Details of the Target

General Information of Target

Target ID LDTP09188
Target Name Lysophosphatidylcholine acyltransferase 1 (LPCAT1)
Gene Name LPCAT1
Gene ID 79888
Synonyms
AYTL2; PFAAP3; Lysophosphatidylcholine acyltransferase 1; LPC acyltransferase 1; LPCAT-1; LysoPC acyltransferase 1; EC 2.3.1.23; 1-acylglycerol-3-phosphate O-acyltransferase; EC 2.3.1.51; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; EC 2.3.1.25; 1-alkylglycerophosphocholine O-acetyltransferase; EC 2.3.1.67; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; Acyltransferase-like 2; Phosphonoformate immuno-associated protein 3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMTLTLFPVRLLV
AAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGR
QALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIQYIRPVFVSRSDQ
DSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPN
KLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAE
ALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEKDLDRYSERAR
MKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVDLRECVVALSVVCRPARTLDT
IQLAFKMYGAQEDGSVGEGDLSCILKTALGVAELTVTDLFRAIDQEEKGKITFADFHRFA
EMYPAFAEEYLYPDQTHFESCAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD
Target Bioclass
Enzyme
Family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Exhibits acyltransferase activity. Exhibits acetyltransferase activity. Activity is calcium-independent. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size.
Uniprot ID
Q8NF37
Ensemble ID
ENST00000283415.4
HGNC ID
HGNC:25718
ChEMBL ID
CHEMBL4295903

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
HDSF-alk
 Probe Info  		1.52  LDD0197  [2]
AZ-5
 Probe Info  		6.34  LDD0394  [3]
DA-P2
 Probe Info  		7.03  LDD0348  [4]
HRP
 Probe Info  		6.62  LDD0347  [4]
AZ-9
 Probe Info  		D328(10.00)  LDD2209  [3]
BTD
 Probe Info  		C6(0.87)  LDD2092  [5]
DA-P3
 Probe Info  		8.38  LDD0179  [4]
AHL-Pu-1
 Probe Info  		C514(2.76)  LDD0168  [6]
HPAP
 Probe Info  		3.45  LDD0062  [7]
EA-probe
 Probe Info  		C330(0.97)  LDD2210  [8]
DBIA
 Probe Info  		C330(1.13)  LDD0080  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C330(0.00); C211(0.00); C216(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C330(0.00); C216(0.00); C211(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		C330(0.00); C443(0.00)  LDD0026  [12]
NAIA_4
 Probe Info  		C211(0.00); C330(0.00)  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
IPM
 Probe Info  		C211(0.00); C330(0.00)  LDD0005  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [14]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Acrolein
 Probe Info  		C330(0.00); C443(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C330(0.00); H477(0.00); C443(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C330(0.00); C443(0.00)  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		14.10  LDD0443  [18]
NAIA_5
 Probe Info  		C330(0.00); C443(0.00); C211(0.00); C216(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 56 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		10.56  LDD1728  [19]
C040
 Probe Info  		11.08  LDD1740  [19]
C055
 Probe Info  		14.42  LDD1752  [19]
C056
 Probe Info  		21.56  LDD1753  [19]
C072
 Probe Info  		13.27  LDD1768  [19]
C091
 Probe Info  		11.96  LDD1782  [19]
C092
 Probe Info  		31.12  LDD1783  [19]
C094
 Probe Info  		32.00  LDD1785  [19]
C095
 Probe Info  		5.17  LDD1786  [19]
C100
 Probe Info  		5.35  LDD1789  [19]
C106
 Probe Info  		20.68  LDD1793  [19]
C112
 Probe Info  		21.56  LDD1799  [19]
C129
 Probe Info  		6.32  LDD1811  [19]
C134
 Probe Info  		31.78  LDD1816  [19]
C135
 Probe Info  		11.31  LDD1817  [19]
C143
 Probe Info  		20.11  LDD1825  [19]
C158
 Probe Info  		25.28  LDD1838  [19]
C161
 Probe Info  		16.00  LDD1841  [19]
C169
 Probe Info  		48.84  LDD1849  [19]
C186
 Probe Info  		10.34  LDD1864  [19]
C196
 Probe Info  		11.63  LDD1872  [19]
C201
 Probe Info  		30.91  LDD1877  [19]
C210
 Probe Info  		40.22  LDD1884  [19]
C219
 Probe Info  		5.28  LDD1893  [19]
C220
 Probe Info  		30.06  LDD1894  [19]
C225
 Probe Info  		8.22  LDD1898  [19]
C228
 Probe Info  		19.70  LDD1901  [19]
C245
 Probe Info  		7.46  LDD1918  [19]
C246
 Probe Info  		15.78  LDD1919  [19]
C252
 Probe Info  		8.28  LDD1925  [19]
C288
 Probe Info  		6.73  LDD1958  [19]
C289
 Probe Info  		35.26  LDD1959  [19]
C339
 Probe Info  		9.78  LDD2002  [19]
C349
 Probe Info  		21.26  LDD2010  [19]
C350
 Probe Info  		41.07  LDD2011  [19]
C355
 Probe Info  		25.28  LDD2016  [19]
C356
 Probe Info  		7.94  LDD2017  [19]
C388
 Probe Info  		42.81  LDD2047  [19]
C390
 Probe Info  		38.59  LDD2049  [19]
C403
 Probe Info  		14.52  LDD2061  [19]
C407
 Probe Info  		13.00  LDD2064  [19]
C419
 Probe Info  		13.45  LDD2074  [19]
C429
 Probe Info  		15.89  LDD2084  [19]
C431
 Probe Info  		16.22  LDD2086  [19]
FFF probe11
 Probe Info  		20.00  LDD0471  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		16.06  LDD0477  [20]
FFF probe15
 Probe Info  		7.24  LDD0478  [20]
FFF probe2
 Probe Info  		20.00  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
JN0003
 Probe Info  		20.00  LDD0469  [20]
STS-1
 Probe Info  		N.A.  LDD0136  [21]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
A-DA
 Probe Info  		3.06  LDD0145  [22]
Alk-rapa
 Probe Info  		3.53  LDD0213  [23]
OEA-DA
 Probe Info  		3.69  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C330(1.82)  LDD2112  [5]
 LDCM0025  4SU-RNA HEK-293T C514(2.76)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C514(3.54); C501(3.31)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C211(0.95); C216(0.94); C330(1.14); C443(0.94)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C211(0.71); C216(0.86); C330(1.03)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C211(0.72); C216(0.73); C330(1.05); C443(0.54)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C211(0.72); C216(0.58); C330(0.95); C443(0.77)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C211(0.71); C216(0.62); C330(1.00); C443(0.92)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C211(0.69); C216(0.53); C330(0.93); C443(0.87)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C211(0.67); C216(0.51); C330(1.02); C443(0.77)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C211(0.60); C216(0.58); C330(0.97); C443(0.78)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C211(0.71); C216(0.55); C330(0.97); C443(1.09)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C211(0.72); C216(0.57); C330(1.04); C443(1.16)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C211(0.76); C216(0.77); C330(0.99); C443(0.87)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C211(0.81); C216(0.68); C330(0.97); C443(0.82)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C211(0.75); C216(0.89); C330(0.90)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C211(0.70); C216(0.68); C330(0.97); C443(1.11)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C211(0.77); C216(0.62); C330(0.96); C443(1.47)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C211(0.68); C216(0.54); C330(0.94); C443(0.89)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C211(1.07); C216(1.10); C330(0.98); C443(1.10)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C211(1.10); C216(0.96); C330(0.99); C443(0.93)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C211(1.00); C216(0.87); C330(0.98); C443(1.08)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C211(0.99); C216(0.96); C330(0.99); C443(1.11)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C211(0.94); C216(0.82); C330(1.11); C443(0.73)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C211(1.00); C216(0.88); C330(1.08); C443(0.76)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C211(1.17); C216(0.89); C330(1.03); C443(0.85)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C211(0.98); C216(0.98); C330(1.10)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C211(1.07); C216(0.89); C330(1.03); C443(0.80)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C211(1.01); C216(0.76); C330(1.24); C443(0.98)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C211(0.91); C216(0.77); C330(1.17); C443(1.17)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C211(0.97); C216(0.68); C330(1.27); C443(1.14)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C211(1.08); C216(0.91); C330(1.20); C443(1.02)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C211(1.13); C216(0.99); C330(1.16); C443(1.04)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C211(1.07); C216(1.00); C330(1.16); C443(0.95)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C211(1.14); C216(0.86); C330(1.13); C443(0.98)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C211(0.98); C216(1.21); C330(1.44); C443(0.76)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C211(1.19); C216(1.34); C330(1.41); C443(0.77)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C211(1.00); C216(1.15); C330(1.31); C443(0.64)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C211(1.12); C216(1.15); C330(1.30); C443(0.92)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C211(1.34); C216(1.42); C330(1.29); C443(0.88)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C211(1.01); C216(1.18); C330(1.35); C443(0.71)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C211(1.13); C216(1.03); C330(1.17); C443(0.76)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C211(1.07); C216(1.18); C330(1.26); C443(0.79)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C211(1.08); C216(1.05); C330(1.21); C443(0.83)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C211(1.21); C216(1.12); C330(1.37); C443(0.83)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C211(1.16); C216(0.88); C330(1.22); C443(0.73)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C211(1.14); C216(1.10); C330(1.18); C443(0.83)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C211(0.62); C216(0.78); C330(0.85)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C211(1.15); C216(1.05); C330(1.13); C443(0.74)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C211(1.19); C216(1.01); C330(1.09); C443(0.91)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C211(1.18); C216(1.04); C330(1.30); C443(0.83)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C216(0.77); C330(0.81); C443(1.00)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C443(0.55); C216(0.58); C330(1.09)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C216(0.66); C443(0.70); C330(1.21)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C216(0.70); C443(0.72); C330(1.12)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C443(0.57); C216(0.57); C330(1.06)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C443(0.57); C216(0.69); C330(1.16)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C443(0.69); C216(0.69); C330(1.15)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C216(0.83); C211(0.94); C330(1.03)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C216(0.73); C443(0.78); C330(1.08)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C443(0.71); C216(0.79); C330(1.15)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C443(0.63); C216(0.67); C330(1.20)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C443(0.60); C216(0.71); C330(1.64)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C216(0.68); C330(1.13); C443(0.64)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C216(0.66); C330(1.22); C443(0.64)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C216(0.92); C330(1.21); C443(1.21)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C216(0.84); C330(1.18); C443(0.90)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C211(0.96); C216(1.05); C443(1.16); C330(1.24)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C211(0.79); C443(0.87); C216(0.96); C330(1.20)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C211(0.78); C443(0.93); C216(1.20); C330(1.29)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C216(1.01); C330(1.02); C443(1.07); C211(1.10)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C443(0.90); C211(0.95); C216(1.01); C330(1.28)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C211(0.77); C443(0.79); C216(0.89); C330(1.21)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C443(0.95); C211(0.99); C216(1.04); C330(1.36)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C443(0.85); C211(0.92); C216(1.05); C330(1.32)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C443(1.08); C211(1.14); C216(1.14); C330(1.33)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C330(0.78); C443(0.84); C211(0.90); C216(1.11)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C443(0.69); C211(0.86); C330(0.93); C216(0.98)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C443(0.70); C330(0.77); C211(0.78); C216(0.89)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C443(0.73); C211(0.81); C216(0.99); C330(1.00)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C443(0.70); C211(0.76); C216(0.84); C330(1.04)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C443(1.07); C216(1.11); C211(1.15); C330(1.17)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C443(0.73); C211(0.76); C216(0.82); C330(0.93)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C443(0.69); C211(0.79); C216(0.92); C330(0.95)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C443(0.69); C216(0.76); C211(0.85); C330(1.14)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C443(0.69); C211(0.71); C216(0.72); C330(0.87)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C443(0.64); C216(0.69); C330(0.80); C211(0.82)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C330(0.99); C443(1.04); C216(1.17); C211(1.29)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C443(0.84); C330(1.01); C211(1.05); C216(1.09)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C443(0.76); C211(0.91); C330(0.93); C216(1.11)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C443(0.90); C211(0.97); C330(0.98); C216(1.02)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C443(0.85); C330(0.98); C216(1.03); C211(1.16)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C211(1.03); C443(1.06); C216(1.08); C330(1.18)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C443(0.76); C216(0.91); C330(0.93); C211(0.95)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C443(0.84); C211(0.93); C330(0.94); C216(1.00)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C443(0.87); C211(0.90); C216(0.94); C330(0.97)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C211(0.86); C443(0.92); C330(0.98); C216(1.07)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C443(0.79); C211(0.88); C216(0.94); C330(1.09)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C443(0.84); C211(0.92); C330(0.95); C216(0.96)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C211(0.82); C443(0.93); C216(0.99); C330(1.07)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C211(0.90); C443(0.95); C330(1.07); C216(1.08)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C211(0.65); C443(0.96); C216(0.96); C330(1.06)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C211(0.75); C443(0.83); C216(0.90); C330(0.99)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C216(1.06); C211(1.06); C443(1.06); C330(1.17)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C211(0.74); C443(0.81); C216(0.88); C330(1.00)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C211(1.01); C443(1.01); C330(1.03); C216(1.21)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C443(0.90); C330(1.01); C211(1.02); C216(1.04)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C211(0.87); C443(0.90); C216(0.90); C330(0.99)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C211(0.80); C443(0.87); C216(0.96); C330(1.02)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C211(0.80); C330(0.92); C443(0.92); C216(0.93)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C211(0.68); C443(0.83); C216(0.86); C330(0.99)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C216(0.93); C443(1.01); C211(1.06); C330(1.11)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C216(0.75); C443(0.84); C330(0.96); C211(1.04)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C216(0.84); C443(0.92); C330(0.94); C211(1.14)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C216(0.74); C211(0.83); C330(0.91)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C216(0.73); C443(0.86); C211(0.92); C330(0.93)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C216(0.78); C443(0.85); C211(1.01); C330(1.05)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C216(0.81); C443(0.83); C211(0.99); C330(1.03)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C216(0.81); C330(1.11); C443(1.13); C211(1.33)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C443(0.74); C216(0.89); C330(1.06); C211(1.07)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C443(0.80); C211(0.92); C330(1.03); C216(1.13)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C211(0.85); C330(1.00); C216(1.13); C443(1.22)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C443(0.85); C216(0.90); C211(0.93); C330(1.02)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C211(0.79); C216(0.85); C443(0.89); C330(0.97)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C211(0.77); C443(0.87); C216(0.89); C330(1.10)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C216(0.92); C330(0.99); C211(0.99)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C211(0.76); C443(0.78); C330(0.91); C216(1.05)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C211(0.90); C330(0.93); C216(0.99); C443(1.23)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C211(0.77); C443(0.97); C216(0.99); C330(1.03)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C443(0.88); C211(0.95); C216(0.97); C330(1.06)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C330(0.83); C216(0.95); C443(0.98); C211(1.07)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C211(0.78); C330(0.85); C216(1.06); C443(1.06)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C330(0.92); C443(0.96); C211(1.12); C216(1.17)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C211(0.78); C330(0.84); C443(0.85); C216(0.89)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C216(0.82); C211(0.88); C330(0.92); C443(0.92)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C330(0.76); C211(0.82); C216(1.06); C443(1.18)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C330(0.81); C216(0.83); C211(0.90)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C330(0.85); C211(0.87); C443(0.89); C216(0.99)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C211(0.77); C216(1.05); C443(1.08); C330(1.20)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C211(0.79); C330(0.91); C216(0.94); C443(0.96)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C443(0.75); C216(0.87); C211(0.89); C330(0.93)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C443(0.70); C216(0.87); C330(0.95); C211(0.97)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C443(0.76); C216(0.90); C211(0.97); C330(0.97)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C443(0.86); C211(1.04); C330(1.07); C216(1.07)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C211(0.85); C330(1.00); C216(1.02); C443(1.08)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C211(0.95); C443(0.98); C330(1.03); C216(1.06)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C443(0.85); C211(0.88); C330(0.90); C216(0.99)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C330(0.90); C443(1.08); C211(1.12); C216(1.62)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C443(0.83); C211(0.88); C216(0.94); C330(0.99)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C443(0.65); C211(0.81); C216(1.01); C330(1.11)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C443(0.83); C211(0.89); C216(0.93); C330(1.11)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C443(0.84); C216(0.99); C211(1.04); C330(1.11)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C443(0.84); C211(0.84); C216(0.85); C330(0.99)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C443(0.85); C216(0.95); C211(0.98); C330(1.13)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C443(0.85); C211(0.85); C330(0.89); C216(0.95)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C216(0.50); C211(0.56); C443(0.64); C330(0.88)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C216(0.83); C211(0.93); C443(0.99); C330(1.00)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C211(1.01); C216(1.03); C330(1.11)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C330(0.84); C216(0.85); C211(0.94)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C211(0.60); C216(0.75); C330(1.02)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C216(1.25); C330(1.11)  LDD2171  [9]
 LDCM0108  Chloroacetamide HeLa C443(0.00); C330(0.00); C216(0.00); H34(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C216(1.31); C330(0.93)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C330(0.96); C211(0.99); C443(1.01); C216(1.06)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C443(0.73); C330(0.90); C211(0.92); C216(1.03)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C216(1.00); C443(1.00); C330(1.08); C211(1.09)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C330(0.77); C211(0.78); C216(0.87)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C330(0.82); C216(0.94); C211(0.96)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C211(0.91); C330(0.93); C216(0.97)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C330(0.80); C216(0.83); C211(0.95)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C211(0.75); C443(0.78); C216(0.91); C330(1.23)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C211(0.54); C443(0.76); C216(0.91); C330(1.38)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C211(0.71); C443(0.89); C216(0.93); C330(1.29)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C211(0.71); C216(0.92); C443(1.02); C330(1.35)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C211(0.74); C443(0.84); C216(0.87); C330(1.18)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C211(0.81); C443(0.81); C330(1.02); C216(1.02)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C211(0.65); C216(0.78); C443(0.90); C330(1.44)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C211(0.78); C443(0.85); C216(0.88); C330(1.26)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C443(0.92); C211(0.96); C216(1.01); C330(1.06)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C443(0.68); C211(0.75); C216(0.76); C330(0.98)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C443(0.74); C216(0.74); C211(0.83); C330(0.91)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C216(0.79); C443(0.79); C330(0.87); C211(0.87)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C216(0.75); C443(0.82); C211(0.83); C330(0.94)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C443(0.89); C216(0.89); C330(1.03); C211(1.09)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C443(0.86); C211(0.91); C330(0.95); C216(1.05)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C211(0.89); C443(0.97); C330(1.00); C216(1.13)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C211(0.88); C443(0.96); C330(1.07); C216(1.26)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C443(0.94); C330(0.98); C211(1.00); C216(1.19)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C443(0.71); C211(0.72); C330(0.86); C216(1.06)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C211(0.73); C443(0.76); C216(0.78); C330(1.02)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C211(0.71); C216(0.87); C443(0.92); C330(0.92)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C216(0.87); C211(0.87); C443(0.91); C330(0.94)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C330(0.99); C211(1.06); C216(1.08); C443(1.21)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C216(0.93); C330(0.94); C211(0.98); C443(1.58)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C330(0.97); C443(0.97); C216(0.98); C211(0.99)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C216(0.96); C211(0.97); C330(1.02); C443(1.06)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C443(0.83); C211(0.84); C216(0.89); C330(0.99)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C443(0.86); C216(0.98); C211(0.98); C330(1.00)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C443(0.79); C216(0.92); C330(0.98); C211(0.98)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C443(0.76); C211(0.88); C330(0.91); C216(0.97)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C211(0.75); C443(0.79); C330(0.87); C216(1.23)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C211(0.63); C443(0.75); C330(0.90); C216(1.05)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C443(0.77); C211(0.83); C330(0.95); C216(1.12)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C330(1.04); C443(1.06); C216(1.10); C211(1.14)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C211(0.61); C443(0.74); C330(1.01); C216(1.04)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C211(0.61); C443(0.72); C330(0.98); C216(1.17)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C211(0.72); C216(0.76); C443(0.81); C330(1.08)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C211(0.73); C216(0.77); C443(0.90); C330(0.95)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C443(0.73); C211(0.78); C330(0.95); C216(1.17)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C211(0.88); C216(1.15); C330(0.93); C443(0.82)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C211(0.83); C216(0.93); C330(0.99); C443(0.79)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C211(0.85); C216(1.22); C330(1.05); C443(0.81)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C211(0.69); C216(1.33); C330(0.91); C443(0.83)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C211(0.64); C216(1.23); C330(0.98); C443(0.82)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C211(1.05); C216(1.09); C330(0.99); C443(0.94)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C211(1.09); C216(1.34); C330(0.99); C443(0.92)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C211(0.84); C216(1.29); C330(1.00); C443(1.02)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C211(0.66); C216(1.04); C330(0.96); C443(0.69)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C211(0.59); C216(0.96); C330(0.89); C443(0.72)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C211(0.68); C216(1.00); C330(0.97); C443(0.82)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C211(0.74); C216(1.04); C330(0.99); C443(0.76)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C211(0.73); C216(0.90); C330(1.00); C443(0.86)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C211(0.74); C216(0.99); C330(1.01); C443(0.79)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C211(0.72); C216(1.00); C330(1.01); C443(0.89)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C211(0.85); C216(0.93); C330(0.94); C443(0.86)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C211(0.80); C216(1.01); C330(0.93); C443(0.71)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C211(0.73); C216(0.86); C330(0.99); C443(0.89)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C211(0.76); C216(0.87); C330(1.13); C443(0.73)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C211(0.67); C216(1.27); C330(1.01); C443(0.88)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C211(0.64); C216(1.29); C330(0.95); C443(0.78)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C211(0.66); C216(1.33); C330(0.99); C443(0.77)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C211(1.40); C216(1.09); C330(1.11)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C211(1.35); C216(0.96); C330(1.04)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C211(1.25); C216(0.89); C330(1.02)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C211(1.15); C216(1.51); C330(1.00)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C211(1.04); C216(1.13); C330(1.01); C443(0.87)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C211(1.25); C216(1.00); C330(1.01)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C211(1.27); C216(1.35); C330(1.06)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C211(1.04); C216(1.08); C330(1.16)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C211(1.16); C216(0.63); C330(1.09)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C211(1.24); C216(0.95); C330(1.11)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C211(1.25); C216(1.11); C330(1.11)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C211(1.08); C216(0.90); C330(1.08)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C211(1.13); C216(0.89); C330(1.03)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C211(1.20); C216(1.11); C330(1.05)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C211(1.19); C216(1.18); C330(1.12)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C211(0.84); C216(0.96); C330(0.90); C443(0.84)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C211(1.17); C216(1.16); C330(1.17)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C211(0.92); C216(0.84); C330(1.09); C443(0.84)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C211(0.85); C216(0.95); C330(0.98); C443(0.86)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C211(0.76); C216(0.65); C330(0.91); C443(0.78)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C211(0.78); C216(0.95); C330(1.00); C443(0.73)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C211(0.89); C216(0.95); C330(1.03); C443(0.90)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C211(0.64); C216(0.85); C330(0.99); C443(0.65)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C211(0.69); C216(0.76); C330(0.88); C443(0.72)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C211(0.62); C216(0.56); C330(0.96); C443(0.66)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C211(0.57); C216(0.70); C330(0.97); C443(0.67)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C211(0.88); C216(1.18); C330(1.00); C443(0.95)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C211(0.69); C216(0.85); C330(1.09); C443(0.71)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C211(0.81); C216(0.80); C330(1.10); C443(0.75)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C211(0.93); C216(0.76); C330(1.15); C443(0.93)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C211(0.82); C216(0.84); C330(1.03); C443(0.66)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C211(0.77); C216(0.80); C330(1.08); C443(0.71)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C211(0.89); C216(0.79); C330(1.08)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C211(0.86); C216(0.78); C330(1.13)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C211(0.88); C216(0.83); C330(1.08)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C211(0.95); C216(0.83); C330(1.19)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C211(0.95); C216(0.79); C330(0.96); C443(0.84)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C211(0.88); C216(0.79); C330(1.15)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C211(1.01); C216(0.88); C330(1.17)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C211(0.82); C216(1.06); C330(1.38)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C211(0.85); C216(0.87); C330(1.19)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C211(0.79); C216(0.73); C330(1.07)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C211(0.86); C216(0.87); C330(1.16)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C211(1.13); C216(0.94); C330(1.18)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C211(0.96); C216(1.08); C330(1.19)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C211(0.96); C216(0.95); C330(1.13)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C211(0.92); C216(0.77); C330(1.17)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C211(0.98); C216(0.97); C330(1.04); C443(0.96)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C211(1.31); C216(0.89); C330(1.08)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C211(1.04); C216(0.88); C330(1.03); C443(0.89)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C211(1.06); C216(0.86); C330(1.03); C443(1.08)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C211(1.04); C216(1.02); C330(1.17); C443(1.02)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C211(0.94); C216(0.85); C330(1.02); C443(0.90)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C211(0.88); C216(0.87); C330(0.97); C443(0.87)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C211(1.05); C216(0.91); C330(1.07); C443(1.00)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C211(1.01); C216(0.90); C330(1.02); C443(0.94)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C211(1.02); C216(0.89); C330(1.12); C443(0.96)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C211(1.02); C216(0.94); C330(1.13); C443(1.01)  LDD0811  [9]
 LDCM0634  CY-0357 Hep-G2 C330(0.41)  LDD2228  [13]
 LDCM0028  Dobutamine HEK-293T 15.79  LDD0180  [4]
 LDCM0027  Dopamine HEK-293T 8.38  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C216(0.83); C330(0.94); C314(1.14); C443(0.98)  LDD1698  [25]
 LDCM0175  Ethacrynic acid HeLa C330(0.97)  LDD2210  [8]
 LDCM0625  F8 Ramos C330(1.43); C443(0.92)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C443(0.97)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C330(20.00); C443(15.14)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C443(1.40)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C330(1.38); C443(0.93)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C330(3.53); C443(1.15)  LDD2193  [26]
 LDCM0580  Fragment21 Ramos C330(1.58); C443(0.82)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C443(0.67)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C443(0.70)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C330(0.58); C443(1.86)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C443(1.00)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C330(1.63); C443(0.96)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C443(1.22)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C211(0.74); C216(0.78); C330(0.98); C443(0.77)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C330(0.91); C443(1.01)  LDD2203  [26]
 LDCM0427  Fragment51 HCT 116 C211(0.77); C216(0.99); C330(1.02); C443(0.73)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C330(1.46); C443(1.25)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C330(0.97); C443(0.87)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C330(1.80); C443(1.06)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C443(1.66)  LDD2188  [26]
 LDCM0107  IAA HeLa C443(0.00); C330(0.00); H34(0.00); H477(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C330(1.13)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C330(0.90)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C330(1.23)  LDD0082  [9]
 LDCM0109  NEM HeLa H34(0.00); H477(0.00)  LDD0223  [16]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C6(0.87)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C6(1.13)  LDD2094  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C6(0.69)  LDD2108  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C6(1.15)  LDD2127  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C330(1.01)  LDD2207  [27]
 LDCM0014  Panhematin HEK-293T 3.45  LDD0062  [7]
 LDCM0131  RA190 MM1.R C443(1.28)  LDD0304  [28]
 LDCM0090  Rapamycin JHH-7 3.53  LDD0213  [23]
 LDCM0084  Ro 48-8071 A-549 3.06  LDD0145  [22]
 LDCM0021  THZ1 HCT 116 C216(1.25); C330(1.11)  LDD2173  [9]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
23 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.