Details of the Target

General Information of Target

Target ID LDTP06308
Target Name Mitochondrial inner membrane protein OXA1L (OXA1L)
Gene Name OXA1L
Gene ID 5018
Synonyms
Mitochondrial inner membrane protein OXA1L; Hsa; OXA1Hs; Oxidase assembly 1-like protein; OXA1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMGLMCGRRELLRLLQSGRRVHSVAGPSQWLGKPLTTRLLFPAAPCCCRPHYLFLAASG
PRSLSTSAISFAEVQVQAPPVVAATPSPTAVPEVASGETADVVQTAAEQSFAELGLGSYT
PVGLIQNLLEFMHVDLGLPWWGAIAACTVFARCLIFPLIVTGQREAARIHNHLPEIQKFS
SRIREAKLAGDHIEYYKASSEMALYQKKHGIKLYKPLILPVTQAPIFISFFIALREMANL
PVPSLQTGGLWWFQDLTVSDPIYILPLAVTATMWAVLELGAETGVQSSDLQWMRNVIRMM
PLITLPITMHFPTAVFMYWLSSNLFSLVQVSCLRIPAVRTVLKIPQRVVHDLDKLPPREG
FLESFKKGWKNAEMTRQLREREQRMRNQLELAARGPLRQTFTHNPLLQPGKDNPPNIPSS
SSKPKSKYPWHDTLG
Target Bioclass
Transporter and channel
Family
OXA1/ALB3/YidC family
Subcellular location
Mitochondrion inner membrane
Function
Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria.
Uniprot ID
Q15070
Ensemble ID
ENST00000358043.5
HGNC ID
HGNC:8526

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		12.16  LDD0122  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
ONAyne
 Probe Info  		K187(8.85)  LDD0275  [3]
DBIA
 Probe Info  		C153(1.95)  LDD0080  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
NHS
 Probe Info  		K187(0.00); K366(0.00); K207(0.00)  LDD0010  [8]
SF
 Probe Info  		Y195(0.00); Y196(0.00)  LDD0028  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [8]
Acrolein
 Probe Info  		C153(0.00); H170(0.00)  LDD0217  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		11.20  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 123 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.82  LDD1714  [13]
C017
 Probe Info  		5.82  LDD1725  [13]
C022
 Probe Info  		19.16  LDD1728  [13]
C026
 Probe Info  		9.45  LDD1732  [13]
C027
 Probe Info  		8.63  LDD1733  [13]
C040
 Probe Info  		26.72  LDD1740  [13]
C041
 Probe Info  		6.23  LDD1741  [13]
C049
 Probe Info  		7.57  LDD1747  [13]
C053
 Probe Info  		7.52  LDD1751  [13]
C055
 Probe Info  		32.22  LDD1752  [13]
C056
 Probe Info  		44.94  LDD1753  [13]
C063
 Probe Info  		20.97  LDD1760  [13]
C070
 Probe Info  		9.65  LDD1766  [13]
C082
 Probe Info  		6.28  LDD1774  [13]
C087
 Probe Info  		9.58  LDD1779  [13]
C091
 Probe Info  		21.11  LDD1782  [13]
C092
 Probe Info  		40.79  LDD1783  [13]
C094
 Probe Info  		41.93  LDD1785  [13]
C095
 Probe Info  		5.90  LDD1786  [13]
C100
 Probe Info  		8.00  LDD1789  [13]
C106
 Probe Info  		30.06  LDD1793  [13]
C107
 Probe Info  		8.22  LDD1794  [13]
C108
 Probe Info  		9.32  LDD1795  [13]
C112
 Probe Info  		47.18  LDD1799  [13]
C129
 Probe Info  		6.50  LDD1811  [13]
C130
 Probe Info  		6.50  LDD1812  [13]
C134
 Probe Info  		45.25  LDD1816  [13]
C135
 Probe Info  		13.64  LDD1817  [13]
C141
 Probe Info  		11.79  LDD1823  [13]
C143
 Probe Info  		31.78  LDD1825  [13]
C153
 Probe Info  		31.78  LDD1834  [13]
C158
 Probe Info  		9.00  LDD1838  [13]
C159
 Probe Info  		10.85  LDD1839  [13]
C160
 Probe Info  		15.24  LDD1840  [13]
C161
 Probe Info  		24.42  LDD1841  [13]
C163
 Probe Info  		6.11  LDD1843  [13]
C165
 Probe Info  		12.55  LDD1845  [13]
C166
 Probe Info  		9.99  LDD1846  [13]
C169
 Probe Info  		38.05  LDD1849  [13]
C186
 Probe Info  		23.92  LDD1864  [13]
C187
 Probe Info  		34.78  LDD1865  [13]
C191
 Probe Info  		18.25  LDD1868  [13]
C193
 Probe Info  		13.74  LDD1869  [13]
C194
 Probe Info  		13.55  LDD1870  [13]
C196
 Probe Info  		17.63  LDD1872  [13]
C198
 Probe Info  		11.31  LDD1874  [13]
C201
 Probe Info  		70.03  LDD1877  [13]
C206
 Probe Info  		40.50  LDD1881  [13]
C210
 Probe Info  		51.98  LDD1884  [13]
C218
 Probe Info  		28.25  LDD1892  [13]
C219
 Probe Info  		11.16  LDD1893  [13]
C220
 Probe Info  		39.95  LDD1894  [13]
C225
 Probe Info  		12.64  LDD1898  [13]
C226
 Probe Info  		6.68  LDD1899  [13]
C228
 Probe Info  		58.49  LDD1901  [13]
C229
 Probe Info  		9.45  LDD1902  [13]
C231
 Probe Info  		37.53  LDD1904  [13]
C232
 Probe Info  		47.84  LDD1905  [13]
C233
 Probe Info  		14.62  LDD1906  [13]
C234
 Probe Info  		7.26  LDD1907  [13]
C235
 Probe Info  		39.12  LDD1908  [13]
C238
 Probe Info  		24.42  LDD1911  [13]
C239
 Probe Info  		5.78  LDD1912  [13]
C240
 Probe Info  		11.96  LDD1913  [13]
C243
 Probe Info  		15.78  LDD1916  [13]
C244
 Probe Info  		19.29  LDD1917  [13]
C245
 Probe Info  		17.15  LDD1918  [13]
C246
 Probe Info  		31.78  LDD1919  [13]
C264
 Probe Info  		22.63  LDD1935  [13]
C265
 Probe Info  		18.64  LDD1936  [13]
C270
 Probe Info  		6.77  LDD1940  [13]
C273
 Probe Info  		6.23  LDD1943  [13]
C277
 Probe Info  		11.55  LDD1947  [13]
C278
 Probe Info  		99.73  LDD1948  [13]
C280
 Probe Info  		9.85  LDD1950  [13]
C282
 Probe Info  		39.67  LDD1952  [13]
C284
 Probe Info  		36.00  LDD1954  [13]
C285
 Probe Info  		49.87  LDD1955  [13]
C287
 Probe Info  		11.96  LDD1957  [13]
C288
 Probe Info  		12.64  LDD1958  [13]
C289
 Probe Info  		53.82  LDD1959  [13]
C293
 Probe Info  		41.64  LDD1963  [13]
C296
 Probe Info  		21.26  LDD1966  [13]
C299
 Probe Info  		7.26  LDD1968  [13]
C305
 Probe Info  		9.58  LDD1974  [13]
C310
 Probe Info  		38.59  LDD1977  [13]
C322
 Probe Info  		12.04  LDD1988  [13]
C326
 Probe Info  		7.73  LDD1990  [13]
C343
 Probe Info  		19.70  LDD2005  [13]
C348
 Probe Info  		12.13  LDD2009  [13]
C349
 Probe Info  		35.26  LDD2010  [13]
C350
 Probe Info  		91.14  LDD2011  [13]
C355
 Probe Info  		39.12  LDD2016  [13]
C356
 Probe Info  		14.52  LDD2017  [13]
C357
 Probe Info  		20.39  LDD2018  [13]
C362
 Probe Info  		95.01  LDD2023  [13]
C363
 Probe Info  		24.76  LDD2024  [13]
C364
 Probe Info  		28.25  LDD2025  [13]
C366
 Probe Info  		24.93  LDD2027  [13]
C367
 Probe Info  		10.34  LDD2028  [13]
C382
 Probe Info  		11.79  LDD2041  [13]
C388
 Probe Info  		73.01  LDD2047  [13]
C390
 Probe Info  		70.52  LDD2049  [13]
C391
 Probe Info  		14.42  LDD2050  [13]
C403
 Probe Info  		29.24  LDD2061  [13]
C407
 Probe Info  		52.35  LDD2064  [13]
C409
 Probe Info  		6.41  LDD2066  [13]
C413
 Probe Info  		14.03  LDD2069  [13]
C419
 Probe Info  		12.91  LDD2074  [13]
C420
 Probe Info  		18.38  LDD2075  [13]
C426
 Probe Info  		14.12  LDD2081  [13]
C429
 Probe Info  		16.56  LDD2084  [13]
C431
 Probe Info  		18.38  LDD2086  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe15
 Probe Info  		15.74  LDD0478  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
FFF probe3
 Probe Info  		20.00  LDD0464  [14]
FFF probe4
 Probe Info  		13.43  LDD0466  [14]
JN0003
 Probe Info  		20.00  LDD0469  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]
OEA-DA
 Probe Info  		11.65  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C153(0.77)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C153(0.75)  LDD0532  [4]
 LDCM0216  AC100 PaTu 8988t C153(0.90)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C153(1.03)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C153(1.08)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C153(0.82)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C153(0.99)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C153(0.96)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C153(0.90)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C153(1.08)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C153(0.82)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C153(0.82)  LDD1104  [4]
 LDCM0226  AC11 HCT 116 C153(0.70)  LDD0543  [4]
 LDCM0227  AC110 PaTu 8988t C153(0.82)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C153(0.85)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C153(0.80)  LDD1108  [4]
 LDCM0230  AC113 HCT 116 C153(0.93)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C153(0.83)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C153(0.84)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C153(0.78)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C153(0.88)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C153(0.95)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C153(0.79)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C153(0.84)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C153(0.73)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C153(0.96)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C153(0.76)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C153(0.93)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C153(0.92)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C153(0.80)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C153(0.68)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C153(0.70)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C153(1.08)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C153(0.71)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C153(0.89)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C153(1.26)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C153(1.41)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C153(1.20)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C153(0.94)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C153(1.42)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C153(1.48)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C153(1.29)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C153(1.47)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C153(1.02)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C153(0.80)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C153(0.97)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C153(1.05)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C153(0.81)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C153(0.88)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C153(0.71)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C153(0.86)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C153(0.59)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C153(0.71)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C153(0.76)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C153(0.64)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C153(0.74)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C153(0.78)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C153(0.84)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C153(0.68)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C153(0.77)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C153(0.70)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C153(0.62)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C153(0.93)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C153(0.84)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C153(0.77)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C153(0.73)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C153(0.77)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C153(0.99)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C153(0.81)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C153(0.73)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C153(0.84)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C153(0.84)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C153(0.94)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C153(0.78)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C153(0.72)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C153(0.76)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C153(0.65)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C153(0.77)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C153(1.01)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C153(0.74)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C153(0.65)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C153(0.63)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C153(0.66)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C153(0.59)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C153(1.05)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C153(1.16)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C153(1.19)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C153(1.07)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C153(0.91)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C153(0.89)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C153(1.12)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C153(0.98)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C153(1.08)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C153(1.01)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C153(1.08)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C153(1.08)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C153(0.94)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C153(0.92)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C153(0.78)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C153(0.89)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C153(0.87)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C153(0.89)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C153(1.09)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C153(0.94)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C153(0.96)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C153(0.93)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C153(0.95)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C153(1.04)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C153(0.81)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C153(0.87)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C153(0.91)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C153(0.79)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C153(0.69)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C153(0.73)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C153(0.90)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C153(0.87)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C153(0.87)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C153(0.97)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C153(0.95)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C153(0.85)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C153(0.97)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C153(0.95)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C153(0.96)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C153(0.81)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C153(0.93)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C153(0.92)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C153(1.10)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C153(1.02)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C153(1.12)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C153(1.02)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C153(1.07)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C153(0.82)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C153(0.97)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C153(0.76)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C153(1.01)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C153(0.97)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C153(1.17)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C153(0.82)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C153(0.77)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C153(0.67)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C153(0.95)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C153(0.88)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C153(0.86)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C153(0.80)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C153(1.22)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C153(0.90)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C153(0.83)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C153(0.77)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C153(0.71)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C153(0.76)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C153(0.77)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C153(0.78)  LDD0681  [4]
 LDCM0365  AC98 PaTu 8988t C153(0.86)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C153(1.01)  LDD1245  [4]
 LDCM0248  AKOS034007472 HCT 116 C153(1.00)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C153(0.84)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C153(0.80)  LDD0592  [4]
 LDCM0108  Chloroacetamide HeLa C153(0.00); H170(0.00)  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C153(1.16)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C153(0.93)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C153(0.90)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C153(0.77)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C153(0.94)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C153(0.90)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C153(0.87)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C153(0.69)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C153(0.56)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C153(0.70)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C153(0.70)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C153(0.74)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C153(0.95)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C153(0.63)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C153(0.68)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C153(0.87)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C153(0.61)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C153(0.77)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C153(0.68)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C153(0.70)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C153(1.20)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C153(1.05)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C153(1.02)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C153(1.08)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C153(1.03)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C153(1.22)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C153(0.88)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C153(0.90)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C153(1.03)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C153(1.06)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C153(0.93)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C153(0.89)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C153(0.86)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C153(0.92)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C153(0.96)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C153(1.11)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C153(0.86)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C153(0.74)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C153(0.67)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C153(0.61)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C153(1.20)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C153(0.76)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C153(0.80)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C153(0.82)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C153(0.75)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C153(0.71)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C153(0.75)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C153(0.83)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C153(0.72)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C153(0.66)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C153(0.76)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C153(1.04)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C153(0.74)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C153(0.96)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C153(1.35)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C153(1.22)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C153(0.88)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C153(1.13)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C153(0.99)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C153(1.14)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C153(1.32)  LDD1026  [4]
 LDCM0429  CL4 HCT 116 C153(0.97)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C153(1.40)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C153(1.16)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C153(1.28)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C153(1.36)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C153(1.15)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C153(1.86)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C153(1.47)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C153(1.08)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C153(0.91)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C153(1.21)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C153(1.10)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C153(1.57)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C153(1.74)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C153(0.95)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C153(1.27)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C153(1.23)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C153(1.33)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C153(1.22)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C153(1.19)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C153(1.10)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C153(1.18)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C153(1.07)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C153(1.40)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C153(1.01)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C153(0.90)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C153(0.85)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C153(0.88)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C153(0.89)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C153(0.90)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C153(0.81)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C153(0.73)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C153(0.83)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C153(1.16)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C153(0.84)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C153(0.79)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C153(0.92)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C153(0.78)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C153(0.88)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C153(0.90)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C153(0.93)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C153(0.90)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C153(0.87)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C153(1.09)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C153(0.80)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C153(0.96)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C153(0.92)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C153(0.87)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C153(0.98)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C153(0.91)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C153(0.99)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C153(0.93)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C153(0.86)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C153(1.09)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C153(1.17)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C153(1.33)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C153(1.05)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C153(1.05)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C153(1.09)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C153(0.87)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C153(0.90)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C153(0.90)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C153(0.97)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C153(0.86)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C153(0.95)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C153(0.84)  LDD1698  [17]
 LDCM0625  F8 Ramos C153(0.55)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C153(1.29)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C153(0.88)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C153(1.73)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C153(0.98)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C153(8.13)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C153(12.51)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C153(0.68)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C153(1.52)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C153(0.64)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C153(0.46)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C153(1.20)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C153(1.11)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C153(1.52)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C153(0.81)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C153(1.16)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C153(2.64)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C153(1.02)  LDD1025  [4]
 LDCM0610  Fragment52 Ramos C153(2.91)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C153(1.27)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C153(1.50)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C153(6.72)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C153(1.95)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C153(9.20)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C153(2.59)  LDD0082  [4]
 LDCM0109  NEM HeLa H170(0.00); H172(0.00)  LDD0227  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C153(0.98)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C153(1.91)  LDD2207  [19]

References

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Mass spectrometry data entry: PXD028270
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.