Details of the Target

General Information of Target

Target ID LDTP02364
Target Name Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)
Gene Name HNRNPA1
Gene ID 3178
Synonyms
HNRPA1; Heterogeneous nuclear ribonucleoprotein A1; hnRNP A1; Helix-destabilizing protein; Single-strand RNA-binding protein; hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFV
TYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHH
LRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKA
LSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGS
GDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGG
GSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGS
SSSSSYGSGRRF
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm; Nucleus
Function
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins.; (Microbial infection) May play a role in HCV RNA replication.; (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis.
TTD ID
T12052
Uniprot ID
P09651
DrugMap ID
TTPJ9XK
Ensemble ID
ENST00000340913.11
HGNC ID
HGNC:5031
ChEMBL ID
CHEMBL1955709

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 52 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		2.22  LDD0448  [1]
P2
 Probe Info  		2.71  LDD0449  [1]
P3
 Probe Info  		1.94  LDD0450  [1]
P8
 Probe Info  		2.35  LDD0451  [1]
A-EBA
 Probe Info  		2.86  LDD0215  [2]
CY4
 Probe Info  		3.98  LDD0244  [3]
C-Sul
 Probe Info  		4.10  LDD0066  [4]
TH211
 Probe Info  		Y167(20.00); Y347(20.00); Y357(20.00); Y366(20.00)  LDD0257  [5]
TH214
 Probe Info  		Y357(20.00); Y366(20.00); Y167(15.84); Y341(9.59)  LDD0258  [5]
TH216
 Probe Info  		Y167(20.00); Y341(20.00); Y347(20.00); Y357(20.00)  LDD0259  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
AZ-9
 Probe Info  		E126(0.79); E132(0.99); D123(1.21); E135(10.00)  LDD2208  [7]
ONAyne
 Probe Info  		K105(0.00); K8(0.00); K350(0.00); K52(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K350(3.42); K8(4.27); K113(4.81); K166(7.94)  LDD3494  [9]
Probe 1
 Probe Info  		Y124(30.24); Y128(42.73); Y167(13.61); Y244(44.50)  LDD3495  [10]
BTD
 Probe Info  		C175(2.53)  LDD1700  [11]
HHS-482
 Probe Info  		Y167(0.97); Y341(0.91); Y347(0.97); Y357(0.92)  LDD0285  [12]
HHS-475
 Probe Info  		Y167(0.68); Y347(0.78); Y341(0.80); Y357(0.81)  LDD0264  [13]
HHS-465
 Probe Info  		Y167(10.00); Y341(5.35); Y347(7.79); Y357(9.81)  LDD2237  [14]
DBIA
 Probe Info  		C43(1.30); C175(1.43)  LDD0080  [15]
5E-2FA
 Probe Info  		H101(0.00); H119(0.00); H156(0.00); H77(0.00)  LDD2235  [16]
AMP probe
 Probe Info  		N.A.  LDD0200  [17]
ATP probe
 Probe Info  		K350(0.00); K15(0.00); K166(0.00); K105(0.00)  LDD0199  [17]
m-APA
 Probe Info  		H101(0.00); H120(0.00); H119(0.00); H156(0.00)  LDD2231  [16]
N1
 Probe Info  		C43(0.00); C175(0.00); D42(0.00); E176(0.00)  LDD0245  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C43(0.00); C175(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C175(0.00); C43(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [20]
IPIAA_L
 Probe Info  		C43(0.00); C175(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C43(0.00); C175(0.00)  LDD0037  [18]
ATP probe
 Probe Info  		K161(0.00); K106(0.00); K350(0.00); K166(0.00)  LDD0035  [21]
IPM
 Probe Info  		N.A.  LDD0025  [22]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [22]
TFBX
 Probe Info  		N.A.  LDD0027  [22]
aONE
 Probe Info  		N.A.  LDD0002  [23]
1d-yne
 Probe Info  		N.A.  LDD0356  [24]
Compound 10
 Probe Info  		C175(0.00); C43(0.00)  LDD2216  [25]
Compound 11
 Probe Info  		N.A.  LDD2213  [25]
ENE
 Probe Info  		N.A.  LDD0006  [23]
NHS
 Probe Info  		K350(0.00); K3(0.00); K8(0.00); K105(0.00)  LDD0010  [23]
OSF
 Probe Info  		Y341(0.00); Y357(0.00); Y366(0.00); Y347(0.00)  LDD0029  [26]
SF
 Probe Info  		K78(0.00); K113(0.00); Y167(0.00); Y237(0.00)  LDD0028  [26]
STPyne
 Probe Info  		K3(0.00); K350(0.00); K8(0.00)  LDD0009  [23]
Phosphinate-6
 Probe Info  		C175(0.00); C43(0.00)  LDD0018  [27]
Ox-W18
 Probe Info  		N.A.  LDD2175  [28]
1c-yne
 Probe Info  		K8(0.00); K166(0.00); K15(0.00); K78(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		C175(0.00); H173(0.00); H168(0.00)  LDD0217  [29]
Cinnamaldehyde
 Probe Info  		C175(0.00); H168(0.00)  LDD0220  [29]
Crotonaldehyde
 Probe Info  		C175(0.00); H168(0.00); H173(0.00)  LDD0219  [29]
Methacrolein
 Probe Info  		C175(0.00); H173(0.00)  LDD0218  [29]
W1
 Probe Info  		N.A.  LDD0236  [30]
NAIA_5
 Probe Info  		N.A.  LDD2223  [31]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C338
 Probe Info  		11.24  LDD2001  [32]
FFF probe11
 Probe Info  		6.04  LDD0471  [33]
FFF probe13
 Probe Info  		9.84  LDD0475  [33]
FFF probe14
 Probe Info  		5.18  LDD0477  [33]
FFF probe2
 Probe Info  		8.64  LDD0463  [33]
FFF probe3
 Probe Info  		6.63  LDD0464  [33]
JN0003
 Probe Info  		6.10  LDD0469  [33]
Diazir
 Probe Info  		N.A.  LDD0011  [23]
BD-F
 Probe Info  		T169(0.00); H168(0.00)  LDD0024  [34]
LD-F
 Probe Info  		G241(0.00); N249(0.00); G246(0.00); N245(0.00)  LDD0015  [34]
STS-1
 Probe Info  		N.A.  LDD0068  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C175(0.76); C43(0.57)  LDD2142  [11]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C175(0.82)  LDD2112  [11]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C175(0.46)  LDD2095  [11]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C175(0.98)  LDD2130  [11]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C175(1.51); C43(1.09)  LDD2117  [11]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C175(1.93)  LDD2152  [11]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C175(1.17)  LDD2103  [11]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C175(0.71)  LDD2132  [11]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C175(0.61)  LDD2131  [11]
 LDCM0214  AC1 HCT 116 C175(1.25); C43(1.68)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C175(0.61); C43(0.67)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C175(1.44); C43(2.29)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C175(1.44); C43(0.78)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C175(2.44); C43(0.73)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C175(1.12); C43(0.48)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C175(0.81); C43(0.72)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C175(1.22); C43(0.57)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C175(0.97); C43(0.59)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C175(0.82); C43(0.45)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C175(0.37); C43(0.51)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C175(0.86); C43(0.60)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C175(0.60); C43(0.65)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C175(0.58); C43(0.54)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C175(0.63); C43(0.53)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C175(0.68); C43(0.43)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C43(1.35)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C43(1.00)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C43(0.95)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C43(1.01)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C43(1.18)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C43(1.04)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C43(0.97)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C175(0.77); C43(0.97)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C43(0.96)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C43(1.17)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C43(0.93)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C43(1.52)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C43(1.11)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C43(0.95)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C43(0.97)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C43(1.03)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C175(0.41); C43(0.88)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C175(1.29); C43(1.21)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C175(0.87); C43(1.26)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C175(0.88); C43(1.24)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C175(1.18); C43(1.10)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C175(1.02); C43(1.13)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C175(0.89); C43(0.79)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C175(0.71); C43(0.71)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C175(0.83); C43(0.88)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C175(1.02); C43(1.17)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C175(0.96); C43(0.67)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C175(0.99); C43(0.69)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C175(0.98); C43(0.83)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C175(0.84); C43(0.64)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C175(0.80); C43(0.61)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C175(1.91); C43(1.30)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C43(0.76)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C43(0.47)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C43(0.74)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C43(0.79)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C43(0.43)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C43(0.09)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C43(0.36)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C43(0.71); C175(1.53)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C43(1.32)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C43(0.67)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C43(0.29)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C43(0.07)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C43(0.40)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C43(0.61)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C43(1.00)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C43(0.76)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C43(0.95); C175(0.97)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C175(0.51); C43(0.68)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C175(0.88); C43(0.99)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C43(1.02); C175(1.18)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C43(0.86); C175(0.98)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C175(0.75); C43(0.83)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C175(0.81); C43(1.00)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C175(0.76); C43(0.81)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C175(0.87); C43(1.00)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C43(1.07)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C43(0.95)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C43(0.97)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C43(0.86)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C43(0.87)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C175(1.15); C43(1.42)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C43(0.75)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C43(1.09)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C43(0.72)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C43(1.19)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C43(0.96)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C175(1.25); C43(1.29)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C175(1.47); C43(1.48)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C175(1.40); C43(1.44)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C43(1.23); C175(1.30)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C175(0.75); C43(0.95)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C175(1.07); C43(1.91)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C43(0.61); C175(0.68)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C43(0.83); C175(0.99)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C43(0.77); C175(1.12)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C175(1.06); C43(1.07)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C175(0.70); C43(0.75)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C43(0.55); C175(0.60)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C43(1.04); C175(1.64)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C43(1.15); C175(1.80)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C43(1.81); C175(2.27)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C175(0.20); C43(0.47)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C175(1.01); C43(1.62)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C43(0.48); C175(1.46)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C43(1.71); C175(2.43)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C43(0.93); C175(1.28)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C43(0.99); C175(1.96)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C175(0.73); C43(0.97)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C43(0.80); C175(1.07)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C43(0.28); C175(0.75)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C43(1.05); C175(1.49)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C43(1.05); C175(1.21)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C43(0.61); C175(0.99)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C43(0.59); C175(0.73)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C43(1.29); C175(1.35)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C175(1.33); C43(2.01)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C43(0.65); C175(0.90)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C175(0.95); C43(1.12)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C43(0.60); C175(0.79)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C43(0.91); C175(1.50)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C175(1.02); C43(1.17)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C43(0.17); C175(0.26)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C43(0.89); C175(2.66)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C43(0.84); C175(1.27)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C175(0.83); C43(0.90)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C43(0.52); C175(1.68)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C43(1.43); C175(1.86)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C43(1.04); C175(1.36)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C43(0.23); C175(0.27)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C43(0.28); C175(0.41)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C43(0.10); C175(0.12)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C43(0.67); C175(0.86)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C43(0.73); C175(1.30)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C43(1.20); C175(1.58)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C43(1.02); C175(1.58)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C43(0.65); C175(0.80)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C43(0.84); C175(1.04)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C43(0.72); C175(1.02)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C43(0.07); C175(0.10)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C43(0.92)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C43(0.64)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C43(1.25)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C43(0.91)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C43(1.14)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C43(0.80)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C43(0.79)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C43(1.44)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C43(0.86)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C43(0.92)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C43(0.98)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C43(1.62)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C43(1.97)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C43(1.31)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C43(0.72)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C175(0.06); C43(0.14)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C43(0.67); C175(1.42)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C175(0.67)  LDD2138  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C175(0.85)  LDD2113  [11]
 LDCM0248  AKOS034007472 HCT 116 C175(1.07); C43(1.01)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C175(0.78); C43(0.84)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C43(0.28); C175(0.70)  LDD0592  [15]
 LDCM0498  BS-3668 MDA-MB-231 C175(0.63)  LDD2091  [11]
 LDCM0108  Chloroacetamide HeLa C175(0.00); H168(0.00); H173(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C175(20.00)  LDD2227  [31]
 LDCM0367  CL1 HCT 116 C43(1.12)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C43(0.62)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C175(0.90); C43(1.34)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C43(0.70); C175(0.83)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C43(0.93); C175(1.17)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C43(0.61); C175(0.84)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C43(0.76); C175(0.86)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C175(0.63); C43(0.85)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C175(0.56); C43(0.68)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C175(0.61); C43(0.72)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C43(0.61); C175(0.63)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C175(0.63); C43(0.73)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C43(0.53)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C43(0.62); C175(0.64)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C43(0.67); C175(1.26)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C43(1.09)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C43(0.82)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C43(0.90)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C43(0.80)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C43(1.21)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C43(0.16); C175(0.24)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C175(0.78); C43(0.89)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C175(0.62); C43(0.78)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C43(0.49)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C43(1.12); C175(1.13)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C175(0.47); C43(1.11)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C43(1.05); C175(1.54)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C43(0.72); C175(1.38)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C43(0.61); C175(1.20)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C175(1.08); C43(1.83)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C43(1.47); C175(2.05)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C43(1.41); C175(1.62)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C43(0.85); C175(1.06)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C43(0.84)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C43(0.91)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C43(0.39)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C43(0.83)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C43(1.25)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C43(1.58)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C43(0.88)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C43(0.96)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C43(0.63)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C43(0.41)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C43(0.08)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C43(0.64)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C43(0.35)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C43(0.45)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C43(0.80)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C43(0.79)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C43(0.52)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C43(0.57)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C43(0.90)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C43(0.94)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C43(0.73)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C43(1.07)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C43(0.58)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C43(0.51)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C43(0.39)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C43(0.45)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C43(0.44)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C43(0.45)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C43(0.99)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C43(0.46)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C43(0.48)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C43(0.30)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C43(0.37)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C43(0.54)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C43(0.41)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C43(1.40)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C43(1.36)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C43(1.28)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C43(1.08)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C43(0.86)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C43(1.32)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C43(1.31)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C43(1.38)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C43(1.29)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C43(1.29)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C43(1.32)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C43(1.07)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C43(1.37)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C43(1.32)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C43(1.07)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C43(1.22)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C43(1.08)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C43(1.18)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C43(1.03)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C43(1.00)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C43(0.96)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C43(1.05)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C43(0.80)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C43(0.89)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C43(1.03)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C43(1.23)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C43(0.71)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C43(1.00)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C43(0.84)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C43(0.97)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C43(0.81)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C43(0.90)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C175(1.10); C43(0.96)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C175(0.72); C43(0.39)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C175(1.34); C43(0.60)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C175(0.79); C43(0.56)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C43(0.42)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C175(1.36); C43(1.10)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C175(1.22); C43(0.65)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C175(0.43); C43(0.42)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C175(0.88); C43(0.46)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C175(0.25); C43(0.35)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C175(1.12); C43(0.67)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C175(0.88); C43(0.79)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C175(0.93); C43(0.99)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C175(0.63); C43(0.45)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C175(0.14); C43(0.27)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C43(0.73)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C175(1.19); C43(0.54)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C175(1.11); C43(0.20)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C175(1.31); C43(0.76)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C175(1.05); C43(1.31)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C175(1.10); C43(1.32)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C175(1.07); C43(0.98)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C175(1.18); C43(0.86)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C175(0.98); C43(0.80)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C175(1.09); C43(1.65)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C175(1.32); C43(1.79)  LDD0811  [15]
 LDCM0495  E2913 HEK-293T C175(0.87); C43(1.02)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C175(1.10)  LDD1702  [11]
 LDCM0625  F8 Ramos C175(2.75); C43(3.79)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C175(0.60)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C175(0.09); C43(0.04)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C175(0.42)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C175(0.44)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C175(0.90); C43(0.83)  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C175(0.50)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C175(0.47)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C175(1.22)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C175(0.91)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C175(0.68); C43(2.03)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C175(0.59)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C175(0.56)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C175(0.76)  LDD2201  [37]
 LDCM0468  Fragment33 HCT 116 C43(0.91)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C175(0.98)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C175(0.84); C43(0.64)  LDD2184  [37]
 LDCM0427  Fragment51 HCT 116 C43(0.21)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C175(0.68)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C175(0.43)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C175(0.77); C43(0.35)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C175(0.23)  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y167(0.68); Y347(0.78); Y341(0.80); Y357(0.81)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y167(0.62); Y341(0.78); Y357(0.80); Y366(0.80)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y167(0.50); Y357(0.69); Y366(0.69); Y347(0.71)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y167(0.80); Y347(0.84); Y341(0.88); Y366(0.89)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y347(0.78); Y357(0.79); Y366(0.80); Y167(0.81)  LDD0268  [13]
 LDCM0107  IAA HeLa H173(0.00); C175(0.00); H168(0.00)  LDD0221  [29]
 LDCM0123  JWB131 DM93 Y167(0.97); Y341(0.91); Y347(0.97); Y357(0.92)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y167(0.89); Y341(0.67); Y347(0.70); Y357(0.66)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y167(1.02); Y341(1.10); Y347(1.14); Y357(1.07)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y167(3.01); Y341(2.44); Y347(2.57); Y357(2.48)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y167(2.30); Y341(1.97); Y347(1.67); Y357(1.94)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y167(1.47); Y341(1.04); Y347(1.15); Y357(1.11)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y167(0.72); Y341(0.52); Y347(0.50); Y357(0.45)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y167(0.97); Y341(1.00); Y347(0.92); Y357(0.89)  LDD0292  [12]
 LDCM0022  KB02 HCT 116 C43(1.30); C175(1.43)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C43(1.49); C175(1.48)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C43(1.31); C175(1.31)  LDD0082  [15]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C175(1.07)  LDD2102  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C175(0.90)  LDD2121  [11]
 LDCM0109  NEM HeLa H173(0.00); C175(0.00); H168(0.00)  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C175(0.88)  LDD2089  [11]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C175(1.09); C43(1.03)  LDD2092  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C175(1.50)  LDD2093  [11]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C175(1.19)  LDD2094  [11]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C175(0.21)  LDD2096  [11]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C175(1.11)  LDD2097  [11]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C175(0.86); C43(1.15)  LDD2098  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C175(1.56); C43(1.24)  LDD2099  [11]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C175(0.74)  LDD2100  [11]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C175(1.83)  LDD2101  [11]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C175(0.57)  LDD2104  [11]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C175(2.13); C43(1.88)  LDD2105  [11]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C175(0.56)  LDD2106  [11]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C175(1.28); C43(1.24)  LDD2107  [11]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C175(1.03); C43(0.66)  LDD2109  [11]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C175(1.45)  LDD2111  [11]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C175(0.58); C43(0.79)  LDD2114  [11]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C175(0.60)  LDD2115  [11]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C175(0.42)  LDD2116  [11]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C175(0.48)  LDD2118  [11]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C175(1.79); C43(0.67)  LDD2119  [11]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C175(0.58)  LDD2120  [11]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C175(0.27)  LDD2122  [11]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C175(1.38); C43(0.69)  LDD2123  [11]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C175(0.26)  LDD2124  [11]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C175(1.29); C43(1.01)  LDD2125  [11]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C175(0.27)  LDD2126  [11]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C175(1.70); C43(0.91)  LDD2127  [11]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C175(0.76)  LDD2128  [11]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C175(1.30)  LDD2129  [11]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C175(0.78)  LDD2133  [11]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C175(0.52)  LDD2134  [11]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C175(1.63)  LDD2135  [11]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C175(1.66); C43(1.36)  LDD2136  [11]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C175(1.39); C43(0.80)  LDD2137  [11]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C175(2.53)  LDD1700  [11]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C175(1.40)  LDD2140  [11]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C175(0.83); C43(0.32)  LDD2141  [11]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C175(0.73)  LDD2143  [11]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C175(2.13)  LDD2144  [11]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C43(0.53)  LDD2145  [11]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C175(1.24)  LDD2146  [11]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C175(2.28)  LDD2147  [11]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C175(0.50)  LDD2148  [11]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C175(0.28)  LDD2149  [11]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C175(0.61)  LDD2150  [11]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C175(0.22)  LDD2151  [11]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C175(1.60)  LDD2153  [11]
 LDCM0131  RA190 MM1.R C175(1.30)  LDD0304  [38]
 LDCM0111  W14 Hep-G2 K106(0.58); E114(0.60)  LDD0238  [30]
 LDCM0113  W17 Hep-G2 H173(67.95)  LDD0240  [30]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome non-ATPase regulatory subunit 9 (PSMD9) Proteasome subunit p27 family O00233
Septin-6 (SEPTIN6) Septin GTPase family Q14141
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transportin-1 (TNPO1) Importin beta family Q92973
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) KHDRBS family Q07666
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) . P51991
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) . P31942
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) . P22626
Ubiquilin-2 (UBQLN2) . Q9UHD9

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 15 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 111992 Antisense drug D0D9OL
Isis 111993 Antisense drug D0Y4TS
Isis 111997 Antisense drug D0H0YU
Isis 112000 Antisense drug D00LSM
Isis 112001 Antisense drug D0N7OK
Isis 112002 Antisense drug D07FSX
Isis 112003 Antisense drug D0GD1R
Isis 112004 Antisense drug D0H6OL
Isis 112005 Antisense drug D06QZK
Isis 112019 Antisense drug D04XOE
Isis 112020 Antisense drug D0T0XZ
Isis 112021 Antisense drug D0Z4RI
Isis 112022 Antisense drug D00SQD
Isis 112023 Antisense drug D07RUF
Isis 112024 Antisense drug D0QU6S

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
26 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
27 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
28 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
29 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
30 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
31 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
32 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
33 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
34 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
35 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
36 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
38 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.