444(1.07); C428(1.17); C433(1.21); C447(1.63)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C428(1.09); C444(1.15); C433(1.22); C447(1.55)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C428(1.11); C433(1.21); C444(1.21); C447(1.69)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C444(1.20); C428(1.25); C433(1.41); C447(2.74)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C444(1.20); C428(1.28); C433(1.52); C447(2.22)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C428(0.63); C433(0.79); C447(1.11); C444(1.15)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C428(0.54); C433(0.76); C447(1.37); C444(1.38)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C433(0.73); C428(0.85); C447(1.36); C444(1.39)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C428(0.93); C433(1.01); C444(1.04); C447(1.05)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C428(0.68); C433(0.93); C447(1.07); C444(1.09)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C433(0.68); C428(0.82); C447(1.05); C444(1.15)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C428(0.84); C433(0.99); C447(1.18); C444(1.19)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C428(0.57); C433(0.83); C447(1.75); C444(1.83)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C428(0.67); C433(1.06); C447(1.24); C444(1.29)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C428(0.70); C433(1.23); C447(1.69); C444(1.72)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C428(0.65); C433(0.77); C444(1.27); C447(1.28)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C428(0.77); C433(0.83); C447(1.43); C444(1.45)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C433(1.08); C447(1.09); C428(1.14); C444(1.46)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C433(0.89); C428(0.95); C447(0.98); C444(1.18)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C447(1.02); C433(1.06); C428(1.07); C444(1.39)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C428(1.30); C433(1.33); C447(1.72); C444(1.80)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C433(0.44); C428(0.74); C447(0.82); C444(0.93)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C433(1.41); C428(1.47); C447(1.66); C444(1.79)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C433(1.01); C428(1.06); C444(1.54); C447(1.79)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C433(0.97); C428(1.02); C447(1.36); C444(1.68)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C433(1.19); C428(1.27); C447(1.34); C444(1.59)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C447(0.81); C444(0.91); C433(1.09); C428(1.14)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C447(1.39); C433(1.58); C444(1.74); C428(1.76)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C433(2.34); C428(2.43); C447(2.53); C444(2.67)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C428(1.11); C433(1.11); C444(1.24); C447(1.24)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C444(1.29); C447(1.31); C428(1.40); C433(1.40)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C428(1.11); C433(1.11); C444(1.13); C447(1.14)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C428(0.99); C433(0.99); C447(1.10); C444(1.23)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C428(1.29); C433(1.29); C444(1.38); C447(1.41)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C428(1.00); C433(1.00); C444(1.35); C447(1.36)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C428(1.12); C433(1.12); C444(1.33); C447(1.34)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C428(1.40); C433(1.40); C447(1.56); C444(1.57)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C428(1.17); C433(1.17); C444(1.39); C447(1.41)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C428(1.01); C433(1.01); C444(1.22); C447(1.23)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C428(0.98); C433(0.98); C447(1.14); C444(1.14)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C428(1.17); C433(1.17); C444(1.41); C447(1.42)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C428(0.99); C433(1.08); C444(1.52); C447(1.79)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C428(1.21); C433(1.35); C444(1.43); C447(1.75)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C428(0.87); C433(0.87); C447(0.92); C444(0.99)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C433(1.03); C428(1.08); C444(1.51); C447(1.79)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C428(0.88); C433(0.94); C444(1.13); C447(1.26)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C428(1.05); C433(1.12); C444(1.47); C447(1.79)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C428(1.38); C433(1.56); C444(1.65); C447(1.82)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C428(1.34); C444(1.43); C433(1.49); C447(1.53)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C428(1.88); C444(1.91); C447(2.28); C433(2.29)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C428(1.12); C433(1.24); C444(1.46); C447(1.73)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C428(1.20); C433(1.35); C444(1.73); C447(2.11)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C433(0.95); C428(0.99); C444(1.43); C447(1.59)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C428(1.00); C433(1.04); C444(1.30); C447(1.54)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C444(0.87); C447(0.87); C428(0.88); C433(0.88)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C428(0.99); C433(0.99); C444(1.20); C447(1.45)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C428(1.17); C433(1.20); C444(1.38); C447(1.80)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C428(1.03); C433(1.11); C444(1.72); C447(2.07)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C428(1.00); C433(1.05); C444(1.41); C447(1.44)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C428(0.94); C433(1.00); C444(1.26); C447(1.31)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C428(0.70); C433(0.76); C444(0.91); C447(0.95)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C428(0.78); C433(0.82); C444(0.91); C447(0.92)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C428(0.83); C433(0.88); C444(1.32); C447(1.36)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C444(0.95); C447(0.98); C428(1.11); C433(1.16)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C428(0.99); C433(1.03); C444(2.17); C447(2.19)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C428(0.72); C433(0.79); C444(1.34); C447(1.38)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C428(1.24); C447(1.26); C444(1.28); C433(1.28)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C428(1.28); C433(1.33); C444(1.57); C447(1.61)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C428(0.98); C433(1.03); C444(1.50); C447(1.51)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C444(0.83); C447(0.85); C428(0.90); C433(0.94)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C428(1.03); C433(1.08); C444(1.20); C447(1.21)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C428(1.09); C433(1.13); C444(1.51); C447(1.53)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C428(1.00); C433(1.06); C447(1.34); C444(1.37)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C428(0.98); C433(0.98); C447(1.14); C444(1.32)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C428(0.72); C433(0.72); C447(0.78); C444(0.79)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C447(0.71); C444(0.71)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C428(0.83); C433(0.83); C444(0.92); C447(0.90)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C428(0.94); C433(0.94); C447(1.02); C444(1.14)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C428(1.30); C433(1.30); C447(1.39); C444(1.51)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 10.42  LDD0403  [5]
 LDCM0020  ARS-1620 HCC44 C428(1.75); C433(1.75); C444(1.44); C447(1.44)  LDD2171  [10]
 LDCM0108  Chloroacetamide HeLa H463(0.00); H275(0.00); C444(0.00)  LDD0222  [23]
 LDCM0367  CL1 HCT 116 C433(0.84); C428(0.86); C444(1.04); C447(1.06)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C428(1.05); C433(1.14); C444(1.41); C447(1.50)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C433(0.68); C428(0.89); C447(1.11); C444(1.16)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C447(1.20); C428(1.43); C433(1.43); C444(1.49)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C447(0.89); C444(0.91); C428(1.23); C433(1.23)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C447(0.96); C444(0.99); C428(1.22); C433(1.22)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C447(1.04); C444(1.12); C428(1.19); C433(1.19)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C428(0.53); C433(0.87); C444(0.97); C447(1.07)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C428(0.48); C447(1.27); C433(1.34); C444(1.38)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C428(0.47); C447(1.06); C444(1.11); C433(1.12)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C428(0.50); C447(0.92); C444(0.98); C433(1.15)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C428(0.45); C433(0.95); C444(1.42); C447(1.51)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C428(1.12); C433(1.29); C447(1.58); C444(1.62)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C428(0.47); C433(0.90); C444(1.02); C447(1.09)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C428(0.53); C444(0.96); C447(1.05); C433(1.15)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C428(0.70); C433(0.71); C444(0.80); C447(1.22)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C428(1.03); C444(1.05); C433(1.21); C447(1.53)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C444(0.83); C428(0.86); C433(0.92); C447(1.88)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C444(0.87); C428(1.00); C433(1.16); C447(2.09)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C428(0.80); C433(0.87); C444(0.90); C447(2.13)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C428(0.96); C447(1.11); C433(1.13); C444(1.14)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C428(0.65); C447(0.99); C444(1.01); C433(1.08)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C428(0.76); C433(1.25); C447(1.79); C444(1.81)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C428(1.17); C433(1.32); C447(1.73); C444(1.74)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C428(0.74); C433(1.31); C447(1.58); C444(1.65)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C444(0.72); C447(0.83); C433(2.00); C428(2.39)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C428(0.79); C433(0.81); C444(1.29); C447(1.45)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C447(0.59); C444(0.93); C433(1.20); C428(1.26)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C447(1.10); C444(1.25); C428(1.31); C433(1.34)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C428(0.87); C433(0.87); C447(1.07); C444(1.07)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C444(1.13); C447(1.13); C428(2.04); C433(2.04)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C447(1.08); C444(1.08); C428(1.15); C433(1.15)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C428(1.17); C433(1.17); C444(1.21); C447(1.22)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C428(1.07); C433(1.27); C444(1.42); C447(1.53)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C444(1.21); C428(1.23); C433(1.27); C447(1.32)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C433(1.03); C428(1.09); C444(1.33); C447(1.35)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C447(1.00); C444(1.05); C433(1.24); C428(1.28)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C444(0.91); C433(0.94); C428(1.01); C447(1.28)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C444(1.75); C447(1.79); C428(2.12); C433(2.22)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C444(1.10); C447(1.11); C433(1.33); C428(1.37)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C444(1.05); C447(1.07); C428(1.09); C433(1.13)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C428(1.46); C444(1.47); C433(1.51); C447(1.55)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C444(1.37); C447(1.56); C433(1.83); C428(1.89)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C444(1.80); C447(1.82); C433(2.15); C428(2.23)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C447(1.37); C444(1.49); C428(2.34); C433(2.55)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C444(1.50); C428(1.63); C447(1.66); C433(1.76)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C428(1.70); C433(1.53); C444(1.46); C447(1.42)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C428(1.41); C433(1.45); C444(1.27); C447(1.33)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C428(1.38); C433(1.43); C444(1.24); C447(1.34)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C428(1.66); C433(1.63); C444(1.53); C447(1.61)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C428(1.41); C433(1.36); C444(1.43); C447(1.37)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C428(1.25); C433(1.21); C444(1.25); C447(1.49)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C428(1.52); C433(1.82); C444(1.35); C447(2.05)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C433(1.17); C444(0.92); C447(0.93)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C428(0.82); C433(1.12); C444(1.23); C447(1.48)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C428(0.70); C433(0.89); C444(1.11); C447(1.04)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C428(1.14); C433(1.34); C444(1.27); C447(1.37)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C428(0.65); C433(1.26); C444(1.38); C447(1.64)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C428(1.65); C433(1.48); C444(1.21); C447(1.24)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C428(0.64); C433(1.12); C444(1.62); C447(1.42)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C428(0.73); C433(1.08); C444(1.54); C447(1.49)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C428(1.22); C433(1.17); C444(1.27); C447(1.36)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C428(0.74); C433(1.04); C444(1.18); C447(1.41)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C428(1.71); C433(1.70); C444(1.31); C447(1.33)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C428(0.82); C433(1.25); C444(1.68); C447(1.70)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C428(1.20); C433(1.56); C444(1.68); C447(1.73)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C428(0.82); C433(1.22); C444(1.37); C447(1.48)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C428(0.82); C433(1.30); C444(1.41); C447(1.44)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C428(0.77); C433(0.83); C447(0.95)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C428(0.92); C433(0.97); C447(0.79)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C428(0.83); C433(1.04); C447(0.92)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C428(0.73); C433(0.83); C447(1.02)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C428(1.27); C433(1.28); C444(1.21); C447(1.20)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C428(0.90); C433(1.09); C447(1.07)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C428(0.85); C433(1.00); C447(1.07)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C428(1.12); C433(1.23); C447(0.90)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C428(0.98); C433(1.04); C447(0.81)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C428(1.23); C433(1.14); C447(0.82)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C428(0.91); C433(0.93); C447(0.80)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C428(1.32); C433(1.25); C447(0.83)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C428(0.91); C433(1.03); C447(0.98)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C428(1.28); C433(1.23); C447(1.06)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C428(1.04); C433(1.16); C447(0.92)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C428(1.25); C433(1.25); C444(1.15); C447(1.31)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C428(1.29); C433(1.24); C447(1.21)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C428(1.19); C433(1.12); C444(1.02); C447(1.08)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C428(1.44); C433(1.20); C444(0.98); C447(0.97)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C428(0.84); C433(0.91); C444(1.04); C447(1.06)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C428(0.78); C433(0.96); C444(0.93); C447(0.98)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C428(0.73); C433(0.80); C444(0.84); C447(0.93)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C428(0.86); C433(0.90); C444(1.13); C447(1.09)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C428(0.76); C433(0.94); C444(1.09); C447(1.24)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C428(0.91); C433(1.11); C444(1.13); C447(1.21)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C428(1.01); C433(1.22); C444(1.34); C447(1.26)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C428(1.26); C433(1.44); C444(1.48); C447(1.62)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C428(0.78); C433(1.04); C444(1.21); C447(1.25)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C428(0.91); C433(1.00); C444(1.22); C447(1.18)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C428(0.82); C433(0.96); C444(1.10); C447(1.15)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C428(0.99); C433(1.73); C444(1.17); C447(1.24)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C428(0.89); C433(1.27); C444(1.15); C447(1.23)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C428(0.78); C433(0.78); C444(1.11); C447(1.05)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C428(0.65); C433(0.65); C444(1.01); C447(0.91)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C428(0.70); C433(0.70); C444(1.24); C447(1.18)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C428(0.78); C433(0.78); C444(1.22); C447(1.17)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C428(1.30); C433(1.43); C444(1.36); C447(1.60)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C428(0.82); C433(0.82); C444(1.04); C447(1.00)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C428(0.69); C433(0.69); C444(1.12); C447(1.09)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C428(0.73); C433(0.73); C444(1.14); C447(1.11)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C428(0.71); C433(0.71); C444(1.12); C447(1.00)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C428(0.85); C433(0.85); C444(1.23); C447(1.14)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C428(0.76); C433(0.76); C444(0.99); C447(0.90)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C428(0.85); C433(0.85); C444(0.85); C447(0.75)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C428(0.72); C433(0.72); C444(0.99); C447(0.87)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C428(0.74); C433(0.74); C444(1.15); C447(1.01)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C428(0.87); C433(0.87); C444(1.40); C447(1.32)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C428(1.26); C433(1.35); C444(1.34); C447(1.42)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C428(0.69); C433(0.69); C444(0.81); C447(0.68)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C428(0.85); C433(0.62); C444(1.28); C447(1.12)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C428(0.80); C433(0.50); C444(1.21); C447(1.18)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C428(0.95); C433(0.91); C444(1.27); C447(1.21)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C428(1.06); C433(0.92); C444(1.33); C447(1.21)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C428(0.78); C433(0.60); C444(1.02); C447(0.98)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C428(1.00); C433(0.83); C444(1.22); C447(1.23)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C428(0.93); C433(0.52); C444(1.08); C447(1.04)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C428(0.78); C433(0.55); C444(1.22); C447(1.23)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C428(0.79); C433(0.60); C444(1.03); C447(1.03)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C433(1.03); C428(0.98); C444(0.93)  LDD1698  [30]
 LDCM0468  Fragment33 HCT 116 C428(0.84); C433(0.95); C444(1.12); C447(1.11)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C428(0.81); C433(1.40); C444(1.74); C447(1.72)  LDD0744  [10]
 LDCM0116  HHS-0101 DM93 Y468(0.49); Y325(1.49)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y468(0.82); Y325(1.13)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y468(0.34); Y325(1.30)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y468(0.51); Y325(2.05)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y325(0.78); Y468(0.81)  LDD0268  [8]
 LDCM0107  IAA HeLa H463(0.00); C444(0.00)  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y325(1.12); Y468(0.92)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y325(1.47); Y468(0.83)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y325(1.38); Y468(1.18)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y325(3.24); Y468(3.09)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y325(2.13); Y468(1.75)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y325(2.98); Y468(1.31)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y325(2.49); Y468(0.74)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y325(1.31); Y468(0.97)  LDD0292  [7]
 LDCM0022  KB02 HCT 116 C444(1.85); C447(1.85); C433(1.94); C428(1.47)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C444(1.50); C447(1.50); C433(1.21); C428(1.45)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C444(1.91); C447(1.91); C433(1.90); C428(1.57)  LDD0082  [10]
 LDCM0109  NEM HeLa H463(0.00); H275(0.00)  LDD0223  [23]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C447(1.12)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C447(0.66); C444(0.55)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C447(0.64)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C447(0.92)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C447(0.83)  LDD2097  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C447(1.01)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C447(0.95); C444(0.92)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C447(0.43); C444(0.39)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C447(0.86)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C447(0.32)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C447(0.92)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C447(0.68)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C447(0.60)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C447(0.43)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C447(0.78); C444(0.76)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C447(0.50); C444(0.69)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C447(0.66); C444(0.41)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C447(0.75); C444(0.71)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C447(1.64)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C447(1.07); C444(0.54)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C447(1.25); C444(0.78)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C447(0.57); C444(0.45)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C447(0.74); C444(1.05)  LDD2124  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C447(0.77); C444(0.70)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C447(0.57)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C447(0.56)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C447(0.56); C444(0.42)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C447(0.43); C444(0.43)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C447(0.53); C444(0.41)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C447(0.35); C444(0.37)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C444(0.82)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C447(0.71); C444(0.71)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C447(1.42); C444(1.36)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C447(0.86); C444(0.86)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C447(1.01); C444(0.94)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C447(0.74); C444(0.82)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C447(2.70); C444(2.76)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C447(0.35); C444(0.64)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C447(0.74); C444(0.73)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C447(2.09); C444(1.62)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C447(0.64); C444(0.45)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C447(1.26)  LDD2149  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C447(0.67)  LDD2153  [6]
 LDCM0021  THZ1 HCT 116 C428(1.75); C433(1.75); C444(1.44); C447(1.44)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 1 (PRMT1) Protein arginine N-methyltransferase family Q99873
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
Ribonuclease 3 (DROSHA) Ribonuclease III family Q9NRR4
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
Histone acetyltransferase p300 (EP300) . Q09472
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate receptor ionotropic, NMDA 1 (GRIN1) Glutamate-gated ion channel (TC 1.A.10.1) family Q05586
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoic acid receptor RXR-alpha (RXRA) Nuclear hormone receptor family P19793
Tumor protein 63 (TP63) P53 family Q9H3D4
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome complex subunit SEM1 (SEM1) DSS1/SEM1 family P60896
Plectin (PLEC) Plakin or cytolinker family Q15149
RNA-binding protein Raly (RALY) RRM HNRPC family Q9UKM9
RNA-binding protein EWS (EWSR1) RRM TET family Q01844
RNA-binding protein FUS (FUS) RRM TET family P35637
TATA-binding protein-associated factor 2N (TAF15) RRM TET family Q92804
Eukaryotic translation initiation factor 1b (EIF1B) SUI1 family O60739
Breast cancer anti-estrogen resistance protein 3 (BCAR3) . O75815
Melanoma-associated antigen B2 (MAGEB2) . O15479
RING1 and YY1-binding protein (RYBP) . Q8N488
RNA-binding motif protein, X chromosome (RBMX) . P38159
Scaffold attachment factor B1 (SAFB) . Q15424
Spermatogenesis-associated protein 22 (SPATA22) . Q8NHS9
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

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2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402