Details of the Target

General Information of Target

Target ID LDTP14099
Target Name Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22)
Gene Name TIMM22
Gene ID 29928
Synonyms
TEX4; TIM22; Mitochondrial import inner membrane translocase subunit Tim22; Testis-expressed protein 4
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHE
VSVPYAMNLLNGIKLYGRPIKIQFRSGSSHAPQDVSLSYPQHHVGNSSPTSTSPSRYERT
MDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHS
FNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDR
NHDDWSHDYDNRRDSSRDGKWRSSRH
Target Bioclass
Transporter and channel
Family
Tim17/Tim22/Tim23 family
Subcellular location
Mitochondrion inner membrane
Function
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Uniprot ID
Q9Y584
Ensemble ID
ENST00000327158.5
HGNC ID
HGNC:17317

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K112(7.69)  LDD0277  [1]
BTD
 Probe Info  		C69(0.77)  LDD2127  [2]
DBIA
 Probe Info  		C160(0.90)  LDD0580  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
PAL-AfBPP Probe
Click To Hide/Show 70 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.28  LDD1714  [5]
C007
 Probe Info  		6.36  LDD1716  [5]
C039
 Probe Info  		6.36  LDD1739  [5]
C040
 Probe Info  		32.22  LDD1740  [5]
C041
 Probe Info  		15.03  LDD1741  [5]
C051
 Probe Info  		5.13  LDD1749  [5]
C053
 Probe Info  		8.11  LDD1751  [5]
C055
 Probe Info  		24.76  LDD1752  [5]
C056
 Probe Info  		48.17  LDD1753  [5]
C063
 Probe Info  		25.81  LDD1760  [5]
C095
 Probe Info  		16.22  LDD1786  [5]
C100
 Probe Info  		13.18  LDD1789  [5]
C106
 Probe Info  		55.72  LDD1793  [5]
C107
 Probe Info  		16.45  LDD1794  [5]
C108
 Probe Info  		22.01  LDD1795  [5]
C112
 Probe Info  		48.50  LDD1799  [5]
C129
 Probe Info  		26.17  LDD1811  [5]
C130
 Probe Info  		15.45  LDD1812  [5]
C177
 Probe Info  		19.84  LDD1856  [5]
C178
 Probe Info  		99.73  LDD1857  [5]
C210
 Probe Info  		99.73  LDD1884  [5]
C211
 Probe Info  		14.62  LDD1885  [5]
C213
 Probe Info  		27.10  LDD1887  [5]
C229
 Probe Info  		13.36  LDD1902  [5]
C231
 Probe Info  		49.18  LDD1904  [5]
C232
 Probe Info  		68.59  LDD1905  [5]
C233
 Probe Info  		31.34  LDD1906  [5]
C234
 Probe Info  		21.11  LDD1907  [5]
C235
 Probe Info  		52.71  LDD1908  [5]
C238
 Probe Info  		31.78  LDD1911  [5]
C240
 Probe Info  		13.36  LDD1913  [5]
C258
 Probe Info  		5.24  LDD1931  [5]
C264
 Probe Info  		39.40  LDD1935  [5]
C265
 Probe Info  		21.56  LDD1936  [5]
C266
 Probe Info  		9.32  LDD1937  [5]
C269
 Probe Info  		6.06  LDD1939  [5]
C270
 Probe Info  		10.13  LDD1940  [5]
C285
 Probe Info  		64.89  LDD1955  [5]
C286
 Probe Info  		5.06  LDD1956  [5]
C287
 Probe Info  		24.59  LDD1957  [5]
C288
 Probe Info  		16.80  LDD1958  [5]
C289
 Probe Info  		99.73  LDD1959  [5]
C290
 Probe Info  		7.57  LDD1960  [5]
C293
 Probe Info  		39.95  LDD1963  [5]
C296
 Probe Info  		28.64  LDD1966  [5]
C297
 Probe Info  		4.92  LDD1967  [5]
C322
 Probe Info  		14.52  LDD1988  [5]
C326
 Probe Info  		16.22  LDD1990  [5]
C348
 Probe Info  		30.91  LDD2009  [5]
C349
 Probe Info  		50.91  LDD2010  [5]
C350
 Probe Info  		99.73  LDD2011  [5]
C353
 Probe Info  		7.67  LDD2014  [5]
C354
 Probe Info  		10.06  LDD2015  [5]
C362
 Probe Info  		99.73  LDD2023  [5]
C363
 Probe Info  		46.53  LDD2024  [5]
C364
 Probe Info  		50.91  LDD2025  [5]
C366
 Probe Info  		22.16  LDD2027  [5]
C367
 Probe Info  		11.88  LDD2028  [5]
C383
 Probe Info  		23.43  LDD2042  [5]
C386
 Probe Info  		14.22  LDD2045  [5]
C388
 Probe Info  		99.73  LDD2047  [5]
C389
 Probe Info  		5.54  LDD2048  [5]
C405
 Probe Info  		9.65  LDD2063  [5]
C407
 Probe Info  		70.52  LDD2064  [5]
C408
 Probe Info  		6.82  LDD2065  [5]
C409
 Probe Info  		11.63  LDD2066  [5]
C429
 Probe Info  		43.11  LDD2084  [5]
C431
 Probe Info  		51.98  LDD2086  [5]
C433
 Probe Info  		5.62  LDD2088  [5]
OEA-DA
 Probe Info  		20.00  LDD0046  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C69(0.97)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C69(1.07)  LDD1508  [7]
 LDCM0216  AC100 HEK-293T C69(0.49)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C69(0.89)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C69(0.58)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C69(0.49)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C69(0.53)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C69(0.81)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C69(1.15)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C69(0.55)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C69(0.97)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C69(0.59)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C69(0.91)  LDD1509  [7]
 LDCM0227  AC110 HEK-293T C69(0.52)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C69(0.64)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C69(0.53)  LDD0827  [3]
 LDCM0237  AC12 HEK-293T C69(1.04)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C160(1.10)  LDD1512  [7]
 LDCM0263  AC143 HCT 116 C160(0.90)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C160(0.99)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C160(1.27)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C160(1.07)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C160(1.04)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C160(1.36)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C160(1.08)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C160(0.99)  LDD1513  [7]
 LDCM0271  AC150 HCT 116 C160(0.83)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C160(0.91)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C160(0.95)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C160(1.25)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C160(1.05)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C160(1.14)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C160(1.11)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C160(1.08)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C160(1.09)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C160(0.95)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C160(0.81)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C69(1.05)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C160(0.95)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C160(0.93)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C160(0.92)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C160(0.86)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C160(1.05)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C160(1.48)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C160(1.16)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C160(1.22)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C160(1.03)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C160(1.37)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C69(0.94)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C160(1.47)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C160(1.52)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C160(1.31)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C160(1.29)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C160(1.66)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C69(0.91)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C69(1.02)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C69(1.15)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C160(0.97)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C160(1.05)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C69(1.19)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C69(0.87); C160(0.99)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C69(0.97)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C69(0.94)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C69(0.95)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C69(1.18)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C69(1.01)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C160(1.05)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C160(1.45)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C69(0.78); C160(1.12)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C69(0.83)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C69(1.13)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C69(1.03)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C69(0.95)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C69(1.09)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C69(1.09)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C160(1.14)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C160(1.14)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C69(0.90); C160(1.04)  LDD1558  [7]
 LDCM0320  AC57 HCT 116 C160(1.13)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C160(0.88)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C160(0.88)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C160(1.24)  LDD1562  [7]
 LDCM0324  AC60 HCT 116 C160(0.86)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C160(0.82)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C160(0.84)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C160(0.88)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C160(0.88)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C160(0.94)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C160(0.91)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C160(0.78)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C160(1.25)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C160(1.48)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C160(1.01)  LDD1568  [7]
 LDCM0335  AC70 HCT 116 C160(1.22)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C160(1.33)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C160(1.16)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C160(1.30)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C160(1.14)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C160(1.17)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C160(1.14)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C160(1.25)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C160(1.21)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C160(1.22)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C69(0.87); C160(1.07)  LDD1569  [7]
 LDCM0346  AC80 HCT 116 C160(1.34)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C160(1.09)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C160(1.13)  LDD0665  [3]
 LDCM0365  AC98 HEK-293T C69(0.58)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C69(0.53)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C69(1.08)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C69(0.95)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C69(0.83); C160(1.02)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C160(1.24); C69(0.74)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C160(0.97); C69(0.43)  LDD0966  [3]
 LDCM0370  CL101 HEK-293T C69(1.01); C160(1.04)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C69(1.09)  LDD1575  [7]
 LDCM0374  CL105 HCT 116 C160(1.09)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C160(1.02)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C160(0.94)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C160(1.11)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C160(1.01)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C160(1.04); C69(0.42)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C160(1.10)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C160(0.97)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C160(1.36)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C160(1.33)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C160(1.13)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C160(1.67)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C160(1.67)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C69(0.99); C160(1.03)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C69(1.15)  LDD1592  [7]
 LDCM0390  CL12 HEK-293T C160(1.11); C69(0.86)  LDD0988  [3]
 LDCM0392  CL121 HEK-293T C69(1.01); C160(1.05)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C69(1.07)  LDD1597  [7]
 LDCM0396  CL125 HCT 116 C160(1.21)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C160(1.08)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C160(0.81)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C160(1.06)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C160(1.26); C69(0.60)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C160(1.39); C69(0.54)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C160(1.08); C69(0.47)  LDD1000  [3]
 LDCM0404  CL17 HEK-293T C69(1.00)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C69(0.88)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C69(0.78)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C160(1.10); C69(0.60)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C69(0.86)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C69(0.63)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C160(1.12)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C160(0.73)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C69(1.13); C160(1.03)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C69(1.24); C160(1.20)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C69(1.07)  LDD1618  [7]
 LDCM0417  CL29 HEK-293T C69(0.89)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C160(1.10); C69(0.75)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C69(0.98)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C69(0.80)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C69(0.91)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C69(0.63)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C160(1.12)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C160(0.62)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C69(1.17); C160(1.06)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C69(1.03); C160(0.92)  LDD1630  [7]
 LDCM0429  CL4 HEK-293T C160(1.09); C69(0.54)  LDD1027  [3]
 LDCM0431  CL41 HEK-293T C69(0.91)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C69(0.93)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C69(0.82)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C69(0.98)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C69(0.71)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C160(0.93)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C160(0.57)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C69(1.01); C160(0.93)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C69(1.05); C160(0.95)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C160(1.30); C69(0.68)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C69(1.29)  LDD1645  [7]
 LDCM0444  CL53 HEK-293T C69(0.90)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C69(0.95)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C69(0.75)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C69(0.97)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C69(0.75)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C160(1.12)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C160(0.70)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C160(1.34); C69(0.59)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C69(0.97); C160(0.97)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C69(1.12); C160(1.06)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C69(1.07)  LDD1657  [7]
 LDCM0457  CL65 HEK-293T C69(1.02)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C69(0.92)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C69(0.80)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C69(0.89)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C69(0.74)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C160(1.23); C69(0.46)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C160(0.79)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C160(0.65)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C69(1.08); C160(0.93)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C69(1.08); C160(0.97)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C69(1.24)  LDD1670  [7]
 LDCM0470  CL77 HEK-293T C69(0.98)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C69(1.00)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C69(0.93)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C160(0.65)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C69(1.02)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C69(0.78)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C160(1.10)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C160(0.78)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C69(1.04); C160(1.02)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C69(1.08); C160(1.04)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C69(1.31)  LDD1683  [7]
 LDCM0483  CL89 HEK-293T C69(0.89)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C160(0.64)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C69(0.86)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C69(1.03)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C69(1.03)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C69(0.93)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C160(1.03)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C160(0.87)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C69(0.81); C160(0.84)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C69(1.14); C160(1.04)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C69(1.22)  LDD1696  [7]
 LDCM0625  F8 Ramos C179(1.05)  LDD2187  [8]
 LDCM0566  Fragment4 Ramos C179(0.84)  LDD2184  [8]
 LDCM0427  Fragment51 HEK-293T C69(1.21)  LDD1631  [7]
 LDCM0569  Fragment7 Ramos C179(1.06)  LDD2186  [8]
 LDCM0022  KB02 A2058 C69(2.41)  LDD2253  [9]
 LDCM0023  KB03 Hs 936.T C160(2.67)  LDD2780  [9]
 LDCM0024  KB05 COLO792 C160(3.02)  LDD3310  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C69(0.77)  LDD2127  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C69(0.28)  LDD2141  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840