Details of the Target

General Information of Target

Target ID LDTP00970
Target Name Gasdermin-E (GSDME)
Gene Name GSDME
Gene ID 1687
Synonyms
DFNA5; ICERE1; Gasdermin-E; Inversely correlated with estrogen receptor expression 1; ICERE-1; Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal; GSDME-NT; Gasdermin-E, C-terminal; GSDME-CT)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQFLSLTLGD
VLIEDQFPSPVVVESDFVKYEGKFANHVSGTLETALGKVKLNLGGSSRVESQSSFGTLRK
QEVDLQQLIRDSAERTINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVISEHMQVEEKC
GGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLLRGK
QGGFENKKRIDSVYLDPLVFREFAFIDMPDAAHGISSQDGPLSVLKQATLLLERNFHPFA
ELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGLSPTVAVLGELKPRQQQDLVAFL
QLVGCSLQGGCPGPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLL
RALSDDGVSDLEDPTLTPLKDTERFGIVQRLFASADISLERLKSSVKAVILKDSKVFPLL
LCITLNGLCALGREHS
Target Bioclass
Transporter and channel
Family
Gasdermin family
Subcellular location
Cytoplasm, cytosol; Cell membrane
Function
[Gasdermin-E]: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis.; [Gasdermin-E, N-terminal]: Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively. After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukins (IL1B and IL16) and triggering pyroptosis. Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity. Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity. Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression. May play a role in the p53/TP53-regulated cellular response to DNA damage.; [Gasdermin-E, N-terminal]: (Microbial infection) Pore-forming protein, which promotes maternal placental pyroptosis in response to Zika virus infection, contributing to adverse fetal outcomes.
Uniprot ID
O60443
Ensemble ID
ENST00000342947.9
HGNC ID
HGNC:2810

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.V390A .
NCIH1650 SNV: p.S23L DBIA    Probe Info 
SW620 SNV: p.E197K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-5
 Probe Info  		7.49  LDD0394  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
FBP2
 Probe Info  		2.56  LDD0317  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K100(5.26)  LDD0277  [6]
BTD
 Probe Info  		C156(1.56)  LDD2099  [7]
Sulforaphane-probe2
 Probe Info  		3.05  LDD0160  [8]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [9]
AHL-Pu-1
 Probe Info  		C45(2.61); C417(2.36)  LDD0170  [10]
DBIA
 Probe Info  		C45(1.40); C180(0.88)  LDD0078  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
IPM
 Probe Info  		N.A.  LDD0147  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		16.00  LDD1728  [16]
C026
 Probe Info  		10.78  LDD1732  [16]
C070
 Probe Info  		11.88  LDD1766  [16]
C141
 Probe Info  		16.22  LDD1823  [16]
C143
 Probe Info  		19.70  LDD1825  [16]
C264
 Probe Info  		23.26  LDD1935  [16]
C265
 Probe Info  		19.70  LDD1936  [16]
C266
 Probe Info  		9.13  LDD1937  [16]
C269
 Probe Info  		5.82  LDD1939  [16]
C349
 Probe Info  		11.79  LDD2010  [16]
C350
 Probe Info  		26.17  LDD2011  [16]
C376
 Probe Info  		11.79  LDD2036  [16]
C380
 Probe Info  		6.11  LDD2039  [16]
C382
 Probe Info  		9.65  LDD2041  [16]
C385
 Probe Info  		5.78  LDD2044  [16]
C386
 Probe Info  		12.30  LDD2045  [16]
C387
 Probe Info  		5.03  LDD2046  [16]
C388
 Probe Info  		38.59  LDD2047  [16]
C424
 Probe Info  		11.88  LDD2079  [16]
C426
 Probe Info  		13.55  LDD2081  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C156(1.45)  LDD2117  [7]
 LDCM0025  4SU-RNA DM93 C45(2.61); C417(2.36)  LDD0170  [10]
 LDCM0214  AC1 HCT 116 C417(1.48)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C417(1.06)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C180(0.52)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C180(0.62)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C180(0.77)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C180(0.87)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C180(0.74)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C180(1.21)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C180(1.05)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C180(1.00)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C180(0.77)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C180(0.88)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C417(1.13)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C180(1.01)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C180(0.84)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C180(0.94)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C417(0.80)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C417(0.86)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C417(1.01)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C417(1.14)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C417(0.90)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C417(0.98)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C417(1.05)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C417(1.04)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C417(0.93)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C417(0.98)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C417(0.98)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C417(0.75)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C417(1.06)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C417(0.98)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C417(0.98)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C417(0.91)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C180(1.08)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C180(0.62)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C180(0.97)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C180(0.64)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C180(0.89)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C180(0.84)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C180(0.87)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C180(1.55)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C180(0.84)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C180(0.67)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C180(0.84)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C180(1.16)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C417(1.17)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C180(0.85)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C180(0.89)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C180(0.91)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C417(0.92)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C417(1.15)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C417(0.99)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C417(0.98)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C417(1.11)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C417(1.45)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C417(1.21)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C417(1.24)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C417(0.97)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C417(0.88)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C417(1.19)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C417(1.54)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C417(1.03)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C417(0.99)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C417(0.88)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C417(0.81)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C417(1.03)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C417(1.33)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C417(1.00)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C417(1.54)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C417(1.05)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C417(1.04)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C417(0.92)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C417(0.95)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C417(1.01)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C417(1.02)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C417(1.14)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C417(1.07)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C417(1.16)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C417(0.98)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C417(1.52)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C417(1.16)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C417(0.98)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C417(1.43)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C417(1.22)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C417(1.27)  LDD0612  [11]
 LDCM0296  AC35 PaTu 8988t C417(1.11)  LDD1175  [11]
 LDCM0297  AC36 PaTu 8988t C417(1.13)  LDD1176  [11]
 LDCM0298  AC37 PaTu 8988t C417(1.01)  LDD1177  [11]
 LDCM0299  AC38 PaTu 8988t C417(1.07)  LDD1178  [11]
 LDCM0300  AC39 PaTu 8988t C417(1.29)  LDD1179  [11]
 LDCM0301  AC4 HCT 116 C417(1.67)  LDD0618  [11]
 LDCM0302  AC40 PaTu 8988t C417(1.07)  LDD1181  [11]
 LDCM0303  AC41 PaTu 8988t C417(1.03)  LDD1182  [11]
 LDCM0304  AC42 PaTu 8988t C417(1.08)  LDD1183  [11]
 LDCM0305  AC43 PaTu 8988t C417(0.95)  LDD1184  [11]
 LDCM0306  AC44 PaTu 8988t C417(1.28)  LDD1185  [11]
 LDCM0307  AC45 PaTu 8988t C417(0.94)  LDD1186  [11]
 LDCM0308  AC46 HCT 116 C417(0.98)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C417(0.95)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C417(0.85)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C417(1.35)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C417(1.85)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C417(1.23)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C417(0.82)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C417(0.94)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C417(1.16)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C417(1.16)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C417(1.28)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C417(1.63)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C180(1.36)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C180(1.44)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C180(1.16)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C417(1.34)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C180(1.31)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C180(1.41)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C180(1.12)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C180(1.20)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C180(1.25)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C180(1.99)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C180(1.60)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C180(1.77)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C417(1.10); C180(1.93)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C417(1.26); C180(1.27)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C417(1.08)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C417(0.99); C180(1.15)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C417(1.04); C180(1.36)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C180(1.03); C417(1.05)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C417(1.34); C180(1.57)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C417(1.68); C180(1.85)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C417(1.59); C180(1.90)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C417(1.18); C180(1.58)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C180(1.01); C417(1.25)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C180(0.92); C417(1.10)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C417(1.09); C180(1.38)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C417(1.12)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C417(0.99); C180(1.25)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C417(0.51); C180(2.29)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C417(1.73); C180(1.77)  LDD0665  [11]
 LDCM0349  AC83 PaTu 8988t C417(0.90); C180(0.99)  LDD1228  [11]
 LDCM0350  AC84 PaTu 8988t C417(0.99); C180(0.90)  LDD1229  [11]
 LDCM0351  AC85 PaTu 8988t C417(0.88); C180(1.04)  LDD1230  [11]
 LDCM0352  AC86 PaTu 8988t C417(0.98); C180(0.93)  LDD1231  [11]
 LDCM0353  AC87 PaTu 8988t C417(0.84); C180(1.06)  LDD1232  [11]
 LDCM0354  AC88 PaTu 8988t C417(0.90); C180(0.93)  LDD1233  [11]
 LDCM0355  AC89 PaTu 8988t C417(1.02); C180(0.92)  LDD1234  [11]
 LDCM0357  AC90 PaTu 8988t C417(0.97); C180(0.96)  LDD1236  [11]
 LDCM0358  AC91 PaTu 8988t C417(0.96); C180(0.90)  LDD1237  [11]
 LDCM0359  AC92 PaTu 8988t C417(1.05); C180(0.94)  LDD1238  [11]
 LDCM0360  AC93 PaTu 8988t C417(0.89); C180(0.79)  LDD1239  [11]
 LDCM0361  AC94 PaTu 8988t C417(0.95); C180(0.88)  LDD1240  [11]
 LDCM0362  AC95 PaTu 8988t C417(1.02); C180(0.94)  LDD1241  [11]
 LDCM0363  AC96 PaTu 8988t C417(1.00); C180(0.82)  LDD1242  [11]
 LDCM0364  AC97 PaTu 8988t C417(1.11); C180(0.83)  LDD1243  [11]
 LDCM0365  AC98 HCT 116 C180(0.78)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C180(1.03)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C417(1.06)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C417(1.10)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C417(1.52)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 12.17  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C45(1.40); C180(0.88)  LDD0078  [11]
 LDCM0367  CL1 HCT 116 C417(0.94)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C417(1.13)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C417(1.73)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C417(1.22)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C417(1.03)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C417(0.97)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C417(1.03)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C417(1.16)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C417(1.42)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C417(1.28)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C417(1.45)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C417(1.14)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C417(1.32)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C417(1.11)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C417(1.10)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C417(1.11)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C417(1.13)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C417(0.90)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C417(1.06)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C417(1.15)  LDD0703  [11]
 LDCM0387  CL117 PaTu 8988t C417(1.20)  LDD1266  [11]
 LDCM0388  CL118 PaTu 8988t C417(1.18)  LDD1267  [11]
 LDCM0389  CL119 PaTu 8988t C417(1.14)  LDD1268  [11]
 LDCM0390  CL12 HCT 116 C417(1.43)  LDD0707  [11]
 LDCM0391  CL120 PaTu 8988t C417(1.11)  LDD1270  [11]
 LDCM0392  CL121 HCT 116 C417(0.93)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C417(1.08)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C417(1.14)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C417(1.23)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C180(0.95)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C180(0.88)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C180(1.13)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C180(1.29)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C417(1.24)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C417(1.04)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C417(1.23)  LDD0719  [11]
 LDCM0403  CL16 PaTu 8988t C417(1.30); C180(1.05)  LDD1282  [11]
 LDCM0404  CL17 PaTu 8988t C417(1.44); C180(1.22)  LDD1283  [11]
 LDCM0405  CL18 PaTu 8988t C417(1.13); C180(1.33)  LDD1284  [11]
 LDCM0406  CL19 PaTu 8988t C417(1.31); C180(1.21)  LDD1285  [11]
 LDCM0407  CL2 HCT 116 C417(0.99)  LDD0724  [11]
 LDCM0408  CL20 PaTu 8988t C417(1.30); C180(1.10)  LDD1287  [11]
 LDCM0409  CL21 PaTu 8988t C417(1.50); C180(1.28)  LDD1288  [11]
 LDCM0410  CL22 PaTu 8988t C417(1.49); C180(1.27)  LDD1289  [11]
 LDCM0411  CL23 PaTu 8988t C417(1.35); C180(1.46)  LDD1290  [11]
 LDCM0412  CL24 PaTu 8988t C417(1.08); C180(1.34)  LDD1291  [11]
 LDCM0413  CL25 PaTu 8988t C417(1.21); C180(1.10)  LDD1292  [11]
 LDCM0414  CL26 PaTu 8988t C417(1.27); C180(1.11)  LDD1293  [11]
 LDCM0415  CL27 PaTu 8988t C417(1.20); C180(1.18)  LDD1294  [11]
 LDCM0416  CL28 PaTu 8988t C417(1.62); C180(1.41)  LDD1295  [11]
 LDCM0417  CL29 PaTu 8988t C417(1.62); C180(1.41)  LDD1296  [11]
 LDCM0418  CL3 HCT 116 C417(0.96)  LDD0735  [11]
 LDCM0419  CL30 PaTu 8988t C417(1.33); C180(1.24)  LDD1298  [11]
 LDCM0420  CL31 HCT 116 C180(1.42); C417(1.25)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C180(0.98); C417(1.13)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C180(0.91); C417(1.04)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C180(1.28); C417(1.42)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C180(1.52); C417(1.43)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C180(1.46); C417(1.30)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C180(1.44); C417(1.41)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C180(1.39); C417(1.42)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C417(1.06)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C180(1.27); C417(1.31)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C180(1.42); C417(1.20)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C180(1.46); C417(1.76)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C180(1.32); C417(1.49)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C180(1.29); C417(1.30)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C180(1.23); C417(1.49)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C180(1.27); C417(0.86)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C180(1.07); C417(0.88)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C180(0.96); C417(0.78)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C180(1.16); C417(0.79)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C417(1.09)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C180(1.14); C417(0.89)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C180(1.19); C417(0.78)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C180(1.18); C417(0.76)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C180(1.00); C417(0.74)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C180(1.08); C417(0.86)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C180(1.01); C417(0.75)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C180(0.98); C417(0.95)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C180(1.13); C417(0.81)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C180(1.02); C417(0.84)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C180(1.04); C417(0.89)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C417(1.04)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C180(1.13); C417(0.89)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C180(0.89); C417(1.11)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C180(1.15); C417(1.14)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C180(1.00); C417(1.08)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C180(1.32); C417(1.41)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C180(1.22); C417(1.30)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C180(1.15); C417(1.53)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C180(0.94); C417(1.45)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C180(1.15); C417(1.28)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C180(1.16); C417(1.01)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C417(1.28)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C180(0.93); C417(1.08)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C180(0.97); C417(1.21)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C180(1.13); C417(1.17)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C180(1.01); C417(1.10)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C180(1.27); C417(1.21)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C417(1.06)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C417(0.98)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C417(1.05)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C417(1.28)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C417(1.31)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C417(0.97)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C417(1.19)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C417(1.60)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C417(1.29)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C417(1.83)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C417(1.29)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C417(1.16)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C417(1.26)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C417(1.49)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C417(2.11)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C417(1.10)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C417(1.08)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C417(1.10)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C417(1.25)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C417(1.18)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C417(1.19)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C417(1.22)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C417(1.20)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C417(1.45)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C417(1.81)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C417(1.56)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C180(0.95)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C180(1.27)  LDD1702  [7]
 LDCM0468  Fragment33 HCT 116 C180(1.10); C417(1.35)  LDD0785  [11]
 LDCM0427  Fragment51 HCT 116 C180(1.45); C417(1.69)  LDD0744  [11]
 LDCM0616  Fragment61 Jurkat _(12.98)  LDD1489  [9]
 LDCM0615  Fragment63-R Jurkat _(15.87)  LDD1487  [9]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [9]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [9]
 LDCM0022  KB02 HEK-293T C180(0.87)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C180(0.97)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C417(4.09)  LDD3310  [18]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C156(1.56)  LDD2099  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C156(1.29)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C156(0.57)  LDD2109  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C156(1.00)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C156(1.14)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C156(0.96)  LDD2127  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C156(1.61)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C156(1.34)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C156(1.11)  LDD2137  [7]
 LDCM0003  Sulforaphane MDA-MB-231 3.05  LDD0160  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TRAF-interacting protein with FHA domain-containing protein A (TIFA) TIFA family Q96CG3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
9 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840