Details of the Target

General Information of Target

Target ID LDTP03060
Target Name Proteasome subunit beta type-1 (PSMB1)
Gene Name PSMB1
Gene ID 5689
Synonyms
PSC5; Proteasome subunit beta type-1; Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
D
Target Bioclass
Enzyme
Family
Peptidase T1B family
Subcellular location
Cytoplasm
Function
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Uniprot ID
P20618
Ensemble ID
ENST00000262193.7
HGNC ID
HGNC:9537
ChEMBL ID
CHEMBL4208

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.08  LDD0215  [1]
AZ-9
 Probe Info  		10.00  LDD0393  [2]
C-Sul
 Probe Info  		3.56  LDD0066  [3]
TH211
 Probe Info  		Y135(14.38); Y133(13.92); Y158(8.89)  LDD0257  [4]
TH216
 Probe Info  		Y158(15.83); Y135(7.51)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K104(5.56); K184(5.72); K204(6.40)  LDD0277  [6]
BTD
 Probe Info  		C224(2.37)  LDD1699  [7]
OPA-S-S-alkyne
 Probe Info  		K204(2.46)  LDD3494  [8]
Probe 1
 Probe Info  		Y133(15.60); Y150(12.94); Y158(38.81); Y216(10.94)  LDD3495  [9]
m-APA
 Probe Info  		11.40  LDD0403  [10]
Cep-alkyne
 Probe Info  		2.14  LDD0284  [11]
DA-P3
 Probe Info  		6.14  LDD0183  [12]
HHS-482
 Probe Info  		Y133(1.09); Y135(1.06)  LDD0285  [13]
HHS-475
 Probe Info  		Y158(0.87); Y135(1.64); Y133(2.13)  LDD0264  [14]
HHS-465
 Probe Info  		Y132(1.98); Y133(4.97); Y135(4.98); Y158(4.38)  LDD2237  [15]
DBIA
 Probe Info  		C82(1.04); C89(1.04)  LDD0078  [16]
5E-2FA
 Probe Info  		N.A.  LDD2235  [17]
ATP probe
 Probe Info  		K228(0.00); K204(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C89(0.00); C82(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C89(0.00); C82(0.00)  LDD0036  [19]
Lodoacetamide azide
 Probe Info  		C89(0.00); C82(0.00)  LDD0037  [19]
IPM
 Probe Info  		N.A.  LDD0025  [20]
NAIA_4
 Probe Info  		C89(0.00); C82(0.00)  LDD2226  [21]
NHS
 Probe Info  		K204(0.00); K184(0.00)  LDD0010  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
TFBX
 Probe Info  		N.A.  LDD0148  [20]
1c-yne
 Probe Info  		K204(0.00); K184(0.00)  LDD0228  [24]
1d-yne
 Probe Info  		N.A.  LDD0357  [24]
Acrolein
 Probe Info  		C82(0.00); C89(0.00); C224(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [25]
Methacrolein
 Probe Info  		C224(0.00); C82(0.00); C89(0.00)  LDD0218  [25]
AOyne
 Probe Info  		11.60  LDD0443  [26]
MPP-AC
 Probe Info  		N.A.  LDD0428  [27]
NAIA_5
 Probe Info  		C89(0.00); C82(0.00)  LDD2223  [21]
TER-AC
 Probe Info  		N.A.  LDD0426  [27]
PAL-AfBPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C059
 Probe Info  		5.13  LDD1756  [28]
C085
 Probe Info  		5.10  LDD1777  [28]
C158
 Probe Info  		11.71  LDD1838  [28]
C160
 Probe Info  		9.25  LDD1840  [28]
C197
 Probe Info  		5.10  LDD1873  [28]
C211
 Probe Info  		9.71  LDD1885  [28]
C213
 Probe Info  		19.70  LDD1887  [28]
C216
 Probe Info  		5.43  LDD1890  [28]
C277
 Probe Info  		11.24  LDD1947  [28]
C280
 Probe Info  		8.75  LDD1950  [28]
C284
 Probe Info  		22.16  LDD1954  [28]
C286
 Probe Info  		7.16  LDD1956  [28]
C303
 Probe Info  		5.98  LDD1972  [28]
C305
 Probe Info  		16.22  LDD1974  [28]
C313
 Probe Info  		14.72  LDD1980  [28]
C348
 Probe Info  		20.82  LDD2009  [28]
C350
 Probe Info  		24.76  LDD2011  [28]
C363
 Probe Info  		33.82  LDD2024  [28]
C376
 Probe Info  		7.41  LDD2036  [28]
C387
 Probe Info  		9.45  LDD2046  [28]
C403
 Probe Info  		14.52  LDD2061  [28]
C420
 Probe Info  		12.13  LDD2075  [28]
FFF probe11
 Probe Info  		6.27  LDD0471  [29]
FFF probe13
 Probe Info  		20.00  LDD0475  [29]
FFF probe14
 Probe Info  		20.00  LDD0477  [29]
FFF probe15
 Probe Info  		6.56  LDD0478  [29]
FFF probe2
 Probe Info  		14.36  LDD0463  [29]
FFF probe3
 Probe Info  		8.68  LDD0465  [29]
FFF probe6
 Probe Info  		7.05  LDD0482  [29]
JN0003
 Probe Info  		12.21  LDD0469  [29]
BD-F
 Probe Info  		Y132(0.00); Y133(0.00); Y135(0.00)  LDD0024  [30]
LD-F
 Probe Info  		Y132(0.00); V134(0.00); P131(0.00); Y133(0.00)  LDD0015  [30]
DA-2
 Probe Info  		N.A.  LDD0070  [31]
OEA-DA
 Probe Info  		20.00  LDD0046  [32]
STS-1
 Probe Info  		N.A.  LDD0068  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C224(0.43); C71(1.64); C89(0.56)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C71(0.92)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C224(0.42)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C224(0.74)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C224(1.34); C89(1.27)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C82(1.55)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C224(1.57)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C224(0.48); C82(0.54)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C224(0.48); C89(0.80)  LDD2131  [7]
 LDCM0214  AC1 HCT 116 C82(0.92); C89(0.92)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C82(0.62); C89(0.62)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C82(0.84); C89(0.84)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C82(1.01); C89(1.01)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C82(1.01); C89(1.01)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C82(1.06); C89(1.06)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C82(1.02); C89(1.02)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C82(0.88); C89(0.88)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C82(0.83); C89(0.83)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C82(0.75); C89(0.75)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C82(0.79); C89(0.79)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C82(0.88); C89(0.88)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C82(0.72); C89(0.72)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C82(0.88); C89(0.88)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C82(0.70); C89(0.70)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C82(0.83); C89(0.83)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C82(0.62); C89(0.89)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C82(1.09); C89(1.23)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C82(0.74); C89(1.10)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C82(0.52); C89(1.56)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C82(0.66); C89(1.11)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C82(0.52); C89(1.28)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C82(0.83); C89(1.04)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C82(0.55); C89(0.55)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C82(0.76); C89(1.32)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C82(1.05); C89(0.90)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C82(0.82); C89(1.02)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C82(0.63); C89(0.89)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C82(0.68); C89(0.85)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C82(0.56); C89(0.99)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C82(0.80); C89(1.09)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C82(0.70); C89(0.96)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C82(0.84); C89(0.84)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C82(0.75); C89(0.75)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C82(0.66); C89(0.66)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C82(0.98); C89(0.98)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C82(0.65); C89(0.65)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C82(0.85); C89(0.85)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C82(0.96); C89(0.96)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C82(0.87); C89(0.87)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C82(0.82); C89(0.82)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C82(0.71); C89(0.71)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C82(1.02); C89(1.02)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C82(1.19); C89(1.19)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C82(0.81); C89(0.81)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C82(0.91); C89(0.91)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C82(0.83); C89(0.83)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C82(0.89); C89(0.89)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C82(0.96); C89(0.96)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C82(1.05); C89(1.05)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C82(1.05); C89(1.05)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C82(1.10); C89(1.10)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C82(1.16); C89(1.16)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C82(1.05); C89(1.05)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C82(1.02); C89(1.02)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C82(0.73); C89(0.73)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C82(1.13); C89(1.13)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C82(0.97); C89(0.97)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C82(1.21); C89(1.21)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C82(1.45); C89(1.45)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C82(1.25); C89(1.25)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C82(0.96); C89(0.96)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C82(1.09); C89(1.09)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C82(1.12); C89(1.12)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C82(0.90); C89(0.90)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C82(1.15); C89(1.15)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C82(0.87); C89(0.87)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C82(0.87); C89(0.87)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C82(0.93); C89(0.93)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C82(0.90); C89(0.90)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C82(0.79); C89(0.79)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C82(1.02); C89(1.02)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C82(1.04); C89(1.04)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C82(0.70); C89(0.70)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C82(0.59); C89(0.59)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C82(0.62); C89(0.62)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C82(0.53); C89(0.53)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C82(0.65); C89(0.65)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C82(0.88); C89(0.88)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C82(0.63); C89(0.63)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C82(0.59); C89(0.59)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C82(0.45); C89(0.45)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C82(0.52); C89(0.52)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C82(0.99); C89(0.99)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C82(1.03); C89(1.03)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C82(0.87); C89(0.87)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C82(0.87); C89(0.87)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C82(1.07); C89(1.07)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C82(0.84); C89(0.84)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C82(0.81); C89(0.81)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C82(1.11); C89(1.11)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C82(0.96); C89(0.96)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C82(0.97); C89(0.97)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C82(0.93); C89(0.93)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C82(1.05); C89(1.05)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C82(1.47); C89(1.47)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C82(0.78); C89(0.78)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C82(0.60); C89(0.60)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C82(0.78); C89(0.78)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C82(0.79); C89(0.79)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C82(0.90); C89(0.90)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C82(0.62); C89(0.62)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C82(0.73); C89(0.73)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C82(0.76); C89(0.76)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C82(0.60); C89(0.60)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C82(0.86); C89(0.86)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C82(0.58); C89(0.58)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C82(0.75); C89(0.75)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C82(0.74); C89(0.74)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C82(0.81); C89(0.81)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C82(0.81); C89(0.81)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C82(0.80); C89(0.80)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C82(0.81); C89(0.81)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C82(0.74); C89(0.74)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C82(0.58); C89(0.58)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C82(0.58); C89(0.58)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C82(0.60); C89(0.60)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C82(0.65); C89(0.65)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C82(0.77); C89(0.77)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C82(0.64); C89(0.64)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C82(1.11); C89(1.11)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C82(1.08); C89(1.08)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C82(0.85); C89(0.85)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C82(0.86); C89(0.86)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C82(0.96); C89(0.96)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C82(0.82); C89(0.82)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C82(0.85); C89(0.85)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C82(0.85); C89(0.85)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C82(0.76); C89(0.76)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C82(0.71); C89(0.71)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C82(0.77); C89(0.77)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C82(0.87); C89(0.87)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C82(0.90); C89(0.90)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C82(0.83); C89(0.83)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C82(0.85); C89(0.85)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C82(0.82); C89(0.82)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C82(0.80); C89(0.80)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C82(0.76); C89(0.76)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C82(0.91); C89(0.91)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C82(0.85); C89(0.85)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C82(0.82); C89(0.82)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C82(0.70); C89(0.70)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C82(0.82); C89(0.82)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C82(0.74); C89(0.74)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C82(0.60); C89(0.60)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C82(0.67); C89(0.67)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C82(0.65); C89(0.65)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C82(0.80); C89(0.80)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C82(0.62); C89(0.62)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C82(0.73); C89(0.73)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C82(0.85); C89(0.85)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C82(0.70); C89(0.70)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C82(0.89); C89(0.89)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C82(1.01); C89(1.01)  LDD0683  [16]
 LDCM0545  Acetamide MDA-MB-231 C224(1.03); C71(1.05)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C224(0.68); C82(0.73)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C82(0.86); C89(0.86)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C82(0.66); C89(0.66)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C82(0.75); C89(0.75)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 11.40  LDD0403  [10]
 LDCM0020  ARS-1620 HCC44 C82(1.04); C89(1.04)  LDD0078  [16]
 LDCM0498  BS-3668 MDA-MB-231 C224(1.07); C71(0.40)  LDD2091  [7]
 LDCM0122  Cepafungin 1 RPMI-8226 2.14  LDD0284  [11]
 LDCM0108  Chloroacetamide HeLa C224(0.00); C82(0.00); C89(0.00)  LDD0222  [25]
 LDCM0367  CL1 HCT 116 C82(1.08); C89(1.08)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C82(0.82); C89(0.82)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C82(0.77); C89(0.77)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C82(0.76); C89(0.76)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C82(0.94); C89(0.94)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C82(0.70); C89(0.70)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C82(0.62); C89(0.62)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C82(0.87); C89(0.87)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C82(0.81); C89(0.81)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C82(0.76); C89(0.76)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C82(0.89); C89(0.89)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C82(0.97); C89(0.97)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C82(0.78); C89(0.78)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C82(0.98); C89(0.98)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C82(0.99); C89(0.99)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C82(0.79); C89(0.79)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C82(0.55); C89(0.55)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C82(0.99); C89(0.99)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C82(0.74); C89(0.74)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C82(0.66); C89(0.66)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C82(0.99); C89(0.99)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C82(0.85); C89(0.85)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C82(0.89); C89(0.89)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C82(0.57); C89(0.57)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C82(0.89); C89(0.89)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C82(0.92); C89(0.92)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C82(1.53); C89(1.53)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C82(1.29); C89(1.29)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C82(0.78); C89(0.78)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C82(0.80); C89(0.80)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C82(0.85); C89(0.85)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C82(0.91); C89(0.91)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C82(0.76); C89(0.76)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C82(0.77); C89(0.77)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C82(0.81); C89(0.81)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C82(1.03); C89(1.03)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C82(0.99); C89(0.99)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C82(1.18); C89(1.18)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C82(0.89); C89(0.89)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C82(0.88); C89(0.88)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C82(0.98); C89(0.98)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C82(0.86); C89(0.86)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C82(0.83); C89(0.83)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C82(0.75); C89(0.75)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C82(0.99); C89(0.99)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C82(0.82); C89(0.82)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C82(0.88); C89(0.88)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C82(0.89); C89(0.89)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C82(0.87); C89(0.87)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C82(1.00); C89(1.00)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C82(0.95); C89(0.95)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C82(1.18); C89(1.18)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C82(0.86); C89(0.86)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C82(0.98); C89(0.98)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C82(0.84); C89(0.84)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C82(0.84); C89(0.84)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C82(0.82); C89(0.82)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C82(0.81); C89(0.81)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C82(0.74); C89(0.74)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C82(0.74); C89(0.74)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C82(0.78); C89(0.78)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C82(0.81); C89(0.81)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C82(0.84); C89(0.84)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C82(0.80); C89(0.80)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C82(0.83); C89(0.83)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C82(0.69); C89(0.69)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C82(0.74); C89(0.74)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C82(0.84); C89(0.84)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C82(0.94); C89(0.94)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C82(0.92); C89(0.92)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C82(0.89); C89(0.89)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C82(0.96); C89(0.96)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C82(0.90); C89(0.90)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C82(0.89); C89(0.89)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C82(0.91); C89(0.91)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C82(0.84); C89(0.84)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C82(0.86); C89(0.86)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C82(1.01); C89(1.01)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C82(0.89); C89(0.89)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C82(1.00); C89(1.00)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C82(0.91); C89(0.91)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C82(0.95); C89(0.95)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C82(0.98); C89(0.98)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C82(1.12); C89(1.12)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C82(0.93); C89(0.93)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C82(0.71); C89(0.71)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C82(0.60); C89(0.60)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C82(0.88); C89(0.88)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C82(0.60); C89(0.60)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C82(0.71); C89(0.71)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C82(0.66); C89(0.66)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C82(0.95); C89(0.95)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C82(1.80); C89(1.80)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C82(0.87); C89(0.87)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C82(0.84); C89(0.84)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C82(1.05); C89(1.05)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C82(0.91); C89(0.91)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C82(0.93); C89(0.93)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C82(0.97); C89(0.97)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C82(0.95); C89(0.95)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C82(0.82); C89(0.82)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C82(1.09); C89(1.09)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C82(0.87); C89(0.87)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C82(0.84); C89(0.84)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C82(0.79); C89(0.79)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C82(0.79); C89(0.79)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C82(0.66); C89(0.66)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C82(0.74); C89(0.74)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C82(0.72); C89(0.72)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C82(0.72); C89(0.72)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C82(0.78); C89(0.78)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C82(0.85); C89(0.85)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C82(0.80); C89(0.80)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C82(0.82); C89(0.82)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C82(0.78); C89(0.78)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C82(0.87); C89(0.87)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C82(1.07); C89(1.07)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C82(0.96); C89(0.96)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C82(1.00); C89(1.00)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C82(0.88); C89(0.88)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C82(0.91); C89(0.91)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C82(1.01); C89(1.01)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C82(1.06); C89(1.06)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C82(1.02); C89(1.02)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C82(0.86); C89(0.86)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C82(0.86); C89(0.86)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C89(0.99)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C224(0.89)  LDD1702  [7]
 LDCM0031  Epigallocatechin gallate HEK-293T 6.14  LDD0183  [12]
 LDCM0468  Fragment33 HCT 116 C82(0.78); C89(0.78)  LDD0785  [16]
 LDCM0427  Fragment51 HCT 116 C82(0.86); C89(0.86)  LDD0744  [16]
 LDCM0116  HHS-0101 DM93 Y158(0.87); Y135(1.64); Y133(2.13)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y158(0.81); Y133(1.28); Y135(1.46)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y158(0.89); Y133(2.84); Y135(5.05)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y158(1.25); Y133(1.82); Y135(2.19)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y158(1.00); Y133(2.70); Y135(2.73)  LDD0268  [14]
 LDCM0107  IAA HeLa C82(0.00); C224(0.00); C89(0.00)  LDD0221  [25]
 LDCM0123  JWB131 DM93 Y133(1.09); Y135(1.06)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y133(0.54); Y135(0.60)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y133(1.73); Y135(1.57)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y133(1.79); Y135(1.75)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y133(6.90); Y135(8.35)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y133(1.14); Y135(1.08)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y133(3.56); Y135(4.08)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y133(1.07); Y135(1.18)  LDD0292  [13]
 LDCM0022  KB02 HEK-293T C82(1.02); C82(1.02); C89(1.02)  LDD1492  [34]
 LDCM0023  KB03 HEK-293T C82(1.02); C82(0.93); C89(0.93)  LDD1497  [34]
 LDCM0024  KB05 HMCB C224(1.62)  LDD3312  [35]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C224(1.41)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C224(1.29); C71(0.41)  LDD2121  [7]
 LDCM0109  NEM HeLa C82(0.00); C224(0.00); C89(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C224(1.30); C71(1.17)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C224(1.21)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C224(1.31); C71(4.09)  LDD2092  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C224(2.51)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C224(0.67); C71(0.47); C82(0.08)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C224(0.99); C89(0.97); C82(0.97)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C224(0.84); C71(1.39)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C224(1.82)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C224(0.36); C71(0.84)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C224(0.95); C89(0.99); C82(1.00)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C224(0.30); C71(1.52); C89(0.65)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C224(1.88)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C224(0.15); C71(0.53); C82(0.26)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C224(1.21); C71(1.01)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C224(0.47); C71(0.87)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C224(0.71)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C224(0.36); C71(0.79)  LDD2110  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C224(0.31); C71(1.85); C89(0.41); C82(0.36)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C224(0.39); C89(0.60)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C224(1.03); C71(0.98); C89(0.23)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C224(1.02); C89(0.22); C82(0.49)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C224(1.42)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C224(0.48); C71(0.85); C89(0.58); C82(0.58)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C224(0.80); C89(0.17)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C224(1.08)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C224(0.91); C71(0.30); C89(0.15); C82(0.16)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C224(1.13); C71(0.94)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C224(0.96); C82(0.23)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C224(1.19); C89(0.94)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C71(0.55); C89(0.69); C82(0.73)  LDD2128  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C224(0.54); C82(0.74)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C224(0.60); C89(0.88)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C224(1.71); C89(1.23)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C224(1.18); C89(1.86)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C224(1.00); C89(1.16)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C224(1.30); C71(0.78); C89(1.23); C82(1.27)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C224(0.59); C71(0.67)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C224(0.51); C71(0.67); C89(0.49); C82(0.54)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C224(1.69); C89(1.67)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C71(0.17); C82(0.26)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C224(1.24)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C224(0.79); C89(1.02); C82(1.15)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C224(0.39)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C224(0.98); C71(0.35)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C71(0.22)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C71(0.32); C89(0.18)  LDD2151  [7]
 LDCM0021  THZ1 HCT 116 C82(1.25); C89(1.25)  LDD2173  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) Complex I 51 kDa subunit family P49821
Protein DDI1 homolog 1 (DDI1) DDI1 family Q8WTU0
Baculoviral IAP repeat-containing protein 7 (BIRC7) IAP family Q96CA5
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
OTU domain-containing protein 7B (OTUD7B) Peptidase C64 family Q6GQQ9
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Proteasome subunit beta type-2 (PSMB2) Peptidase T1B family P49721
Proteasome subunit beta type-3 (PSMB3) Peptidase T1B family P49720
Proteasome subunit beta type-4 (PSMB4) Peptidase T1B family P28070
Proteasome subunit beta type-5 (PSMB5) Peptidase T1B family P28074
Proteasome subunit beta type-7 (PSMB7) Peptidase T1B family Q99436
Dual specificity protein phosphatase CDC14B (CDC14B) Protein-tyrosine phosphatase family O60729
Pyrroline-5-carboxylate reductase 3 (PYCR3) Pyrroline-5-carboxylate reductase family Q53H96
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
GTP-binding protein 2 (GTPBP2) Classic translation factor GTPase family Q9BX10
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
RWD domain-containing protein 2A (RWDD2A) . Q9UIY3
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Leucine zipper transcription factor-like protein 1 (LZTFL1) LZTFL1 family Q9NQ48
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) . Q9HBZ2
High mobility group protein 20A (HMG20A) . Q9NP66
THAP domain-containing protein 6 (THAP6) . Q8TBB0
Other
Click To Hide/Show 45 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-hemoglobin-stabilizing protein (AHSP) AHSP family Q9NZD4
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Cerebral cavernous malformations 2 protein-like (CCM2L) CCM2 family Q9NUG4
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Endophilin-A2 (SH3GL1) Endophilin family Q99961
Protein FAM136A (FAM136A) FAM136 family Q96C01
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Gem-associated protein 2 (GEMIN2) Gemin-2 family O14893
Protein IMPACT (IMPACT) IMPACT family Q9P2X3
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Janus kinase and microtubule-interacting protein 1 (JAKMIP1) JAKMIP family Q96N16
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Late cornified envelope protein 1C (LCE1C) LCE family Q5T751
Late cornified envelope protein 1F (LCE1F) LCE family Q5T754
LIM domain-binding protein 2 (LDB2) LDB family O43679
Protein lin-7 homolog B (LIN7B) Lin-7 family Q9HAP6
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Protein Mis18-beta (OIP5) Mis18 family O43482
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
MRN complex-interacting protein (MRNIP) MRNIP family Q6NTE8
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Proteasome maturation protein (POMP) POMP/UMP1 family Q9Y244
Protein ripply3 (RIPPLY3) Ripply family P57055
Stathmin-2 (STMN2) Stathmin family Q93045
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Vasculin (GPBP1) Vasculin family Q86WP2
DNA repair protein complementing XP-A cells (XPA) XPA family P23025
Cytohesin-4 (CYTH4) . Q9UIA0
Gem-associated protein 4 (GEMIN4) . P57678
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
KATNB1-like protein 1 (KATNBL1) . Q9H079
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Puratrophin-1 (PLEKHG4) . Q58EX7
Rhombotin-1 (LMO1) . P25800
RING1 and YY1-binding protein (RYBP) . Q8N488
TCF3 fusion partner (TFPT) . P0C1Z6
Tetratricopeptide repeat protein 33 (TTC33) . Q6PID6
TNF receptor-associated factor 1 (TRAF1) . Q13077

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bortezomib Small molecular drug DB00188
Carfilzomib Small molecular drug DB08889
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(3ar6r6as)-6-((S)-((S)-cyclohex-2-enyl)(Hydroxy)Methyl)-6a-methyl-4-oxo-hexahydro-2h-furo[32-c]Pyrrole-6-carbaldehyde . DB08515

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
11 Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I. Cell Chem Biol. 2020 Oct 15;27(10):1318-1326.e18. doi: 10.1016/j.chembiol.2020.07.012. Epub 2020 Aug 6.
12 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
28 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
31 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
32 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
33 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840