Details of the Target

General Information of Target

Target ID LDTP06511
Target Name Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH)
Gene Name ETFDH
Gene ID 2110
Synonyms
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; ETF-QO; ETF-ubiquinone oxidoreductase; EC 1.5.5.1; Electron-transferring-flavoprotein dehydrogenase; ETF dehydrogenase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVPLAKLSCLAYQCFHALKIKKNYLPLCATRWSSTSTVPRITTHYTIYPRDKDKRWEGV
NMERFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLD
PGAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLV
SWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAK
VTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLD
RHTYGGSFLYHLNEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIA
YGARALNEGGFQSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTS
ENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRG
MEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLTLR
DDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINAQNCVHCKTCDIKDPSQN
INWVVPEGGGGPAYNGM
Target Bioclass
Enzyme
Family
ETF-QO/FixC family
Subcellular location
Mitochondrion inner membrane
Function Accepts electrons from ETF and reduces ubiquinone.
Uniprot ID
Q16134
Ensemble ID
ENST00000307738.5
HGNC ID
HGNC:3483

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P332L DBIA    Probe Info 
HT115 SNV: p.I601S .
KYM1 SNV: p.D596H DBIA    Probe Info 
LS123 SNV: p.A6T .
MEWO SNV: p.A6T DBIA    Probe Info 
MFE319 SNV: p.K23N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K153(6.79); K489(4.01)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C586(0.85); C589(0.85)  LDD0078  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C266(0.00); C561(0.00); C248(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C266(0.00); C561(0.00); C248(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C118(0.00); C561(0.00); C266(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		C266(0.00); C561(0.00)  LDD0148  [7]
NAIA_5
 Probe Info  		C118(0.00); C266(0.00); C502(0.00); C387(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		7.36  LDD1761  [8]
C094
 Probe Info  		26.91  LDD1785  [8]
C106
 Probe Info  		49.52  LDD1793  [8]
C129
 Probe Info  		6.45  LDD1811  [8]
C134
 Probe Info  		67.65  LDD1816  [8]
C160
 Probe Info  		22.47  LDD1840  [8]
C161
 Probe Info  		9.78  LDD1841  [8]
C163
 Probe Info  		15.56  LDD1843  [8]
C225
 Probe Info  		8.75  LDD1898  [8]
C277
 Probe Info  		22.32  LDD1947  [8]
C288
 Probe Info  		6.96  LDD1958  [8]
C343
 Probe Info  		34.54  LDD2005  [8]
C366
 Probe Info  		5.24  LDD2027  [8]
C367
 Probe Info  		8.28  LDD2028  [8]
C376
 Probe Info  		13.09  LDD2036  [8]
C380
 Probe Info  		6.19  LDD2039  [8]
C387
 Probe Info  		8.75  LDD2046  [8]
C407
 Probe Info  		13.36  LDD2064  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]
OEA-DA
 Probe Info  		7.16  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C248(0.99); C266(1.01); C118(1.07); C561(1.00)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C248(1.02); C266(1.04); C118(1.06); C561(1.10)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C248(0.91); C266(0.94); C118(0.92); C561(0.97)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C248(1.03); C266(0.94); C118(0.94); C561(0.84)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C248(0.96); C266(1.00); C118(0.84); C561(0.97)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C248(0.90); C266(1.01); C118(0.97); C561(0.99)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C248(0.98); C266(0.96); C118(1.07); C561(1.06)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C248(1.01); C266(0.96); C118(1.05); C561(1.12)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C248(0.92); C266(0.84); C118(0.78); C561(1.03)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C248(1.03); C266(1.01); C118(1.04); C561(0.98)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C248(1.01); C266(1.02); C118(1.03); C561(0.96)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C248(0.98); C266(0.98); C118(0.95); C561(1.10)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C248(1.04); C266(1.01); C118(0.90); C561(1.02)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C248(0.95); C266(0.99); C118(1.01); C561(0.98)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C248(1.04); C266(1.07); C118(0.99); C561(1.12)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C248(0.95); C266(1.07); C118(1.02); C561(1.16)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C248(0.98); C266(1.07); C118(1.00); C561(0.97)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C248(0.97); C266(0.97); C118(0.97); C561(0.93)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C248(1.10); C266(0.93); C118(0.97); C561(1.30)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C248(0.96); C266(0.98); C118(0.98); C561(1.03)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C248(0.94); C266(1.01); C118(0.94); C561(1.00)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C248(0.98); C266(1.03); C118(0.93); C561(1.02)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C248(0.96); C266(0.97); C118(1.01); C561(0.99)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C248(0.99); C266(1.06); C118(1.06); C561(1.11)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C248(0.97); C266(0.99); C118(1.00); C561(1.06)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C248(0.94); C266(1.07); C118(1.08); C561(1.06)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C248(0.87); C266(0.96); C118(0.93); C561(1.00)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C248(1.06); C266(0.98); C118(1.00); C561(0.96)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C248(1.06); C266(1.03); C118(0.93); C561(1.11)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C248(0.93); C266(1.02); C118(0.93); C561(0.96)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C248(0.92); C266(0.99); C118(0.98); C561(0.90)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C248(1.05); C266(0.96); C118(1.04); C561(0.81)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C248(0.97); C266(0.97); C118(1.04); C561(1.01)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C248(0.93); C266(1.01); C118(1.03); C561(1.05)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C248(0.94); C266(0.99); C118(1.13); C561(1.22)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C248(0.81); C266(0.92); C118(0.95); C561(0.98)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C248(0.99); C266(0.98); C118(0.96); C561(1.00)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C248(0.96); C266(1.02); C118(1.05); C561(1.11)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C248(1.01); C266(0.98); C118(0.96); C561(0.94)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C248(0.87); C266(0.99); C118(1.00); C561(1.21)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C248(0.98); C266(0.99); C118(1.00); C561(1.22)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C248(0.92); C266(0.97); C118(1.02); C561(1.23)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C248(1.01); C266(1.05); C118(1.01); C561(1.04)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C248(0.98); C266(1.07); C118(1.08); C561(1.03)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C248(0.98); C266(0.99); C118(0.94); C561(1.00)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C248(1.06); C266(0.98); C118(1.04); C561(1.04)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C248(0.97); C266(0.96); C118(0.96); C561(1.09)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C248(0.97); C266(1.04); C118(0.96); C561(0.99)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C248(0.88); C266(1.00); C118(0.98); C561(0.94)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C248(0.99); C266(0.96); C118(0.94); C561(1.05)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C248(0.96); C266(1.01); C118(1.01); C561(1.06)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C248(0.98); C266(1.04); C118(1.05); C561(1.09)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C248(0.88); C266(1.01); C118(0.92); C561(1.09)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C248(0.96); C266(1.02); C118(0.96); C561(1.00)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C248(1.02); C266(0.96); C118(1.03); C561(1.37)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C248(0.93); C266(1.01); C118(0.98); C561(1.00)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C248(0.95); C266(1.01); C118(0.96); C561(1.02)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C248(0.92); C266(0.95); C118(0.99); C561(1.00)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C248(1.03); C266(0.96); C118(1.03); C561(0.98)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C248(0.89); C266(1.03); C118(1.00); C561(0.96)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C248(0.98); C266(1.00); C118(1.02); C561(1.10)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C248(0.92); C266(0.98); C118(0.89); C561(1.00)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C248(0.93); C266(1.04); C118(1.02); C561(1.02)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C248(0.96); C266(0.96); C118(0.99); C561(0.90)  LDD1514  [11]
 LDCM0020  ARS-1620 HCC44 C586(0.85); C589(0.85)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C248(1.04); C266(1.04); C118(0.95); C561(0.99)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C248(0.86); C266(0.93); C118(0.94); C561(1.01)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C248(0.98); C266(0.95); C118(1.04); C561(1.03)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C248(1.04); C266(1.00); C118(0.96); C561(0.99)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C248(0.91); C266(0.96); C118(0.89); C561(1.13)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C248(1.00); C266(1.04); C118(0.93); C561(0.96)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C248(0.84); C266(1.03); C118(1.05); C561(1.13)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C248(0.97); C266(0.88); C118(0.96); C561(0.94)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C248(0.92); C266(0.93); C118(0.98); C561(1.01)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C248(1.00); C266(1.01); C118(0.98); C561(1.13)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C248(0.93); C266(0.97); C118(1.01); C561(1.17)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C248(0.94); C266(1.00); C118(0.97); C561(0.86)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C248(0.85); C266(1.06); C118(0.90); C561(0.93)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C248(0.91); C266(0.90); C118(0.97); C561(0.93)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C248(0.94); C266(0.98); C118(0.96); C561(0.97)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C248(0.83); C266(0.99); C118(0.97); C561(1.08)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C248(1.01); C266(0.96); C118(1.02); C561(0.90)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C248(0.91); C266(0.83); C118(0.94); C561(0.84)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C248(1.04); C266(1.07); C118(1.00); C561(1.19)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C248(0.90); C266(1.04); C118(1.07); C561(0.94)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C248(1.03); C266(0.94); C118(0.99); C561(1.08)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C248(0.96); C266(0.94); C118(0.91); C561(1.05)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C248(1.05); C266(1.07); C118(0.97); C561(1.04)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C248(0.96); C266(1.12); C118(0.88); C561(0.89)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C248(0.92); C266(0.94); C118(1.07); C561(0.93)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C248(0.99); C266(0.96); C118(1.01); C561(1.02)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C248(0.95); C266(0.96); C118(0.92); C561(0.80)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C248(0.89); C266(0.94); C118(0.88); C561(1.00)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C248(0.83); C266(1.06); C118(1.02); C561(1.05)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C248(0.99); C266(1.00); C118(1.00); C561(0.89)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C248(1.04); C266(0.92); C118(0.94); C561(1.00)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C248(1.11); C266(0.97); C118(0.96); C561(1.14)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C248(0.89); C266(1.00); C118(1.04); C561(0.99)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C248(1.01); C266(1.12); C118(0.96); C561(0.99)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C248(0.95); C266(0.94); C118(0.95); C561(0.94)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C248(0.91); C266(1.00); C118(0.89); C561(0.95)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C248(0.85); C266(1.05); C118(1.02); C561(1.09)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C248(0.86); C266(1.00); C118(0.90); C561(1.00)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C248(0.98); C266(1.12); C118(0.98); C561(1.09)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C248(0.80); C266(1.02); C118(0.88); C561(1.10)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C248(0.97); C266(1.02); C118(1.01); C561(1.20)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C248(1.07); C266(1.17); C118(0.91); C561(1.01)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C248(0.89); C266(1.01); C118(0.77); C561(1.02)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C248(0.94); C266(1.09); C118(0.88); C561(0.94)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C248(0.90); C266(1.05); C118(0.90); C561(0.89)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C248(0.97); C266(1.00); C118(0.92); C561(0.98)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C248(0.98); C266(1.01); C118(1.04); C561(0.88)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C248(0.93); C266(1.07); C118(0.97); C561(1.16)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C248(1.04); C266(1.03); C118(0.96); C561(1.20)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C248(0.78); C266(1.04); C118(0.96); C561(1.13)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C248(0.91); C266(1.03); C118(1.00); C561(1.09)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C248(0.99); C266(1.03); C118(0.95); C561(1.14)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C248(0.97); C266(1.06); C118(0.97); C561(0.98)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C248(0.91); C266(0.97); C118(0.85); C561(1.02)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C248(1.06); C266(1.10); C118(0.94); C561(1.30)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C248(0.93); C266(0.88); C118(0.84); C561(1.02)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C248(0.90); C266(0.99); C118(0.86); C561(1.00)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C248(0.94); C266(1.07); C118(0.93); C561(1.09)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C248(0.92); C266(0.99); C118(0.86); C561(0.99)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C248(0.96); C266(0.99); C118(1.12); C561(0.95)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C248(1.10); C266(0.99); C118(0.94); C561(1.25)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C248(0.91); C266(1.03); C118(0.92); C561(0.89)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C248(0.93); C266(1.09); C118(0.95); C561(1.08)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C248(0.97); C266(0.93); C118(1.02); C561(1.03)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C248(0.90); C266(1.04); C118(0.99); C561(0.90)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C248(0.87); C266(0.98); C118(0.82); C561(0.93)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C248(0.98); C266(0.99); C118(0.85); C561(1.05)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C248(0.86); C266(0.93); C118(0.86); C561(1.09)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C248(1.00); C266(1.06); C118(0.91); C561(0.92)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C248(0.95); C266(1.00); C118(0.92); C561(1.03)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C248(0.95); C266(0.99); C118(0.92); C561(0.99)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C248(1.05); C266(0.99); C118(1.00); C561(0.92)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C248(0.98); C266(1.06); C118(0.94); C561(1.11)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C248(1.01); C266(0.93); C118(0.91); C561(0.92)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C248(0.89); C266(0.97); C118(1.06); C561(0.98)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C248(0.91); C266(0.95); C118(0.88); C561(1.02)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C248(0.81); C266(0.87); C118(0.83); C561(0.92)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C248(0.91); C266(1.00); C118(0.91); C561(0.91)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C248(1.02); C266(0.99); C118(0.88); C561(1.07)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C248(0.84); C266(0.85); C118(0.73); C561(1.04)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C248(0.83); C266(0.91); C118(0.76); C561(1.00)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C248(0.91); C266(0.99); C118(0.89); C561(0.98)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C248(0.91); C266(1.03); C118(0.87); C561(0.95)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C248(0.86); C266(0.90); C118(0.86); C561(0.99)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C248(1.13); C266(1.10); C118(1.02); C561(0.95)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C248(1.02); C266(1.05); C118(1.00); C561(1.03)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C248(1.07); C266(1.07); C118(0.92); C561(1.05)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C248(0.83); C266(1.04); C118(0.99); C561(1.03)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C248(0.94); C266(1.07); C118(0.95); C561(1.08)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C248(0.90); C266(1.09); C118(0.99); C561(1.12)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C248(0.90); C266(0.93); C118(0.89); C561(0.97)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C248(1.06); C266(0.94); C118(0.83); C561(0.85)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C248(0.89); C266(0.91); C118(0.81); C561(1.01)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C248(0.92); C266(1.03); C118(0.85); C561(1.00)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C248(1.00); C266(1.05); C118(0.87); C561(0.97)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C248(0.94); C266(1.03); C118(0.89); C561(1.13)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C248(0.99); C266(1.02); C118(0.88); C561(0.98)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C248(0.97); C266(1.02); C118(1.01); C561(0.88)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C248(0.99); C266(0.96); C118(1.02); C561(0.92)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C248(0.87); C266(1.06); C118(0.96); C561(0.93)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C248(0.85); C266(0.98); C118(0.90); C561(1.08)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C248(1.00); C266(1.14); C118(1.00); C561(0.96)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C248(0.92); C266(0.95); C118(0.88); C561(0.96)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C248(0.86); C266(0.83); C118(0.84); C561(1.16)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C248(1.06); C266(1.01); C118(0.89); C561(0.85)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C248(0.94); C266(1.07); C118(0.86); C561(1.05)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C248(0.97); C266(1.00); C118(0.85); C561(0.89)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C248(0.88); C266(0.99); C118(0.89); C561(0.90)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C248(0.96); C266(1.07); C118(0.83); C561(0.87)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C248(1.11); C266(1.11); C118(1.01); C561(0.95)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C248(0.96); C266(0.89); C118(0.95); C561(1.02)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C248(1.04); C266(1.07); C118(0.93); C561(1.42)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C248(0.92); C266(1.00); C118(0.99); C561(0.97)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C248(0.94); C266(1.05); C118(0.95); C561(1.02)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C248(0.94); C266(1.11); C118(0.81); C561(0.98)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C248(0.84); C266(0.89); C118(1.17); C561(0.80)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C248(0.96); C266(1.04); C118(0.79); C561(1.01)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C248(0.90); C266(0.89); C118(0.84); C561(0.92)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C248(0.87); C266(0.93); C118(0.79); C561(1.06)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C248(1.00); C266(0.95); C118(0.88); C561(0.87)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C248(0.77); C266(0.89); C118(0.82); C561(0.95)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C248(0.92); C266(0.95); C118(0.82); C561(0.92)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C248(0.95); C266(0.93); C118(0.99); C561(1.05)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C248(0.98); C266(0.97); C118(0.98); C561(0.91)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C248(0.99); C266(0.96); C118(1.00); C561(1.24)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C248(0.98); C266(1.03); C118(1.00); C561(1.54)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C248(1.07); C266(1.07); C118(0.95); C561(1.04)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C248(0.99); C266(0.99); C118(0.97); C561(0.95)  LDD1631  [11]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HCT 116 C586(2.87); C589(2.87)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C586(2.69); C589(2.69)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C586(3.59); C589(3.59)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C586(1.20); C589(1.20)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Metformin Small molecular drug DB00331
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-hexyloxy-6-hydroxymethyl-tetrahydro-pyran-345-triol . DB04141

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402