Details of the Target

General Information of Target

Target ID LDTP07476
Target Name RAD50-interacting protein 1 (RINT1)
Gene Name RINT1
Gene ID 60561
Synonyms
RAD50-interacting protein 1; RAD50 interactor 1; HsRINT-1; RINT-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPAGEIGASPAAPCCSESGDERKNLEEKSDINVTVLIGSKQVSEGTDNGDLPSYVSAFI
EKEVGNDLKSLKKLDKLIEQRTVSKMQLEEQVLTISSEIPKRIRSALKNAEESKQFLNQF
LEQETHLFSAINSHLLTAQPWMDDLGTMISQIEEIERHLAYLKWISQIEELSDNIQQYLM
TNNVPEAASTLVSMAELDIKLQESSCTHLLGFMRATVKFWHKILKDKLTSDFEEILAQLH
WPFIAPPQSQTVGLSRPASAPEIYSYLETLFCQLLKLQTSDELLTEPKQLPEKYSLPASP
SVILPIQVMLTPLQKRFRYHFRGNRQTNVLSKPEWYLAQVLMWIGNHTEFLDEKIQPILD
KVGSLVNARLEFSRGLMMLVLEKLATDIPCLLYDDNLFCHLVDEVLLFERELHSVHGYPG
TFASCMHILSEETCFQRWLTVERKFALQKMDSMLSSEAAWVSQYKDITDVDEMKVPDCAE
TFMTLLLVITDRYKNLPTASRKLQFLELQKDLVDDFRIRLTQVMKEETRASLGFRYCAIL
NAVNYISTVLADWADNVFFLQLQQAALEVFAENNTLSKLQLGQLASMESSVFDDMINLLE
RLKHDMLTRQVDHVFREVKDAAKLYKKERWLSLPSQSEQAVMSLSSSACPLLLTLRDHLL
QLEQQLCFSLFKIFWQMLVEKLDVYIYQEIILANHFNEGGAAQLQFDMTRNLFPLFSHYC
KRPENYFKHIKEACIVLNLNVGSALLLKDVLQSASGQLPATAALNEVGIYKLAQQDVEIL
LNLRTNWPNTGK
Target Bioclass
Other
Family
RINT1 family
Subcellular location
Cytoplasm
Function
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.
Uniprot ID
Q6NUQ1
Ensemble ID
ENST00000257700.7
HGNC ID
HGNC:21876

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		4.41  LDD0348  [2]
STPyne
 Probe Info  		K502(9.72); K603(7.86)  LDD0277  [3]
NAIA_5
 Probe Info  		C720(0.93)  LDD2227  [4]
DA-P3
 Probe Info  		52.33  LDD0179  [2]
Acrolein
 Probe Info  		N.A.  LDD0226  [5]
DBIA
 Probe Info  		C720(1.03)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
AOyne
 Probe Info  		14.00  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C059
 Probe Info  		8.00  LDD1756  [10]
C070
 Probe Info  		17.51  LDD1766  [10]
C108
 Probe Info  		14.62  LDD1795  [10]
C112
 Probe Info  		18.90  LDD1799  [10]
C141
 Probe Info  		18.90  LDD1823  [10]
C160
 Probe Info  		9.00  LDD1840  [10]
C163
 Probe Info  		7.26  LDD1843  [10]
C178
 Probe Info  		20.53  LDD1857  [10]
C187
 Probe Info  		17.27  LDD1865  [10]
C191
 Probe Info  		17.88  LDD1868  [10]
C193
 Probe Info  		5.90  LDD1869  [10]
C194
 Probe Info  		30.27  LDD1870  [10]
C206
 Probe Info  		18.25  LDD1881  [10]
C277
 Probe Info  		11.39  LDD1947  [10]
C282
 Probe Info  		15.89  LDD1952  [10]
C296
 Probe Info  		14.52  LDD1966  [10]
C310
 Probe Info  		8.06  LDD1977  [10]
C338
 Probe Info  		10.34  LDD2001  [10]
C351
 Probe Info  		5.98  LDD2012  [10]
C376
 Probe Info  		8.75  LDD2036  [10]
C383
 Probe Info  		16.91  LDD2042  [10]
C387
 Probe Info  		10.85  LDD2046  [10]
C407
 Probe Info  		15.67  LDD2064  [10]
C429
 Probe Info  		19.97  LDD2084  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [11]
FFF probe14
 Probe Info  		20.00  LDD0477  [11]
FFF probe15
 Probe Info  		20.00  LDD0478  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]
OEA-DA
 Probe Info  		11.10  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C720(0.91)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C720(0.93)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C720(0.90)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C720(0.89)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C720(0.83)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C720(1.05)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C720(0.91)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C720(0.85)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C720(0.91)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C720(0.93)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C720(0.77)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C720(0.80)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C720(0.90)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C720(0.85)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C720(0.82)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C720(0.88)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C206(1.03); C720(0.92)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C206(0.96); C720(1.02)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C206(1.05); C720(1.08)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C206(1.10); C720(0.91)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C206(0.99); C720(0.95)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C206(1.15); C720(0.92)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C206(1.07); C720(0.92)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C720(0.91)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C206(0.83); C720(0.97)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C206(0.96); C720(0.94)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C206(0.90); C720(0.92)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C206(1.00); C720(0.95)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C206(0.90); C720(0.91)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C206(1.01); C720(0.94)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C206(0.97); C720(0.95)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C206(1.08); C720(0.91)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C720(0.92)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C720(1.02)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C720(0.87)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C720(1.20)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C720(0.99)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C720(1.02)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C720(1.13)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C720(0.87)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C720(0.91)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C720(0.84)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C720(1.20)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C720(0.87)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C720(0.97)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C720(1.17)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C720(1.16)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C720(0.88)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C720(0.97)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C720(0.98)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C720(0.96)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C720(0.93)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C720(0.97)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C720(0.97)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C720(0.99)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C720(0.94)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C720(0.90)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C720(0.93)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C720(0.87)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C720(0.88)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C720(0.92)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C720(0.84)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C720(0.87)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C720(0.90)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C720(1.11)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C720(1.19)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C720(1.29)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C720(0.95)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C720(1.29)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C720(1.25)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C720(0.94)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C720(1.08)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C720(1.50)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C720(0.87)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C720(0.94)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C720(0.87)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C720(0.90)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C720(0.98)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C720(0.91)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C720(1.02)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C720(1.02)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C720(0.99)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C720(0.95)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C720(1.05)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C720(0.90)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C720(0.93)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C720(0.91)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C720(0.99)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C720(0.91)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C720(1.01)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C720(1.01)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C720(1.01)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C720(0.99)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C720(0.99)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C720(1.04)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C720(1.04)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C720(0.97)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C720(0.97)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C720(0.93)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C720(1.31)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C720(0.99)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C720(1.16)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C720(0.80)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C720(0.95)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C720(0.97)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C720(1.06)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C720(1.18)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C720(1.41)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C720(0.90)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C720(1.06)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C720(1.04)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C720(1.14)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C720(0.99)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C720(1.00)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C720(1.12)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C720(0.98)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C720(0.98)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C720(1.04)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C720(1.03)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C720(1.10)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C720(0.96)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C720(1.02)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C720(0.91)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C720(1.04)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C720(0.97)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C720(1.09)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C720(1.28)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C720(1.29)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C720(1.34)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C720(1.04)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C720(1.09)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C720(0.97)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C720(0.99)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C720(0.97)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C720(1.00)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C720(0.90)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C720(1.22)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C206(0.95); C720(1.13)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C206(0.98); C720(1.21)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C206(1.01); C720(1.07)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C720(1.04); C206(1.33)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C720(0.85); C206(0.96)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C206(0.94); C720(0.97)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C720(0.96); C206(1.03)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C720(0.91); C206(1.20)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C720(1.10); C206(1.25)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C206(1.01); C720(1.04)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C206(0.96); C720(0.97)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C720(0.94); C206(1.16)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C720(0.86); C206(1.16)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C720(0.92); C206(1.21)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C720(1.00); C206(1.02)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C720(1.11)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C720(0.87)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C720(0.84)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C720(0.90)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C720(1.18)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C720(1.03)  LDD0078  [6]
 LDCM0632  CL-Sc Hep-G2 C720(0.93)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C720(0.83)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C720(0.86)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C720(0.89)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C720(0.94)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C720(0.93)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C720(0.83)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C720(0.88)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C720(0.99)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C720(1.09)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C720(1.12)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C720(0.95)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C720(1.07)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C720(0.86)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C720(0.96)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C720(1.04)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C720(0.87)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C720(0.98)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C720(0.91)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C720(0.88)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C720(0.90)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C720(1.28)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C720(1.00)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C720(0.99)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C720(0.86)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C720(0.88)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C720(0.87)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C720(1.18)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C720(1.02)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C720(1.22)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C720(0.85)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C720(1.03)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C720(0.90)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C720(0.96)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C720(0.89)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C720(0.81)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C720(0.84)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C720(0.93)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C720(0.88); C206(1.18)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C720(0.88); C206(1.09)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C720(0.91); C206(1.33)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C720(0.89)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C720(0.98); C206(1.19)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C720(1.00); C206(1.11)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C720(1.16); C206(1.44)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C720(0.93); C206(1.04)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C206(1.25); C720(1.02)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C206(1.26); C720(0.90)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C206(1.11); C720(0.99)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C206(1.03); C720(0.90)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C206(1.00); C720(0.87)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C206(1.14); C720(1.07)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C720(0.89)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C206(1.09); C720(1.11)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C206(1.10); C720(1.00)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C206(0.94); C720(1.07)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C206(0.81); C720(0.96)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C206(0.97); C720(1.18)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C206(1.14); C720(1.18)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C206(0.94); C720(1.16)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C206(1.17); C720(1.15)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C206(0.94); C720(1.13)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C720(0.85)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C206(1.03); C720(0.99)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C206(1.00); C720(1.04)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C206(0.89); C720(1.34)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C206(0.85); C720(1.23)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C206(0.85); C720(1.03)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C206(0.90); C720(1.05)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C720(0.75)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C720(0.83)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C720(0.83)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C720(0.97)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C720(0.93)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C720(0.80)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C720(0.82)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C720(0.76)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C720(0.89)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C720(0.76)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C720(0.88)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C720(0.90)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C720(0.87)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C720(0.80)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C720(0.85)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C720(0.86)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C720(0.82)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C720(1.03)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C720(0.98)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C720(0.96)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C720(1.06)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C720(1.05)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C720(1.06)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C720(1.06)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C720(1.29)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C720(1.02)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C720(0.87)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C720(1.11)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C720(1.01)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C720(1.10)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C720(1.12)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C720(1.09)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C720(1.14)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C720(1.14)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C720(1.04)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C720(1.15)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C720(0.97)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C720(1.10)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C720(1.05)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C720(1.33)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C720(1.23)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C720(1.36)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C720(1.03)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C720(1.10)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C720(1.10)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C720(1.17)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C720(1.37)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C720(0.85)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C720(0.85)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C720(0.94)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C720(1.00)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C720(0.94)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C720(1.04)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C720(0.92)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C720(0.91)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C720(0.98)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C720(0.98)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C720(0.95)  LDD0811  [6]
 LDCM0028  Dobutamine HEK-293T 29.73  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 52.33  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C720(0.88); C734(0.93); C272(0.87); C478(1.09)  LDD1698  [14]
 LDCM0625  F8 Ramos C720(1.56)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C720(1.71)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C720(1.91)  LDD2190  [15]
 LDCM0576  Fragment14 Ramos C720(2.90)  LDD2193  [15]
 LDCM0580  Fragment21 Ramos C720(0.99)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C720(0.56)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C720(1.19)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C720(1.15)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C720(1.13)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C720(1.00)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C720(1.94)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C720(0.99)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C720(20.00)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C720(3.99)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C206(1.05); C720(1.33)  LDD0744  [6]
 LDCM0614  Fragment56 Ramos C720(0.69)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C720(2.41)  LDD2186  [15]
 LDCM0022  KB02 HCT 116 C720(1.93)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C720(1.54)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C720(4.04)  LDD0082  [6]
 LDCM0030  Luteolin HEK-293T 61.61  LDD0182  [2]
 LDCM0109  NEM HeLa N.A.  LDD0226  [5]
 LDCM0032  Oleacein HEK-293T 28.59  LDD0184  [2]
 LDCM0029  Quercetin HEK-293T 35.02  LDD0181  [2]
 LDCM0021  THZ1 HCT 116 C720(1.04)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 4 (HDAC4) Histone deacetylase family P56524
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
tRNA-splicing endonuclease subunit Sen54 (TSEN54) SEN54 family Q7Z6J9
RING finger protein 39 (RNF39) . Q9H2S5
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Huntingtin (HTT) Huntingtin family P42858
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor interleukin-3-regulated protein (NFIL3) BZIP family Q16649
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Teashirt homolog 2 (TSHZ2) Teashirt C2H2-type zinc-finger protein family Q9NRE2
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Zinc finger and SCAN domain-containing protein 5B (ZSCAN5B) . A6NJL1
Other
Click To Hide/Show 48 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) BLOC1S6 family Q9UL45
Coiled-coil domain-containing protein 88B (CCDC88B) CCDC88 family A6NC98
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Dynactin subunit 2 (DCTN2) Dynactin subunit 2 family Q13561
Enhancer of polycomb homolog 1 (EPC1) Enhancer of polycomb family Q9H2F5
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Protein FAM124B (FAM124B) FAM124 family Q9H5Z6
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM81B (FAM81B) FAM81 family Q96LP2
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Keratin, type II cytoskeletal 1 (KRT1) Intermediate filament family P04264
Phakinin (BFSP2) Intermediate filament family Q13515
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
Zinc finger protein ubi-d4 (DPF2) Requiem/DPF family Q92785
RIB43A-like with coiled-coils protein 1 (RIBC1) RIB43A family Q8N443
Swi5-dependent recombination DNA repair protein 1 homolog (SFR1) SFR1/MEI5 family Q86XK3
SAGA-associated factor 29 (SGF29) SGF29 family Q96ES7
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Translational activator of cytochrome c oxidase 1 (TACO1) TACO1 family Q9BSH4
Alpha-taxilin (TXLNA) Taxilin family P40222
UPF0449 protein C19orf25 (C19orf25) UPF0449 family Q9UFG5
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Striatin (STRN) WD repeat striatin family O43815
Centromere/kinetochore protein zw10 homolog (ZW10) ZW10 family O43264
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 121 (CCDC121) . Q6ZUS5
Guanine nucleotide exchange factor VAV3 (VAV3) . Q9UKW4
LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1) . Q96S90
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
Neuronal migration protein doublecortin (DCX) . O43602
Protein PIMREG (PIMREG) . Q9BSJ6
Receptor-transporting protein 5 (RTP5) . Q14D33
Rho GTPase-activating protein 45 (ARHGAP45) . Q92619
Rhombotin-2 (LMO2) . P25791
RNA-binding protein 41 (RBM41) . Q96IZ5
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
UV radiation resistance-associated gene protein (UVRAG) . Q9P2Y5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578